Ca2+ channel currents and contraction in CaVbeta3-deficient ileum smooth muscle from mouse.

abstract：:Ca2+ signals are known to mediate an array of cellular functions including secretion, contraction, and conductivity changes. In spite of the obvious role of Ca2+ in signalling, the control of Ca2+ within cells is known to be a complex phenomenon involving a number of distinct active and passive transport systems funct...

journal_title：Cell calcium

authors： Gill DL,Ghosh TK,Mullaney JM

更新日期：1989-07-01 00:00:00

abstract：:The endoplasmic reticulum (ER) acts as a dynamic calcium store and is involved in the generation of specific patterns of calcium signals in neurons. Calcium is mobilized from the ER store by multiple signaling cascades, and neuronal activity is known to regulate ER calcium levels. We asked how neurons regulate ER calc...

journal_title：Cell calcium

authors： Samtleben S,Wachter B,Blum R

更新日期：2015-08-01 00:00:00

abstract：:Light-sensitive channels encoded by the Drosophila transient receptor potential-like gene (trpl) are activated in situ by an unknown mechanism requiring activation of Gq and phospholipase C (PLC). Recent studies have variously concluded that heterologously expressed TRPL channels are activated by direct Gq-protein int...

journal_title：Cell calcium

authors： Hardie RC,Raghu P

更新日期：1998-09-01 00:00:00

abstract：:In previous works, we have shown that L-type voltage-operated calcium channels, N-methyl-d-aspartate receptors (NMDAr), neuronal nitric oxide synthase (nNOS) and cytochrome b5 reductase (Cb5R) co-localize within the same lipid rafts-associated nanodomains in mature cerebellar granule neurons (CGN). In this work, we sh...

journal_title：Cell calcium

authors： Marques-da-Silva D,Gutierrez-Merino C

更新日期：2014-08-01 00:00:00

abstract：:Rapid formation of high-Ca2+ perimitochondrial cytoplasmic microdomains has been shown to evoke mitochondrial Ca2+ signal and activate mitochondrial dehydrogenases, however, the significance of submicromolar cytoplasmic Ca2+ concentrations in the control of mitochondrial metabolism has not been sufficiently elucidated...

journal_title：Cell calcium

authors： Pitter JG,Maechler P,Wollheim CB,Spät A

更新日期：2002-02-01 00:00:00

abstract：:Previously we demonstrated that stimulation of cultured neonatal rat ventricular myocytes by either alpha 1-adrenergic agonist or endothelin-1 resulted in a rapid formation of total inositolphosphates, although the levels of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate did not rise significantly...

journal_title：Cell calcium

authors： De Jonge HW,Atsma DE,van der Valk-Kokshoorn EJ,van Heugten HA,van der Laarse A,Lamers JM

更新日期：1995-12-01 00:00:00

abstract：:Dopamine is one of the key neurotransmitters in the central nervous system and plays an important role in physiological processes, as well as in the development of many diseases. Here we report a receptor-independent signalling pathway induced by dopamine in CNS neurons. In cultured neurons from midbrain, cortex and h...

journal_title：Cell calcium

authors： Vaarmann A,Gandhi S,Gourine AV,Abramov AY

更新日期：2010-08-01 00:00:00

abstract：:There is growing evidence indicating that the pore structure of voltage-gated ion channels (VGICs) influences gating besides their conductance. Regarding low voltage-activated (LVA) Ca2+ channels, it has been demonstrated that substitutions of the pore aspartate (D) by a glutamate (D-to-E substitution) in domains III ...

journal_title：Cell calcium

authors： Garza-López E,Aldana A,Darszon A,Nishigaki T,López-González I

更新日期：2020-07-01 00:00:00

abstract：:The Bcl-2 protein, best known for its ability to inhibit apoptosis, interacts with the inositol 1,4,5-trisphosphate receptor (IP(3)R) Ca(2+) channel to regulate IP(3)-mediated Ca(2+) release from the endoplasmic reticulum. This review summarizes the current state of knowledge regarding the interaction of Bcl-2, and al...

journal_title：Cell calcium

authors： Distelhorst CW,Bootman MD

更新日期：2011-09-01 00:00:00

abstract：:Specific sequences (cis-acting elements) in the 3'-untranslated region (UTR) of RNA, together with stabilizing and destabilizing proteins (trans-acting factors), determine the mRNA stability, and consequently, the level of expression of several proteins. Such interactions were discovered initially for short-lived mRNA...

journal_title：Cell calcium

authors： Misquitta CM,Chen T,Grover AK

更新日期：2006-10-01 00:00:00

abstract：:A decrease of cytoplasmic Ca(2+)-concentration in vertebrate photoreceptor cells after illumination is necessary for light adaptation. Although the mechanisms of adaptation is not completely understood, several Ca(2+)-dependent cellular processes have been discovered. Some involve calcium-binding proteins like recover...

journal_title：Cell calcium

authors： Koch KW

更新日期：1995-10-01 00:00:00

abstract：:A potential role of arachidonic acid in the modulation of insulin secretion was investigated by measuring its effects on calmodulin-dependent protein kinase and protein kinase C in islet subcellular fractions. The results were interpreted in the light of arachidonic acid effects on insulin secretion from intact islets...

journal_title：Cell calcium

authors： Landt M,Easom RA,Colca JR,Wolf BA,Turk J,Mills LA,McDaniel ML

更新日期：1992-03-01 00:00:00

abstract：:Great insight has been gained into the structure and function of the inositol 1,4,5 trisphosphate receptor (InsP(3)R) by studies employing mutagenesis of the cDNA encoding the receptor. Notably, early studies using this approach defined the key constituents required for InsP(3) binding in the N-terminus and the membra...

journal_title：Cell calcium

authors： Yule DI,Betzenhauser MJ,Joseph SK

更新日期：2010-06-01 00:00:00

abstract：:Numerous lines of evidence indicate that nuclear calcium concentration ([Ca2+]n) may be controlled independently from cytosolic events by a local machinery. In particular, the perinuclear space between the inner nuclear membrane (INM) and the outer nuclear membrane (ONM) of the nuclear envelope (NE) likely serves as a...

journal_title：Cell calcium

authors： Secondo A,Petrozziello T,Tedeschi V,Boscia F,Pannaccione A,Molinaro P,Annunziato L

更新日期：2020-03-01 00:00:00

abstract：:TRPA1, a Ca(2+)-permeable cation channel that is expressed in sensory neurones, is involved in the perception of chemical irritants and mechanical hyperalgesia. TRPA1 is activated by either covalent or reversible binding of various chemical compounds, including allylisothiocyanate or acrolein, and is further sensitise...

journal_title：Cell calcium

authors： Hill K,Schaefer M

更新日期：2009-02-01 00:00:00

abstract：:Intracellular Ca(2+) signals are essential for stem cell differentiation due to their ability to control signaling pathways involved in this process. Arginine vasopression (AVP) is a neurohypophyseal hormone that increases intracellular Ca(2+) concentration during adipogenesis via V1a receptors, Gq-proteins and the PL...

journal_title：Cell calcium

authors： Tran TD,Gimble JM,Cheng H

更新日期：2016-03-01 00:00:00

abstract：:Amyloid beta (Aβ) oligomers accumulate in the brain tissue of Alzheimer disease patients and are related to disease pathogenesis. The precise mechanisms by which Aβ oligomers cause neurotoxicity remain unknown. We recently reported that Aβ oligomers cause intracellular Ca(2+) overload and neuronal death that can be pr...

journal_title：Cell calcium

authors： Texidó L,Martín-Satué M,Alberdi E,Solsona C,Matute C

更新日期：2011-03-01 00:00:00

abstract：:Ca(2+) signals control DNA synthesis and repair, gene transcription, and other cell functions that occur within the nucleus. The nuclear envelope can store Ca(2+) and release it into the nucleus via either the inositol 1,4,5-trisphosphate receptor (InsP3R) or the ryanodine receptor (RyR). Furthermore, many cell types ...

journal_title：Cell calcium

authors： Marius P,Guerra MT,Nathanson MH,Ehrlich BE,Leite MF

更新日期：2006-01-01 00:00:00

abstract：:The sphingosine derivatives sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) caused a similar elevation of the intracellular Ca2+ concentration ([Ca2+]i) in an immortalized airway epithelial cell line (CFNP9o-) incubated in Ca(2+)-free medium. The maximal effect was obtained with 2 microM SPC and 0....

journal_title：Cell calcium

authors： Orlati S,Porcelli AM,Hrelia S,Rugolo M

更新日期：1998-06-01 00:00:00

abstract：:Burst firing of the thalamic neurons is driven by the low threshold Ca2+ spike generated by Ca2+ influx through T-type Ca2+ channels when these channels are activated by membrane hyperpolarization due to inhibitory inputs. The major inhibitory inputs to the thalamocortical (TC) neurons are from the GABAergic neurons i...

journal_title：Cell calcium

authors： Shin HS

更新日期：2006-08-01 00:00:00

abstract：:A fluid stream induced by a concentration clamp system evokes in Xenopus oocytes a deformation of the membrane which results in transient chloride currents of high amplitude (stream-evoked inward current, I(i,st)) during calcium-activated chloride current oscillations. The involvement of cytoskeleton elements and of c...

journal_title：Cell calcium

authors： Montag S,Krüger K,Madeja M,Speckmann EJ,Musshoff U

更新日期：2004-04-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a progressive muscle disease with severe cardiac complications. It is believed that cellular oxidative stress and augmented Ca(2+) signaling drives the development of cardiac pathology. Some mitochondrial and metabolic dysfunctions have also been reported. Here we investigate cellu...

journal_title：Cell calcium

authors： Kyrychenko V,Poláková E,Janíček R,Shirokova N

更新日期：2015-08-01 00:00:00

abstract：:The ability of the ectodermal cells to be induced and to differentiate toward neural tissue, called neural competence, is acquired shortly before gastrulation and lost during late gastrula stages in Pleurodeles waltl embryos. We have examined ectodermal cells' neural competence in relation to the evolution of the dens...

journal_title：Cell calcium

authors： Leclerc C,Duprat AM,Moreau M

更新日期：1995-03-01 00:00:00

abstract：:The tissue/medium distribution of the nonmetabolized glucose analog [14C]-3-O-methyl-D-glucose was measured in pigeon erythrocytes and related to changes in 45Ca uptake and efflux, total calcium content and ATP levels. Sugar transport was not affected by changes in external Ca2+. However, both sugar and 45Ca influx we...

journal_title：Cell calcium

authors： Bihler I,Charles P,Sawh PC

更新日期：1982-08-01 00:00:00

abstract：:The mechanisms that regulate ion and fluid transport by the human intrahepatic bile duct have not been well defined. Human intrahepatic biliary cell lines that we have developed were used to identify and characterize purinoceptors based on increases in intracellular calcium in response to ATP and other nucleotides. In...

journal_title：Cell calcium

authors： Wolkoff LI,Perrone RD,Grubman SA,Lee DW,Soltoff SP,Rogers LC,Beinborn M,Fang SL,Cheng SH,Jefferson DM

更新日期：1995-05-01 00:00:00

abstract：:The release of Ca2+ ions from the sarcoplasmic reticulum through ryanodine receptor calcium release channels represents the critical step linking electrical excitation to muscular contraction in the heart and skeletal muscle (excitation-contraction coupling). Two small Ca2+ binding proteins, S100A1 and calmodulin, hav...

journal_title：Cell calcium

authors： Prosser BL,Hernández-Ochoa EO,Schneider MF

更新日期：2011-10-01 00:00:00

abstract：:NAADP (nicotinic acid adenine dinucleotide phosphate) is a recently discovered second messenger, and as such, we have much yet to learn about its functions in health and disease. A bottleneck in this basic research is due to NAADP, like all second messengers, being charged to prevent it from leaking out of cells. This...

journal_title：Cell calcium

authors： Parkesh R,Lewis AM,Aley PK,Arredouani A,Rossi S,Tavares R,Vasudevan SR,Rosen D,Galione A,Dowden J,Churchill GC

更新日期：2008-06-01 00:00:00

abstract：:Infrared neural stimulation (INS) is a promising neurostimulation technique that can activate neural tissue with high spatial precision and without the need for exogenous agents. However, little is understood about how infrared light interacts with neural tissue on a cellular level, particularly within the living brai...

journal_title：Cell calcium

authors： Cayce JM,Bouchard MB,Chernov MM,Chen BR,Grosberg LE,Jansen ED,Hillman EM,Mahadevan-Jansen A

更新日期：2014-04-01 00:00:00

abstract：:In smooth muscle, Ca(2+) regulates cell division, growth and cell death as well as providing the main trigger for contraction. Ion channels provide the major access route to elevate the cytoplasmic Ca(2+) concentration ([Ca(2+)](c)) in smooth muscle by permitting Ca(2+) entry across the plasma membrane and release of ...

journal_title：Cell calcium

authors： Chalmers S,Olson ML,MacMillan D,Rainbow RD,McCarron JG

更新日期：2007-10-01 00:00:00

abstract：:Quartered pituitaries from castrated (72 h) +/- estradiol (E2)-treated (24 h) rats were used in a perifusion system to investigate estradiol modulation of ionomycin and ionomycin + PMA stimulated LH secretion. Estradiol enhanced the LH responses to GnRH (1 nM) and ionomycin (10 microM), and was necessary for the manif...

journal_title：Cell calcium

authors： Fahmy NW,Bourne GA

更新日期：1993-01-01 00:00:00