Abstract:
:Primary pulmonary acinic cell carcinoma (ACC) is rare. The clinicopathological features are not identical to that of classic ACC that leads to misdiagnosis. In this article, we summarized the clinicopathological features of 25 such cases, including 6 cases in this series and additional 19 cases in the literature. Pulmonary ACCs showed an overwhelming solid growth pattern. The neoplastic cells had eosinophilic granular and clear cytoplasm in most cases and displayed basophilic cytoplasm in only 4 cases. Intratumoral fibrous septa, mitotic figure, necrosis, and psammoma bodies were observed in some cases. Prominent nuclear atypia and perineural invasion might suggest high-grade transformation, metastasis, and recurrence. The tumor cells were strongly positive for CK8/18 and negative for TTF-1, p63, S-100, mammaglobin, MUC5b, MUC5ac, and DOG1. CK7 was exclusively positive for neoplastic cells with ductal differentiation. Of the 25 included cases, 10 cases were initially misdiagnosed. The tumor was prone to involve the right bronchus. The patient outcome was favorable. The accurate diagnosis of primary pulmonary ACC relies on comprehensive evaluation of histological and immunohistochemical features and realization of the difference from classic ACC.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Nie L,Zhou C,Wu H,Zhou Q,Meng Fdoi
10.1177/1066896919836499subject
Has Abstractpub_date
2019-09-01 00:00:00pages
584-592issue
6eissn
1066-8969issn
1940-2465journal_volume
27pub_type
杂志文章,评审abstract::In this study, we examined aberrant methylation of the E-cadherin, estrogen receptor, RB1 , p16, p15, p14, and MGMT genes by the methylation-specific polymerase chain reaction method in 101 gastric carcinomas. Hypermethylation was detected in E-cadherin, estrogen receptor, RB1, p16, p14, p15, and MGMT at the rates of ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907302117
更新日期:2007-07-01 00:00:00
abstract::Dedifferentiated liposarcoma is typically a nonlipogenic high-grade sarcoma that arises from well-differentiated liposarcoma. It most commonly presents as a large mass in the retroperitoneum. Significant involvement of the gastrointestinal tract by dedifferentiated liposarcoma is uncommon. We present a unique case of ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917731517
更新日期:2018-04-01 00:00:00
abstract::Unlike their cutaneous counterparts, head and neck mucosal malignant melanomas (HNMM) behave much more aggressively and their prognostic markers have not been fully elucidated. Therefore, the aim of this study was to review the clinicopathologic features of a contemporary series of primary HNMM, retrieved from archiva...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911417970
更新日期:2012-02-01 00:00:00
abstract::A 25-year-old patient presented with epigastric pain, which on gastric biopsy revealed the characteristic appearance of collagenous gastritis. There was a thick prominent subepithelial band that was confirmed to be collagen with a Masson's trichrome stain. There was associated Helicobacter pylori gastritis but no evid...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908329588
更新日期:2010-12-01 00:00:00
abstract::Background. In this single-institution study, we applied the current (eighth edition) American Joint Committee on Cancer pathologic staging criteria to 64 low-grade mucinous neoplasms of the appendix (LAMNs), examined their histopathologic features, and studied the patients' clinical outcomes. Design. Sixty-four LAMNs...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919883679
更新日期:2020-05-01 00:00:00
abstract::The true incidence of light chain deposition disease (LCDD) restricted to the central nervous system (CNS) is unknown. To our knowledge only 7 cases of LCDD restricted to the brain have been previously reported. We herein describe an unusual example. A 44-year-old man presented with a history of ischemic retinopathy i...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896917717338
更新日期:2017-12-01 00:00:00
abstract::Mixed squamous and glandular papilloma (mixed papilloma) of the lung has been reported in fewer than 25 cases in the English literature. Although it is known as a benign tumor, malignant transformation has been reported. Papillary cystic carcinoma is characterized by papillary and cystic growth patterns and has been r...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920908330
更新日期:2020-09-01 00:00:00
abstract::We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies (MUC5AC, MUC6, SOX2, and CDX2). Nonmetaplastic mucosa had histologic evidence o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916672332
更新日期:2017-05-01 00:00:00
abstract::Primary leiomyosarcoma arising from the ovarian vein is extremely rare, with only 10 cases reported in the literature. We report on a case of leiomyosarcoma of the left ovarian vein in a 67-year-old woman who presented with abdominal discomfort. Pelvic ultrasound revealed a large, solid, irregular mass in close relati...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896916679888
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:Renal cell carcinomas (RCCs) in children and adolescents are much rarer than in adults. In this age group, Xp11.2 translocation RCCs were the most common subtype of pediatric RCCs. Information regarding the clinical behavior of pediatric RCCs remains controversial because of their relatively rare incidence. ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,meta分析
doi:10.1177/1066896910375565
更新日期:2010-12-01 00:00:00
abstract::The small cell and lymphohistiocytic variants of anaplastic large cell lymphoma are commonly misdiagnosed as reactive lymphadenopathies. A helpful histologic clue is the presence of perivascular cuffs of large lymphoid cells, and the diagnosis can be readily confirmed by immunostaining for CD30 and ALK. Int J Surg Pat...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690000800210
更新日期:2000-04-01 00:00:00
abstract::We assessed the contribution of histopathological features to systemic recurrence (SR) in patients with colorectal cancer, using a case-control design: 71 cases and 184 controls were included, with a mean time until SR of 1.4 ± 0.1 years and a mean follow-up of controls of 1.6 ± 0.06 years. Cases had significantly gre...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914534464
更新日期:2014-09-01 00:00:00
abstract::Peribiliary cysts, otherwise known as cystic dilatation of the peribiliary glands, are uncommon, and are usually discovered incidentally at autopsy, or in explants following liver transplantation. Preoperative diagnosis is often difficult owing to their asymptomatic nature and small size. Exclusion of a premalignant o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690501300416
更新日期:2005-10-01 00:00:00
abstract::Aims Epithelial mesenchymal transition (EMT) is a crucial process for acquisition of malignant phenotype, aggressiveness, and metastatic capacity in neoplasms. It is characterized by loss of epithelial markers and gain of mesenchymal markers. Studies on EMT and its potential association with the histological grading a...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916654763
更新日期:2016-12-01 00:00:00
abstract::Epithelioid sarcoma is a rare malignant mesenchymal neoplasm (less than 1% of all sarcomas) with epithelioid morphology. Among the 2 subtypes, proximal represents only one-third of cases and commonly involves deep tissues of pelvic region, including the perineum, genital area, and groin, and occurs more frequently in ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917696744
更新日期:2017-08-01 00:00:00
abstract::Ninety-eight consecutive surgical biopsies of oral mucosa from 96 patients were evaluated immunohistochemically with an anti-cytokeratin 20 (CK 20) anti-body to evidence Merkel cells (MC). Fifteen cases, showing the highest number of MC, were additionally studied with chromogranin A, S-100 protein, neuro filaments, ep...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896906290053
更新日期:2006-07-01 00:00:00
abstract::Here we present the case of a 73-year-old woman with an ulcerated, advanced, hepatoid, and α-fetoprotein-producing poorly differentiated (G3) primary gastric adenocarcinoma pT3 N3a M1 with multinucleated cells and evident neuroendocrine component. This tumor was consistent with giant cell tumor type gastric carcinoma ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915586807
更新日期:2015-10-01 00:00:00
abstract::Ectopic adrenal cortical neoplasms are extremely rare, and only a few have involved the CNS. We report the first case of an intramedullary oncocytic adrenal cortical neoplasm of the spinal cord with immunohistochemical (IMHC) confirmation. A 27-year-old man presented with progressive lower extremity weakness, spastic ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200309
更新日期:2004-07-01 00:00:00
abstract::Metastases to cervical lymph nodes (LNs) are an important independent adverse indicator in the prognosis of oral squamous cell carcinoma (OSCC). An accurate evaluation of molecular patterns favoring the metastatic process can be helpful in predicting cases of OSCC with elevated probability of early or late metastases ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912471851
更新日期:2013-04-01 00:00:00
abstract::Microvillous inclusion disease (MVID) is a congenital condition presenting with intractable diarrhea. Biopsies demonstrate abnormal apical PAS and CD10 staining in surface enterocytes correlating with the presence of characteristic cytoplasmic inclusions. MVID has been linked to mutations in myosin Vb, important in ap...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911430959
更新日期:2012-06-01 00:00:00
abstract::Spitz tumors are a group of melanocytic neoplasms with distinct morphological features that tend to affect young individuals. Distinguishing benign from malignant Spitz tumors can be challenging, but cytogenetic and molecular tests have contributed to improvements in diagnostic accuracy. Spitz tumors harbor diverse ge...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916630375
更新日期:2016-05-01 00:00:00
abstract::The International Society of Urological Pathology in 2010 recommended weighing prostates without seminal vesicles (SV) to include only prostate weight in prostate-specific antigen (PSA) density (PSAD) calculation, because SV do not produce PSA. Large retrospective cohorts exist with combined weight recorded that needs...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915600519
更新日期:2015-12-01 00:00:00
abstract::We present the first documented case of hemangioblastoma located in the left colon. A 75-year-old woman undergoing adjuvant chemotherapy for breast cancer experienced rectal bleeding. Colonoscopy revealed a roundish mass covered with normal mucosa in the sigmoid colon. Endoscopic ultrasound showed an isoechoic lesion ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912475082
更新日期:2013-04-01 00:00:00
abstract::Primitive neuroepithelial differentiation in malignant peripheral nerve sheath tumors (MPNSTs) has been reported in children but is extremely rare in adults. The authors report the case of a 70-year-old woman who presented with swelling of the right leg of 1-month duration. Fine-needle aspiration cytology was suggesti...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911432453
更新日期:2012-10-01 00:00:00
abstract::Neuromuscular and vascular hamartoma (NMVH) is an unusual lesion presenting as intestinal obstruction by stricture formation. It is characterized by a hamartomatous mass comprising haphazardly arranged mesenchymal tissue native to the intestinal mucosa and submucosa. We aimed to characterize the clinicohistopathologic...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919890129
更新日期:2020-06-01 00:00:00
abstract::Alveolar soft part sarcoma (ASPS) is a rare neoplasm that most commonly presents in the lower extremities. Although ASPS has distinctive histologic features, it may cause diagnostic problems when it arises in unusual locations. To our knowledge, only 1 case of ASPS arising within the breast has previously been reporte...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690501300112
更新日期:2005-01-01 00:00:00
abstract::A rare case of primary pleomorphic liposarcoma of the thigh with a myxoid component, in which divergent differentiation to a well-differentiated chondrosarcoma was focally present, is described. Presence of heterologous elements has mainly been recognized in the context of dedifferentiated liposarcomas. Few cases of b...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200115
更新日期:2004-01-01 00:00:00
abstract::Sclerosing cholangitis is an autoimmune condition characterized by lymphocytic infiltration within the biliary epithelium leading to multifocal stricturing of the biliary tree. Primary sclerosing cholangitis (PSC) is the most common type encountered clinically. However, a similar process may occur in conjunction with ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908319777
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:In this study, we retrospectively evaluated cases of patients who had undergone appendectomy in our hospital and aimed to present the efficiency of diagnostic tests and demographic data of cases. Pathological reports were analyzed for the following parameters: age, gender, and pathological diagnosis. In addi...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918784650
更新日期:2019-04-01 00:00:00
abstract::Intrasellar rhabdomyosarcoma is rare, and when arising in collusion with an unrelated entity, can present a diagnostic pitfall. We describe a case of a 56-year-old woman who presented with right eye ptosis and a pituitary mass, which was resected and diagnosed as atypical pituitary adenoma. Because of residual disease...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916658955
更新日期:2016-12-01 00:00:00