Abstract:
:Germinotropic lymphoproliferative disorder (GLPD) is a poorly characterized lymphoproliferative entity, recently included in the World Health Organization classification of hematolymphoid neoplasms. The histological pattern of this disease comprises monotypic plasmablasts that involve the germinal centers of the lymphoid follicles (germinotrophism), forming confluent aggregates positive for both human herpes virus type 8 (HHV8) and Epstein-Barr virus. Currently, after 17 years of its first description, only 18 cases have been reported. In this article, we describe a case of a GLPD presenting in an immunocompetent 79-year-old woman with localized axillary lymphadenopathy, showing a prominent sinusoidal growth pattern, with no evidence of germinotrophism or extrasinusoidal spread. Stinking pleomorphism in tumor cells was also noted. An extension study has not revealed involvement of other groups of lymph nodes or extralymphoid sites. The patient is alive and has shown no relapse after 8 years follow-up (the longest follow-up reported period for this entity). This previously unrecognized pure sinusoidal growth pattern along with the striking pleomorphism in neoplastic cells closely mimics the appearance of an anaplastic large cell lymphoma. GLPD is not usually considered in such a setting, but it should be included in the differential diagnosis of sinusoidal proliferations. Our findings contribute to the expansion of the morphological spectrum of HHV8-associated lymphoproliferative lesions and aids in the characterization of the very infrequent GLPD entity.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Martinez-Ciarpaglini C,Valkov A,Hurtado M,Agustí J,Malave G,Ferrández Adoi
10.1177/1066896920921238subject
Has Abstractpub_date
2020-10-01 00:00:00pages
804-811issue
7eissn
1066-8969issn
1940-2465journal_volume
28pub_type
杂志文章abstract:OBJECTIVE:To assess the pathologic characteristics and prognostic significance of periprostatic lymph node (LN) metastasis of prostate cancer. The latter was performed by comparing biochemical recurrence (BCR)-free survival in cases of periprostatic LN metastasis versus matched patients showing pelvic LN metastasis. M...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896913482729
更新日期:2013-08-01 00:00:00
abstract::Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916646448
更新日期:2016-10-01 00:00:00
abstract::A 61-year-old woman presented with solitary lymphadenopathy suspicious for lymphoma. An excisional biopsy of a right inguinal lymph node demonstrated metastatic Merkel cell carcinoma (MCC). No skin lesions were detected, but a primary nasopharyngeal mass was identified. A microscopic examination of the nasopharyngeal ...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896910371638
更新日期:2010-10-01 00:00:00
abstract::A 37-year-old woman was found to have multiple peritoneal nodules, including on the uterine serosa, at Cesarean section. Histology showed yellow crystalline material surrounded by histiocytes and occasional multinucleate giant cells. Further enquiry revealed that the patient underwent a cholecystectomy for a perforate...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896911409930
更新日期:2012-02-01 00:00:00
abstract::Cystic squamous cell carcinomas (SCCs) of the jaws, including carcinoma cuniculatum, are rare, slow growing, and relentlessly invasive. The aim of this article is to present 12 cases, 4 of which were designated as carcinoma cuniculatum on the basis of deeply endophytic, anastomosing channels of cystic stratified squam...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896920903388
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abstract::Intrasellar rhabdomyosarcoma is rare, and when arising in collusion with an unrelated entity, can present a diagnostic pitfall. We describe a case of a 56-year-old woman who presented with right eye ptosis and a pituitary mass, which was resected and diagnosed as atypical pituitary adenoma. Because of residual disease...
journal_title:International journal of surgical pathology
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更新日期:2016-12-01 00:00:00
abstract::We report the case of a well-differentiated chondrosarcoma of the proximal humerus in a 60-year-old man that featured a prominent component of granular cells, the granules being shown by electron microscopy to be lysosomal. Although secondary granular cell changes have been described in a large variety of tumor types,...
journal_title:International journal of surgical pathology
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doi:10.1177/106689690601400211
更新日期:2006-04-01 00:00:00
abstract::Carcinomas in the breast with a predominantly clear cytoplasm are rare. In this article, we review the differential diagnosis of clear cell breast neoplasms and report a case of invasive lobular carcinoma with extensive clear cell morphology that was diagnosed as invasive ductal carcinoma, not otherwise specified, on ...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896919881705
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abstract::SMARCB1 (INI1) deficient sinonasal carcinoma is a recently recognized entity with wide histomorphologic spectrum. We present a case of this carcinoma that contained, in addition to a "common" morphology, scattered foci of yolk sac tumor differentiation. The tumor occurred in paranasal sinuses in a 44-year-old woman. I...
journal_title:International journal of surgical pathology
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abstract::Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare tumor-like lesion with unclear pathogenesis. Collision lesions of CAPNONs with neoplasms are occasionally reported. In this article, we report the first case of collision lesions between CAPNON and rheumatoid nodules (RNs) in a patient with systemic lupus er...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896920941939
更新日期:2020-07-15 00:00:00
abstract::Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920917445
更新日期:2020-12-01 00:00:00
abstract::A completely infarcted lymph node should alert the pathologist to the high possibility of malignant lymphoma. The lymph node lesion of infectious mononucleosis (IM) shows marked histologic diversity and occasionally may be confused with malignant lymphoma. We report a rare case of IM showing extensive lymph node infar...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690201000312
更新日期:2002-07-01 00:00:00
abstract::Cystic neoplasms of the pancreas are rare and often mistaken for pseudocyst by imaging studies and macroscopic examination. We describe an unusual tumor of the pancreas composed of a mural nodule of anaplastic carcinoma arising from a huge ductal adenocarcinoma undergoing cystic degeneration. The cyst measured 27 x 13...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100315
更新日期:2003-07-01 00:00:00
abstract::Synovial sarcoma is a high-grade sarcoma commonly affecting young adults. The sites of involvement include soft tissue near joints, lung, pleura, mediastinum, larynx, kidney, and buttocks. Histologic types include monophasic, biphasic, and undifferentiated. We report a unique case of synovial sarcoma with low-grade hi...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917723463
更新日期:2018-02-01 00:00:00
abstract::We report a fourth case of papilliferous keratoameloblastoma, with a 6-year follow-up. A 62-year-old man underwent resection of a right mandibular neoplasm infiltrating bone and soft tissues. Microscopically, there were cysts lined by papillary projections and containing necrotic debris. Cribriform, solid, and tubular...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/106689690201000210
更新日期:2002-04-01 00:00:00
abstract::Malignant melanoma (MM), the most common metastatic solid tumor to involve the breast, may present as a diagnostic problem, frequently requiring the use of ancillary studies for accurate diagnosis. The implication of hormonal interplay is strong since metastatic MM to the breast is seen nearly always in women. However...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690501300102
更新日期:2005-01-01 00:00:00
abstract::Rhabdomyosarcoma is an aggressive malignant tumor often developing in the head and neck in children. In the sinonasal region, rhabdomyosarcoma constitutes a clinically important group because of the difficulty of surgical resection and its generally poor prognosis. We reviewed the archival pathology materials of 39 ca...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896906299122
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Epithelioid hemangioendothelioma (EHE) is an uncommon malignant endothelial neoplasm that most commonly arises in soft tissue, bone, lung, and liver. Crohn's disease (CD) is an inflammatory bowel disease of unknown etiology that is frequently associated with complications including strictures, fistulas/fissu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918801527
更新日期:2019-06-01 00:00:00
abstract::Rosai-Dorfman disease (RDD; sinus histiocytosis with massive lymphoadenopathy) is a rare, usually nodal self-limited disease. Sometimes nodal disease is coupled with extranodal localizations, in which case the disease can follow a protracted clinical course characterized by remissions and relapses and, exceptionally, ...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896908329590
更新日期:2010-12-01 00:00:00
abstract::This study describes the clinical, histologic, and immunohistochemical features of four cases of GI PEComa. The size of the tumors ranged from 3.5 to 6.0cm in diameter, and all were located in wall of the large bowel. Microscopically, the tumors were characterized by an epithelioid arrangement of tumor cells, which ha...
journal_title:International journal of surgical pathology
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更新日期:2010-08-01 00:00:00
abstract::The majority of alveolar RMSs have t(2;13)(q35;q14) or (1:13)(p36;q14),which generate PAX3/7 -FKHR fusion genes. Here, the authors detected the PAX3/7-FKHR fusion transcripts in 17 formalin-fixed, paraffin-embedded RMSs and 26 other SRCTs using one-step RT-PCR. PAX3 -FKHR and PAX7-FKHR transcripts were positive in 4/8...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896908323922
更新日期:2009-02-01 00:00:00
abstract::Malakoplakia is a rare granulomatous disease that commonly involves the genitourinary tract, with the urinary bladder being the most frequently affected site. Grossly, malakoplakia can present as soft yellow plaques, nodules, bladder mass, or even without any visible lesion. In this article, we present a 74-year-old f...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896915595464
更新日期:2015-10-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) with primary involvement of the upper gastrointestinal (GI) tract is rare. We report 2 adult cases of localized LCH in the upper-GI tract, including the second reported adult case of esophageal LCH and review 11 previously reported cases. Case 1 involved the esophagus of a 61-year-o...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896920964566
更新日期:2020-10-09 00:00:00
abstract::Warthin tumor is the second most common salivary gland neoplasm. It occurs more commonly in males than in females. Malignant transformation in Warthin tumor is a rare but well-recognized phenomenon; however, the development or presentation of lymphoma in a Warthin tumor is rare. An 80-year-old man presented with painl...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896917734371
更新日期:2018-05-01 00:00:00
abstract::We report a cytohistologic and immunohistochemical study of 2 cases of papillary thyroid carcinoma occurring in a thyroglossal duct cyst. The patients were a 21-year-old woman and a 48-year-old man. Needle aspiration cytology smears were consistent with papillary thyroid carcinoma. The Sistrunk procedure was done. Pap...
journal_title:International journal of surgical pathology
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doi:10.1177/106689690100900114
更新日期:2001-01-01 00:00:00
abstract::In this article, we report a very rare case of secondary angiosarcoma in a young woman with no prior history of breast cancer who had bilateral prophylactic mastectomies with autologous reconstruction due to a strong family history of breast cancer and BRCA1 gene variant of uncertain significance. The surgery was comp...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896920930100
更新日期:2020-06-18 00:00:00
abstract::Myositis ossificans (MO) and fibroosseous pseudotumor of digits (FP) are pseudotumoral mimics of malignancy. A review of 50 cases of MO and 14 cases of FP showed that a malignant diagnosis was suggested by referring pathologists in 23% of MO and 9% of FP. The most common misdiagnosis was osteosarcoma. Awareness of the...
journal_title:International journal of surgical pathology
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更新日期:2003-07-01 00:00:00
abstract::The aim of this study was to investigate the role of UbcH10 expression in the differential diagnosis of benign, hyperplastic, and malignant endometrial tissues and also the relationship of UbcH10 with the clinicopathologic parameters of malignant cases. A tissue microarray was performed for 81 endometrial curettage bi...
journal_title:International journal of surgical pathology
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更新日期:2012-08-01 00:00:00
abstract::Sclerosing spindle cell rhabdomyosarcoma (SSRMS) is a newly recognized entity in adults. The authors report a new case of SSRMS in a 31-year-old woman who presented with a large right leg mass. Biopsy revealed a malignant spindle cell neoplasm with focal sclerotic areas. A diagnosis of monophasic synovial sarcoma was ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896908327166
更新日期:2010-10-01 00:00:00
abstract::The sarcomatoid variant of anaplastic large cell lymphoma is an extremely rare histologic pattern of anaplastic large cell lymphoma that consists of spindle-shaped neoplastic cells and is easily misdiagnosed as a soft tissue sarcoma. We report a case of the sarcomatoid variant of anaplastic large cell lymphoma that wa...
journal_title:International journal of surgical pathology
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更新日期:2021-01-11 00:00:00