Abstract：
:Objectives. The criteria for "active surveillance" depend in part on quantification of tumor extent and grade on prostate biopsies. It is known that false-negative biopsies may occur from incomplete sectioning of cores within the paraffin blocks. Methods. We retrospectively analyzed a prostate biopsy series, which were subjected to a second round of sections, in order to determine the rate of missed cancers. Results. Of 1324 sets of prostate biopsies, 4.5% (60) showed additional involved cores or higher grade tumor on recut sections. In 27 patients (2.0%), the changed diagnosis resulted in a potential mild increase in National Comprehensive Cancer Network (NCCN) risk, from negative to very low (12), very low to low (12), and low to favorable intermediate (3). In 3 patients (0.2%), the changed diagnosis resulted in a significant increase in NCCN risk. Comparison of the initial sets of slides to the recuts demonstrated areas of absent tissue in many of the cases in which tumor segments were missed. In 2/3 cases with the significant grade increase, gaps were present in one that should have alerted the pathologist to incomplete sections, and the tumor was fragmented at the edge of the core appearing incompletely sampled. Conclusions. A significant increase in risk was seen in this study in 0.2% of patients when blocks were recut for further sampling, with minor increases in 2%. While embedding issues only rarely resulted in clinically significant sampling error, the 3 significantly underdiagnosed cases underscore the need for pathologists to be alert to incomplete sections of prostate cores.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Paulk AT,Sesterhenn IA,Burke APdoi
10.1177/1066896920907690subject
Has Abstractpub_date
2020-08-01 00:00:00pages
490-495issue
5eissn
1066-8969issn
1940-2465journal_volume
28pub_type
杂志文章abstract：:Warthin tumor is the second most common salivary gland neoplasm. It occurs more commonly in males than in females. Malignant transformation in Warthin tumor is a rare but well-recognized phenomenon; however, the development or presentation of lymphoma in a Warthin tumor is rare. An 80-year-old man presented with painl...
journal_title：International journal of surgical pathology
pub_type： 杂志文章,评审
doi：10.1177/1066896917734371
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Epithelioid hemangioendothelioma (EHE) is an uncommon malignant endothelial neoplasm that most commonly arises in soft tissue, bone, lung, and liver. Crohn's disease (CD) is an inflammatory bowel disease of unknown etiology that is frequently associated with complications including strictures, fistulas/fissu...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896918801527
更新日期：2019-06-01 00:00:00
abstract：:Malignant melanoma has a variety of morphologic patterns and can metastasize and mimic any type of neoplastic process creating significant diagnostic difficulty. When metastasis to the gastrointestinal system is identified, it is most commonly associated with widely metastatic disease. We report a rare case of isolate...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896915588932
更新日期：2015-08-01 00:00:00
abstract：:A 16-year-old boy presented with a tumor located in fourth ventricle, which showed histological features of an ependymoma replete with perivascular pseudorosettes and true ependymal rosettes. Interestingly, many of the tumor cells exhibited abundant cytoplasm stuffed with a grayish brown pigment. Histochemical stains ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896920926700
更新日期：2021-02-01 00:00:00
abstract：:Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896916646448
更新日期：2016-10-01 00:00:00
abstract：:Dedifferentiated liposarcoma is typically a nonlipogenic high-grade sarcoma that arises from well-differentiated liposarcoma. It most commonly presents as a large mass in the retroperitoneum. Significant involvement of the gastrointestinal tract by dedifferentiated liposarcoma is uncommon. We present a unique case of ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896917731517
更新日期：2018-04-01 00:00:00
abstract：:Gastric duplication cysts are rare congenital anomalies that are mostly discovered in children but can remain asymptomatic and undetected into adulthood. Malignant transformation in gastric duplications is extremely rare, with most reported cases being adenocarcinomas. Herein, the authors report the first case of a hi...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896906295777
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:To assess the pathologic characteristics and prognostic significance of periprostatic lymph node (LN) metastasis of prostate cancer. The latter was performed by comparing biochemical recurrence (BCR)-free survival in cases of periprostatic LN metastasis versus matched patients showing pelvic LN metastasis. M...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896913482729
更新日期：2013-08-01 00:00:00
abstract：:A 38-year-old immunocompetent man with occupational exposure to Aspergillus presented with dyspnea, pleuritic chest pain, and hemoptysis. Chest roentgenograms and computed tomography scans demonstrated multiple pulmonary nodules bilaterally. An initial set of bronchial washing cultures grew Aspergillus fumigatus, sero...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/106689690301100112
更新日期：2003-01-01 00:00:00
abstract：:Metastases to cervical lymph nodes (LNs) are an important independent adverse indicator in the prognosis of oral squamous cell carcinoma (OSCC). An accurate evaluation of molecular patterns favoring the metastatic process can be helpful in predicting cases of OSCC with elevated probability of early or late metastases ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896912471851
更新日期：2013-04-01 00:00:00
abstract：:The aim of this study was to investigate protein expression of adenomatous polyposis coli (APC) in primary and metastatic serous ovarian carcinoma. The expression of beta-catenin and E-cadherin was additionally analyzed. One hundred and thirteen primary (n = 56) and metastatic (n = 57) lesions were immunohistochemical...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/106689690201000302
更新日期：2002-07-01 00:00:00
abstract：:Rosai-Dorfman disease (RDD; sinus histiocytosis with massive lymphoadenopathy) is a rare, usually nodal self-limited disease. Sometimes nodal disease is coupled with extranodal localizations, in which case the disease can follow a protracted clinical course characterized by remissions and relapses and, exceptionally, ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896908329590
更新日期：2010-12-01 00:00:00
abstract：:In this article, we report the case of a 40-year-old woman with a sessile polyp of the rectosigmoid junction that underwent endoscopic resection. The resected specimen showed spindle cell proliferation with eosinophilic cytoplasm between mucosal crypts, mimicking mucosal prolapse syndrome. However, these were immunohi...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896918818897
更新日期：2019-08-01 00:00:00
abstract：:A completely infarcted lymph node should alert the pathologist to the high possibility of malignant lymphoma. The lymph node lesion of infectious mononucleosis (IM) shows marked histologic diversity and occasionally may be confused with malignant lymphoma. We report a rare case of IM showing extensive lymph node infar...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/106689690201000312
更新日期：2002-07-01 00:00:00
abstract：:Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia. This report describes a juvenile granulosa cell tumor arising in the testis of a neonate. Chromosome analysis of the tumor showed a normal male karyotype...
journal_title：International journal of surgical pathology
pub_type： 杂志文章,评审
doi：10.1177/1066896907302423
更新日期：2007-07-01 00:00:00
abstract：:Malignant melanoma (MM), the most common metastatic solid tumor to involve the breast, may present as a diagnostic problem, frequently requiring the use of ancillary studies for accurate diagnosis. The implication of hormonal interplay is strong since metastatic MM to the breast is seen nearly always in women. However...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/106689690501300102
更新日期：2005-01-01 00:00:00
abstract：:We report our experience with Chromogenic in Situ Hybridization (CISH) for the evaluation of HER2 amplification on 55 cases of formalin-fixed, paraffin-embedded invasive breast carcinomas of different histology. All the results were corrected for chromosome 17 aneusomy and compared with immunohistochemistry (IHC); a s...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/106689690501300406
更新日期：2005-10-01 00:00:00
abstract：:NET-1 is a member of the NET-x family. To explore the potential role of NET-1 in hepatocellular carcinoma (HCC), the expression of NET-1 and the relationship with HCC were examined for the first time. We found that NET-1 was frequently expressed in HCC and the peritumor tissue. The relative amounts of NET-1 mRNA in HC...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896907306083
更新日期：2007-10-01 00:00:00
abstract：:Epithelioid sarcoma is a rare malignant mesenchymal neoplasm (less than 1% of all sarcomas) with epithelioid morphology. Among the 2 subtypes, proximal represents only one-third of cases and commonly involves deep tissues of pelvic region, including the perineum, genital area, and groin, and occurs more frequently in ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896917696744
更新日期：2017-08-01 00:00:00
abstract：:Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896920917445
更新日期：2020-12-01 00:00:00
abstract：:Cervical cancer is the most common gynecologic malignancy of the developing world. The oncogenic role of human papilloma virus (HPV) is well known. Attention is now focusing on the complicit genetic changes, which allow progression of these tumors. Regarding these changes, deletion of tumor suppressor genes (loss of h...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/106689690301100402
更新日期：2003-10-01 00:00:00
abstract：:Aims Epithelial mesenchymal transition (EMT) is a crucial process for acquisition of malignant phenotype, aggressiveness, and metastatic capacity in neoplasms. It is characterized by loss of epithelial markers and gain of mesenchymal markers. Studies on EMT and its potential association with the histological grading a...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896916654763
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:The rate of incidental prostate adenocarcinoma (PCa) detection in radical cystoprostatectomy (RCP) varies widely, ranging from 15% to 54%. Such variability may be explained by institutional differences in prostate grossing protocols. Either partial or complete submission of the prostate gland in RCP may resu...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896917696745
更新日期：2017-08-01 00:00:00
abstract：:Sinonasal adenocarcinoma is a rare tumor of the head and neck accounting for 10% to 20% of all primary malignancies of the nose and paranasal sinuses. There tumors are classified as salivary, intestinal and nonintestinal, nonsalivary. Low-grade nonintestinal nonsalivary are rare tumors whose diagnosis is essentially t...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896915599060
更新日期：2015-12-01 00:00:00
abstract：:Spermatocytic tumor, formerly known as spermatocytic seminoma, is an uncommon testicular neoplasm which is a distinct clinicopathologic entity from classic seminoma. These tumors are not associated with germ cell neoplasia in situ, other germ cell tumors, or isochromosome 12p. Although typically, these tumors have an ...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896917706156
更新日期：2017-09-01 00:00:00
abstract：:Intralymphatic histiocytosis (ILH) is a peculiar pathological process characterized by the collections of benign histiocytes in dilated lymph vessels. Although the majority of ILH patients present clinically with various forms of cutaneous manifestation, rare extracutaneous incidences have been reported in the literat...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896916688307
更新日期：2017-06-01 00:00:00
abstract：:Vascular transformation of lymph node sinuses represents a rare benign entity mimicking malignant counterparts such as nodal Kaposi sarcoma. The presence of mildly atypical benign mesothelial cells within nodal sinuses raises the possibility of metastatic malignancy. Herein, a rare case of vascular transformation of l...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896915622277
更新日期：2016-04-01 00:00:00
abstract：:Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically...
journal_title：International journal of surgical pathology
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doi：10.1177/1066896908328575
更新日期：2009-12-01 00:00:00
abstract：:We report a cytohistologic and immunohistochemical study of 2 cases of papillary thyroid carcinoma occurring in a thyroglossal duct cyst. The patients were a 21-year-old woman and a 48-year-old man. Needle aspiration cytology smears were consistent with papillary thyroid carcinoma. The Sistrunk procedure was done. Pap...
journal_title：International journal of surgical pathology
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doi：10.1177/106689690100900114
更新日期：2001-01-01 00:00:00
abstract：:Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special tec...
journal_title：International journal of surgical pathology
pub_type： 杂志文章
doi：10.1177/1066896908323505
更新日期：2011-02-01 00:00:00
