Verruciform Xanthoma of the Esophagus: Two Case Reports With Review of the Literature.

Abstract:

:Verruciform xanthoma is a rare benign verrucopapillary lesion that develops in the oral mucosa and genital skin. Its development in the esophagus is extremely rare, with only 5 reported cases. We present 2 cases of verruciform xanthoma of the esophagus. Case 1 involved a 91-year-old woman, who had hypertension and chronic gastritis with Helicobacter pylori infection, with a 12-year history of a 10-mm white-yellow elevated lesion on the esophagus, 35 cm from the incisor teeth. Case 2 involved a 70-year-old man with fundic gland polyp, hyperlipidemia, and lung cancer, who had a 10-mm whitish granular/verrucoid lesion on the esophagus, 28 cm from the incisor teeth. Microscopically, these lesions show verrucous and papillomatous epithelial hyperplasia with neutrophilic intraepithelial exocytosis. The histological hallmark is the presence of numerous foamy histiocytes infiltrating the elongated squamous epithelial papillae. Although its etiology is unknown, irritation or trauma caused by radiotherapy has been suggested.

journal_name

Int J Surg Pathol

authors

Noguchi H,Kitazono I,Hamada K,Tanaka T,Tasaki T,Shirahama H,Yamamoto Y,Tanimoto A

doi

10.1177/1066896919879495

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

302-305

issue

3

eissn

1066-8969

issn

1940-2465

journal_volume

28

pub_type

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