Abstract:
:Micrometastases in lymph nodes and blood may provide important prognostic information. In this study, cytokeratin 20 (CK20) positive cells in lymph nodes and circulating CK20 mRNA were studied using 57 paraffin-embedded lymph node specimens and blood from 24 patients with pN0 colorectal cancer (CRC), respectively. Results showed that 29 out of 56 (52%) lymph node specimens had CK20-positive cells (range: 1-35). Follow-up of the patients for 12 months indicated that 4 patients (7%) had CRC metastases to liver, lung, and bone. In addition, 8 out of 24 (33%) samples had at least 2-fold circulating CK20 mRNA expression higher than the pooled normal sample. This study provides evidence that CK20-positive cells were found in the lymph nodes and differentially expressed circulating CK20 mRNA was also detected in the blood from patients with pN0 CRC. Long-term follow-up is necessary to study their prognostic use in patients with non-metastatic CRC.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Wong CS,Cheung MT,Ma BB,Pun Hui E,Chan AC,Chan CK,Lee KC,Cheuk W,Lam MY,Wong MC,Chan CM,Chan JK,Chan ATdoi
10.1177/1066896907311901subject
Has Abstractpub_date
2008-04-01 00:00:00pages
119-26issue
2eissn
1066-8969issn
1940-2465pii
1066896907311901journal_volume
16pub_type
杂志文章abstract::Vascular transformation of lymph node sinuses represents a rare benign entity mimicking malignant counterparts such as nodal Kaposi sarcoma. The presence of mildly atypical benign mesothelial cells within nodal sinuses raises the possibility of metastatic malignancy. Herein, a rare case of vascular transformation of l...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915622277
更新日期:2016-04-01 00:00:00
abstract::Pleomorphic adenoma with foci of squamous and mucinous differentiation can potentially be misdiagnosed as low-grade mucoepidermoid carcinoma. The circumscribed borders of the tumor, gradual merging of mucoepidermoid foci into areas typical of pleomorphic adenoma, and presence of keratinization are features against the...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909335509
更新日期:2009-08-01 00:00:00
abstract::Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920917445
更新日期:2020-12-01 00:00:00
abstract::Ectopic adrenal cortical neoplasms are extremely rare, and only a few have involved the CNS. We report the first case of an intramedullary oncocytic adrenal cortical neoplasm of the spinal cord with immunohistochemical (IMHC) confirmation. A 27-year-old man presented with progressive lower extremity weakness, spastic ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200309
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:The phenomenon of vanishing carcinomas, first described in context of prostatic carcinomas, has been documented in endometrial carcinomas as well. METHODS:The archives of the department were searched for case files of endometrial carcinoma diagnosed on endometrial curetting/biopsy but which did not reveal a...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918783581
更新日期:2019-02-01 00:00:00
abstract::Background. Solitary circumscribed neuroma (SCN), also known as palisaded encapsulated neuroma (PEN), is a benign neural tumor. It may be mistaken as either schwannoma or neurofibroma in pathology practice. In this study, we aimed to define clinicopathologic and immunohistochemical features and discuss its differentia...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919833172
更新日期:2019-08-01 00:00:00
abstract::In this article, we report the case of a 40-year-old woman with a sessile polyp of the rectosigmoid junction that underwent endoscopic resection. The resected specimen showed spindle cell proliferation with eosinophilic cytoplasm between mucosal crypts, mimicking mucosal prolapse syndrome. However, these were immunohi...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918818897
更新日期:2019-08-01 00:00:00
abstract::The true incidence of light chain deposition disease (LCDD) restricted to the central nervous system (CNS) is unknown. To our knowledge only 7 cases of LCDD restricted to the brain have been previously reported. We herein describe an unusual example. A 44-year-old man presented with a history of ischemic retinopathy i...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896917717338
更新日期:2017-12-01 00:00:00
abstract::To further study the characteristics of renal cell carcinoma (RCC) in young patients and better define their biological features, 46 RCCs of patients younger than 25 years were morphologically and immunohistochemically characterized with follow-up. Loss of heterozygosity (LOH) analysis of the von Hippel-Lindau (VHL) g...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909354337
更新日期:2011-04-01 00:00:00
abstract::A 37-year-old woman was found to have multiple peritoneal nodules, including on the uterine serosa, at Cesarean section. Histology showed yellow crystalline material surrounded by histiocytes and occasional multinucleate giant cells. Further enquiry revealed that the patient underwent a cholecystectomy for a perforate...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911409930
更新日期:2012-02-01 00:00:00
abstract::Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908328575
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:To avoid diagnostic errors such as missed diagnosis and errors in staging tumors due to inadequate tissue sampling, pathologists submit additional sections (AS). OBJECTIVE:This study assessed frequency, diagnostic yield, distribution, and cost of AS. METHOD:Among 1542 AS cases, we calculated mean AS per ca...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918755008
更新日期:2018-08-01 00:00:00
abstract::Goblet cell carcinoid (GCC) of the appendix is characterized by a dual differentiation of both endocrine and gland. This study, therefore, explores its clinicopathological and immunohistochemical features. The authors reviewed clinicopathological and immunohistochemical features of 26 GCC cases in Southwest China betw...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896910379404
更新日期:2010-12-01 00:00:00
abstract::Objectives. The criteria for "active surveillance" depend in part on quantification of tumor extent and grade on prostate biopsies. It is known that false-negative biopsies may occur from incomplete sectioning of cores within the paraffin blocks. Methods. We retrospectively analyzed a prostate biopsy series, which wer...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920907690
更新日期:2020-08-01 00:00:00
abstract::Malignant melanoma has a variety of morphologic patterns and can metastasize and mimic any type of neoplastic process creating significant diagnostic difficulty. When metastasis to the gastrointestinal system is identified, it is most commonly associated with widely metastatic disease. We report a rare case of isolate...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915588932
更新日期:2015-08-01 00:00:00
abstract::Primary pulmonary acinic cell carcinoma (ACC) is rare. The clinicopathological features are not identical to that of classic ACC that leads to misdiagnosis. In this article, we summarized the clinicopathological features of 25 such cases, including 6 cases in this series and additional 19 cases in the literature. Pulm...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896919836499
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Acetylcholinesterase (AchE) histochemistry has been established as an accurate diagnostic tool for Hirschsprung's disease (HD). In addition, calretinin immunohistochemistry is also reported as a reliable and adjunctive method to diagnose HD. We investigated the diagnostic value of combined AchE histochemistr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918761235
更新日期:2018-09-01 00:00:00
abstract::A 61-year-old woman presented with solitary lymphadenopathy suspicious for lymphoma. An excisional biopsy of a right inguinal lymph node demonstrated metastatic Merkel cell carcinoma (MCC). No skin lesions were detected, but a primary nasopharyngeal mass was identified. A microscopic examination of the nasopharyngeal ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896910371638
更新日期:2010-10-01 00:00:00
abstract::Cervical cancer is the most common gynecologic malignancy of the developing world. The oncogenic role of human papilloma virus (HPV) is well known. Attention is now focusing on the complicit genetic changes, which allow progression of these tumors. Regarding these changes, deletion of tumor suppressor genes (loss of h...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100402
更新日期:2003-10-01 00:00:00
abstract::Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine neoplasms (NENs) can also occur. The majority of NENs are represented by neuroendocrine carcinomas (NECs), while neuroendocrine tumors (NETs) are extremely rare in this lo...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920986987
更新日期:2021-01-09 00:00:00
abstract::We present a case of clear cell meningioma with unusual clinical and pathologic features. The patient was a 54-year-old man who underwent laminectomy and durotomy for an intradural tumor in the lumbar spinal canal. Sections showed a predominance of dense collagenous tissue with irregularly shaped and irregularly sized...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912470165
更新日期:2013-08-01 00:00:00
abstract::Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare tumor-like lesion with unclear pathogenesis. Collision lesions of CAPNONs with neoplasms are occasionally reported. In this article, we report the first case of collision lesions between CAPNON and rheumatoid nodules (RNs) in a patient with systemic lupus er...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920941939
更新日期:2020-07-15 00:00:00
abstract::Juvenile xanthogranuloma (JXG) is a benign histiocytic disorder usually affecting the head and trunk region of a child. The isolated occurrence of JXG in the penile shaft of a young adult is hitherto unreported. This lesion is amenable to surgical resection although systemic and/or internal visceral involvement can oc...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920916242
更新日期:2020-09-01 00:00:00
abstract::We describe a rare case of glomus tumor of the duodenum. The tumor was detected in a 46-year-old man being investigated for episodes of gastrointestinal bleeding. The excised specimen showed a 2.3 x 1.5 x 1.5 cm gray-tan tumor involving the mucosa and the submucosa. The overlying mucosa was focally ulcerated. Histolog...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200417
更新日期:2004-10-01 00:00:00
abstract::Palisaded mammary-type myofibroblastoma is a rare variant of benign stromal spindle cell tumor whose histological features are well known. Nevertheless, no cytological features have been reported to date. In this article, we describe the cytological features of a case of palisaded mammary-type myofibroblastoma in whic...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916665699
更新日期:2017-04-01 00:00:00
abstract::We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies (MUC5AC, MUC6, SOX2, and CDX2). Nonmetaplastic mucosa had histologic evidence o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916672332
更新日期:2017-05-01 00:00:00
abstract::Primitive neuroepithelial differentiation in malignant peripheral nerve sheath tumors (MPNSTs) has been reported in children but is extremely rare in adults. The authors report the case of a 70-year-old woman who presented with swelling of the right leg of 1-month duration. Fine-needle aspiration cytology was suggesti...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911432453
更新日期:2012-10-01 00:00:00
abstract::Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) are round-cell sarcomas with varying degrees of neuroectodermal differentiation; they are considered members of the same family of tumors based on their common genetic profile. ES/PNET are very infrequent in the female genital tract, the vagina being the ra...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896911424898
更新日期:2012-06-01 00:00:00
abstract::Specimen misidentification is a common cause of errors in surgical pathology. We report a case where bone-marrow biopsies from patients of different genders were mislabeled and molecular methods were applied to resolve the identity. A short tandem repeat (STR)-polymerase chain reaction-based assay, commonly used in pa...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690501300304
更新日期:2005-07-01 00:00:00
abstract::Clear cell chondrosarcoma (CCCS) is a rare variant of conventional chondrosarcoma with low-grade malignant features that may be confused radiographically and histologically with chondroblastoma. We report a case of a 50-year-old female who presented with 6 months of left hip pain. Initial radiographs demonstrated an o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918776092
更新日期:2018-12-01 00:00:00