Abstract:
:Specimen misidentification is a common cause of errors in surgical pathology. We report a case where bone-marrow biopsies from patients of different genders were mislabeled and molecular methods were applied to resolve the identity. A short tandem repeat (STR)-polymerase chain reaction-based assay, commonly used in paternity testing, was employed in an attempt to assign the correct identity to the specimens. However, the specimens had been processed by decalcification and the DNA yield was poor. One of the markers in the assay is the non-STR amelogenin locus that distinguishes the X and Y chromosomes. This amelogenin marker results in a product of low molecular weight, enabling unequivocal resolution of identity despite a poor DNA yield. The prevalence of errors in pathology due to specimen misidentifications is reviewed.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Mariappan MR,Zehnder J,Arber DA,Lay M,Fadare O,Schrijver Idoi
10.1177/106689690501300304keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
253-8issue
3eissn
1066-8969issn
1940-2465journal_volume
13pub_type
杂志文章abstract::Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) are round-cell sarcomas with varying degrees of neuroectodermal differentiation; they are considered members of the same family of tumors based on their common genetic profile. ES/PNET are very infrequent in the female genital tract, the vagina being the ra...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896911424898
更新日期:2012-06-01 00:00:00
abstract::The aim of this study is to analyze all the cases of benign fibro-osseous lesions treated at School and Hospital of Stomatology, Wuhan University, to compare the results obtained in this study with those previously documented by other authors. The 127 cases diagnosed as a fibro-osseous lesion were retrieved, and infor...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896908318744
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Benign neurogenic tumor involving the urinary bladder is a very rare and heterogeneous disease group. The clinical and radiological diagnosis may be difficult because of the disease's rarity and the histological similarities of each disease especially in needle biopsy specimens. However, accurate diagnosis i...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917742722
更新日期:2018-05-01 00:00:00
abstract::Sclerosing cholangitis is an autoimmune condition characterized by lymphocytic infiltration within the biliary epithelium leading to multifocal stricturing of the biliary tree. Primary sclerosing cholangitis (PSC) is the most common type encountered clinically. However, a similar process may occur in conjunction with ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908319777
更新日期:2011-02-01 00:00:00
abstract::Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908328575
更新日期:2009-12-01 00:00:00
abstract::The development of squamous metaplasia or carcinoma is a rare occurrence in the setting of a ruptured or leaking silicone breast implant capsule. However, the oncogenic process in such a context is yet another intriguing example of how chronic inflammation plays an integral role in the tumorigenic process. Recent pape...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908329587
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Acetylcholinesterase (AchE) histochemistry has been established as an accurate diagnostic tool for Hirschsprung's disease (HD). In addition, calretinin immunohistochemistry is also reported as a reliable and adjunctive method to diagnose HD. We investigated the diagnostic value of combined AchE histochemistr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918761235
更新日期:2018-09-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) with primary involvement of the upper gastrointestinal (GI) tract is rare. We report 2 adult cases of localized LCH in the upper-GI tract, including the second reported adult case of esophageal LCH and review 11 previously reported cases. Case 1 involved the esophagus of a 61-year-o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920964566
更新日期:2020-10-09 00:00:00
abstract:BACKGROUND:Phyllodes tumors (PTs) of the breast are rare biphasic neoplasms and are classified as benign, borderline, or malignant. Many biological markers have been studied to discriminate between different grades of PTs. IMP3 is a member of the insulin-like growth factor II mRNA binding protein (IMP) family and is ex...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915603119
更新日期:2016-02-01 00:00:00
abstract::The International Society of Urological Pathology in 2010 recommended weighing prostates without seminal vesicles (SV) to include only prostate weight in prostate-specific antigen (PSA) density (PSAD) calculation, because SV do not produce PSA. Large retrospective cohorts exist with combined weight recorded that needs...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915600519
更新日期:2015-12-01 00:00:00
abstract::The true incidence of light chain deposition disease (LCDD) restricted to the central nervous system (CNS) is unknown. To our knowledge only 7 cases of LCDD restricted to the brain have been previously reported. We herein describe an unusual example. A 44-year-old man presented with a history of ischemic retinopathy i...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896917717338
更新日期:2017-12-01 00:00:00
abstract::Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special tec...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908323505
更新日期:2011-02-01 00:00:00
abstract::Crystalloid granuloma (CG) of salivary gland is an extremely rare inflammatory disease, and only 6 cases have been reported in the English literature. CG is histologically characterized by a granulomatous reaction to amylase crystalloid deposition. A 73-year-old woman presented with a painful left neck mass. Computed ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896918791031
更新日期:2019-04-01 00:00:00
abstract:AIM:To describe a case of metastasis of malignant peritoneal epithelioid mesothelioma in gastric antral mucosa in a patient with a cryptogenic liver cirrhosis associated with esophageal varices, abdominal pain and distension, ascites, and weight loss. MATERIALS AND METHOD:The patient underwent esophageal gastric endos...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908324257
更新日期:2011-04-01 00:00:00
abstract::Tumor-to-tumor metastasis is an unusual phenomenon wherein one distinct malignancy is present within the substance of another independent tumor. This event is rare, difficult to detect with imaging, and, due to conflicting terminology in the literature, can be challenging to classify. This article reports the first do...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919872805
更新日期:2020-04-01 00:00:00
abstract::Myositis ossificans (MO) and fibroosseous pseudotumor of digits (FP) are pseudotumoral mimics of malignancy. A review of 50 cases of MO and 14 cases of FP showed that a malignant diagnosis was suggested by referring pathologists in 23% of MO and 9% of FP. The most common misdiagnosis was osteosarcoma. Awareness of the...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100305
更新日期:2003-07-01 00:00:00
abstract:CONTEXT.:Follicular cholecystitis (FC) is a poorly characterized entity. OBJECTIVE.:To determine its frequency/clinicopathologic associations. DESIGN.:A total of 2550 cholecystectomy specimens were examined. Two hundred three of these were consecutive routine cholecystectomies submitted entirely for microscopic exami...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920924079
更新日期:2020-12-01 00:00:00
abstract::Gustav Giemsa was born in Germany in 1867, worked mainly as a chemist, and died in 1948. The staining method, which carries his name, was designed primarily for the demonstration of parasites in malaria, but it was also employed in histology because of the high-quality staining of the chromatin and the nuclear membran...
journal_title:International journal of surgical pathology
pub_type: 传,历史文章,杂志文章
doi:10.1177/1066896907302239
更新日期:2007-07-01 00:00:00
abstract::Lanthanum carbonate (LC) is a new type of phosphate adsorbent used to treat patients with hyperphosphatemia caused by chronic kidney diseases. Recent studies have pointed out that lanthanum deposition can be found in the cytoplasm of histiocytes in the gastroduodenal mucosa of these patients. On the other hand, it is ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917718623
更新日期:2017-12-01 00:00:00
abstract::Primary carcinoid tumor of the skin (PCTS) is an uncommon indolent neoplasm, with 10 cases described in the literature. The tumors affect patients in the sixth to ninth decades of life (mean = 66.3 years) with an equal gender distribution and predilection for the head and trunk. They present as slowly enlarging nodule...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896913516672
更新日期:2014-04-01 00:00:00
abstract::Studies on the expression of beta-catenin (beta-ct) in gastric carcinoma have provided conflicting results, and the role played by beta-ct mutations in gastric carcinogenesis remains unclear. In an attempt to clarify the aforementioned issues we undertook the retrospective study of 157 gastric carcinomas by using immu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100102
更新日期:2003-01-01 00:00:00
abstract::The majority of alveolar RMSs have t(2;13)(q35;q14) or (1:13)(p36;q14),which generate PAX3/7 -FKHR fusion genes. Here, the authors detected the PAX3/7-FKHR fusion transcripts in 17 formalin-fixed, paraffin-embedded RMSs and 26 other SRCTs using one-step RT-PCR. PAX3 -FKHR and PAX7-FKHR transcripts were positive in 4/8...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908323922
更新日期:2009-02-01 00:00:00
abstract::A 59-year-old female received a matched related donor stem cell transplant for chronic myelogenous leukemia. After being successfully treated with prednisone for chronic graft versus host disease that initially started 50 days posttransplant, she developed hepatic dysfunction during the steroid taper on day 531, as ev...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915610817
更新日期:2016-04-01 00:00:00
abstract::Here we present the case of a 73-year-old woman with an ulcerated, advanced, hepatoid, and α-fetoprotein-producing poorly differentiated (G3) primary gastric adenocarcinoma pT3 N3a M1 with multinucleated cells and evident neuroendocrine component. This tumor was consistent with giant cell tumor type gastric carcinoma ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915586807
更新日期:2015-10-01 00:00:00
abstract::We report the case of a well-differentiated chondrosarcoma of the proximal humerus in a 60-year-old man that featured a prominent component of granular cells, the granules being shown by electron microscopy to be lysosomal. Although secondary granular cell changes have been described in a large variety of tumor types,...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690601400211
更新日期:2006-04-01 00:00:00
abstract::Malakoplakia is a rare granulomatous disease that commonly involves the genitourinary tract, with the urinary bladder being the most frequently affected site. Grossly, malakoplakia can present as soft yellow plaques, nodules, bladder mass, or even without any visible lesion. In this article, we present a 74-year-old f...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915595464
更新日期:2015-10-01 00:00:00
abstract::Gastric duplication cysts are rare congenital anomalies that are mostly discovered in children but can remain asymptomatic and undetected into adulthood. Malignant transformation in gastric duplications is extremely rare, with most reported cases being adenocarcinomas. Herein, the authors report the first case of a hi...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896906295777
更新日期:2007-04-01 00:00:00
abstract::Sentinel lymph node biopsy is the current standard procedure used to stage patients with breast cancer. The best histological method in evaluating sentinel nodes is highly debated among institutions and is thus not standardized. The optimal histological analysis is a balance between comprehensive evaluation of the sen...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915596811
更新日期:2015-10-01 00:00:00
abstract::Pseudomembranes in colonic biopsies are normally associated with antibiotic related pseudomembranous colitis. Although pseudomembranes have rarely been reported in other conditions, their presence in rectal prolapse has not been previously reported. ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912468213
更新日期:2013-08-01 00:00:00
abstract::Mucoepidermoid carcinoma (MEC) shows a wide morphologic spectrum, including epithelium with oncocytic or squamous metaplastic changes overlying a prominent cystic architecture, as well as tumor-associated lymphoid tissue. We illustrate a case of MEC of the parotid in a 17-year-old female, in which all these features o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917724889
更新日期:2018-02-01 00:00:00