Del(5q) is associated with clinical and histological parameters in small cell neuroendocrine lung carcinoma.

Abstract:

:To elucidate the relationship between del(5q) and the clinical and histological features of small cell neuroendocrine lung carcinoma, 33 tissue samples from patients with this tumor were evaluated. By using fluorescence in situ hybridization, del(5q) was identified in almost 50% of cases (15/33, 45%). Clinically, patients with tumors showing del(5q) were older (mean age = 71 years) with a correspondingly greater pack-year smoking history (mean = 61) than patients with tumors (mean age = 59 years, mean pack-years = 44) without del(5q). Histologically, tumors with del(5q) had a greater frequency of spindle cell morphology (11/14 [79%] vs 6/16 [38%], P < .025) than those without del(5q). This is the first study to find an association between del(5q) and tumor histology in small cell neuroendocrine lung carcinoma.

journal_name

Int J Surg Pathol

authors

Hartel PH,Shackelford AL,Hartel JV,Wenger SL

doi

10.1177/1066896908318935

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

419-23

issue

4

eissn

1066-8969

issn

1940-2465

pii

1066896908318935

journal_volume

16

pub_type

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