Abstract:
:The aerial parts of L. cultratus were submitted to a phytopharmacological investigation in order to isolate and identify the major secondary metabolites and evaluate its crude extract, fractions and isolated compounds for antiproliferative activity. Seven compounds were isolated and identified as the chalcones 2',4'-dihydroxy-5'-prenylchalcone (1) and isocordoin (2), the flavanone 8-prenylpinocembrin (3), the alkaloid 4-hydroxy-N-methylproline (4), the triterpenes lupeol and lupenone. These compounds were identified by nuclear magnetic resonance of 1H and 13C data in comparison with literature. Hexanic fraction and chalcone 2',4'-dihydroxy-5'-prenylchalcone showed potent results against human cancer cell lines tested.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
da Silva Landim EMBM,Ruiz ALTG,de Carvalho JE,Pomini AM,Pastorini LH,Oliveira Santin SMdoi
10.1080/14786419.2019.1647427subject
Has Abstractpub_date
2019-08-12 00:00:00pages
1-4eissn
1478-6419issn
1478-6427pub_type
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