Squamous metaplasia on the breast implant capsule.


:The development of squamous metaplasia or carcinoma is a rare occurrence in the setting of a ruptured or leaking silicone breast implant capsule. However, the oncogenic process in such a context is yet another intriguing example of how chronic inflammation plays an integral role in the tumorigenic process. Recent papers have shed light on how inflammation involving M2-tpe macrophages, lymphocytes, and other inflammatory cells at first provide the cytokines necessary to fend off an inciting foreign-body attack such as silicone from a ruptured or leaking implant. Although such a response is beneficial in keeping infection or foreign material in check, there are instances when the response may be exaggerated. It is thought that the extent and length of the response, the balance between pro-inflammatory/ anti-apoptotic and anti-inflammatory/pro-apoptotic, as well as genetic factors play important roles in determining the final result of an inflammatory insult.


Int J Surg Pathol


Alikhan MB,Nassar A,Mansoor I




Has Abstract


2010-12-01 00:00:00














  • Evanescence of Endometrial Carcinomas in Hysterectomy Specimens: Observations on the "Vanishing Cancer" Phenomenon.

    abstract:BACKGROUND:The phenomenon of vanishing carcinomas, first described in context of prostatic carcinomas, has been documented in endometrial carcinomas as well. METHODS:The archives of the department were searched for case files of endometrial carcinoma diagnosed on endometrial curetting/biopsy but which did not reveal a...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Bharani V,Rai B,Rajwanshi A,Gupta N,Dey P,Kalra J,Suri V,Srinivasan R

    更新日期:2019-02-01 00:00:00

  • Composite Hemangioendothelioma With Neuroendocrine Marker Expression: Report of a "Paraganglioma-Like" Paravertebral Case.

    abstract::Composite hemangioendothelioma is a rare vascular tumor morphologically comprising several distinct vascular components and exhibits a borderline malignant potential. We described the case of a 53-year-old female who presented with an infiltrative mass in the paravertebral soft tissue. The tumor showed discrete nests ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Cheuk W,Shum KS,Ng WK,Chan JKC

    更新日期:2020-10-01 00:00:00

  • Ocular Sebaceous Carcinoma In Situ With Biphenotypic Differentiation: A Reappraisal of the Alternative Origin of the Tumor.

    abstract::Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Yim CL,Lam SC,Yuen HKL,Cheuk W

    更新日期:2020-12-01 00:00:00

  • Identification of mislabeled specimen by molecular methods: case report and review.

    abstract::Specimen misidentification is a common cause of errors in surgical pathology. We report a case where bone-marrow biopsies from patients of different genders were mislabeled and molecular methods were applied to resolve the identity. A short tandem repeat (STR)-polymerase chain reaction-based assay, commonly used in pa...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Mariappan MR,Zehnder J,Arber DA,Lay M,Fadare O,Schrijver I

    更新日期:2005-07-01 00:00:00

  • A Subcentimetric Nodule on the Penile Shaft.

    abstract::Juvenile xanthogranuloma (JXG) is a benign histiocytic disorder usually affecting the head and trunk region of a child. The isolated occurrence of JXG in the penile shaft of a young adult is hitherto unreported. This lesion is amenable to surgical resection although systemic and/or internal visceral involvement can oc...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Majumder R,Biswas D,Mishra TS,Mitra S

    更新日期:2020-09-01 00:00:00

  • Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis.

    abstract::Clear cell chondrosarcoma (CCCS) is a rare variant of conventional chondrosarcoma with low-grade malignant features that may be confused radiographically and histologically with chondroblastoma. We report a case of a 50-year-old female who presented with 6 months of left hip pain. Initial radiographs demonstrated an o...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Kiefer RM,Wojcik J,Cooper K,Weber KL,Sebro R

    更新日期:2018-12-01 00:00:00

  • Lymph node ratio: a new feature for defining risk category of node-positive breast cancer patients.

    abstract::St. Gallen 2005 expert consensus guideline modified its criteria for the risk category of breast cancer (BC) patients by integrating a combination of lymph nodes with metastasis (positive lymph nodes [PLNs]) and HER-2/neu status of tumor. Recently, some studies have shown that lymph node ratio (LNR), defined as the ra...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Yang C,Liu F,Li S,Li W,Zhai L,Ren M,Li Y,Lang R,Fan Y,Zhang X,Fu L

    更新日期:2012-12-01 00:00:00

  • Multifocal Polymorphous Hemangioendothelioma of the Liver: Case Report and Review of Literature.

    abstract::We report a case of polymorphous hemangioendothelioma, a rare vascular neoplasm, arising in the liver of a 51-year-old woman. Microscopically, this neoplasm is characterized by a polymorphous blend of solid, primitive vascular and angiomatous areas in variable proportions. Polymorphous hemangioendothelioma is consider...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: El Hussein S,Omarzai Y

    更新日期:2017-05-01 00:00:00

  • Pindborg Tumor Presenting as a Nasal Polyp: Immunohistology and Ultrastructural Features of a Rare Case, With Review of the Literature.

    abstract::Calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a rare benign odontogenic tumor. This tumor predominantly involves the mandible, though the maxilla can also be involved in some cases. The involvement of maxillary sinuses, however, has been previously reported in only 8 case reports English li...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: Mitra S,Kaur G,Nada R,Mohindra S

    更新日期:2016-09-01 00:00:00

  • Lymphoplasmacyte-Rich Meningioma With Atypical Angiomatous Feature and an Increased Deposition of IgG4-Positive Plasma Cells: An Unusual Case Report.

    abstract::Lymphoplasmacyte-rich meningioma (LPRM) is an extremely rare variant of meningioma, and a small percentage of LPRM may be associated with IgG4-related disease. To date, the coexistence of 2 rare meningioma variants consisting of LPRM and angiomatous meningioma within one neoplasm has not been reported in the literatur...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Son HJ,Yu IK,Kim SM

    更新日期:2018-02-01 00:00:00

  • T-cell-rich B-cell lymphoma presenting in the spleen: a clinicopathologic analysis of 3 cases.

    abstract::We review the clinical, pathologic, and molecular genetic features of 3 splenic T-cell-rich B-cell lymphomas and discuss their differential diagnosis. All patients presented with symptomatic splenomegaly and underwent diagnostic/therapeutic splenectomy. Microscopically, the spleen in all cases showed a micronodular pr...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Li S,Mann KP,Holden JT

    更新日期:2004-01-01 00:00:00

  • Intra-Alveolar Intestinal Epithelium: A Reappraisal of the So-Called Mucinous Goblet-Cell Rich Carcinoma Apropos of Two Cases With Prolonged Follow-up and Literature Review.

    abstract::Primary pulmonary mucin-rich lesions with abundant goblet cells growing within alveolar spaces are either classified as mucinous adenocarcinoma (previously called mucinous bronchioloalveolar carcinoma) or colloid carcinoma. Some of these lesions display a morphologic pattern characterized by paucicellular discontinuou...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: Jessurun J

    更新日期:2015-05-01 00:00:00

  • Clinicopathologic analysis of 4 perivascular epithelioid cell tumors (PEComas) of the gastrointestinal tract.

    abstract::This study describes the clinical, histologic, and immunohistochemical features of four cases of GI PEComa. The size of the tumors ranged from 3.5 to 6.0cm in diameter, and all were located in wall of the large bowel. Microscopically, the tumors were characterized by an epithelioid arrangement of tumor cells, which ha...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Shi HY,Wei LX,Sun L,Guo AT

    更新日期:2010-08-01 00:00:00

  • Warty Carcinoma Arising in Condyloma Acuminatum of Urinary Bladder: A Case Report.

    abstract::We describe the case of a 62-year-old man with chronic irritation of the urinary bladder resulting in dysuria and hypogastric pain. Three neoplasms measuring 0.5, 1, and 1.5 cm, respectively, were observed by cystoscopy and removed by transurethral resection (TUR). Histologic examination showed a complex folding of sq...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Botella E,Burgués O,Navarro S,Ramos D,Ferrer J,Gimeno C,Llombart-Bosch A

    更新日期:2000-07-01 00:00:00

  • Uterine glomeruloid hemangioma in a patient without POEMS syndrome.

    abstract::Cutaneous glomeruloid hemangioma is a hallmark of POEMS syndrome. These patients have elevated serum levels of vascular endothelial growth factor. The authors report an extracutaneous uterine glomeruloid hemangioma in an 82-year-old woman with a history of breast and endometrial carcinomas. Within the lumen of myometr...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Giner F,Compañ A,Monteagudo C

    更新日期:2012-08-01 00:00:00

  • Malignant mesothelioma masquerading as a multinodular bronchioloalveolar cell adenocarcinoma with widespread pulmonary nodules.

    abstract::A 72-year-old man had a unilateral pleural effusion and multiple bilateral pulmonary nodules. Thoracoscopic biopsy revealed multiple discrete nodules in the pleura and lung. The latter consisted of tall columnar malignant cells arranged on alveolar surfaces in a lepidic growth pattern. Mucin filled the alveolar lumina...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Felner KJ,Wieczorek R,Kline M,Smith RL,Sidhu GS

    更新日期:2006-07-01 00:00:00

  • Primary Leiomyosarcoma of the Ovarian Vein: Case Report and Literature Review.

    abstract::Primary leiomyosarcoma arising from the ovarian vein is extremely rare, with only 10 cases reported in the literature. We report on a case of leiomyosarcoma of the left ovarian vein in a 67-year-old woman who presented with abdominal discomfort. Pelvic ultrasound revealed a large, solid, irregular mass in close relati...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: López-Ruiz ME,Yébenes L,Berjón A,Hardisson D

    更新日期:2017-06-01 00:00:00

  • Dysplasia in Chronic Ulcerative Colitis: A Molecular Approach to Its Differential Diagnosis.

    abstract::Ulcerative colitis-related epithelial dysplasia represents a premalignant lesion, which may lead to the development of ulcerative colitis-related adenocarcinoma. The proper management of this condition requires proctocolectomy before the acquisition of the invasive phenotype. Patients with chronic ulcerative colitis, ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Urbanski SJ,Fogt F

    更新日期:2000-01-01 00:00:00

  • Warthin Tumor-Like Mucoepidermoid Carcinoma.

    abstract::Mucoepidermoid carcinoma (MEC) shows a wide morphologic spectrum, including epithelium with oncocytic or squamous metaplastic changes overlying a prominent cystic architecture, as well as tumor-associated lymphoid tissue. We illustrate a case of MEC of the parotid in a 17-year-old female, in which all these features o...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Heatley N,Harrington KJ,Thway K

    更新日期:2018-02-01 00:00:00

  • Giardia Is Often Overlooked on Histopathologic Examination: A High-Volume, Single-Institution Experience.

    abstract:AIMS. GIARDIA:is sometimes missed by the pathologist, and we sought to determine how often this occurs at our institution-a large tertiary care center with a subspecialty gastrointestinal pathology service and what certain clinical and histologic clues can be used to flag cases with a higher likelihood of infection, ta...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Shen MJ,Voltaggio L,Robertson S

    更新日期:2020-08-10 00:00:00

  • Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma.

    abstract::The role and diagnostic efficacy of gene and protein products RB1, CDK4, CHMP2B, HSP90, and cPLA2G4A, all previously shown to be involved in tumor genesis and cell proliferation, were examined by immunohistochemical techniques in 32 cases of myxofibrosarcomas and 29 myxoid liposarcomas (all diagnosis had been confirme...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Wang T,Goodman MA,McGough RL,Weiss KR,Rao UN

    更新日期:2014-10-01 00:00:00

  • Minimal (Limited) Pseudohyperplastic Prostatic Adenocarcinoma in Needle Prostatic Biopsy.

    abstract:BACKGROUND:Study of minimum adenocarcinoma has been done almost exclusively on conventional acinar adenocarcinoma. Pseudohyperplastic adenocarcinoma can be confused with benign lesions because of its well-differentiated appearance and has not been studied when the biopsy shows few malignant glands (limited carcinoma). ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Arista-Nasr J,Martinez-Benitez B,Mijangos-Trejo A,Bornstein-Quevedo L,Albores-Saavedra J

    更新日期:2017-10-01 00:00:00

  • Peribiliary cysts can mimic Caroli's disease: a case report.

    abstract::Peribiliary cysts, otherwise known as cystic dilatation of the peribiliary glands, are uncommon, and are usually discovered incidentally at autopsy, or in explants following liver transplantation. Preoperative diagnosis is often difficult owing to their asymptomatic nature and small size. Exclusion of a premalignant o...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Fusai G,Tucker O,Nik Sulaiman NM,Karani J,Rela M,Portmann B

    更新日期:2005-10-01 00:00:00

  • Del(5q) is associated with clinical and histological parameters in small cell neuroendocrine lung carcinoma.

    abstract::To elucidate the relationship between del(5q) and the clinical and histological features of small cell neuroendocrine lung carcinoma, 33 tissue samples from patients with this tumor were evaluated. By using fluorescence in situ hybridization, del(5q) was identified in almost 50% of cases (15/33, 45%). Clinically, pati...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Hartel PH,Shackelford AL,Hartel JV,Wenger SL

    更新日期:2008-10-01 00:00:00

  • IgG4-positive sclerosing cholangitis following autoimmune pancreatitis with deranged CA19.9.

    abstract::Sclerosing cholangitis is an autoimmune condition characterized by lymphocytic infiltration within the biliary epithelium leading to multifocal stricturing of the biliary tree. Primary sclerosing cholangitis (PSC) is the most common type encountered clinically. However, a similar process may occur in conjunction with ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Ong SL,Garcea G,Puls F,Richards C,Mulcahy K,Grant A,Dennison AR,Berry DP

    更新日期:2011-02-01 00:00:00

  • Ductal adenocarcinoma of the pancreas with huge cystic degeneration: a lesion to be distinguished from pseudocyst and mucinous cystadenocarcinoma.

    abstract::Cystic neoplasms of the pancreas are rare and often mistaken for pseudocyst by imaging studies and macroscopic examination. We describe an unusual tumor of the pancreas composed of a mural nodule of anaplastic carcinoma arising from a huge ductal adenocarcinoma undergoing cystic degeneration. The cyst measured 27 x 13...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Lee LY,Hsu HL,Chen HM,Hsueh C

    更新日期:2003-07-01 00:00:00

  • Pseudomembranes in rectal prolapse: a report of two cases.

    abstract::Pseudomembranes in colonic biopsies are normally associated with antibiotic related pseudomembranous colitis. Although pseudomembranes have rarely been reported in other conditions, their presence in rectal prolapse has not been previously reported. ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Coyne JD

    更新日期:2013-08-01 00:00:00

  • A case of clear cell meningioma with tyrosine-rich crystals.

    abstract::We present a case of clear cell meningioma with unusual clinical and pathologic features. The patient was a 54-year-old man who underwent laminectomy and durotomy for an intradural tumor in the lumbar spinal canal. Sections showed a predominance of dense collagenous tissue with irregularly shaped and irregularly sized...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Schollenberg E,Easton AS

    更新日期:2013-08-01 00:00:00

  • UbcH10 expression in benign, hyperplastic, and malignant endometrial curetted materials: a tissue microarray study.

    abstract::The aim of this study was to investigate the role of UbcH10 expression in the differential diagnosis of benign, hyperplastic, and malignant endometrial tissues and also the relationship of UbcH10 with the clinicopathologic parameters of malignant cases. A tissue microarray was performed for 81 endometrial curettage bi...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Kefeli M,Yildiz L,Celik H,Tosun M,Karagoz F

    更新日期:2012-08-01 00:00:00

  • Abundant hepatic Gaucher-like cells following chemotherapy and bone marrow transplantation for hematologic malignancy: report of two cases.

    abstract::Cells with a resemblance to Gaucher cells, sometimes called pseudo-Gaucher cells, are seen in the bone marrow of some patients with hematologic malignancy or anemia. These cells are derived from cells of the monocytic lineage but do not show the characteristic inclusions of true Gaucher cells when examined by electron...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Stenzel P,Weeks DA

    更新日期:2013-02-01 00:00:00