Massive Exfoliation of Markedly Atypical Cells in Urine Resulting from Polyoma Virus Interstitial Nephritis.

Abstract:

:Polyoma virus nephritis is increasingly being recognized as a cause of allograft dysfunction in renal transplant patients. We describe and illustrate the findings in a renal biopsy and a concurrent urine sample from a patient with polyoma virus nephritis. The urine cytology findings were highly suggestive of a tumor due to the presence of large number of atypical cells with marked hyperchromasia, high nuclear/cytoplasmic ratio in a necrotic background. Scattered cells with viral cytopathic changes were also identified, therefore indicating an infectious process with associated reactive cellular changes rather than a tumor. The cytological findings could thus be explained by the viral cytopathic and cytolytic changes, as well as marked reactive and degenerative changes in tubular epithelial cells. Int J Surg Pathol 8(4):329-331, 2000

journal_name

Int J Surg Pathol

authors

Papadimitriou JC,Drachenberg CB,Bourquin PM

doi

10.1177/106689690000800412

keywords:

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

329-331

issue

4

eissn

1066-8969

issn

1940-2465

journal_volume

8

pub_type

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