Abstract:
BACKGROUND:Protein kinase C βII promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro. OBJECTIVE:To investigate PKC-βII expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations. METHODS:Expression of PKC-βII was semiquantitatively assessed in the various existing compartments (intraepidermal [not nested], junctional [nested], and dermal) of benign (n = 43) and malignant (n = 28) melanocytic lesions by immunohistochemistry. RESULTS:Melanocytes in the basal layer of normal skin or in lentigo simplex stained strongly for PKC-βII. Common nevi lacked completely PKC-βII. All other lesions expressed variably PKC-βII, with cutaneous melanoma metastases displaying the lowest rate of positivity (14%). In the topographical analysis within a lesion, PKC-βII expression was largely retained in the intraepidermal and junctional part of all other lesions (dysplastic nevus, lentigo maligna, and melanoma). Reduced expression of PKC-βII was found in the dermal component of benign and malignant lesions ( P = .041 vs intraepidermal). PKC-βII expression in the various compartments did not differ significantly between benign and malignant lesions. CONCLUSIONS:The current study revealed a significant correlation between PKC-βII expression and spatial localization of melanocytes, with the lowest expression found in the dermal compartment and the highest in the epidermal compartment.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Krasagakis K,Tsentelierou E,Chlouverakis G,Stathopoulos ENdoi
10.1177/1066896917706026subject
Has Abstractpub_date
2017-09-01 00:00:00pages
497-501issue
6eissn
1066-8969issn
1940-2465journal_volume
25pub_type
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journal_title:International journal of surgical pathology
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journal_title:International journal of surgical pathology
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journal_title:International journal of surgical pathology
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abstract::Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...
journal_title:International journal of surgical pathology
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journal_title:International journal of surgical pathology
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