A Novel Case of Mammary-Type Myofibroblastoma With Sarcomatous Features.

Abstract:

:Mammary-type myofibroblastoma (MFB) is a benign spindle cell tumor of the breast and soft tissue characterized by 13q14 alterations leading to loss of Rb-1 protein expression, a feature shared among spindle cell lipoma and cellular angiofibroma. In this article, we present a novel case of MFB arising in the left breast of a 70-year old man that microscopically showed an abrupt transition from classic MFB morphology to an area with cytologic atypia and mitotic activity, akin to sarcomatous transformation described in cellular angiofibromas. A thorough workup of the molecular underpinnings of both components using chromosomal microarray and next-generation sequencing platforms supported a clonal relationship. Nearly identical copy number changes, including a single copy loss of 13q14, were found in both components; in addition, the sarcomatous component harbored biallelic TP53 alterations. It is important for pathologists to recognize that sarcomatous features can occur in mammary-type MFB to arrive at the correct diagnosis.

journal_name

Int J Surg Pathol

authors

Strait AM,Linos K,Tafe LJ,Muller KE

doi

10.1177/1066896920947465

subject

Has Abstract

pub_date

2020-08-05 00:00:00

pages

1066896920947465

eissn

1066-8969

issn

1940-2465

pub_type

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