Abstract:
:We assessed the contribution of histopathological features to systemic recurrence (SR) in patients with colorectal cancer, using a case-control design: 71 cases and 184 controls were included, with a mean time until SR of 1.4 ± 0.1 years and a mean follow-up of controls of 1.6 ± 0.06 years. Cases had significantly greater odds of rectal site (odds ratio [OR] = 1.82), stage ≥ pT3 (OR = 2.11), suboptimal (<12) lymph node yield (OR = 4.6), stage ≥ pN1 (OR = 2.46), KRAS mutation (OR = 2.76), and extramural venous invasion (OR = 1.97). By multiple regression analysis, rectal site, stage ≥ pT3, suboptimal lymph node yield, and lymph node positivity independently predicted SR. Rectal cancers were more likely to have a suboptimal node yield than nonrectal cancers (relative risk = 1.6) among the entire cohort. We conclude that rectal cancers have greater risk of SR than colon cancers. A lower yield of lymph nodes in rectal cancer specimens may contribute to this.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Hayes BD,O'Riordan JM,Stuart C,Muldoon Cdoi
10.1177/1066896914534464subject
Has Abstractpub_date
2014-09-01 00:00:00pages
505-11issue
6eissn
1066-8969issn
1940-2465pii
1066896914534464journal_volume
22pub_type
杂志文章abstract::Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome-associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma th...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916680745
更新日期:2017-05-01 00:00:00
abstract::In this article, we report a very rare case of secondary angiosarcoma in a young woman with no prior history of breast cancer who had bilateral prophylactic mastectomies with autologous reconstruction due to a strong family history of breast cancer and BRCA1 gene variant of uncertain significance. The surgery was comp...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920930100
更新日期:2020-06-18 00:00:00
abstract::Pseudofungi are septate hyphae-like structures very similar morphologically to true fungal elements. Histologically their presence poses a diagnostic challenge as they mimic fungal infection. Accurate identification of pseudofungi is required to avoid unnecessary treatment, and this can be accomplished by careful morp...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916645185
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Benign neurogenic tumor involving the urinary bladder is a very rare and heterogeneous disease group. The clinical and radiological diagnosis may be difficult because of the disease's rarity and the histological similarities of each disease especially in needle biopsy specimens. However, accurate diagnosis i...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917742722
更新日期:2018-05-01 00:00:00
abstract::Micrometastases in lymph nodes and blood may provide important prognostic information. In this study, cytokeratin 20 (CK20) positive cells in lymph nodes and circulating CK20 mRNA were studied using 57 paraffin-embedded lymph node specimens and blood from 24 patients with pN0 colorectal cancer (CRC), respectively. Res...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907311901
更新日期:2008-04-01 00:00:00
abstract::A rare case of primary pleomorphic liposarcoma of the thigh with a myxoid component, in which divergent differentiation to a well-differentiated chondrosarcoma was focally present, is described. Presence of heterologous elements has mainly been recognized in the context of dedifferentiated liposarcomas. Few cases of b...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200115
更新日期:2004-01-01 00:00:00
abstract::Fibroadenoma and phyllodes tumors of the breast exhibit a continuum of pathologic features. We examined phyllodes tumors initially called fibroadenoma for features that may accurately classify the tumor as phyllodes tumor on the first biopsy specimen. The phyllodes tumors initially called fibroadenoma for features tha...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907311378
更新日期:2008-04-01 00:00:00
abstract::We report a case of polymorphous hemangioendothelioma, a rare vascular neoplasm, arising in the liver of a 51-year-old woman. Microscopically, this neoplasm is characterized by a polymorphous blend of solid, primitive vascular and angiomatous areas in variable proportions. Polymorphous hemangioendothelioma is consider...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896916679517
更新日期:2017-05-01 00:00:00
abstract::Intrasellar rhabdomyosarcoma is rare, and when arising in collusion with an unrelated entity, can present a diagnostic pitfall. We describe a case of a 56-year-old woman who presented with right eye ptosis and a pituitary mass, which was resected and diagnosed as atypical pituitary adenoma. Because of residual disease...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916658955
更新日期:2016-12-01 00:00:00
abstract::Vascular transformation of lymph node sinuses represents a rare benign entity mimicking malignant counterparts such as nodal Kaposi sarcoma. The presence of mildly atypical benign mesothelial cells within nodal sinuses raises the possibility of metastatic malignancy. Herein, a rare case of vascular transformation of l...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915622277
更新日期:2016-04-01 00:00:00
abstract::Ectopic adrenal cortical neoplasms are extremely rare, and only a few have involved the CNS. We report the first case of an intramedullary oncocytic adrenal cortical neoplasm of the spinal cord with immunohistochemical (IMHC) confirmation. A 27-year-old man presented with progressive lower extremity weakness, spastic ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200309
更新日期:2004-07-01 00:00:00
abstract::Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special tec...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908323505
更新日期:2011-02-01 00:00:00
abstract::Myositis ossificans (MO) and fibroosseous pseudotumor of digits (FP) are pseudotumoral mimics of malignancy. A review of 50 cases of MO and 14 cases of FP showed that a malignant diagnosis was suggested by referring pathologists in 23% of MO and 9% of FP. The most common misdiagnosis was osteosarcoma. Awareness of the...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100305
更新日期:2003-07-01 00:00:00
abstract::Mixed adenoneuroendocrine carcinomas (MANECs) of the biliary tract are rare tumors, and to date only a few cases arising in the gallbladder have been reported. Their histogenesis is a matter of debate, since the biliary tract normally lacks neuroendocrine cells. However, the immunohistochemical identification of nonne...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896915580433
更新日期:2015-08-01 00:00:00
abstract::The role of histopathology for diagnosing celiac disease (CD) has been recently challenged. However, based in our experience with roughly 4,600 distal duodenal and jejunal biopsies in children it is apparent that appropriate biopsy site, handling, processing, and microscopic evaluation result in a consistent pattern o...
journal_title:International journal of surgical pathology
pub_type: 社论
doi:10.1177/106689690100900401
更新日期:2001-10-01 00:00:00
abstract::Combined lung cancers containing both small cell and non-small cell carcinoma elements are uncommon but well recognized. Lung tumors with neuroendocrine differentiation form a group of histologically distinct tumors with differing clinical behavior ranging from low-grade tumors with good prognosis (typical carcinoid) ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896910397883
更新日期:2011-04-01 00:00:00
abstract::The rare reports of mucinous variant of follicular carcinoma of the thyroid gland have not provided enough evidence to support the recognition of these tumors as a distinct clinicopathologic entity or to understand their etiopathogenesis. We report the fourth case of mucinous variant of follicular carcinoma displaying...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896915617026
更新日期:2016-04-01 00:00:00
abstract::Pseudomembranes in colonic biopsies are normally associated with antibiotic related pseudomembranous colitis. Although pseudomembranes have rarely been reported in other conditions, their presence in rectal prolapse has not been previously reported. ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912468213
更新日期:2013-08-01 00:00:00
abstract::Malakoplakia is a rare granulomatous disease that commonly involves the genitourinary tract, with the urinary bladder being the most frequently affected site. Grossly, malakoplakia can present as soft yellow plaques, nodules, bladder mass, or even without any visible lesion. In this article, we present a 74-year-old f...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915595464
更新日期:2015-10-01 00:00:00
abstract::Spermatocytic tumor, formerly known as spermatocytic seminoma, is an uncommon testicular neoplasm which is a distinct clinicopathologic entity from classic seminoma. These tumors are not associated with germ cell neoplasia in situ, other germ cell tumors, or isochromosome 12p. Although typically, these tumors have an ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917706156
更新日期:2017-09-01 00:00:00
abstract::Rare cases of metastasis to uterine polyps have been reported in English literature but not, to the best of our knowledge, to uterine adenomyomas. All these cases are represented by breast cancer, most of them involving tamoxifen-associated polyps. We first report a case of cutaneous malignant melanoma metastatic to u...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690501300217
更新日期:2005-04-01 00:00:00
abstract::Background. In this single-institution study, we applied the current (eighth edition) American Joint Committee on Cancer pathologic staging criteria to 64 low-grade mucinous neoplasms of the appendix (LAMNs), examined their histopathologic features, and studied the patients' clinical outcomes. Design. Sixty-four LAMNs...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919883679
更新日期:2020-05-01 00:00:00
abstract::The purpose of our study was to investigate the diagnostic value of expression of IMP3, nucleophosmin, and correlation of these markers with Ki-67 proliferation index in papillary thyroid carcinoma and benign neoplasms of thyroid gland. The aim was also to investigate whether there is a difference between papillary an...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914554832
更新日期:2015-02-01 00:00:00
abstract::A 46-year-old man presented with nonproductive cough and lower limb swelling. Chest radiograph showed a left lower lobe lung mass and multiple subpleural nodules. Other investigations revealed that he had nephrotic syndrome. Core biopsies of the left lower lobe lung mass showed features of inflammatory pseudotumor wit...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920928584
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Acetylcholinesterase (AchE) histochemistry has been established as an accurate diagnostic tool for Hirschsprung's disease (HD). In addition, calretinin immunohistochemistry is also reported as a reliable and adjunctive method to diagnose HD. We investigated the diagnostic value of combined AchE histochemistr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918761235
更新日期:2018-09-01 00:00:00
abstract::Crystalloid granuloma (CG) of salivary gland is an extremely rare inflammatory disease, and only 6 cases have been reported in the English literature. CG is histologically characterized by a granulomatous reaction to amylase crystalloid deposition. A 73-year-old woman presented with a painful left neck mass. Computed ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896918791031
更新日期:2019-04-01 00:00:00
abstract::Cutaneous glomeruloid hemangioma is a hallmark of POEMS syndrome. These patients have elevated serum levels of vascular endothelial growth factor. The authors report an extracutaneous uterine glomeruloid hemangioma in an 82-year-old woman with a history of breast and endometrial carcinomas. Within the lumen of myometr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911429297
更新日期:2012-08-01 00:00:00
abstract:AIMS. GIARDIA:is sometimes missed by the pathologist, and we sought to determine how often this occurs at our institution-a large tertiary care center with a subspecialty gastrointestinal pathology service and what certain clinical and histologic clues can be used to flag cases with a higher likelihood of infection, ta...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920947795
更新日期:2020-08-10 00:00:00
abstract::In keeping with the stated goal of providing the surgical pathologist with tools to recognize abnormalities of the gastrointestinal (GI) tract due to drugs (AGIDS), in part II of this review we embark in a more organ-based description of AGIDS. Adequate space is given to the numerous adverse gastrointestinal effects o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896913502230
更新日期:2014-05-01 00:00:00
abstract::Intralymphatic histiocytosis (ILH) is a peculiar pathological process characterized by the collections of benign histiocytes in dilated lymph vessels. Although the majority of ILH patients present clinically with various forms of cutaneous manifestation, rare extracutaneous incidences have been reported in the literat...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916688307
更新日期:2017-06-01 00:00:00