Microsatellite analysis of early stage (Ia-IIb) uterine cervical squamous carcinoma.

Abstract:

:Cervical cancer is the most common gynecologic malignancy of the developing world. The oncogenic role of human papilloma virus (HPV) is well known. Attention is now focusing on the complicit genetic changes, which allow progression of these tumors. Regarding these changes, deletion of tumor suppressor genes (loss of heterozygosity [LOH]) is the preferred pathway of progression with only a subset manifesting microsatellite instability (MSI). Implicated loci include 3p14.1-22. Several studies suggest that the mutator phenotype in cervical cancer may correlate with higher grade tumors, more advanced disease stage, and poor outcome. Unlike colorectal cancer, in which an inverse relationship has been demonstrated between microsatellite instability and loss of heterozygosity, cervical cancers expressing MSI have been found to coexpress LOH at other loci. In this study we analyzed 8-microsatellite loci including p53, DCC, APC, the MMR gene hMLH1 and 2 regions of interest on chromosome 3 in a high-risk population group in which HPV infection is endemic.

journal_name

Int J Surg Pathol

authors

Clarke B,Gordon M,Moodley M,Naidoo R,Chetty R

doi

10.1177/106689690301100402

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

253-60

issue

4

eissn

1066-8969

issn

1940-2465

journal_volume

11

pub_type

杂志文章
  • Pleomorphic adenoma with mucinous and squamous differentiation: a mimicker of mucoepidermoid carcinoma.

    abstract::Pleomorphic adenoma with foci of squamous and mucinous differentiation can potentially be misdiagnosed as low-grade mucoepidermoid carcinoma. The circumscribed borders of the tumor, gradual merging of mucoepidermoid foci into areas typical of pleomorphic adenoma, and presence of keratinization are features against the...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896909335509

    authors: Guo SP,Cheuk W,Chan JK

    更新日期:2009-08-01 00:00:00

  • Ductal adenocarcinoma of the pancreas with huge cystic degeneration: a lesion to be distinguished from pseudocyst and mucinous cystadenocarcinoma.

    abstract::Cystic neoplasms of the pancreas are rare and often mistaken for pseudocyst by imaging studies and macroscopic examination. We describe an unusual tumor of the pancreas composed of a mural nodule of anaplastic carcinoma arising from a huge ductal adenocarcinoma undergoing cystic degeneration. The cyst measured 27 x 13...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690301100315

    authors: Lee LY,Hsu HL,Chen HM,Hsueh C

    更新日期:2003-07-01 00:00:00

  • Cystic Squamous Cell Carcinomas of the Jaws: Twelve Cases Highlighting Histopathological Pitfalls.

    abstract::Cystic squamous cell carcinomas (SCCs) of the jaws, including carcinoma cuniculatum, are rare, slow growing, and relentlessly invasive. The aim of this article is to present 12 cases, 4 of which were designated as carcinoma cuniculatum on the basis of deeply endophytic, anastomosing channels of cystic stratified squam...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920903388

    authors: Barrett AW,Garg M,Armstrong D,Bisase BS,Newman L,Norris PM,Shelley M,Tighe JV,Hyde NC,Chaston NJ,Gulati A

    更新日期:2020-09-01 00:00:00

  • Primary carcinoid tumor of the skin: a literature review.

    abstract::Primary carcinoid tumor of the skin (PCTS) is an uncommon indolent neoplasm, with 10 cases described in the literature. The tumors affect patients in the sixth to ninth decades of life (mean = 66.3 years) with an equal gender distribution and predilection for the head and trunk. They present as slowly enlarging nodule...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896913516672

    authors: Jedrych J,Pulitzer M

    更新日期:2014-04-01 00:00:00

  • Adenomatous polyposis coli (APC) protein expression in primary and metastatic serous ovarian carcinoma.

    abstract::The aim of this study was to investigate protein expression of adenomatous polyposis coli (APC) in primary and metastatic serous ovarian carcinoma. The expression of beta-catenin and E-cadherin was additionally analyzed. One hundred and thirteen primary (n = 56) and metastatic (n = 57) lesions were immunohistochemical...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690201000302

    authors: Karbova E,Davidson B,Metodiev K,Tropé CG,Nesland JM

    更新日期:2002-07-01 00:00:00

  • Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis.

    abstract::Clear cell chondrosarcoma (CCCS) is a rare variant of conventional chondrosarcoma with low-grade malignant features that may be confused radiographically and histologically with chondroblastoma. We report a case of a 50-year-old female who presented with 6 months of left hip pain. Initial radiographs demonstrated an o...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896918776092

    authors: Kiefer RM,Wojcik J,Cooper K,Weber KL,Sebro R

    更新日期:2018-12-01 00:00:00

  • Early colonic perineurioma: a report of 11 cases.

    abstract::Colonic perineurioma has been depicted as characterized by a mucosal proliferation of monomorphic spindle perineurial cells leading to an evident separation, distortion, and entrapment of colonic crypts. The authors, however, believe that a sizable subset of the cases differ in that they display only a limited perineu...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896909350883

    authors: Groisman G,Amar M,Alona M

    更新日期:2010-08-01 00:00:00

  • Rectal site and suboptimal nodal yield predict systemic recurrence in resected colorectal carcinoma: a case-control study.

    abstract::We assessed the contribution of histopathological features to systemic recurrence (SR) in patients with colorectal cancer, using a case-control design: 71 cases and 184 controls were included, with a mean time until SR of 1.4 ± 0.1 years and a mean follow-up of controls of 1.6 ± 0.06 years. Cases had significantly gre...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896914534464

    authors: Hayes BD,O'Riordan JM,Stuart C,Muldoon C

    更新日期:2014-09-01 00:00:00

  • Collision Lesions of Calcifying Pseudoneoplasm of the Neuraxis and Rheumatoid Nodules: A Case Report With New Pathogenic Insights.

    abstract::Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare tumor-like lesion with unclear pathogenesis. Collision lesions of CAPNONs with neoplasms are occasionally reported. In this article, we report the first case of collision lesions between CAPNON and rheumatoid nodules (RNs) in a patient with systemic lupus er...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920941939

    authors: Lu JQ,Popovic S,Provias J,Cenic A

    更新日期:2020-07-15 00:00:00

  • Clear cell change in colonic polyps.

    abstract::In this study, the pathogenesis of clear cell change in colorectal epithelial lesions was studied. A total of 4 cases of clear cell change (1 hyperplasic polyp and 3 adenomas) were characterized using histochemistry, immunohistochemistry, and electron microscopy. All lesions developed in the left colon. In all, 1 aden...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908319211

    authors: Eloy C,Lopes JM,Faria G,Moreira H,Brandão A,Silva T,Carneiro F

    更新日期:2009-12-01 00:00:00

  • Clinicopathologic analysis of 4 perivascular epithelioid cell tumors (PEComas) of the gastrointestinal tract.

    abstract::This study describes the clinical, histologic, and immunohistochemical features of four cases of GI PEComa. The size of the tumors ranged from 3.5 to 6.0cm in diameter, and all were located in wall of the large bowel. Microscopically, the tumors were characterized by an epithelioid arrangement of tumor cells, which ha...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908330481

    authors: Shi HY,Wei LX,Sun L,Guo AT

    更新日期:2010-08-01 00:00:00

  • Squamous metaplasia on the breast implant capsule.

    abstract::The development of squamous metaplasia or carcinoma is a rare occurrence in the setting of a ruptured or leaking silicone breast implant capsule. However, the oncogenic process in such a context is yet another intriguing example of how chronic inflammation plays an integral role in the tumorigenic process. Recent pape...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908329587

    authors: Alikhan MB,Nassar A,Mansoor I

    更新日期:2010-12-01 00:00:00

  • Dedifferentiated Liposarcoma Mimicking a Primary Colon Mass.

    abstract::Dedifferentiated liposarcoma is typically a nonlipogenic high-grade sarcoma that arises from well-differentiated liposarcoma. It most commonly presents as a large mass in the retroperitoneum. Significant involvement of the gastrointestinal tract by dedifferentiated liposarcoma is uncommon. We present a unique case of ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896917731517

    authors: Hollowoa B,Lamps LW,Mizell JS,English GW 3rd,Bridge JA,Ram R,Gardner JM

    更新日期:2018-04-01 00:00:00

  • Low-Grade, Nonintestinal Nonsalivary Sinonasal Adenocarcinoma Associated With an Exophytic Schneiderian Papilloma: A Case Report.

    abstract::Sinonasal adenocarcinoma is a rare tumor of the head and neck accounting for 10% to 20% of all primary malignancies of the nose and paranasal sinuses. There tumors are classified as salivary, intestinal and nonintestinal, nonsalivary. Low-grade nonintestinal nonsalivary are rare tumors whose diagnosis is essentially t...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915599060

    authors: Blumberg JM,Escobar-Stein J,Vining EM,Prasad ML

    更新日期:2015-12-01 00:00:00

  • Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway?

    abstract::We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies (MUC5AC, MUC6, SOX2, and CDX2). Nonmetaplastic mucosa had histologic evidence o...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916672332

    authors: Rolim I,Rodrigues RV,Bettencourt A,Barros R,Camilo V,Dias Pereira A,Almeida R,Chaves P

    更新日期:2017-05-01 00:00:00

  • Mucinous Variant of Follicular Carcinoma of the Thyroid Gland: Case Report and Review of the Literature.

    abstract::The rare reports of mucinous variant of follicular carcinoma of the thyroid gland have not provided enough evidence to support the recognition of these tumors as a distinct clinicopathologic entity or to understand their etiopathogenesis. We report the fourth case of mucinous variant of follicular carcinoma displaying...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896915617026

    authors: Squillaci S,Pitino A,Spairani C,Ferrari M,Carlon E,Cosimi MF

    更新日期:2016-04-01 00:00:00

  • Well-differentiated chondrosarcoma of the humerus with prominent granular cell component: a hitherto unreported occurrence.

    abstract::We report the case of a well-differentiated chondrosarcoma of the proximal humerus in a 60-year-old man that featured a prominent component of granular cells, the granules being shown by electron microscopy to be lysosomal. Although secondary granular cell changes have been described in a large variety of tumor types,...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690601400211

    authors: Cremonini A,Kuhn E,De Biase P,Franchi A

    更新日期:2006-04-01 00:00:00

  • Malignant mesothelioma masquerading as a multinodular bronchioloalveolar cell adenocarcinoma with widespread pulmonary nodules.

    abstract::A 72-year-old man had a unilateral pleural effusion and multiple bilateral pulmonary nodules. Thoracoscopic biopsy revealed multiple discrete nodules in the pleura and lung. The latter consisted of tall columnar malignant cells arranged on alveolar surfaces in a lepidic growth pattern. Mucin filled the alveolar lumina...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896906290363

    authors: Felner KJ,Wieczorek R,Kline M,Smith RL,Sidhu GS

    更新日期:2006-07-01 00:00:00

  • A case of clear cell meningioma with tyrosine-rich crystals.

    abstract::We present a case of clear cell meningioma with unusual clinical and pathologic features. The patient was a 54-year-old man who underwent laminectomy and durotomy for an intradural tumor in the lumbar spinal canal. Sections showed a predominance of dense collagenous tissue with irregularly shaped and irregularly sized...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896912470165

    authors: Schollenberg E,Easton AS

    更新日期:2013-08-01 00:00:00

  • Circulating Breast Carcinoma Cells Mimicking Therapy-Related Acute Myeloid Leukemia.

    abstract::Circulating tumor cells are rare in peripheral blood smears. We report the case of a patient with circulating breast carcinoma cells resembling circulating myeloid blasts and provide a brief review of the literature. Peripheral blood smears and a bone marrow aspirate were examined morphologically and by flow cytometry...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916664986

    authors: Rowan DJ,Logunova V,van Tuinen P,Olteanu H,Peterson JF

    更新日期:2017-02-01 00:00:00

  • Pigmented Ependymoma of the Fourth Ventricle-A Curious Entity: Report of a Rare Case With Review of Literature.

    abstract::A 16-year-old boy presented with a tumor located in fourth ventricle, which showed histological features of an ependymoma replete with perivascular pseudorosettes and true ependymal rosettes. Interestingly, many of the tumor cells exhibited abundant cytoplasm stuffed with a grayish brown pigment. Histochemical stains ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920926700

    authors: Malhotra A,Rao S,Santhoshkumar R,Muralidharan N,Mitra S,Shetty S

    更新日期:2021-02-01 00:00:00

  • T-cell-rich B-cell lymphoma presenting in the spleen: a clinicopathologic analysis of 3 cases.

    abstract::We review the clinical, pathologic, and molecular genetic features of 3 splenic T-cell-rich B-cell lymphomas and discuss their differential diagnosis. All patients presented with symptomatic splenomegaly and underwent diagnostic/therapeutic splenectomy. Microscopically, the spleen in all cases showed a micronodular pr...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690401200105

    authors: Li S,Mann KP,Holden JT

    更新日期:2004-01-01 00:00:00

  • Fuzeon-induced collagenophagic granuloma: a peculiar granulomatous injection site reaction to Fuzeon--a case report and review of literature.

    abstract::Enfuvirtide (ENF, T-20, or Fuzeon [Hoffman-La Roche Inc, Nutley, NJ, and Trimeris, Inc, Durham, NC]) is an HIV-1 fusion inhibitor and is the only injectable antiretroviral drug available. Injection site reactions (ISRs) are the most frequently reported adverse events, occurring in about 98% of patients. A granuloma an...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896909332119

    authors: Sidhu HK,Chaffee BH,Tvetenstrand CD,Sidhu JS

    更新日期:2010-10-01 00:00:00

  • Pseudofungi: A Diagnostic Pitfall.

    abstract::Pseudofungi are septate hyphae-like structures very similar morphologically to true fungal elements. Histologically their presence poses a diagnostic challenge as they mimic fungal infection. Accurate identification of pseudofungi is required to avoid unnecessary treatment, and this can be accomplished by careful morp...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916645185

    authors: Lyapichev KA,Agarwal AN,Rosenberg AE,Chapman JR

    更新日期:2016-09-01 00:00:00

  • Benign fibro-osseous lesions of the jaws: a study of 127 Chinese patients and review of the literature.

    abstract::The aim of this study is to analyze all the cases of benign fibro-osseous lesions treated at School and Hospital of Stomatology, Wuhan University, to compare the results obtained in this study with those previously documented by other authors. The 127 cases diagnosed as a fibro-osseous lesion were retrieved, and infor...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896908318744

    authors: Alsharif MJ,Sun ZJ,Chen XM,Wang SP,Zhao YF

    更新日期:2009-04-01 00:00:00

  • Intra-Alveolar Intestinal Epithelium: A Reappraisal of the So-Called Mucinous Goblet-Cell Rich Carcinoma Apropos of Two Cases With Prolonged Follow-up and Literature Review.

    abstract::Primary pulmonary mucin-rich lesions with abundant goblet cells growing within alveolar spaces are either classified as mucinous adenocarcinoma (previously called mucinous bronchioloalveolar carcinoma) or colloid carcinoma. Some of these lesions display a morphologic pattern characterized by paucicellular discontinuou...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896915568992

    authors: Jessurun J

    更新日期:2015-05-01 00:00:00

  • Invasive Lobular Carcinoma With Extensive Clear Cells: A Pitfall in Diagnosis.

    abstract::Carcinomas in the breast with a predominantly clear cytoplasm are rare. In this article, we review the differential diagnosis of clear cell breast neoplasms and report a case of invasive lobular carcinoma with extensive clear cell morphology that was diagnosed as invasive ductal carcinoma, not otherwise specified, on ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896919881705

    authors: Kavesh MH,Sanchez D,Asirvatham JR

    更新日期:2020-04-01 00:00:00

  • Warthin Tumor-Like Mucoepidermoid Carcinoma.

    abstract::Mucoepidermoid carcinoma (MEC) shows a wide morphologic spectrum, including epithelium with oncocytic or squamous metaplastic changes overlying a prominent cystic architecture, as well as tumor-associated lymphoid tissue. We illustrate a case of MEC of the parotid in a 17-year-old female, in which all these features o...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896917724889

    authors: Heatley N,Harrington KJ,Thway K

    更新日期:2018-02-01 00:00:00

  • Synchronous gastric gastrointestinal stromal tumor and signet-ring cell adenocarcinoma: a case report.

    abstract::Synchronous tumors of the stomach are uncommon. We present a unique case of gastric synchronous tumors composed of signet-ring cell adenocarcinoma and gastrointestinal stromal tumor (GIST). The two tumors arose at the same site and were sharply juxtaposed without intermingling of morphologically distinct elements. Coi...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907302369

    authors: Lee FY,Jan YJ,Wang J,Yu CC,Wu CC

    更新日期:2007-10-01 00:00:00

  • Identification of mislabeled specimen by molecular methods: case report and review.

    abstract::Specimen misidentification is a common cause of errors in surgical pathology. We report a case where bone-marrow biopsies from patients of different genders were mislabeled and molecular methods were applied to resolve the identity. A short tandem repeat (STR)-polymerase chain reaction-based assay, commonly used in pa...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690501300304

    authors: Mariappan MR,Zehnder J,Arber DA,Lay M,Fadare O,Schrijver I

    更新日期:2005-07-01 00:00:00