Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis.

Abstract:

:Studies on the expression of beta-catenin (beta-ct) in gastric carcinoma have provided conflicting results, and the role played by beta-ct mutations in gastric carcinogenesis remains unclear. In an attempt to clarify the aforementioned issues we undertook the retrospective study of 157 gastric carcinomas by using immunohistochemistry and molecular genetics. Reduced/absent membranous beta-ct expression was significantly associated with isolated-cell/diffuse histotype both in "pure" diffuse gastric carcinomas and in the isolated-cell/diffuse component of mixed carcinomas. Cytoplasmic and/or nuclear beta-ct expression was particularly prevalent in mixed carcinomas and was significantly associated with lymphatic vessel invasion and lymph node metastases. beta-ct mutations were not detected in any case. We conclude that the pattern of beta-ct expression is closely related to gastric carcinoma histotype. The activation of Wnt/beta-ct pathway is associated with mixed gastric carcinoma and with features of clinical aggressiveness; the mechanism(s) underlying this pathway in gastric carcinoma are not due to beta-ct mutations and remain to be elucidated.

journal_name

Int J Surg Pathol

authors

Nabais S,Machado JC,Lopes C,Seruca R,Carneiro F,Sobrinho-Simões M

doi

10.1177/106689690301100102

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

1-9

issue

1

eissn

1066-8969

issn

1940-2465

journal_volume

11

pub_type

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