Evanescence of Endometrial Carcinomas in Hysterectomy Specimens: Observations on the "Vanishing Cancer" Phenomenon.

Abstract:

BACKGROUND:The phenomenon of vanishing carcinomas, first described in context of prostatic carcinomas, has been documented in endometrial carcinomas as well. METHODS:The archives of the department were searched for case files of endometrial carcinoma diagnosed on endometrial curetting/biopsy but which did not reveal any cancer on the subsequent hysterectomy specimen. Clinical and pathological correlation was established. RESULTS:A total of 5 cases were retrieved with biopsy-diagnosed endometrial carcinomas, 4 endometrioid and 1 serous type, which on subsequent hysterectomies did not reveal any tumor. These 5 cases represented 1.56% of total hysterectomies in our series. All were Stage Ia tumors, which on follow-up (mean = 18.2 months) did not show any local reoccurrence. Adjuvant therapy was instituted in 1 case in the form of pelvic irradiation in view of the serous histology. In all cases, the primary diagnosis was reconfirmed and any remote possibility of incorrect patient identification, laboratory errors, and institution of hormonal therapy were adequately ruled out along with an extensive endometrial sampling in hysterectomy. CONCLUSION:The recognition of "vanishing endometrial carcinoma" as a distinct entity is of utmost importance to avoid mislabeling them as medical errors.

journal_name

Int J Surg Pathol

authors

Bharani V,Rai B,Rajwanshi A,Gupta N,Dey P,Kalra J,Suri V,Srinivasan R

doi

10.1177/1066896918783581

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

43-47

issue

1

eissn

1066-8969

issn

1940-2465

journal_volume

27

pub_type

杂志文章
  • Primary vaginal Ewing sarcoma: case report and review of the literature.

    abstract::Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) are round-cell sarcomas with varying degrees of neuroectodermal differentiation; they are considered members of the same family of tumors based on their common genetic profile. ES/PNET are very infrequent in the female genital tract, the vagina being the ra...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896911424898

    authors: Bancalari E,de Álava E,Tardío JC

    更新日期:2012-06-01 00:00:00

  • Diverticulosis and diverticulitis of the appendix.

    abstract::Diverticulosis of the appendix is a relatively rare pathological finding. The majority are acquired pseudodiverticula. True congenital diverticula are very rare. Appendiceal diverticulosis is usually an incidental finding and clinically asymptomatic. When symptomatic, it is usually complicated by acute or chronic dive...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896909332728

    authors: Abdullgaffar B

    更新日期:2009-06-01 00:00:00

  • Renal cell carcinoma in children and young adults: clinicopathological, immunohistochemical, and VHL gene analysis of 46 cases with follow-up.

    abstract::To further study the characteristics of renal cell carcinoma (RCC) in young patients and better define their biological features, 46 RCCs of patients younger than 25 years were morphologically and immunohistochemically characterized with follow-up. Loss of heterozygosity (LOH) analysis of the von Hippel-Lindau (VHL) g...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896909354337

    authors: Rao Q,Chen JY,Wang JD,Ma HH,Zhou HB,Lu ZF,Zhou XJ

    更新日期:2011-04-01 00:00:00

  • Loss of heterozygosity on chromosome 1 and 9 and hormone receptor analysis of metastatic malignant melanoma presenting in breast.

    abstract::Malignant melanoma (MM), the most common metastatic solid tumor to involve the breast, may present as a diagnostic problem, frequently requiring the use of ancillary studies for accurate diagnosis. The implication of hormonal interplay is strong since metastatic MM to the breast is seen nearly always in women. However...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690501300102

    authors: Beaty MW,Quezado M,Sobel ME,Duray P,Merino MJ

    更新日期:2005-01-01 00:00:00

  • Invasive Lobular Carcinoma With Extensive Clear Cells: A Pitfall in Diagnosis.

    abstract::Carcinomas in the breast with a predominantly clear cytoplasm are rare. In this article, we review the differential diagnosis of clear cell breast neoplasms and report a case of invasive lobular carcinoma with extensive clear cell morphology that was diagnosed as invasive ductal carcinoma, not otherwise specified, on ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896919881705

    authors: Kavesh MH,Sanchez D,Asirvatham JR

    更新日期:2020-04-01 00:00:00

  • Merkel cells in the oral mucosa.

    abstract::Ninety-eight consecutive surgical biopsies of oral mucosa from 96 patients were evaluated immunohistochemically with an anti-cytokeratin 20 (CK 20) anti-body to evidence Merkel cells (MC). Fifteen cases, showing the highest number of MC, were additionally studied with chromogranin A, S-100 protein, neuro filaments, ep...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896906290053

    authors: Righi A,Betts CM,Marchetti C,Marucci G,Montebugnoli L,Prati C,Eusebi LH,Muzzi L,Ragazzini T,Foschini MP

    更新日期:2006-07-01 00:00:00

  • Multifocal Polymorphous Hemangioendothelioma of the Liver: Case Report and Review of Literature.

    abstract::We report a case of polymorphous hemangioendothelioma, a rare vascular neoplasm, arising in the liver of a 51-year-old woman. Microscopically, this neoplasm is characterized by a polymorphous blend of solid, primitive vascular and angiomatous areas in variable proportions. Polymorphous hemangioendothelioma is consider...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896916679517

    authors: El Hussein S,Omarzai Y

    更新日期:2017-05-01 00:00:00

  • Pediatric renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion.

    abstract::Renal cell carcinoma (RCC) in children and young adults is rare and pathologically problematic. RCC can be either hereditary or sporadic and has a guarded prognosis because appropriate management has not been established. A case of RCC in an 11-year-old is reported. The clinical presentation was a right abdominal mass...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907304994

    authors: Winarti NW,Argani P,De Marzo AM,Hicks J,Mulyadi K

    更新日期:2008-01-01 00:00:00

  • Hemangioblastoma of the gastrointestinal tract: a first case.

    abstract::We present the first documented case of hemangioblastoma located in the left colon. A 75-year-old woman undergoing adjuvant chemotherapy for breast cancer experienced rectal bleeding. Colonoscopy revealed a roundish mass covered with normal mucosa in the sigmoid colon. Endoscopic ultrasound showed an isoechoic lesion ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896912475082

    authors: Casadei Gardini A,Pieri F,Fusaroli P,Oboldi D,Passardi A,Monti M,Rosetti P,Calpona S,Valgiusti M,Ragazzini A,Amadori D,Frassineti GL

    更新日期:2013-04-01 00:00:00

  • Unusual Histopathological Findings in Appendectomy Specimens: A Retrospective Analysis of 2047 Cases.

    abstract:BACKGROUND:In this study, we retrospectively evaluated cases of patients who had undergone appendectomy in our hospital and aimed to present the efficiency of diagnostic tests and demographic data of cases. Pathological reports were analyzed for the following parameters: age, gender, and pathological diagnosis. In addi...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896918784650

    authors: Unver N,Coban G,Arıcı DS,Buyukpınarbasılı N,Gucin Z,Malya FÜ,Onaran OI,Topalan K

    更新日期:2019-04-01 00:00:00

  • IMP3 Is Strongly Expressed in Malignant Phyllodes Tumors of the Breast: An Immunohistochemical Study.

    abstract:BACKGROUND:Phyllodes tumors (PTs) of the breast are rare biphasic neoplasms and are classified as benign, borderline, or malignant. Many biological markers have been studied to discriminate between different grades of PTs. IMP3 is a member of the insulin-like growth factor II mRNA binding protein (IMP) family and is ex...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915603119

    authors: Bellezza G,Prosperi E,Del Sordo R,Colella R,Rulli A,Sidoni A

    更新日期:2016-02-01 00:00:00

  • Primary intratesticular spindle cell tumors: interdigitating dendritic cell tumor and inflammatory myofibroblastic tumor.

    abstract::Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special tec...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908323505

    authors: Nistal M,Gonzalez-Peramato P,Serrano A,Reyes-Mugica M,Cajaiba MM

    更新日期:2011-02-01 00:00:00

  • Collision Lesions of Calcifying Pseudoneoplasm of the Neuraxis and Rheumatoid Nodules: A Case Report With New Pathogenic Insights.

    abstract::Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare tumor-like lesion with unclear pathogenesis. Collision lesions of CAPNONs with neoplasms are occasionally reported. In this article, we report the first case of collision lesions between CAPNON and rheumatoid nodules (RNs) in a patient with systemic lupus er...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920941939

    authors: Lu JQ,Popovic S,Provias J,Cenic A

    更新日期:2020-07-15 00:00:00

  • Sclerosing spindle cell rhabdomyosarcoma in an adult: report of a new case and review of the literature.

    abstract::Sclerosing spindle cell rhabdomyosarcoma (SSRMS) is a newly recognized entity in adults. The authors report a new case of SSRMS in a 31-year-old woman who presented with a large right leg mass. Biopsy revealed a malignant spindle cell neoplasm with focal sclerotic areas. A diagnosis of monophasic synovial sarcoma was ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896908327166

    authors: Gavino AC,Spears MD,Peng Y

    更新日期:2010-10-01 00:00:00

  • Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis.

    abstract::Studies on the expression of beta-catenin (beta-ct) in gastric carcinoma have provided conflicting results, and the role played by beta-ct mutations in gastric carcinogenesis remains unclear. In an attempt to clarify the aforementioned issues we undertook the retrospective study of 157 gastric carcinomas by using immu...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690301100102

    authors: Nabais S,Machado JC,Lopes C,Seruca R,Carneiro F,Sobrinho-Simões M

    更新日期:2003-01-01 00:00:00

  • Average Weight of Seminal Vesicles: An Adjustment Factor for Radical Prostatectomy Specimens Weighed With Seminal Vesicles.

    abstract::The International Society of Urological Pathology in 2010 recommended weighing prostates without seminal vesicles (SV) to include only prostate weight in prostate-specific antigen (PSA) density (PSAD) calculation, because SV do not produce PSA. Large retrospective cohorts exist with combined weight recorded that needs...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915600519

    authors: Tjionas GA,Epstein JI,Williamson SR,Diaz M,Menon M,Peabody JO,Gupta NS,Parekh DJ,Cote RJ,Jorda M,Kryvenko ON

    更新日期:2015-12-01 00:00:00

  • Dysplasia in Chronic Ulcerative Colitis: A Molecular Approach to Its Differential Diagnosis.

    abstract::Ulcerative colitis-related epithelial dysplasia represents a premalignant lesion, which may lead to the development of ulcerative colitis-related adenocarcinoma. The proper management of this condition requires proctocolectomy before the acquisition of the invasive phenotype. Patients with chronic ulcerative colitis, ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690000800106

    authors: Urbanski SJ,Fogt F

    更新日期:2000-01-01 00:00:00

  • The Helpful Role of CD10 and Hormonal Receptors Co-Expression in the Histologic Diagnosis of Catamenial Pneumothorax.

    abstract::The histology in cases of primary spontaneous pneumothorax is generally nonspecific, but a careful examination, taking into account clinical data, may reveal subtle tissue alterations leading to a specific diagnosis in cases that might otherwise be taken as primary and spontaneous. In this article, we describe 3 cases...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896919846386

    authors: Mataca E,Rossi G,Colby TV

    更新日期:2019-09-01 00:00:00

  • Detection of Merkel cell carcinoma polyomavirus in mucosal Merkel cell carcinoma.

    abstract::A 61-year-old woman presented with solitary lymphadenopathy suspicious for lymphoma. An excisional biopsy of a right inguinal lymph node demonstrated metastatic Merkel cell carcinoma (MCC). No skin lesions were detected, but a primary nasopharyngeal mass was identified. A microscopic examination of the nasopharyngeal ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896910371638

    authors: Wu KN,McCue PA,Berger A,Spiegel JR,Wang ZX,Witkiewicz AK

    更新日期:2010-10-01 00:00:00

  • Palisaded Encapsulated (Solitary Circumscribed) Neuroma: A Review of 30 Cases.

    abstract::Background. Solitary circumscribed neuroma (SCN), also known as palisaded encapsulated neuroma (PEN), is a benign neural tumor. It may be mistaken as either schwannoma or neurofibroma in pathology practice. In this study, we aimed to define clinicopathologic and immunohistochemical features and discuss its differentia...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896919833172

    authors: Leblebici C,Savli TC,Yeni B,Cin M,Aksu AEK

    更新日期:2019-08-01 00:00:00

  • Squamous metaplasia on the breast implant capsule.

    abstract::The development of squamous metaplasia or carcinoma is a rare occurrence in the setting of a ruptured or leaking silicone breast implant capsule. However, the oncogenic process in such a context is yet another intriguing example of how chronic inflammation plays an integral role in the tumorigenic process. Recent pape...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908329587

    authors: Alikhan MB,Nassar A,Mansoor I

    更新日期:2010-12-01 00:00:00

  • Head and neck mucosal malignant melanoma: clinicopathologic correlation with contemporary review of prognostic indicators.

    abstract::Unlike their cutaneous counterparts, head and neck mucosal malignant melanomas (HNMM) behave much more aggressively and their prognostic markers have not been fully elucidated. Therefore, the aim of this study was to review the clinicopathologic features of a contemporary series of primary HNMM, retrieved from archiva...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896911417970

    authors: Kerr EH,Hameed O,Lewis JS Jr,Bartolucci AA,Wang D,Said-Al-Naief N

    更新日期:2012-02-01 00:00:00

  • Ameloblastic Fibrosarcoma of the mandible evolving from a prior Ameloblastic Fibroma after two years: an unusual finding.

    abstract::Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916646448

    authors: Bertoni F,Del Corso G,Bacchini P,Marchetti C,Tarsitano A

    更新日期:2016-10-01 00:00:00

  • Identification of mislabeled specimen by molecular methods: case report and review.

    abstract::Specimen misidentification is a common cause of errors in surgical pathology. We report a case where bone-marrow biopsies from patients of different genders were mislabeled and molecular methods were applied to resolve the identity. A short tandem repeat (STR)-polymerase chain reaction-based assay, commonly used in pa...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690501300304

    authors: Mariappan MR,Zehnder J,Arber DA,Lay M,Fadare O,Schrijver I

    更新日期:2005-07-01 00:00:00

  • Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway?

    abstract::We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies (MUC5AC, MUC6, SOX2, and CDX2). Nonmetaplastic mucosa had histologic evidence o...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916672332

    authors: Rolim I,Rodrigues RV,Bettencourt A,Barros R,Camilo V,Dias Pereira A,Almeida R,Chaves P

    更新日期:2017-05-01 00:00:00

  • Diagnostic Challenge of Sarcomatoid Variant of ALK-Positive Anaplastic Large Cell Lymphoma: Case Report and Updated Systematic Literature Review.

    abstract::The sarcomatoid variant of anaplastic large cell lymphoma is an extremely rare histologic pattern of anaplastic large cell lymphoma that consists of spindle-shaped neoplastic cells and is easily misdiagnosed as a soft tissue sarcoma. We report a case of the sarcomatoid variant of anaplastic large cell lymphoma that wa...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920986967

    authors: Song F,Yu S,Jia M,Gao H,Sun PL

    更新日期:2021-01-11 00:00:00

  • Ocular Sebaceous Carcinoma In Situ With Biphenotypic Differentiation: A Reappraisal of the Alternative Origin of the Tumor.

    abstract::Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920917445

    authors: Yim CL,Lam SC,Yuen HKL,Cheuk W

    更新日期:2020-12-01 00:00:00

  • Pindborg Tumor Presenting as a Nasal Polyp: Immunohistology and Ultrastructural Features of a Rare Case, With Review of the Literature.

    abstract::Calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a rare benign odontogenic tumor. This tumor predominantly involves the mandible, though the maxilla can also be involved in some cases. The involvement of maxillary sinuses, however, has been previously reported in only 8 case reports English li...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896916644782

    authors: Mitra S,Kaur G,Nada R,Mohindra S

    更新日期:2016-09-01 00:00:00

  • Immunoexpression of Epithelial Mesenchymal Transition Proteins E-Cadherin, β-Catenin, and N-Cadherin in Oral Squamous Cell Carcinoma.

    abstract::Aims Epithelial mesenchymal transition (EMT) is a crucial process for acquisition of malignant phenotype, aggressiveness, and metastatic capacity in neoplasms. It is characterized by loss of epithelial markers and gain of mesenchymal markers. Studies on EMT and its potential association with the histological grading a...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916654763

    authors: Angadi PV,Patil PV,Angadi V,Mane D,Shekar S,Hallikerimath S,Kale AD,Kardesai SG

    更新日期:2016-12-01 00:00:00

  • Early colonic perineurioma: a report of 11 cases.

    abstract::Colonic perineurioma has been depicted as characterized by a mucosal proliferation of monomorphic spindle perineurial cells leading to an evident separation, distortion, and entrapment of colonic crypts. The authors, however, believe that a sizable subset of the cases differ in that they display only a limited perineu...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896909350883

    authors: Groisman G,Amar M,Alona M

    更新日期:2010-08-01 00:00:00