Abstract:
:Ninety-eight consecutive surgical biopsies of oral mucosa from 96 patients were evaluated immunohistochemically with an anti-cytokeratin 20 (CK 20) anti-body to evidence Merkel cells (MC). Fifteen cases, showing the highest number of MC, were additionally studied with chromogranin A, S-100 protein, neuro filaments, epithelial membrane antigen, and double immunostaining for CK 20 and Ki67 antibodies to evaluate MC proliferation. Electron microscopy was performed in 2 cases. MC were observed in 58 cases. The highest number of MC was found in the gingival, buccal, and palate mucosa, especially in chronically damaged oral mucosa (lichen and chronic aspecific inflammation) as well as in the mucosa overlying tumors rather than in normal or acute inflammation. MC were not observed in dysplastic or neoplastic epithelium. MC showed evidence of proliferation, as demonstrated by Ki67 positivity, in 3 cases. In conclusion, MC appear to play a role in the reparative processes of oral mucosa.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Righi A,Betts CM,Marchetti C,Marucci G,Montebugnoli L,Prati C,Eusebi LH,Muzzi L,Ragazzini T,Foschini MPdoi
10.1177/1066896906290053subject
Has Abstractpub_date
2006-07-01 00:00:00pages
206-11issue
3eissn
1066-8969issn
1940-2465pii
14/3/206journal_volume
14pub_type
杂志文章abstract::Pseudofungi are septate hyphae-like structures very similar morphologically to true fungal elements. Histologically their presence poses a diagnostic challenge as they mimic fungal infection. Accurate identification of pseudofungi is required to avoid unnecessary treatment, and this can be accomplished by careful morp...
journal_title:International journal of surgical pathology
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journal_title:International journal of surgical pathology
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