Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway?

Abstract:

:We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies (MUC5AC, MUC6, SOX2, and CDX2). Nonmetaplastic mucosa had histologic evidence of gastroesophageal reflux. In this case, esophageal reepithelization seems to have been modulated by acidic gastroesophageal reflux, which might activate transcription factors leading to phenotypic reprogramming of the regenerative epithelium. Most interestingly, it is a clinical example showcasing the origin of columnar metaplasia from stem cells located within the esophageal epithelium.

journal_name

Int J Surg Pathol

authors

Rolim I,Rodrigues RV,Bettencourt A,Barros R,Camilo V,Dias Pereira A,Almeida R,Chaves P

doi

10.1177/1066896916672332

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

262-265

issue

3

eissn

1066-8969

issn

1940-2465

pii

1066896916672332

journal_volume

25

pub_type

杂志文章
  • Reactive Nodular Fibrous Pseudotumor Mimicking Metastatic Gastrointestinal Stromal Tumor to Perigastric Lymph Node: A Case Report and Review of the Literature.

    abstract::Gastrointestinal stromal tumors (GIST) are the most common mesenchymal lesions of the gastrointestinal tract. Many are treated surgically with or without the use of adjuvant tyrosine kinase inhibitors. Metastases to lymph nodes are infrequent. In this article, we present a case of a perigastric nodule presenting 3 yea...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896918771192

    authors: Moodley J,Cutz JC,Schell M

    更新日期:2018-10-01 00:00:00

  • α-Fetoprotein-Producing Hepatoid Gastric Adenocarcinoma With Osteoclast-Like Giant Cells and Neuroendocrine Differentiation: A Case Study With Molecular Profiling.

    abstract::Here we present the case of a 73-year-old woman with an ulcerated, advanced, hepatoid, and α-fetoprotein-producing poorly differentiated (G3) primary gastric adenocarcinoma pT3 N3a M1 with multinucleated cells and evident neuroendocrine component. This tumor was consistent with giant cell tumor type gastric carcinoma ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915586807

    authors: Wincewicz A,Kowalik A,Zięba S,Lewitowicz P,Góźdź S,Sulkowski S

    更新日期:2015-10-01 00:00:00

  • Sinonasal SMARCB1 (INI1) Deficient Carcinoma With Yolk Sac Tumor Differentiation: Report of a Case and Comparison With INI1 Expression in Gonadal Germ Cell Tumors.

    abstract::SMARCB1 (INI1) deficient sinonasal carcinoma is a recently recognized entity with wide histomorphologic spectrum. We present a case of this carcinoma that contained, in addition to a "common" morphology, scattered foci of yolk sac tumor differentiation. The tumor occurred in paranasal sinuses in a 44-year-old woman. I...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896917741549

    authors: Zamecnik M,Rychnovsky J,Syrovatka J

    更新日期:2018-05-01 00:00:00

  • Primary vaginal Ewing sarcoma: case report and review of the literature.

    abstract::Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) are round-cell sarcomas with varying degrees of neuroectodermal differentiation; they are considered members of the same family of tumors based on their common genetic profile. ES/PNET are very infrequent in the female genital tract, the vagina being the ra...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896911424898

    authors: Bancalari E,de Álava E,Tardío JC

    更新日期:2012-06-01 00:00:00

  • Invasive Lobular Carcinoma With Extensive Clear Cells: A Pitfall in Diagnosis.

    abstract::Carcinomas in the breast with a predominantly clear cytoplasm are rare. In this article, we review the differential diagnosis of clear cell breast neoplasms and report a case of invasive lobular carcinoma with extensive clear cell morphology that was diagnosed as invasive ductal carcinoma, not otherwise specified, on ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896919881705

    authors: Kavesh MH,Sanchez D,Asirvatham JR

    更新日期:2020-04-01 00:00:00

  • Evanescence of Endometrial Carcinomas in Hysterectomy Specimens: Observations on the "Vanishing Cancer" Phenomenon.

    abstract:BACKGROUND:The phenomenon of vanishing carcinomas, first described in context of prostatic carcinomas, has been documented in endometrial carcinomas as well. METHODS:The archives of the department were searched for case files of endometrial carcinoma diagnosed on endometrial curetting/biopsy but which did not reveal a...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896918783581

    authors: Bharani V,Rai B,Rajwanshi A,Gupta N,Dey P,Kalra J,Suri V,Srinivasan R

    更新日期:2019-02-01 00:00:00

  • Low-Grade, Nonintestinal Nonsalivary Sinonasal Adenocarcinoma Associated With an Exophytic Schneiderian Papilloma: A Case Report.

    abstract::Sinonasal adenocarcinoma is a rare tumor of the head and neck accounting for 10% to 20% of all primary malignancies of the nose and paranasal sinuses. There tumors are classified as salivary, intestinal and nonintestinal, nonsalivary. Low-grade nonintestinal nonsalivary are rare tumors whose diagnosis is essentially t...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915599060

    authors: Blumberg JM,Escobar-Stein J,Vining EM,Prasad ML

    更新日期:2015-12-01 00:00:00

  • Dedifferentiated Liposarcoma Mimicking a Primary Colon Mass.

    abstract::Dedifferentiated liposarcoma is typically a nonlipogenic high-grade sarcoma that arises from well-differentiated liposarcoma. It most commonly presents as a large mass in the retroperitoneum. Significant involvement of the gastrointestinal tract by dedifferentiated liposarcoma is uncommon. We present a unique case of ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896917731517

    authors: Hollowoa B,Lamps LW,Mizell JS,English GW 3rd,Bridge JA,Ram R,Gardner JM

    更新日期:2018-04-01 00:00:00

  • HIV-unrelated benign lymphoepithelial cyst of the parotid glands containing lymphoepithelial lesion--like structures: a report of 3 cases.

    abstract::Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908328575

    authors: Kojima M,Nakamura N,Matsuda H,Kaba S,Itoh H,Masawa N

    更新日期:2009-12-01 00:00:00

  • Utility of Additional Tissue Sections in Surgical Pathology.

    abstract:BACKGROUND:To avoid diagnostic errors such as missed diagnosis and errors in staging tumors due to inadequate tissue sampling, pathologists submit additional sections (AS). OBJECTIVE:This study assessed frequency, diagnostic yield, distribution, and cost of AS. METHOD:Among 1542 AS cases, we calculated mean AS per ca...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896918755008

    authors: Hamza A,Alrajjal A,Edens J,Khawar S,Khurram MS,Szpunar S,Bonnett M

    更新日期:2018-08-01 00:00:00

  • Comparison of biochemical recurrence-free survival between periprostatic and pelvic lymph node metastases of prostate cancer.

    abstract:OBJECTIVE:To assess the pathologic characteristics and prognostic significance of periprostatic lymph node (LN) metastasis of prostate cancer. The latter was performed by comparing biochemical recurrence (BCR)-free survival in cases of periprostatic LN metastasis versus matched patients showing pelvic LN metastasis. M...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896913482729

    authors: González-Roibón N,Han JS,Lee S,Feng Z,Arslankoz S,Smith N,Pierorazio PM,Humphreys E,Deweese TL,Partin AW,Bivalacqua TJ,Han M,Trock B,Netto GJ

    更新日期:2013-08-01 00:00:00

  • Pulmonary hyalinizing granuloma associated with Aspergillus infection.

    abstract::A 38-year-old immunocompetent man with occupational exposure to Aspergillus presented with dyspnea, pleuritic chest pain, and hemoptysis. Chest roentgenograms and computed tomography scans demonstrated multiple pulmonary nodules bilaterally. An initial set of bronchial washing cultures grew Aspergillus fumigatus, sero...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690301100112

    authors: Pinckard JK,Rosenbluth DB,Patel K,Dehner LP,Pfeifer JD

    更新日期:2003-01-01 00:00:00

  • Loss of heterozygosity on chromosome 1 and 9 and hormone receptor analysis of metastatic malignant melanoma presenting in breast.

    abstract::Malignant melanoma (MM), the most common metastatic solid tumor to involve the breast, may present as a diagnostic problem, frequently requiring the use of ancillary studies for accurate diagnosis. The implication of hormonal interplay is strong since metastatic MM to the breast is seen nearly always in women. However...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690501300102

    authors: Beaty MW,Quezado M,Sobel ME,Duray P,Merino MJ

    更新日期:2005-01-01 00:00:00

  • Pathologic and clinical features of Hodgkin lymphoma--like posttransplant lymphoproliferative disease.

    abstract::Because of its rarity, pathologic and clinical features of Hodgkin lymphoma-like posttransplant lymphoproliferative disorder (HL-like PTLD) are not well understood, and it is unclear whether its biological behavior is more closely related to classical Hodgkin disease or to monomorphic B-cell PTLD. The authors compared...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896909338597

    authors: Krishnamurthy S,Hassan A,Frater JL,Paessler ME,Kreisel FH

    更新日期:2010-08-01 00:00:00

  • UbcH10 expression in benign, hyperplastic, and malignant endometrial curetted materials: a tissue microarray study.

    abstract::The aim of this study was to investigate the role of UbcH10 expression in the differential diagnosis of benign, hyperplastic, and malignant endometrial tissues and also the relationship of UbcH10 with the clinicopathologic parameters of malignant cases. A tissue microarray was performed for 81 endometrial curettage bi...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896912437414

    authors: Kefeli M,Yildiz L,Celik H,Tosun M,Karagoz F

    更新日期:2012-08-01 00:00:00

  • Mixed Intraepithelial Neoplasia-Well-Differentiated Neuroendocrine Tumor of the Gallbladder: A Hitherto Unreported Combination.

    abstract::Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine neoplasms (NENs) can also occur. The majority of NENs are represented by neuroendocrine carcinomas (NECs), while neuroendocrine tumors (NETs) are extremely rare in this lo...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920986987

    authors: Kővári B,Turkevi-Nagy S,Lauwers GY,Jiang K

    更新日期:2021-01-09 00:00:00

  • High-grade neuroendocrine carcinoma arising in a gastric duplication cyst: a case report with literature review.

    abstract::Gastric duplication cysts are rare congenital anomalies that are mostly discovered in children but can remain asymptomatic and undetected into adulthood. Malignant transformation in gastric duplications is extremely rare, with most reported cases being adenocarcinomas. Herein, the authors report the first case of a hi...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896906295777

    authors: Horne G,Ming-Lum C,Kirkpatrick AW,Parker RL

    更新日期:2007-04-01 00:00:00

  • Spontaneous complete regression of gastric large-cell neuroendocrine carcinoma: mediated by cytomegalovirus-induced cross-autoimmunity?

    abstract::Spontaneous regression of malignant tumour is a rare phenomenon. This report describes such an occurrence in a gastric large cell neuroendocrine carcinoma of a 77-year-old man. The patient presented with dyspepsia, and biopsy of the fungating mass in the cardia showed a high grade neuroendocrine carcinoma. The pre-ope...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896911404412

    authors: Ip YT,Pong WM,Kao SS,Chan JK

    更新日期:2011-06-01 00:00:00

  • Peribiliary cysts can mimic Caroli's disease: a case report.

    abstract::Peribiliary cysts, otherwise known as cystic dilatation of the peribiliary glands, are uncommon, and are usually discovered incidentally at autopsy, or in explants following liver transplantation. Preoperative diagnosis is often difficult owing to their asymptomatic nature and small size. Exclusion of a premalignant o...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690501300416

    authors: Fusai G,Tucker O,Nik Sulaiman NM,Karani J,Rela M,Portmann B

    更新日期:2005-10-01 00:00:00

  • Benign fibro-osseous lesions of the jaws: a study of 127 Chinese patients and review of the literature.

    abstract::The aim of this study is to analyze all the cases of benign fibro-osseous lesions treated at School and Hospital of Stomatology, Wuhan University, to compare the results obtained in this study with those previously documented by other authors. The 127 cases diagnosed as a fibro-osseous lesion were retrieved, and infor...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896908318744

    authors: Alsharif MJ,Sun ZJ,Chen XM,Wang SP,Zhao YF

    更新日期:2009-04-01 00:00:00

  • Unsuspected Xp11 Translocation Renal Neoplasm Associated With Contralateral Clear Cell Carcinoma.

    abstract::In this report, we present for the first time the coexistence of a conventional renal cell carcinoma (RCC) and an undefined Xp11 translocation renal neoplasm in distinct kidneys, which was difficult to definitively classify as either carcinoma or PEComa (perivascular epithelioid cell tumor). While one of the tumors sh...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915597753

    authors: D'Antonio A,Addesso M,Nappi O,Zeppa P

    更新日期:2016-05-01 00:00:00

  • Atypical adenomatous hyperplasia (adenosis) of the prostate: DNA ploidy analysis and immunophenotype.

    abstract::Atypical adenomatous hyperplasia (AAH) of the prostate is a microscopic proliferation of small acini that may be mistaken for adenocarcinoma. Although some data suggest that AAH is associated with adenocarcinoma arising in the transition zone, the clinical significance of this lesion is uncertain. Therefore we studied...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690501300207

    authors: Lopez-Beltran A,Qian J,Montironi R,Luque RJ,Bostwick DG

    更新日期:2005-04-01 00:00:00

  • Clinicopathologic Features of Benign Neurogenic Tumor of Urinary Bladder.

    abstract:BACKGROUND:Benign neurogenic tumor involving the urinary bladder is a very rare and heterogeneous disease group. The clinical and radiological diagnosis may be difficult because of the disease's rarity and the histological similarities of each disease especially in needle biopsy specimens. However, accurate diagnosis i...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896917742722

    authors: Lee C,Kim B,Song B,Park JH,Moon KC

    更新日期:2018-05-01 00:00:00

  • Anaplastic Sarcoma of the Kidney: A Rare Unique Renal Neoplasm.

    abstract::Anaplastic sarcoma of the kidney (ASK) is an extremely rare tumor, which usually presents as a large renal mass. Microscopically, the tumor is composed of pleomorphic mesenchymal spindle cells with marked atypia, associated with chondroid differentiation and focal round primitive mesenchymal cells. Herein, we present ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916639373

    authors: Arabi H,Al-Maghraby H,Yamani A,Yousef Y,Huwait H

    更新日期:2016-09-01 00:00:00

  • Autoimmune-Like Hepatitis: A "Hepatitic" Manifestation of Chronic Graft Versus Host Disease in Post-Stem Cell Transplant.

    abstract::A 59-year-old female received a matched related donor stem cell transplant for chronic myelogenous leukemia. After being successfully treated with prednisone for chronic graft versus host disease that initially started 50 days posttransplant, she developed hepatic dysfunction during the steroid taper on day 531, as ev...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915610817

    authors: Baniak NM,Kanthan R

    更新日期:2016-04-01 00:00:00

  • Spermatocytic Tumor With Sarcoma: A Rare Testicular Neoplasm.

    abstract::Spermatocytic tumor, formerly known as spermatocytic seminoma, is an uncommon testicular neoplasm which is a distinct clinicopathologic entity from classic seminoma. These tumors are not associated with germ cell neoplasia in situ, other germ cell tumors, or isochromosome 12p. Although typically, these tumors have an ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896917706156

    authors: Stueck AE,Grantmyre JE,Wood LA,Wang C,Merrimen J

    更新日期:2017-09-01 00:00:00

  • Simple melanosis of the bladder: a rare entity.

    abstract::Simple melanosis of the bladder is an uncommon condition with fewer than 15 reported cases characterized by multifocal, diffuse melanin pigmentation of the urothelial mucosa. It is frequently associated with urinary incontinence or urgency. Histologically, melanin granules are present within urothelial cells or lamina...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896909352863

    authors: Talmon GA,Khan AU,Koerber RK,Johansson SL

    更新日期:2010-12-01 00:00:00

  • Colorectal liver metastasis with intrabiliary growth: case report and review of the literature.

    abstract::Colorectal liver metastases with intrabiliary growth are uncommon and difficult to characterize by radiology alone. We present the case of a 61-year-old woman previously operated on for a left colon cancer who developed a metacronous lesion at liver segment II-III. Radiologic workup was indicative for cholangiocarcino...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896913491317

    authors: Coppola S,Zucchini N,Romano F,Bovo G,Gilardoni E,Nespoli L,Gianotti L

    更新日期:2014-05-01 00:00:00

  • A Note of Caution: Variable Cytokeratin Staining in Sentinel Node Metastases.

    abstract::Sentinel lymph node biopsy is the current standard procedure used to stage patients with breast cancer. The best histological method in evaluating sentinel nodes is highly debated among institutions and is thus not standardized. The optimal histological analysis is a balance between comprehensive evaluation of the sen...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915596811

    authors: Zeng J,Alexander MA,Nimeh D,Darvishian F

    更新日期:2015-10-01 00:00:00

  • Pediatric renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion.

    abstract::Renal cell carcinoma (RCC) in children and young adults is rare and pathologically problematic. RCC can be either hereditary or sporadic and has a guarded prognosis because appropriate management has not been established. A case of RCC in an 11-year-old is reported. The clinical presentation was a right abdominal mass...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907304994

    authors: Winarti NW,Argani P,De Marzo AM,Hicks J,Mulyadi K

    更新日期:2008-01-01 00:00:00