Abstract:
:Clear cell chondrosarcoma (CCCS) is a rare variant of conventional chondrosarcoma with low-grade malignant features that may be confused radiographically and histologically with chondroblastoma. We report a case of a 50-year-old female who presented with 6 months of left hip pain. Initial radiographs demonstrated an osteolytic lesion with adjacent area of sclerosis in the proximal left femur. Magnetic resonance imaging demonstrated a marrow-infiltrative lesion with periosteal reaction and thickened enhancing periosteum. Biopsy of the sclerotic area demonstrated chondroblastoma-like findings, whereas biopsy of the lytic area showed features suggestive of CCCS. The patient eventually underwent en bloc resection and reconstruction with a proximal femoral megaprosthesis. The final diagnosis was CCCS. We present this unusual case with review of the radiographic and histologic features of CCCS with attention to its ability to mimic chondroblastomas. This case highlights the importance of sampling radiographically heterogeneous areas within a bone lesion to facilitate accurate diagnosis and appropriate management.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Kiefer RM,Wojcik J,Cooper K,Weber KL,Sebro Rdoi
10.1177/1066896918776092subject
Has Abstractpub_date
2018-12-01 00:00:00pages
766-771issue
8eissn
1066-8969issn
1940-2465journal_volume
26pub_type
杂志文章abstract::Pseudomembranes in colonic biopsies are normally associated with antibiotic related pseudomembranous colitis. Although pseudomembranes have rarely been reported in other conditions, their presence in rectal prolapse has not been previously reported. ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912468213
更新日期:2013-08-01 00:00:00
abstract::Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia. This report describes a juvenile granulosa cell tumor arising in the testis of a neonate. Chromosome analysis of the tumor showed a normal male karyotype...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896907302423
更新日期:2007-07-01 00:00:00
abstract::In this study, the pathogenesis of clear cell change in colorectal epithelial lesions was studied. A total of 4 cases of clear cell change (1 hyperplasic polyp and 3 adenomas) were characterized using histochemistry, immunohistochemistry, and electron microscopy. All lesions developed in the left colon. In all, 1 aden...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908319211
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abstract::Objectives. The criteria for "active surveillance" depend in part on quantification of tumor extent and grade on prostate biopsies. It is known that false-negative biopsies may occur from incomplete sectioning of cores within the paraffin blocks. Methods. We retrospectively analyzed a prostate biopsy series, which wer...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920907690
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Cysts of the jaws (JCs) are an important topic of oral pathology, but few epidemiological data are present in the literature, in particular about the potential of recurrence. The aim of this study was to describe a case series of JCs from a single institution, evaluating the frequency, the site, the age dist...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914541000
更新日期:2014-12-01 00:00:00
abstract::Unlike their cutaneous counterparts, head and neck mucosal malignant melanomas (HNMM) behave much more aggressively and their prognostic markers have not been fully elucidated. Therefore, the aim of this study was to review the clinicopathologic features of a contemporary series of primary HNMM, retrieved from archiva...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911417970
更新日期:2012-02-01 00:00:00
abstract::Rhabdomyosarcoma is an aggressive malignant tumor often developing in the head and neck in children. In the sinonasal region, rhabdomyosarcoma constitutes a clinically important group because of the difficulty of surgical resection and its generally poor prognosis. We reviewed the archival pathology materials of 39 ca...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896906299122
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Benign neurogenic tumor involving the urinary bladder is a very rare and heterogeneous disease group. The clinical and radiological diagnosis may be difficult because of the disease's rarity and the histological similarities of each disease especially in needle biopsy specimens. However, accurate diagnosis i...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896917742722
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Phyllodes tumors (PTs) of the breast are rare biphasic neoplasms and are classified as benign, borderline, or malignant. Many biological markers have been studied to discriminate between different grades of PTs. IMP3 is a member of the insulin-like growth factor II mRNA binding protein (IMP) family and is ex...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915603119
更新日期:2016-02-01 00:00:00
abstract::Ulcerative colitis-related epithelial dysplasia represents a premalignant lesion, which may lead to the development of ulcerative colitis-related adenocarcinoma. The proper management of this condition requires proctocolectomy before the acquisition of the invasive phenotype. Patients with chronic ulcerative colitis, ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690000800106
更新日期:2000-01-01 00:00:00
abstract::A 37-year-old woman was found to have multiple peritoneal nodules, including on the uterine serosa, at Cesarean section. Histology showed yellow crystalline material surrounded by histiocytes and occasional multinucleate giant cells. Further enquiry revealed that the patient underwent a cholecystectomy for a perforate...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911409930
更新日期:2012-02-01 00:00:00
abstract::The role of histopathology for diagnosing celiac disease (CD) has been recently challenged. However, based in our experience with roughly 4,600 distal duodenal and jejunal biopsies in children it is apparent that appropriate biopsy site, handling, processing, and microscopic evaluation result in a consistent pattern o...
journal_title:International journal of surgical pathology
pub_type: 社论
doi:10.1177/106689690100900401
更新日期:2001-10-01 00:00:00
abstract::Metanephric stromal tumor (MST) of the kidney is a rare pediatric neoplasm which has rarely been reported in adults. The authors present a case of MST, cellular type, an unreported variant, in a 56-year-old postmenopausal woman. The 9.0-cm tumor was solid, unencapsulated, and well circumscribed, with a firm homogeneou...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896912453851
更新日期:2013-04-01 00:00:00
abstract::This study describes the clinical, histologic, and immunohistochemical features of four cases of GI PEComa. The size of the tumors ranged from 3.5 to 6.0cm in diameter, and all were located in wall of the large bowel. Microscopically, the tumors were characterized by an epithelioid arrangement of tumor cells, which ha...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908330481
更新日期:2010-08-01 00:00:00
abstract::In this article, we report a very rare case of secondary angiosarcoma in a young woman with no prior history of breast cancer who had bilateral prophylactic mastectomies with autologous reconstruction due to a strong family history of breast cancer and BRCA1 gene variant of uncertain significance. The surgery was comp...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920930100
更新日期:2020-06-18 00:00:00
abstract::In this report, a case of metaplastic thymoma arising in a thymic cyst wall is discussed. The patient was a 61-year-old male whose chief complaint was sweating and chest pain. Imaging study revealed a mediastinal mass with right hemithoracic extension. He underwent surgical resection of the mass and remnants of the th...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908315754
更新日期:2009-02-01 00:00:00
abstract::To elucidate the relationship between del(5q) and the clinical and histological features of small cell neuroendocrine lung carcinoma, 33 tissue samples from patients with this tumor were evaluated. By using fluorescence in situ hybridization, del(5q) was identified in almost 50% of cases (15/33, 45%). Clinically, pati...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908318935
更新日期:2008-10-01 00:00:00
abstract::Micrometastases in lymph nodes and blood may provide important prognostic information. In this study, cytokeratin 20 (CK20) positive cells in lymph nodes and circulating CK20 mRNA were studied using 57 paraffin-embedded lymph node specimens and blood from 24 patients with pN0 colorectal cancer (CRC), respectively. Res...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907311901
更新日期:2008-04-01 00:00:00
abstract::Calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a rare benign odontogenic tumor. This tumor predominantly involves the mandible, though the maxilla can also be involved in some cases. The involvement of maxillary sinuses, however, has been previously reported in only 8 case reports English li...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896916644782
更新日期:2016-09-01 00:00:00
abstract::Tumor-to-tumor metastasis is an unusual phenomenon wherein one distinct malignancy is present within the substance of another independent tumor. This event is rare, difficult to detect with imaging, and, due to conflicting terminology in the literature, can be challenging to classify. This article reports the first do...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919872805
更新日期:2020-04-01 00:00:00
abstract::Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920917445
更新日期:2020-12-01 00:00:00
abstract::Fibroadenoma and phyllodes tumors of the breast exhibit a continuum of pathologic features. We examined phyllodes tumors initially called fibroadenoma for features that may accurately classify the tumor as phyllodes tumor on the first biopsy specimen. The phyllodes tumors initially called fibroadenoma for features tha...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907311378
更新日期:2008-04-01 00:00:00
abstract::The aim of this study was to investigate protein expression of adenomatous polyposis coli (APC) in primary and metastatic serous ovarian carcinoma. The expression of beta-catenin and E-cadherin was additionally analyzed. One hundred and thirteen primary (n = 56) and metastatic (n = 57) lesions were immunohistochemical...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690201000302
更新日期:2002-07-01 00:00:00
abstract::Polyoma virus nephritis is increasingly being recognized as a cause of allograft dysfunction in renal transplant patients. We describe and illustrate the findings in a renal biopsy and a concurrent urine sample from a patient with polyoma virus nephritis. The urine cytology findings were highly suggestive of a tumor d...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690000800412
更新日期:2000-10-01 00:00:00
abstract::Esophageal ectopic sebaceous glands are very rare lesions. A series of 5 cases in a single report has been the maximum number described in the English literature to date. We conducted a clinicopathologic study of 8 cases of esophageal ectopic sebaceous glands. The median patient age at the time of diagnosis was 60 yea...
journal_title:International journal of surgical pathology
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更新日期:2020-08-26 00:00:00
abstract::Primary leiomyosarcoma arising from the ovarian vein is extremely rare, with only 10 cases reported in the literature. We report on a case of leiomyosarcoma of the left ovarian vein in a 67-year-old woman who presented with abdominal discomfort. Pelvic ultrasound revealed a large, solid, irregular mass in close relati...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896916679888
更新日期:2017-06-01 00:00:00
abstract::Primary pulmonary acinic cell carcinoma (ACC) is rare. The clinicopathological features are not identical to that of classic ACC that leads to misdiagnosis. In this article, we summarized the clinicopathological features of 25 such cases, including 6 cases in this series and additional 19 cases in the literature. Pulm...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896919836499
更新日期:2019-09-01 00:00:00
abstract::Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically...
journal_title:International journal of surgical pathology
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更新日期:2009-12-01 00:00:00
abstract::Acinar cell carcinoma of the pancreas is rare, accounting for less than 1% of carcinomas arising in the exocrine pancreas. Patients are typically between the fifth and seventh decade of life and show a 2:1 male predominance. Symptoms tend to be nonspecific, and approximately 50% of the patients have metastases at the ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896909339912
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Acetylcholinesterase (AchE) histochemistry has been established as an accurate diagnostic tool for Hirschsprung's disease (HD). In addition, calretinin immunohistochemistry is also reported as a reliable and adjunctive method to diagnose HD. We investigated the diagnostic value of combined AchE histochemistr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918761235
更新日期:2018-09-01 00:00:00