Abstract：
:Objectives. The criteria for "active surveillance" depend in part on quantification of tumor extent and grade on prostate biopsies. It is known that false-negative biopsies may occur from incomplete sectioning of cores within the paraffin blocks. Methods. We retrospectively analyzed a prostate biopsy series, which were subjected to a second round of sections, in order to determine the rate of missed cancers. Results. Of 1324 sets of prostate biopsies, 4.5% (60) showed additional involved cores or higher grade tumor on recut sections. In 27 patients (2.0%), the changed diagnosis resulted in a potential mild increase in National Comprehensive Cancer Network (NCCN) risk, from negative to very low (12), very low to low (12), and low to favorable intermediate (3). In 3 patients (0.2%), the changed diagnosis resulted in a significant increase in NCCN risk. Comparison of the initial sets of slides to the recuts demonstrated areas of absent tissue in many of the cases in which tumor segments were missed. In 2/3 cases with the significant grade increase, gaps were present in one that should have alerted the pathologist to incomplete sections, and the tumor was fragmented at the edge of the core appearing incompletely sampled. Conclusions. A significant increase in risk was seen in this study in 0.2% of patients when blocks were recut for further sampling, with minor increases in 2%. While embedding issues only rarely resulted in clinically significant sampling error, the 3 significantly underdiagnosed cases underscore the need for pathologists to be alert to incomplete sections of prostate cores.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Paulk AT,Sesterhenn IA,Burke APdoi
10.1177/1066896920907690subject
Has Abstractpub_date
2020-08-01 00:00:00pages
490-495issue
5eissn
1066-8969issn
1940-2465journal_volume
28pub_type
杂志文章abstract：:Peritoneal metastasis in colorectal carcinoma is associated with a dismal prognosis; however, features that correlate with patterns of metastatic spread are not well characterized. We analyzed the clinicopathologic and molecular features of 166 patients with colorectal carcinomas stratified by metastases to the perito...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896916664990
更新日期：2017-04-01 00:00:00
abstract：:The development of squamous metaplasia or carcinoma is a rare occurrence in the setting of a ruptured or leaking silicone breast implant capsule. However, the oncogenic process in such a context is yet another intriguing example of how chronic inflammation plays an integral role in the tumorigenic process. Recent pape...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896908329587
更新日期：2010-12-01 00:00:00
abstract：:Pleomorphic adenoma with foci of squamous and mucinous differentiation can potentially be misdiagnosed as low-grade mucoepidermoid carcinoma. The circumscribed borders of the tumor, gradual merging of mucoepidermoid foci into areas typical of pleomorphic adenoma, and presence of keratinization are features against the...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896909335509
更新日期：2009-08-01 00:00:00
abstract：:Ninety-eight consecutive surgical biopsies of oral mucosa from 96 patients were evaluated immunohistochemically with an anti-cytokeratin 20 (CK 20) anti-body to evidence Merkel cells (MC). Fifteen cases, showing the highest number of MC, were additionally studied with chromogranin A, S-100 protein, neuro filaments, ep...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896906290053
更新日期：2006-07-01 00:00:00
abstract：:Rosai-Dorfman disease (RDD; sinus histiocytosis with massive lymphoadenopathy) is a rare, usually nodal self-limited disease. Sometimes nodal disease is coupled with extranodal localizations, in which case the disease can follow a protracted clinical course characterized by remissions and relapses and, exceptionally, ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896908329590
更新日期：2010-12-01 00:00:00
abstract：:Tumor-to-tumor metastasis is an unusual phenomenon wherein one distinct malignancy is present within the substance of another independent tumor. This event is rare, difficult to detect with imaging, and, due to conflicting terminology in the literature, can be challenging to classify. This article reports the first do...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896919872805
更新日期：2020-04-01 00:00:00
abstract：:In this study, we examined aberrant methylation of the E-cadherin, estrogen receptor, RB1 , p16, p15, p14, and MGMT genes by the methylation-specific polymerase chain reaction method in 101 gastric carcinomas. Hypermethylation was detected in E-cadherin, estrogen receptor, RB1, p16, p14, p15, and MGMT at the rates of ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896907302117
更新日期：2007-07-01 00:00:00
abstract：:Primary carcinoid tumor of the skin (PCTS) is an uncommon indolent neoplasm, with 10 cases described in the literature. The tumors affect patients in the sixth to ninth decades of life (mean = 66.3 years) with an equal gender distribution and predilection for the head and trunk. They present as slowly enlarging nodule...
journal_title：International journal of surgical pathology
pub_type： 杂志文章,评审
doi：10.1177/1066896913516672
更新日期：2014-04-01 00:00:00
abstract：:Verruciform xanthoma is a rare benign verrucopapillary lesion that develops in the oral mucosa and genital skin. Its development in the esophagus is extremely rare, with only 5 reported cases. We present 2 cases of verruciform xanthoma of the esophagus. Case 1 involved a 91-year-old woman, who had hypertension and chr...
journal_title：International journal of surgical pathology
pub_type： 杂志文章,评审
doi：10.1177/1066896919879495
更新日期：2020-05-01 00:00:00
abstract：:The authors describe a case of multifocal perivascular epithelioid cell tumor (PEComa) arising in the pelvis of a 39-year-old woman affected by tuberous sclerosis. The tumor presented in the form of multiple fascicular, focally cystic nodules involving the uterine corpus, both ovaries, and the omentum. Microscopically...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896908316067
更新日期：2008-10-01 00:00:00
abstract：:Eccrine porocarcinoma is a potentially fatal form of sweat gland carcinoma, due to its propensity to metastasize through lymph vessels. The authors report the case of a 69-year-old female who presented with swelling of the right leg and an ulcerated lesion of the right great toe. The initial histologic diagnosis was i...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896911428738
更新日期：2012-10-01 00:00:00
abstract：:Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia. This report describes a juvenile granulosa cell tumor arising in the testis of a neonate. Chromosome analysis of the tumor showed a normal male karyotype...
journal_title：International journal of surgical pathology
pub_type： 杂志文章,评审
doi：10.1177/1066896907302423
更新日期：2007-07-01 00:00:00
abstract：:The sarcomatoid variant of anaplastic large cell lymphoma is an extremely rare histologic pattern of anaplastic large cell lymphoma that consists of spindle-shaped neoplastic cells and is easily misdiagnosed as a soft tissue sarcoma. We report a case of the sarcomatoid variant of anaplastic large cell lymphoma that wa...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896920986967
更新日期：2021-01-11 00:00:00
abstract：:Palisaded mammary-type myofibroblastoma is a rare variant of benign stromal spindle cell tumor whose histological features are well known. Nevertheless, no cytological features have been reported to date. In this article, we describe the cytological features of a case of palisaded mammary-type myofibroblastoma in whic...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896916665699
更新日期：2017-04-01 00:00:00
abstract：:Primary leiomyosarcoma arising from the ovarian vein is extremely rare, with only 10 cases reported in the literature. We report on a case of leiomyosarcoma of the left ovarian vein in a 67-year-old woman who presented with abdominal discomfort. Pelvic ultrasound revealed a large, solid, irregular mass in close relati...
journal_title：International journal of surgical pathology
pub_type： 杂志文章,评审
doi：10.1177/1066896916679888
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Study of minimum adenocarcinoma has been done almost exclusively on conventional acinar adenocarcinoma. Pseudohyperplastic adenocarcinoma can be confused with benign lesions because of its well-differentiated appearance and has not been studied when the biopsy shows few malignant glands (limited carcinoma). ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896917715910
更新日期：2017-10-01 00:00:00
abstract：:Lanthanum carbonate (LC) is a new type of phosphate adsorbent used to treat patients with hyperphosphatemia caused by chronic kidney diseases. Recent studies have pointed out that lanthanum deposition can be found in the cytoplasm of histiocytes in the gastroduodenal mucosa of these patients. On the other hand, it is ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896917718623
更新日期：2017-12-01 00:00:00
abstract：:Malignant melanoma (MM), the most common metastatic solid tumor to involve the breast, may present as a diagnostic problem, frequently requiring the use of ancillary studies for accurate diagnosis. The implication of hormonal interplay is strong since metastatic MM to the breast is seen nearly always in women. However...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/106689690501300102
更新日期：2005-01-01 00:00:00
abstract：:Microvillous inclusion disease (MVID) is a congenital condition presenting with intractable diarrhea. Biopsies demonstrate abnormal apical PAS and CD10 staining in surface enterocytes correlating with the presence of characteristic cytoplasmic inclusions. MVID has been linked to mutations in myosin Vb, important in ap...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896911430959
更新日期：2012-06-01 00:00:00
abstract：:The aim of this study is to analyze all the cases of benign fibro-osseous lesions treated at School and Hospital of Stomatology, Wuhan University, to compare the results obtained in this study with those previously documented by other authors. The 127 cases diagnosed as a fibro-osseous lesion were retrieved, and infor...
journal_title：International journal of surgical pathology
pub_type： 杂志文章,评审
doi：10.1177/1066896908318744
更新日期：2009-04-01 00:00:00
abstract：:A 25-year-old patient presented with epigastric pain, which on gastric biopsy revealed the characteristic appearance of collagenous gastritis. There was a thick prominent subepithelial band that was confirmed to be collagen with a Masson's trichrome stain. There was associated Helicobacter pylori gastritis but no evid...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896908329588
更新日期：2010-12-01 00:00:00
abstract：:The role and diagnostic efficacy of gene and protein products RB1, CDK4, CHMP2B, HSP90, and cPLA2G4A, all previously shown to be involved in tumor genesis and cell proliferation, were examined by immunohistochemical techniques in 32 cases of myxofibrosarcomas and 29 myxoid liposarcomas (all diagnosis had been confirme...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896914532539
更新日期：2014-10-01 00:00:00
abstract：:Circulating tumor cells are rare in peripheral blood smears. We report the case of a patient with circulating breast carcinoma cells resembling circulating myeloid blasts and provide a brief review of the literature. Peripheral blood smears and a bone marrow aspirate were examined morphologically and by flow cytometry...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896916664986
更新日期：2017-02-01 00:00:00
abstract：:We present a case of clear cell meningioma with unusual clinical and pathologic features. The patient was a 54-year-old man who underwent laminectomy and durotomy for an intradural tumor in the lumbar spinal canal. Sections showed a predominance of dense collagenous tissue with irregularly shaped and irregularly sized...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896912470165
更新日期：2013-08-01 00:00:00
abstract：:Synovial sarcoma is a high-grade sarcoma commonly affecting young adults. The sites of involvement include soft tissue near joints, lung, pleura, mediastinum, larynx, kidney, and buttocks. Histologic types include monophasic, biphasic, and undifferentiated. We report a unique case of synovial sarcoma with low-grade hi...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896917723463
更新日期：2018-02-01 00:00:00
abstract：:The true incidence of light chain deposition disease (LCDD) restricted to the central nervous system (CNS) is unknown. To our knowledge only 7 cases of LCDD restricted to the brain have been previously reported. We herein describe an unusual example. A 44-year-old man presented with a history of ischemic retinopathy i...
journal_title：International journal of surgical pathology
pub_type： 杂志文章,评审
doi：10.1177/1066896917717338
更新日期：2017-12-01 00:00:00
abstract：:Gastric duplication cysts are rare congenital anomalies that are mostly discovered in children but can remain asymptomatic and undetected into adulthood. Malignant transformation in gastric duplications is extremely rare, with most reported cases being adenocarcinomas. Herein, the authors report the first case of a hi...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896906295777
更新日期：2007-04-01 00:00:00
abstract：:We review the clinical, pathologic, and molecular genetic features of 3 splenic T-cell-rich B-cell lymphomas and discuss their differential diagnosis. All patients presented with symptomatic splenomegaly and underwent diagnostic/therapeutic splenectomy. Microscopically, the spleen in all cases showed a micronodular pr...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/106689690401200105
更新日期：2004-01-01 00:00:00
abstract：:Renal cell carcinoma (RCC) in children and young adults is rare and pathologically problematic. RCC can be either hereditary or sporadic and has a guarded prognosis because appropriate management has not been established. A case of RCC in an 11-year-old is reported. The clinical presentation was a right abdominal mass...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896907304994
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The phenomenon of vanishing carcinomas, first described in context of prostatic carcinomas, has been documented in endometrial carcinomas as well. METHODS:The archives of the department were searched for case files of endometrial carcinoma diagnosed on endometrial curetting/biopsy but which did not reveal a...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896918783581
更新日期：2019-02-01 00:00:00
