Antiproliferative activity and chemical constituents of Lonchocarpus cultratus (Fabaceae).

Abstract:

:The aerial parts of L. cultratus were submitted to a phytopharmacological investigation in order to isolate and identify the major secondary metabolites and evaluate its crude extract, fractions and isolated compounds for antiproliferative activity. Seven compounds were isolated and identified as the chalcones 2',4'-dihydroxy-5'-prenylchalcone (1) and isocordoin (2), the flavanone 8-prenylpinocembrin (3), the alkaloid 4-hydroxy-N-methylproline (4), the triterpenes lupeol and lupenone. These compounds were identified by nuclear magnetic resonance of 1H and 13C data in comparison with literature. Hexanic fraction and chalcone 2',4'-dihydroxy-5'-prenylchalcone showed potent results against human cancer cell lines tested.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

da Silva Landim EMBM,Ruiz ALTG,de Carvalho JE,Pomini AM,Pastorini LH,Oliveira Santin SM

doi

10.1080/14786419.2019.1647427

subject

Has Abstract

pub_date

2019-08-12 00:00:00

pages

1-4

eissn

1478-6419

issn

1478-6427

pub_type

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