An intrinsically fluorescent dendrimer as a nanoprobe of cell transport.

abstract：:This study was designed to exploit the ability of Peyer's patch M cells to recognize antigen-antibody complexes in the targeted delivery of a model antigen for the induction of mucosal immunity. Sensitized liposomes consisted of an entrapped model antigen, ovalbumin (OVA), and coated with unrelated antigen-antibody co...

journal_title：Journal of drug targeting

authors： Velez CN,Tonkonogy SL,Lichtman SN,Cho MJ

更新日期：1997-01-01 00:00:00

abstract：:Tissue factor (TF) is aberrantly expressed on tumor vascular endothelial cells (VECs) and on cancer cells in many malignant tumors, but not on normal VECs, making it a promising target for cancer therapy. As a transmembrane receptor for coagulation factor VIIa (fVIIa), TF forms a high-affinity complex with its cognate...

journal_title：Journal of drug targeting

authors： Shoji M,Sun A,Kisiel W,Lu YJ,Shim H,McCarey BE,Nichols C,Parker ET,Pohl J,Mosley CA,Alizadeh AR,Liotta DC,Snyder JP

更新日期：2008-04-01 00:00:00

abstract：:This study was aimed to generate a new agent, norcantharidin (NCTD) encapsulated liposomes modified with a novel murine anti-human CD19 monoclonal antibody 2E8 (2E8–NCTD–liposomes), to specifically target the B-lineage leukemia stem cells (B-LSCs) and their progeny in vitro. Our results have shown that the positive pe...

journal_title：Journal of drug targeting

authors： Zhang J,Tang Y,Li S,Liao C,Guo X

更新日期：2010-11-01 00:00:00

abstract：:Herein, we report the effect of gold nanoparticles (AuNP) and n-acetylcysteine (NAC) isolated or in association as important anti-inflammatory and antioxidant compounds on brain dysfunction in septic rats. Male Wistar rats after sham operation or caecal ligation and perforation (CLP) were treated with subcutaneously i...

journal_title：Journal of drug targeting

authors： Petronilho F,Tenfen L,Della Giustina A,Joaquim L,Novochadlo M,de Oliveira Junior AN,Bagio E,Goldim MPS,de Carli RJ,Bonfante SRSA,Metzker KLL,Muttini S,Dos Santos TM,de Oliveira MP,Engel NA,Rezin GT,Kanis LA,Barichello T

更新日期：2020-04-01 00:00:00

abstract：:Chemotherapy is still a major challenge for in vivo drug targeting to macrophages. Toxicity remains the major obstacle for the most potent drugs already known in the therapy of leishmaniasis. Thus, new drugs and new delivery systems are sought. By using different vesicular delivery modes e.g. liposomes, niosomes, micr...

journal_title：Journal of drug targeting

authors： Sarkar S,Mandal S,Sinha J,Mukhopadhyay S,Das N,Basu MK

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Histone deacetylases (HDACs) have been revealed to be involved in cerebrovascular diseases, while the role of HDAC9 in intracranial aneurysm (IA) remains seldom studied. We aim to explore the role of the HDAC9/microRNA-92a (miR-92a)/Bcl-2-like protein 11 (BCL2L11) axis in IA progression. METHODS:Expression o...

journal_title：Journal of drug targeting

authors： Cai Y,Huang D,Ma W,Wang M,Qin Q,Jiang Z,Liu M

更新日期：2021-01-22 00:00:00

abstract：:Considering limitations of conventional insulin therapies, the present study characterizes usefulness of novel mucoadhesive multivesicular liposomes as a mucoadhesive sustained release carrier of insulin via nasal and ocular routes, thus attempts to develop non-invasive carrier system for the controlled release of bio...

journal_title：Journal of drug targeting

authors： Jain AK,Chalasani KB,Khar RK,Ahmed FJ,Diwan PV

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:The polycationic nanopeptide RKKRRQRRR is a fragment of HIV-Tat protein known to be a transfection enhancer. Such factors control the transfection efficiency of plasmid DNA complexed with tat peptide. However, their actions are poorly understood. METHODS AND RESULTS:Several cell lines and primary cells were...

journal_title：Journal of drug targeting

authors： Hellgren I,Gorman J,Sylvén C

更新日期：2004-01-01 00:00:00

abstract：:An aspargine-glycine-arginine (NGR) peptide modified single-walled carbon nanotubes (SWCNTs) system, developed by a simple non-covalent approach, could be loaded with the anticancer drug doxorubicin (DOX) and magnetic resonance imaging (MRI) contrast agent gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). This...

journal_title：Journal of drug targeting

authors： Yan C,Chen C,Hou L,Zhang H,Che Y,Qi Y,Zhang X,Cheng J,Zhang Z

更新日期：2017-02-01 00:00:00

abstract：:Diabetes is a condition that is not completely treatable but life of a diabetic patient can be smoothed by preventing or delaying the associate conditions like diabetic retinopathy, nephropathy, impaired wound healing process, etc. Apart from conventional methods to regulate diabetic condition, new techniques using si...

journal_title：Journal of drug targeting

authors： Shende P,Patel C

更新日期：2019-02-01 00:00:00

abstract：:Metal nanoparticles (NPs) may have the potential to overcome problems related to conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in cancer therapy providing better targeting, gene silencing and drug delivery. Functionalised metal NPs with targeting ligands offer a better control of...

journal_title：Journal of drug targeting

authors： Sharma A,Goyal AK,Rath G

更新日期：2018-09-01 00:00:00

abstract：:The objective of this study was to estimate the colon-specific delivery of [Asu1,7]-eel calcitonin (ECT) using chitosan capsules in rats. The intestinal absorption of ECT was evaluated by measuring the plasma calcium levels after oral administration of the chitosan capsules containing ECT and different combinations of...

journal_title：Journal of drug targeting

authors： Fetih G,Fausia H,Okada N,Fujita T,Attia M,Yamamoto A

更新日期：2006-04-01 00:00:00

abstract：:It is well established that overproduction and accumulation of the β-amyloid (Aβ) peptide 1-42 (Aβ(1-42)) is a trigger of the pathological cascade in Alzheimer's disease (AD) that manifests as cognitive impairment. Ginsenoside Rg3 is an important constituent of ginseng, plays an essential role in memory and improved c...

journal_title：Journal of drug targeting

authors： Aalinkeel R,Kutscher HL,Singh A,Cwiklinski K,Khechen N,Schwartz SA,Prasad PN,Mahajan SD

更新日期：2018-02-01 00:00:00

abstract：:A new drug-targeting system for CD13(+) tumors has been developed, based on ultrasound-sensitive nanobubbles (NBs) and cell-permeable peptides (CPPs). Here, the CPP-doxorubicin conjugate (CPP-DOX) was entrapped in the asparagine-glycine-arginine (NGR) peptide modified NB (CPP-DOX/NGR-NB) and the penetration of CPP-DOX...

journal_title：Journal of drug targeting

authors： Lin W,Xie X,Deng J,Liu H,Chen Y,Fu X,Liu H,Yang Y

更新日期：2016-01-01 00:00:00

abstract：:Radiolabelled poly(methylmethacrylate) (PMMA) nanoparticles were coated with rat serum albumin (RSA), serum and inactivated serum, to examine the influence of these blood components on the body distribution of a model colloidal drug carrier. The particles were incubated overnight at 37 degrees C either in a 1% solutio...

journal_title：Journal of drug targeting

authors： Borchard G,Kreuter J

更新日期：1993-01-01 00:00:00

abstract：:Tumour microenvironment provides the 'soil' for tumour growth. Besides tumour cells, there are also numbers of stromal cells, extracellular matrix and other components in the tumour microenvironment. In the past years, kinds of ligands and markers specifically high-expressed on the surface of the tumour stromal cells ...

journal_title：Journal of drug targeting

authors： Li Z,Zheng Z,Li C,Li Z,Wu J,Zhang B

更新日期：2020-08-01 00:00:00

abstract：:Poly(D,L-lactic-co-glycolic) acid (PLGA) microspheres containing plasmid DNA encoding the firefly luciferase gene were prepared using the water-in-oil-in-water (w/o/w) double emulsion and solvent evaporation method. In this study, we investigated the effects of three process parameters on DNA microencapsulation: (1) e...

journal_title：Journal of drug targeting

authors： Hsu YY,Hao T,Hedley ML

更新日期：1999-12-01 00:00:00

abstract：:Oleanolic acid (OA) is a pentacyclic triterpenoid found in various plant species. Triterpenoid compounds have been shown to inhibit tumor proliferation and to induce apoptosis in cancer cells. We synthesized an OA derivative and evaluated its inhibitory effects on cell proliferation in human colon cancer. Radioisotope...

journal_title：Journal of drug targeting

authors： Kim SM,Jeong IH,Yim MS,Chae MK,Kim HN,Kim DK,Kang CM,Choe YS,Lee C,Ryu EK

更新日期：2014-10-07 00:00:00

abstract：:An oral vaccine formulation comprised of starch microparticles with conjugated antigens is being developed. In this report we have examined the uptake of such microparticles by the intestinal mucosa and examined whether the conjugated antigen can influence the uptake. Two model antigens were used: recombinant cholera ...

journal_title：Journal of drug targeting

authors： Larhed A,Stertman L,Edvardsson E,Sjöholm I

更新日期：2004-06-01 00:00:00

abstract：:Necrosis avid agents (NAAs) can be used for diagnose of necrosis-related diseases, evaluation of therapeutic responses and targeted therapeutics of tumor. In order to probe into the effects of molecular skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones, four dianthrone com...

journal_title：Journal of drug targeting

authors： Zhang D,Jiang C,Yang S,Gao M,Huang D,Wang X,Shao H,Feng Y,Sun Z,Ni Y,Zhang J,Yin Z

更新日期：2016-01-01 00:00:00

abstract：:The high-molecular-weight soluble aggregates of Fab fragments of murine antibodies against cardiac myosin were prepared as a potential long-circulating and low immunogenic pharmaceutical carriers by conjugation of thiolated Fab and Fab modified with succinimidyl 3-(2-pyridyldithio)propionate. The clearance time and bi...

journal_title：Journal of drug targeting

authors： Dalkara S,Petrov A,Trubetskoy VS,Khaw BA,Torchilin VP

更新日期：1998-01-01 00:00:00

abstract：:Rabies virus glycoprotein (RVG), a 505 amino acid type-1 glycoprotein, is responsible for the neurotrophic nature of the rabies virus infection. Despite varying reports in the literature as to which receptor is ultimately responsible for interaction of RVG with the nervous system, there is a strong argument for major ...

journal_title：Journal of drug targeting

authors： Huey R,Hawthorne S,McCarron P

更新日期：2017-06-01 00:00:00

abstract：:beta-Glucuronidase (GUSB) is a lysosomal enzyme that could be developed as a brain therapy for Type VII Mucopolysaccharidosis. However, GUSB does not cross the blood-brain barrier (BBB). To enable BBB transport of the enzyme, human GUSB was re-engineered as a fusion protein with the chimeric monoclonal antibody (MAb) ...

journal_title：Journal of drug targeting

authors： Boado RJ,Pardridge WM

更新日期：2010-04-01 00:00:00

abstract：:A targeted delivery system for inflammatory bowel diseases, chitosan-Ca-alginate microparticles efficiently loaded with budesonide (BDS), were designed using one-step spray-drying process. They were eudragit-coated and examined for in vivo efficacy. Experimental colitis was induced by rectal instillation of 2,4,6-trin...

journal_title：Journal of drug targeting

authors： Crcarevska MS,Dodov MG,Petrusevska G,Gjorgoski I,Goracinova K

更新日期：2009-12-01 00:00:00

abstract：:Polynucleotides are anionic macromolecules which are expected to transfer into the targeted cells through specific uptake mechanisms. So, we developed polynucleotides coating complexes of plasmid DNA (pDNA) and polyethylenimine (PEI) for a secure and efficient gene delivery system and evaluated their usefulness. Polya...

journal_title：Journal of drug targeting

authors： Kodama Y,Ohkubo C,Kurosaki T,Egashira K,Sato K,Fumoto S,Nishida K,Higuchi N,Kitahara T,Nakamura T,Sasaki H

更新日期：2015-01-01 00:00:00

abstract：:This study assesses a protective effect of a mitochondria-targeted antioxidant SkQT1 (a mixture of 10-(6'-toluquinonyl) decyltriphenylphosphonium and 10-(5'-toluquinonyl) decyltriphenylphosphonium in proportion of 1.4:1), using an open focal trauma model of the rat brain sensorimotor cortex and a model of amyloid-beta...

journal_title：Journal of drug targeting

authors： Genrikhs EE,Stelmashook EV,Popova OV,Kapay NA,Korshunova GA,Sumbatyan NV,Skrebitsky VG,Skulachev VP,Isaev NK

更新日期：2015-05-01 00:00:00

abstract：:A promising strategy to carry genetic material to brain cells either in vitro or in vivo is using the LDL receptor (LDLr) on blood-brain barrier. LDLr naturally help to low density lipoproteins (LDL(S)) transporting across the BBB by endocytosis. Here we present the idea of using the LDLr-mediated pathway for transpor...

journal_title：Journal of drug targeting

authors： Mousazadeh M,Palizban A,Salehi R,Salehi M

更新日期：2007-04-01 00:00:00

abstract：:The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs) that are commonly used in patients with hypertension, cardiovascular disease and/or...

journal_title：Journal of drug targeting

authors： Akhtar S,Benter IF,Danjuma MI,Doi SAR,Hasan SS,Habib AM

更新日期：2020-08-01 00:00:00

abstract：:Microparticles-adsorbed insulin and zinc insulin (PenfilN) were molded to self-dissolving micropiles (SDMPs) with chondroitin sulfate as the base for the percutaneous administration of insulin. Porous silicon dioxide (Sylysia 320, 440 and 730) and porous calcium silicate (FloriteRE) were used as microparticles. As a r...

journal_title：Journal of drug targeting

authors： Ito Y,Hagiwara E,Saeki A,Sugioka N,Takada K

更新日期：2007-06-01 00:00:00

abstract：:Toxoplasmic encephalitis (TE) is the most common clinical manifestation of reactivated infection with Toxoplasma gondii in immunocompromised patients that is lethal if untreated. The combination of pyrimethamine plus sulfadiazine or clindamycin is the standard therapy for the treatment of TE, but these combinations ar...

journal_title：Journal of drug targeting

authors： Shubar HM,Lachenmaier S,Heimesaat MM,Lohman U,Mauludin R,Mueller RH,Fitzner R,Borner K,Liesenfeld O

更新日期：2011-02-01 00:00:00