Abstract:
:Studies on the expression of beta-catenin (beta-ct) in gastric carcinoma have provided conflicting results, and the role played by beta-ct mutations in gastric carcinogenesis remains unclear. In an attempt to clarify the aforementioned issues we undertook the retrospective study of 157 gastric carcinomas by using immunohistochemistry and molecular genetics. Reduced/absent membranous beta-ct expression was significantly associated with isolated-cell/diffuse histotype both in "pure" diffuse gastric carcinomas and in the isolated-cell/diffuse component of mixed carcinomas. Cytoplasmic and/or nuclear beta-ct expression was particularly prevalent in mixed carcinomas and was significantly associated with lymphatic vessel invasion and lymph node metastases. beta-ct mutations were not detected in any case. We conclude that the pattern of beta-ct expression is closely related to gastric carcinoma histotype. The activation of Wnt/beta-ct pathway is associated with mixed gastric carcinoma and with features of clinical aggressiveness; the mechanism(s) underlying this pathway in gastric carcinoma are not due to beta-ct mutations and remain to be elucidated.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Nabais S,Machado JC,Lopes C,Seruca R,Carneiro F,Sobrinho-Simões Mdoi
10.1177/106689690301100102keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
1-9issue
1eissn
1066-8969issn
1940-2465journal_volume
11pub_type
杂志文章abstract::In this report, a case of metaplastic thymoma arising in a thymic cyst wall is discussed. The patient was a 61-year-old male whose chief complaint was sweating and chest pain. Imaging study revealed a mediastinal mass with right hemithoracic extension. He underwent surgical resection of the mass and remnants of the th...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908315754
更新日期:2009-02-01 00:00:00
abstract::Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896916646448
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abstract::Pleomorphic adenoma with foci of squamous and mucinous differentiation can potentially be misdiagnosed as low-grade mucoepidermoid carcinoma. The circumscribed borders of the tumor, gradual merging of mucoepidermoid foci into areas typical of pleomorphic adenoma, and presence of keratinization are features against the...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896909335509
更新日期:2009-08-01 00:00:00
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journal_title:International journal of surgical pathology
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doi:10.1177/1066896916680745
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journal_title:International journal of surgical pathology
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doi:10.1177/1066896907302117
更新日期:2007-07-01 00:00:00
abstract::A cystic swelling in the parotid gland should lead to a differential diagnosis that includes benign cystic lesion of the gland, benign tumors that are frequently associated with cystic degeneration or entirely cystic de novo, or even a malignant neoplasm. The case presented is that of a cystic parotid swelling of 2 ye...
journal_title:International journal of surgical pathology
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更新日期:2013-04-01 00:00:00
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journal_title:International journal of surgical pathology
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更新日期:2011-02-01 00:00:00
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journal_title:International journal of surgical pathology
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更新日期:2017-02-01 00:00:00
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journal_title:International journal of surgical pathology
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更新日期:2014-09-01 00:00:00
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journal_title:International journal of surgical pathology
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更新日期:2016-09-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
abstract::Ulcerative colitis-related epithelial dysplasia represents a premalignant lesion, which may lead to the development of ulcerative colitis-related adenocarcinoma. The proper management of this condition requires proctocolectomy before the acquisition of the invasive phenotype. Patients with chronic ulcerative colitis, ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690000800106
更新日期:2000-01-01 00:00:00
abstract::Mixed adenoneuroendocrine carcinomas (MANECs) of the biliary tract are rare tumors, and to date only a few cases arising in the gallbladder have been reported. Their histogenesis is a matter of debate, since the biliary tract normally lacks neuroendocrine cells. However, the immunohistochemical identification of nonne...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896915580433
更新日期:2015-08-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200115
更新日期:2004-01-01 00:00:00
abstract:AIMS. GIARDIA:is sometimes missed by the pathologist, and we sought to determine how often this occurs at our institution-a large tertiary care center with a subspecialty gastrointestinal pathology service and what certain clinical and histologic clues can be used to flag cases with a higher likelihood of infection, ta...
journal_title:International journal of surgical pathology
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更新日期:2020-08-10 00:00:00
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更新日期:2020-04-01 00:00:00
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journal_title:International journal of surgical pathology
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更新日期:2020-12-01 00:00:00
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journal_title:International journal of surgical pathology
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更新日期:2018-02-01 00:00:00
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journal_title:International journal of surgical pathology
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更新日期:2003-07-01 00:00:00
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更新日期:2008-10-01 00:00:00
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journal_title:International journal of surgical pathology
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更新日期:2014-08-01 00:00:00
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journal_title:International journal of surgical pathology
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更新日期:2012-08-01 00:00:00
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journal_title:International journal of surgical pathology
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journal_title:International journal of surgical pathology
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journal_title:International journal of surgical pathology
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更新日期:2009-06-01 00:00:00