Abstract:
OBJECTIVE:To assess the pathologic characteristics and prognostic significance of periprostatic lymph node (LN) metastasis of prostate cancer. The latter was performed by comparing biochemical recurrence (BCR)-free survival in cases of periprostatic LN metastasis versus matched patients showing pelvic LN metastasis. METHODS AND MATERIALS:We identified 15 patients who underwent radical prostatectomy in our institution (1984-2011) showing positive periprostatic and negative pelvic LN with available follow-up information (group 1). These patients were matched 1:2 to patients with positive pelvic LN (group 2) for pertinent clinicopathologic parameters. RESULTS:Main locations of positive periprostatic LN were posterior base and mid posterolateral. Overall higher rate of positive margins, smaller LN, and metastasis size were encountered in group 1 compared with group 2. At 5 years postprostatectomy, 69% of patients in group 1 were free of BCR, whereas 26% of those in group 2 remained BCR free, suggesting that patients with periprostatic node metastasis appeared to have a lower risk of BCR. However, the difference was not statistically significant (P = .072). The same was true when adjusted for the effect of prostate-specific antigen, surgical margin status, size of LNs, size of metastasis, age, and year of surgery. CONCLUSION:Patients with periprostatic node metastasis may have a lower risk of BCR compared with those with metastasis to pelvic LN. Future analysis of larger cohorts will help establish the biologic significance of prostate cancer metastasis to periprostatic LN.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
González-Roibón N,Han JS,Lee S,Feng Z,Arslankoz S,Smith N,Pierorazio PM,Humphreys E,Deweese TL,Partin AW,Bivalacqua TJ,Han M,Trock B,Netto GJdoi
10.1177/1066896913482729subject
Has Abstractpub_date
2013-08-01 00:00:00pages
352-7issue
4eissn
1066-8969issn
1940-2465pii
1066896913482729journal_volume
21pub_type
杂志文章abstract::SMARCB1 (INI1) deficient sinonasal carcinoma is a recently recognized entity with wide histomorphologic spectrum. We present a case of this carcinoma that contained, in addition to a "common" morphology, scattered foci of yolk sac tumor differentiation. The tumor occurred in paranasal sinuses in a 44-year-old woman. I...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917741549
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Epithelioid hemangioendothelioma (EHE) is an uncommon malignant endothelial neoplasm that most commonly arises in soft tissue, bone, lung, and liver. Crohn's disease (CD) is an inflammatory bowel disease of unknown etiology that is frequently associated with complications including strictures, fistulas/fissu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918801527
更新日期:2019-06-01 00:00:00
abstract::Sclerosing spindle cell rhabdomyosarcoma (SSRMS) is a newly recognized entity in adults. The authors report a new case of SSRMS in a 31-year-old woman who presented with a large right leg mass. Biopsy revealed a malignant spindle cell neoplasm with focal sclerotic areas. A diagnosis of monophasic synovial sarcoma was ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896908327166
更新日期:2010-10-01 00:00:00
abstract::Diverticulosis of the appendix is a relatively rare pathological finding. The majority are acquired pseudodiverticula. True congenital diverticula are very rare. Appendiceal diverticulosis is usually an incidental finding and clinically asymptomatic. When symptomatic, it is usually complicated by acute or chronic dive...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896909332728
更新日期:2009-06-01 00:00:00
abstract::Eccrine porocarcinoma is a potentially fatal form of sweat gland carcinoma, due to its propensity to metastasize through lymph vessels. The authors report the case of a 69-year-old female who presented with swelling of the right leg and an ulcerated lesion of the right great toe. The initial histologic diagnosis was i...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911428738
更新日期:2012-10-01 00:00:00
abstract::We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies (MUC5AC, MUC6, SOX2, and CDX2). Nonmetaplastic mucosa had histologic evidence o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916672332
更新日期:2017-05-01 00:00:00
abstract::The majority of alveolar RMSs have t(2;13)(q35;q14) or (1:13)(p36;q14),which generate PAX3/7 -FKHR fusion genes. Here, the authors detected the PAX3/7-FKHR fusion transcripts in 17 formalin-fixed, paraffin-embedded RMSs and 26 other SRCTs using one-step RT-PCR. PAX3 -FKHR and PAX7-FKHR transcripts were positive in 4/8...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908323922
更新日期:2009-02-01 00:00:00
abstract::We review the clinical, pathologic, and molecular genetic features of 3 splenic T-cell-rich B-cell lymphomas and discuss their differential diagnosis. All patients presented with symptomatic splenomegaly and underwent diagnostic/therapeutic splenectomy. Microscopically, the spleen in all cases showed a micronodular pr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200105
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:To avoid diagnostic errors such as missed diagnosis and errors in staging tumors due to inadequate tissue sampling, pathologists submit additional sections (AS). OBJECTIVE:This study assessed frequency, diagnostic yield, distribution, and cost of AS. METHOD:Among 1542 AS cases, we calculated mean AS per ca...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918755008
更新日期:2018-08-01 00:00:00
abstract::Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916646448
更新日期:2016-10-01 00:00:00
abstract::Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special tec...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908323505
更新日期:2011-02-01 00:00:00
abstract::A 16-year-old boy presented with a tumor located in fourth ventricle, which showed histological features of an ependymoma replete with perivascular pseudorosettes and true ependymal rosettes. Interestingly, many of the tumor cells exhibited abundant cytoplasm stuffed with a grayish brown pigment. Histochemical stains ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920926700
更新日期:2021-02-01 00:00:00
abstract::A case of endobronchial pagetoid spread of a breast carcinoma metastatic to the lung is described. A 73-year-old woman underwent wedge lung resection after the cytological diagnosis of lung metastasis from ductal invasive breast carcinoma. The breast carcinoma had been surgically removed 6 years previously; at the tim...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916660619
更新日期:2017-02-01 00:00:00
abstract::A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cy...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914553666
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The rate of incidental prostate adenocarcinoma (PCa) detection in radical cystoprostatectomy (RCP) varies widely, ranging from 15% to 54%. Such variability may be explained by institutional differences in prostate grossing protocols. Either partial or complete submission of the prostate gland in RCP may resu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917696745
更新日期:2017-08-01 00:00:00
abstract::Enfuvirtide (ENF, T-20, or Fuzeon [Hoffman-La Roche Inc, Nutley, NJ, and Trimeris, Inc, Durham, NC]) is an HIV-1 fusion inhibitor and is the only injectable antiretroviral drug available. Injection site reactions (ISRs) are the most frequently reported adverse events, occurring in about 98% of patients. A granuloma an...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896909332119
更新日期:2010-10-01 00:00:00
abstract::Diaphragm disease of small intestine usually presents with nonspecific clinical features. Radiological investigations often fail to differentiate it from small intestinal tumors and inflammatory bowel disease. It is therefore diagnosed on final histology after surgical resection. We hereby report an interesting case o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914563392
更新日期:2015-06-01 00:00:00
abstract::Metanephric stromal tumor (MST) of the kidney is a rare pediatric neoplasm which has rarely been reported in adults. The authors present a case of MST, cellular type, an unreported variant, in a 56-year-old postmenopausal woman. The 9.0-cm tumor was solid, unencapsulated, and well circumscribed, with a firm homogeneou...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896912453851
更新日期:2013-04-01 00:00:00
abstract::Colonic perineurioma has been depicted as characterized by a mucosal proliferation of monomorphic spindle perineurial cells leading to an evident separation, distortion, and entrapment of colonic crypts. The authors, however, believe that a sizable subset of the cases differ in that they display only a limited perineu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909350883
更新日期:2010-08-01 00:00:00
abstract::Background. Solitary circumscribed neuroma (SCN), also known as palisaded encapsulated neuroma (PEN), is a benign neural tumor. It may be mistaken as either schwannoma or neurofibroma in pathology practice. In this study, we aimed to define clinicopathologic and immunohistochemical features and discuss its differentia...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919833172
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:The phenomenon of vanishing carcinomas, first described in context of prostatic carcinomas, has been documented in endometrial carcinomas as well. METHODS:The archives of the department were searched for case files of endometrial carcinoma diagnosed on endometrial curetting/biopsy but which did not reveal a...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918783581
更新日期:2019-02-01 00:00:00
abstract::We assessed the contribution of histopathological features to systemic recurrence (SR) in patients with colorectal cancer, using a case-control design: 71 cases and 184 controls were included, with a mean time until SR of 1.4 ± 0.1 years and a mean follow-up of controls of 1.6 ± 0.06 years. Cases had significantly gre...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914534464
更新日期:2014-09-01 00:00:00
abstract::Verruciform xanthoma is a rare benign verrucopapillary lesion that develops in the oral mucosa and genital skin. Its development in the esophagus is extremely rare, with only 5 reported cases. We present 2 cases of verruciform xanthoma of the esophagus. Case 1 involved a 91-year-old woman, who had hypertension and chr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896919879495
更新日期:2020-05-01 00:00:00
abstract::We present a case of clear cell meningioma with unusual clinical and pathologic features. The patient was a 54-year-old man who underwent laminectomy and durotomy for an intradural tumor in the lumbar spinal canal. Sections showed a predominance of dense collagenous tissue with irregularly shaped and irregularly sized...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912470165
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:In this study, we retrospectively evaluated cases of patients who had undergone appendectomy in our hospital and aimed to present the efficiency of diagnostic tests and demographic data of cases. Pathological reports were analyzed for the following parameters: age, gender, and pathological diagnosis. In addi...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918784650
更新日期:2019-04-01 00:00:00
abstract::Rhabdomyosarcoma is an aggressive malignant tumor often developing in the head and neck in children. In the sinonasal region, rhabdomyosarcoma constitutes a clinically important group because of the difficulty of surgical resection and its generally poor prognosis. We reviewed the archival pathology materials of 39 ca...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896906299122
更新日期:2007-04-01 00:00:00
abstract::Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described entity that, despite significant pleomorphism, carries a good prognosis. We briefly describe this tumor and its principal differential diagnoses. Recognition of SCPFTs, including the clinical context in which they arise, is important to avoid...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920938133
更新日期:2020-12-01 00:00:00
abstract::Renal cell carcinoma (RCC) in children and young adults is rare and pathologically problematic. RCC can be either hereditary or sporadic and has a guarded prognosis because appropriate management has not been established. A case of RCC in an 11-year-old is reported. The clinical presentation was a right abdominal mass...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907304994
更新日期:2008-01-01 00:00:00
abstract::Neuromuscular and vascular hamartoma (NMVH) is an unusual lesion presenting as intestinal obstruction by stricture formation. It is characterized by a hamartomatous mass comprising haphazardly arranged mesenchymal tissue native to the intestinal mucosa and submucosa. We aimed to characterize the clinicohistopathologic...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919890129
更新日期:2020-06-01 00:00:00
abstract::We report the case of a sclerosing perineurioma with conspicious collagen rosette formation in a 20-year-old male presenting with a firm, painless nodule on the palmar side of his right ring finger. The main differential diagnosis is a low-grade fibromyxoid sarcoma. The distinction between these entities is important ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917741551
更新日期:2018-04-01 00:00:00