Abstract:
BACKGROUND:Benign neurogenic tumor involving the urinary bladder is a very rare and heterogeneous disease group. The clinical and radiological diagnosis may be difficult because of the disease's rarity and the histological similarities of each disease especially in needle biopsy specimens. However, accurate diagnosis is very important because the clinical course of each disease, even within the same diseases, is quite variable. In this study, we investigated 7 benign neurogenic tumors to better understand the rare disease entity in the urinary bladder by analyzing histological and immunohistochemical findings and comparing clinicopathologic features. METHODS:We collected the cases by searching the medical records database of Seoul National University Hospital from 2000 to 2016. RESULTS:We identified 3 ganglioneuromas, 2 schwannomas, 1 neurofibroma, and 1 granular cell tumor involving the urinary bladder. There were some limitations for the initial clinical and radiological diagnosis and even pathologic diagnosis using needle biopsy specimens. One infant patient was diagnosed radiologically with rhabdomyosarcoma, but the final diagnosis changed to ganglioneuromatosis. The initial needle biopsy diagnosis of 2 ganglioneuroma cases showed neurofibroma. All patients underwent a local resection, and 1 granular cell tumor patient suffered with pain because of a recurrent tumor. One neurofibromatosis patient had a lesion appear 34 months after the bladder operation, so he underwent repeated debulking operations, but he was diagnosed with malignant transformation after 8 years. CONCLUSIONS:An understanding of benign neurogenic tumors involving the urinary bladder and the sharing of rare experiences surrounding them are required to provide accurate diagnoses.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Lee C,Kim B,Song B,Park JH,Moon KCdoi
10.1177/1066896917742722subject
Has Abstractpub_date
2018-05-01 00:00:00pages
221-228issue
3eissn
1066-8969issn
1940-2465journal_volume
26pub_type
杂志文章abstract::Diverticulosis of the appendix is a relatively rare pathological finding. The majority are acquired pseudodiverticula. True congenital diverticula are very rare. Appendiceal diverticulosis is usually an incidental finding and clinically asymptomatic. When symptomatic, it is usually complicated by acute or chronic dive...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896909332728
更新日期:2009-06-01 00:00:00
abstract::A 37-year-old woman was found to have multiple peritoneal nodules, including on the uterine serosa, at Cesarean section. Histology showed yellow crystalline material surrounded by histiocytes and occasional multinucleate giant cells. Further enquiry revealed that the patient underwent a cholecystectomy for a perforate...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911409930
更新日期:2012-02-01 00:00:00
abstract::Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described entity that, despite significant pleomorphism, carries a good prognosis. We briefly describe this tumor and its principal differential diagnoses. Recognition of SCPFTs, including the clinical context in which they arise, is important to avoid...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920938133
更新日期:2020-12-01 00:00:00
abstract::Reduction mammoplasty is a frequently performed procedure for the treatment of macromastia and for the achievement of symmetry in breast cancer patients following lumpectomy. Slides from 516 consecutive bilateral reduction mammoplasties performed for macromastia over 15 years were reviewed. Among these, 92 (18%) low-r...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907307176
更新日期:2008-01-01 00:00:00
abstract::The role of histopathology for diagnosing celiac disease (CD) has been recently challenged. However, based in our experience with roughly 4,600 distal duodenal and jejunal biopsies in children it is apparent that appropriate biopsy site, handling, processing, and microscopic evaluation result in a consistent pattern o...
journal_title:International journal of surgical pathology
pub_type: 社论
doi:10.1177/106689690100900401
更新日期:2001-10-01 00:00:00
abstract::Peritoneal metastasis in colorectal carcinoma is associated with a dismal prognosis; however, features that correlate with patterns of metastatic spread are not well characterized. We analyzed the clinicopathologic and molecular features of 166 patients with colorectal carcinomas stratified by metastases to the perito...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916664990
更新日期:2017-04-01 00:00:00
abstract::In this study based on the study of a centromeric DNA probe specific for chromosome 8 the authors standardized a method for the enzymatic detection of specific chromosome copy numbers on interphase nuclei from tumor tissue samples. Since the in situ hybridization (ISH) of chromosome 8 specific probe was revealed with ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690000800307
更新日期:2000-07-01 00:00:00
abstract::Sclerosing cholangitis is an autoimmune condition characterized by lymphocytic infiltration within the biliary epithelium leading to multifocal stricturing of the biliary tree. Primary sclerosing cholangitis (PSC) is the most common type encountered clinically. However, a similar process may occur in conjunction with ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908319777
更新日期:2011-02-01 00:00:00
abstract::Mixed adenoneuroendocrine carcinomas (MANECs) of the biliary tract are rare tumors, and to date only a few cases arising in the gallbladder have been reported. Their histogenesis is a matter of debate, since the biliary tract normally lacks neuroendocrine cells. However, the immunohistochemical identification of nonne...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896915580433
更新日期:2015-08-01 00:00:00
abstract::Objectives. The criteria for "active surveillance" depend in part on quantification of tumor extent and grade on prostate biopsies. It is known that false-negative biopsies may occur from incomplete sectioning of cores within the paraffin blocks. Methods. We retrospectively analyzed a prostate biopsy series, which wer...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920907690
更新日期:2020-08-01 00:00:00
abstract::In this article, we report the case of a 40-year-old woman with a sessile polyp of the rectosigmoid junction that underwent endoscopic resection. The resected specimen showed spindle cell proliferation with eosinophilic cytoplasm between mucosal crypts, mimicking mucosal prolapse syndrome. However, these were immunohi...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918818897
更新日期:2019-08-01 00:00:00
abstract::Ninety-eight consecutive surgical biopsies of oral mucosa from 96 patients were evaluated immunohistochemically with an anti-cytokeratin 20 (CK 20) anti-body to evidence Merkel cells (MC). Fifteen cases, showing the highest number of MC, were additionally studied with chromogranin A, S-100 protein, neuro filaments, ep...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896906290053
更新日期:2006-07-01 00:00:00
abstract::In this report, we present for the first time the coexistence of a conventional renal cell carcinoma (RCC) and an undefined Xp11 translocation renal neoplasm in distinct kidneys, which was difficult to definitively classify as either carcinoma or PEComa (perivascular epithelioid cell tumor). While one of the tumors sh...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915597753
更新日期:2016-05-01 00:00:00
abstract::Pseudofungi are septate hyphae-like structures very similar morphologically to true fungal elements. Histologically their presence poses a diagnostic challenge as they mimic fungal infection. Accurate identification of pseudofungi is required to avoid unnecessary treatment, and this can be accomplished by careful morp...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916645185
更新日期:2016-09-01 00:00:00
abstract::Pleomorphic adenoma with foci of squamous and mucinous differentiation can potentially be misdiagnosed as low-grade mucoepidermoid carcinoma. The circumscribed borders of the tumor, gradual merging of mucoepidermoid foci into areas typical of pleomorphic adenoma, and presence of keratinization are features against the...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909335509
更新日期:2009-08-01 00:00:00
abstract::A high level of serum alpha-fetoprotein (AFP) is typically indicative of hepatocellular carcinoma in patients with liver lesions. In this article, we describe an exceptional case of intrahepatic cholangiocarcinoma that occurred in a 36-year-old man with a markedly elevated serum AFP level (12310.7 ng/mL). Histopatholo...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907304519
更新日期:2008-04-01 00:00:00
abstract::Simple melanosis of the bladder is an uncommon condition with fewer than 15 reported cases characterized by multifocal, diffuse melanin pigmentation of the urothelial mucosa. It is frequently associated with urinary incontinence or urgency. Histologically, melanin granules are present within urothelial cells or lamina...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909352863
更新日期:2010-12-01 00:00:00
abstract::The sarcomatoid variant of anaplastic large cell lymphoma is an extremely rare histologic pattern of anaplastic large cell lymphoma that consists of spindle-shaped neoplastic cells and is easily misdiagnosed as a soft tissue sarcoma. We report a case of the sarcomatoid variant of anaplastic large cell lymphoma that wa...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920986967
更新日期:2021-01-11 00:00:00
abstract::We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies (MUC5AC, MUC6, SOX2, and CDX2). Nonmetaplastic mucosa had histologic evidence o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916672332
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Protein kinase C βII promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro. OBJECTIVE:To investigate PKC-βII expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations. METHO...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917706026
更新日期:2017-09-01 00:00:00
abstract::Cystic neoplasms of the pancreas are rare and often mistaken for pseudocyst by imaging studies and macroscopic examination. We describe an unusual tumor of the pancreas composed of a mural nodule of anaplastic carcinoma arising from a huge ductal adenocarcinoma undergoing cystic degeneration. The cyst measured 27 x 13...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100315
更新日期:2003-07-01 00:00:00
abstract::Male endometriosis and endomyometriosis (also termed "uterus-like mass") are 2 unusual manifestations of endometriosis. We report a case of male endomyometriosis with immunohistochemical and molecular confirmation. A 52-year-old man presented with stabbing pelvic pain. Computed tomography scan showed a mass in the rig...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896913501385
更新日期:2014-08-01 00:00:00
abstract::Micrometastases in lymph nodes and blood may provide important prognostic information. In this study, cytokeratin 20 (CK20) positive cells in lymph nodes and circulating CK20 mRNA were studied using 57 paraffin-embedded lymph node specimens and blood from 24 patients with pN0 colorectal cancer (CRC), respectively. Res...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907311901
更新日期:2008-04-01 00:00:00
abstract::Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) are round-cell sarcomas with varying degrees of neuroectodermal differentiation; they are considered members of the same family of tumors based on their common genetic profile. ES/PNET are very infrequent in the female genital tract, the vagina being the ra...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896911424898
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:The phenomenon of vanishing carcinomas, first described in context of prostatic carcinomas, has been documented in endometrial carcinomas as well. METHODS:The archives of the department were searched for case files of endometrial carcinoma diagnosed on endometrial curetting/biopsy but which did not reveal a...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918783581
更新日期:2019-02-01 00:00:00
abstract::We report the case of a sclerosing perineurioma with conspicious collagen rosette formation in a 20-year-old male presenting with a firm, painless nodule on the palmar side of his right ring finger. The main differential diagnosis is a low-grade fibromyxoid sarcoma. The distinction between these entities is important ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917741551
更新日期:2018-04-01 00:00:00
abstract::Sclerosing spindle cell rhabdomyosarcoma (SSRMS) is a newly recognized entity in adults. The authors report a new case of SSRMS in a 31-year-old woman who presented with a large right leg mass. Biopsy revealed a malignant spindle cell neoplasm with focal sclerotic areas. A diagnosis of monophasic synovial sarcoma was ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896908327166
更新日期:2010-10-01 00:00:00
abstract::Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine neoplasms (NENs) can also occur. The majority of NENs are represented by neuroendocrine carcinomas (NECs), while neuroendocrine tumors (NETs) are extremely rare in this lo...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920986987
更新日期:2021-01-09 00:00:00
abstract::Lanthanum carbonate (LC) is a new type of phosphate adsorbent used to treat patients with hyperphosphatemia caused by chronic kidney diseases. Recent studies have pointed out that lanthanum deposition can be found in the cytoplasm of histiocytes in the gastroduodenal mucosa of these patients. On the other hand, it is ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917718623
更新日期:2017-12-01 00:00:00
abstract::Carcinomas in the breast with a predominantly clear cytoplasm are rare. In this article, we review the differential diagnosis of clear cell breast neoplasms and report a case of invasive lobular carcinoma with extensive clear cell morphology that was diagnosed as invasive ductal carcinoma, not otherwise specified, on ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919881705
更新日期:2020-04-01 00:00:00