Study on the structure-activity relationships of phoxalone and induction of apoptosis in H446 tumor cells.

abstract：:The microbial transformation studies of 7-O-prenylquercetin (1), 4'-O-prenylquercetin (2) and quercetin (3) were investigated with 20 different microbial strains to discover new metabolites. It was revealed that the fungus Mucor hiemalis was the most appropriate micro-organism which was capable of transforming these f...

journal_title：Natural product research

authors： Xiao Y,Lee IS

更新日期：2018-04-01 00:00:00

abstract：:Methylphophorbide a (MPa) has been isolated from the ethanol extract of the wheat grass plant. Its antioxidative efficacy is evaluated by hydroxyl radical scavenging activities and reducing capacity which are significantly up regulated in comparison with aqueous extract of the plant. The compound shows iron-binding ca...

journal_title：Natural product research

authors： Das P,Mandal S,Gangopadhyay S,Das K,Mitra AG,Dasgupta S,Mukhopadhyay S,Mukhopadhyay A

更新日期：2016-01-01 00:00:00

abstract：:Analgesic and anti-inflammatory activities of the aqueous and ethanol extracts of Thespesia populnea Soland. ex. Correa (Malvaceae) leaves were evaluated in animal models. Orally-administered aqueous and ethanol extracts (100, 200 and 400 mg kg⁻¹ bw) showed significant analgesic activity in chemical-, mechanical- and ...

journal_title：Natural product research

authors： Ilavarasan R,Mohideen S,Venkataraman S

更新日期：2012-01-01 00:00:00

abstract：:The mechanism of inhibition of jack bean and Bacillus pasteurii ureases was investigated by triacontanyl palmitate (1) which is a long-chain fatty ester and has been isolated from Symplocos racemosa Roxb. Lineweaver-Burk, Dixon plots, and their secondary replots showed that 1 is a non-competitive inhibitor of these en...

journal_title：Natural product research

authors： Lodhi MA,Abbasi MA,Choudhary MI,Ahmad VU

更新日期：2007-07-10 00:00:00

abstract：:The chemical composition of the essential oil (EO) obtained from the aerial parts of Rydingia michauxii (Briq.) Scheen & V.A. Albert was analysed by gas chromatography and gas chromatography/mass spectrometry (GC/MS). Eighty components were identified in the oil with caryophyllene oxide (20.1%), trans-verbenol (10.2%)...

journal_title：Natural product research

authors： Karami A,Esmaeili H,Shahbazian D

更新日期：2018-01-01 00:00:00

abstract：:Leaves of Kalanchoe pinnata are used worldwide for healing skin wounds. This study aimed to develop and compare two creams containing a leaf aqueous extract of K. pinnata (KP; 6%) and its major flavonoid [quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside] (0.15%). Both creams were topically evaluated in a ...

journal_title：Natural product research

authors： Coutinho MAS,Casanova LM,Nascimento LBDS,Leal D,Palmero C,Toma HK,Dos Santos EP,Nasciutti LE,Costa SS

更新日期：2020-09-14 00:00:00

abstract：:The aim of this study was to explore the extract/fractions and compounds of Diospyros lotus against various Gram-positive and Gram-negative bacteria strain. The results showed marked susceptibility of extract and its fractions against test pathogens. Among them, chloroform fraction was most dominant and effective agai...

journal_title：Natural product research

authors： Rauf A,Uddin G,Khan H,Arfan M,Siddiqui BS

更新日期：2016-01-01 00:00:00

abstract：:This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic extract were analysed by HPLC method. The main flavonoid component was detected as rutin, and anothe...

journal_title：Natural product research

authors： Can OD,Ismail IB,Oztürk Y,Oztürk N,Potoğlu-Erkara I,Sagratini G,Ricciutelli M,Vittori S,Maggi F

更新日期：2011-09-01 00:00:00

abstract：:Nine lupeol derivatives were synthesised and assayed in vitro for their antitumour activities against three human tumour cells lines, A549, LAC and HepG2. Of lupeol derivaties, six were new compounds, and five compounds against A549 cells, four compounds against HepG2 cells and three compounds against LAC cells were e...

journal_title：Natural product research

authors： Li W,Xiao Y

更新日期：2018-01-01 00:00:00

abstract：:Essential oils derived from six different phenophases, namely early vegetative stage, late vegetative stage, early flowering stage, full flowering stage (FFS), late flowering stage and seed shattering stage of Origanum vulgare L. grown in Kumaon region of Uttarakhand, India were investigated by GC and GC-MS. A total o...

journal_title：Natural product research

authors： Verma RS,Padalia RC,Chauhan A

更新日期：2012-01-01 00:00:00

abstract：:Chemical investigation of the fungus Xylariaceae sp. DPZ-SY43 has led to the isolation of a new compound, xylaolide A (1) together with three known compounds (2-4). The structures were established by analysing the spectroscopic data. Compound 1 was evaluated for its cytotoxicity. ...

journal_title：Natural product research

authors： Yang B,Dong J,Lin X,Tao H,Zhou X,Liu Y

更新日期：2014-01-01 00:00:00

abstract：:The chemical composition of the volatile concentrate prepared by supercritical CO(2) extraction of the needles of Pinus nigra Arnold ssp. laricio Poiret from Corsica was investigated using GC (RI), GC-MS and (13)C NMR spectroscopy. The major component was by far manoyl oxide (63%), a compound of potential interest for...

journal_title：Natural product research

authors： Duquesnoy E,Marongiu B,Castola V,Piras A,Porcedda S,Casanova J

更新日期：2007-07-20 00:00:00

abstract：:A novel oxime polyketide, maydisone (1), along with two known compounds, 7-hydroxy-2,5-dimethylchromone (2) and 2,5-dimethylbenzoic acid (3) were isolated from the cultures of Bipolaris maydis. Their structures were identified by the application of NMR and MS data analyses and comparison with previous reports. Compoun...

journal_title：Natural product research

authors： Tran TM,Nguyen VK,Duong TH,Tran TN,Nguyen NH,Devi AP,Chavasiri W,Dinh MH,Tran NM,Sichaem J

更新日期：2020-05-13 00:00:00

abstract：:Phytochemical investigation of the methylenechloride/methanol extract of the aerial parts of Stachys aegyptiaca afforded a new neoclerodane-type diterpene with a new side chain 1, in addition to two known diterpenes 2 and 3 and a known flavonoid glycoside 4. The structures of the compounds were determined by comprehen...

journal_title：Natural product research

authors： Mohamed Ael-H,Mohamed NS

更新日期：2014-01-01 00:00:00

abstract：:A new 20-membered macrolide named as levantilide C was isolated from the Micromonospora strain FIM07-0019 recovered from shallow coastal waters near the island of Chiloe, Chile. The chemical structure of levantilide C was elucidated on the basis of one- and two-dimensional NMR analysis. Two known indole derivatives we...

journal_title：Natural product research

authors： Fei P,Chuan-Xi W,Yang X,Hong-Lei J,Lu-Jie C,Uribe P,Bull AT,Goodfellow M,Hong J,Yun-Yang L

更新日期：2013-08-01 00:00:00

abstract：:Eight phenolic compounds, including two mixtures of two compounds, were isolated from the ethyl acetate extract of leaves and stems of Homalium brachybotrys. They were identified on the basis of spectroscopic data as quercetin-3-O-beta-glucopyranoside, luteolin-7-O-beta-glucopyranoside, 5,6-dihydro-6-beta-glucopyranos...

journal_title：Natural product research

authors： Mosaddik A,Forster PI,Waterman PG

更新日期：2007-11-01 00:00:00

abstract：:Two new alkaloids, 4'-O-demethylhamatine (1) and ancistrotectoriline C (2), were isolated from the stems and leaves of Ancistrocladus tectorius. These two compounds represent one 5,1'-coupled and one 7,6'-coupled naphthylisoquinoline alkaloid, respectively. Their structures were elucidated by 1D- and 2D-NMR spectra an...

journal_title：Natural product research

authors： Tang CP,Xin ZQ,Li XQ,Ye Y

更新日期：2010-07-01 00:00:00

abstract：:The aims of the present study were to determine the antibacterial activity of bark extract of Cryptomeria japonica D. Don and to isolate potential antibacterial constituents. The results showed that the ethanolic extract of C. japonica bark possessed a good antibacterial activity. Nine compounds including seven diterp...

journal_title：Natural product research

authors： Li WH,Chang ST,Chang SC,Chang HT

更新日期：2008-01-01 00:00:00

abstract：:Herein we report the regioselective synthesis of podophyllotoxin-Glycosyl triazole hybrids catalysed by Ag(I)-N-heterocyclic carbene (Ag(I)-NHC) in a short reaction time (∼30 min) at ambient conditions. In principle, it is the first report of Click alkyne-azide cycloaddition catalysed by Ag(I)-NHC catalyst and moreove...

journal_title：Natural product research

authors： Nerella S,Kankala S,Gavaji B

更新日期：2021-01-01 00:00:00

abstract：:Chemical diversity of the essential oils of twenty wild populations of Tanacetum polycephalum Sch. Bip., was investigated. The aerial parts of T. polycephalum were collected at full flowering stage from West Azerbaijan Province of Iran, air-dried; hydrodistilled to produce essential oils. The essential oils were analy...

journal_title：Natural product research

authors： Mojarrad M,Hosseini Sarghein S,Sonboli A

更新日期：2019-05-01 00:00:00

abstract：:Evaluation of in vitro standard antioxidant assays, such as 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis-3 ethylbenzothiozoline-6-sulphonic acid diammonium salt (ABTS+) radical scavenging, lipid peroxidation inhibitory (or thiobarbituric acid formation inhibitory activity) and ferrous ion (Fe+2) chelating acti...

journal_title：Natural product research

authors： Chakraborty K,Raola VK

更新日期：2018-11-01 00:00:00

abstract：:The cytotoxicity of six ent-kaurene diterpenoids isolated from the leaves of Isodon japonica (Burm.f.) Hara var. galaucocalyx (maxin) Hara was evaluated against three human tumour HepG2, GLC-82 and HL-60 cell lines through SRB assay, and their DNA damage potential (against HepG2 cell line) was assessed by comet assay....

journal_title：Natural product research

authors： Ding L,Zhou Q,Wang L,Wang W,Zhang S,Liu B

更新日期：2011-09-01 00:00:00

abstract：:From a biologically active fraction of extract from the fungus Fomitopsis pinicola, a new lanostane triterpene was isolated, 3alpha-acetyloxylanosta-8,24-diene-21-ol (1), along with two known triterpenic acids, (2) and (3). The structures of the compounds were elucidated based on their spectral properties. [structure:...

journal_title：Natural product research

authors： Petrova A,Popov S,Gjosheva M,Bankova V

更新日期：2007-05-01 00:00:00

abstract：:The aerial parts of L. cultratus were submitted to a phytopharmacological investigation in order to isolate and identify the major secondary metabolites and evaluate its crude extract, fractions and isolated compounds for antiproliferative activity. Seven compounds were isolated and identified as the chalcones 2',4'-d...

journal_title：Natural product research

authors： da Silva Landim EMBM,Ruiz ALTG,de Carvalho JE,Pomini AM,Pastorini LH,Oliveira Santin SM

更新日期：2019-08-12 00:00:00

abstract：:The chemical composition of three rockrose Cistus species, Cistus monspeliensis, Cistus libanotis and Cistus villosus, collected in Tunisia, was studied by HPTLC, focusing on the terpenes and phenols constituents. Diterpenes of Cistus are important as the main constituents of the leaf sticky aromatic resin, known as l...

journal_title：Natural product research

authors： Nicoletti M,Toniolo C,Venditti A,Bruno M,Ben Jemia M

更新日期：2015-02-01 00:00:00

abstract：:A new furostanol saponin, (25R)-26-O-(α-d-glucopyranosyl)-(1→2)-α-l-rhamnopyranosyl-furost-5-ene-3β, 22α, 26-triol-3-O-α-d-glucopyranoside (1), together with four known compounds 2-5 were isolated from the ethanolic extract of the stems of Dendrobium chrysanthum Lindl. The structures of these new compounds were identi...

journal_title：Natural product research

authors： Yang C,Lin W,Zhao L,Cai J

更新日期：2019-09-01 00:00:00

abstract：:The aqueous methanolic extracts of Melastoma malabathricum L. exhibited antibacterial activity when assayed against seven microorganisms by the agar diffusion method. Solvent fractionation afforded active chloroform and ethyl acetate fractions from the leaves and the flowers, respectively. A phytochemical study result...

journal_title：Natural product research

authors： Wong KC,Hag Ali DM,Boey PL

更新日期：2012-01-01 00:00:00

abstract：:The cholesteryl ester transfer protein (CETP), inhibition of which assists in maintaining a high level of high-density lipoprotein cholesterol in the blood, is a target for anti-atherosclerosis treatments. Orange monascus pigment was produced by a Monascus species in a 5 L jar fermenter and various derivative compound...

journal_title：Natural product research

authors： Jang H,Choe D,Shin CS

更新日期：2014-01-01 00:00:00

abstract：:A new malyngamide (1) was isolated along with seven known compounds (2-8) from the marine cyanobacterium Moorea producens collected in Hawaii. Compound 1 represented the first reported malyngamide with a hydroxy moiety at C-7 of the characteristic fatty acid portion of the compound. Compound 1 showed cytotoxicity agai...

journal_title：Natural product research

authors： Jiang W,Zhou W,Othman R,Uchida H,Watanabe R,Suzuki T,Sakamoto B,Nagai H

更新日期：2018-01-01 00:00:00

abstract：:Three new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangamb...

journal_title：Natural product research

authors： El-Mekkawy S,Meselhy MR,Nkobole N,Lall N

更新日期：2013-01-01 00:00:00