Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones.

abstract：:The biodistribution of orally and intravenously administered archaeosomes in mice was compared to that of archaeosomes containing either coenzyme Q10 (archaeosome-CoQ10), polyethylene glycol (archaeosome-PEG), or PEG plus CoQ10 (archaeosome-PEG-CoQ10). The archaeosome formulations were prepared by a reverse-phase evap...

journal_title：Journal of drug targeting

authors： Omri A,Makabi-Panzu B,Agnew BJ,Sprott GD,Patel GB

更新日期：2000-01-01 00:00:00

abstract：:Metal nanoparticles (NPs) may have the potential to overcome problems related to conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in cancer therapy providing better targeting, gene silencing and drug delivery. Functionalised metal NPs with targeting ligands offer a better control of...

journal_title：Journal of drug targeting

authors： Sharma A,Goyal AK,Rath G

更新日期：2018-09-01 00:00:00

abstract：:The ultimate goal of bacterial based cancer therapy is to achieve non-toxic penetration and colonisation of the tumour microenvironment. To overcome this efficacy-limiting toxicity of anticancer immunotherapy, we have tested a therapy comprised of systemic delivery of a vascular disrupting agent to induce intratumoral...

journal_title：Journal of drug targeting

authors： Augustin LB,Milbauer L,Hastings SE,Leonard AS,Saltzman DA,Schottel JL

更新日期：2020-12-21 00:00:00

abstract：:The aim of this work was to formulate minoxidil loaded liposome and niosome formulations to improve skin drug delivery. Multilamellar liposomes were prepared using soy phosphatidylcholine at different purity degrees (Phospholipon 90, 90% purity, soy lecithin (SL), 75% purity) and cholesterol (Chol), whereas niosomes w...

journal_title：Journal of drug targeting

authors： Mura S,Pirot F,Manconi M,Falson F,Fadda AM

更新日期：2007-02-01 00:00:00

abstract：:Targeting of anti-tumor drugs to the urinary bladder for the treatment of bladder carcinoma may be useful, since these agents generally have a low degree of urinary excretion and are highly toxic elsewhere in the body. The anti-tumor drug doxorubicin was coupled to the low-molecular weight protein lysozyme via the aci...

journal_title：Journal of drug targeting

authors： Haas M,Moolenaar F,Elsinga A,Van der Wouden EA,de Jong PE,Meijer DK,de Zeeuw D

更新日期：2002-02-01 00:00:00

abstract：:Drug delivery is an important consideration in disease treatment. There are many opportunities for novel methods and technologies to hold promising roles in overcoming traditional obstacles. Delivery systems functionalised to boast synergistic antimicrobial effects, specific targeting, and enhanced bioavailability all...

journal_title：Journal of drug targeting

authors： Mittal R,Pan DR,Parrish JM,Huang EH,Yang Y,Patel AP,Malhotra AK,Mittal J,Chhibber S,Harjai K

更新日期：2018-09-01 00:00:00

abstract：:This study was aimed to generate a new agent, norcantharidin (NCTD) encapsulated liposomes modified with a novel murine anti-human CD19 monoclonal antibody 2E8 (2E8–NCTD–liposomes), to specifically target the B-lineage leukemia stem cells (B-LSCs) and their progeny in vitro. Our results have shown that the positive pe...

journal_title：Journal of drug targeting

authors： Zhang J,Tang Y,Li S,Liao C,Guo X

更新日期：2010-11-01 00:00:00

abstract：:Oleanolic acid (OA) is a pentacyclic triterpenoid found in various plant species. Triterpenoid compounds have been shown to inhibit tumor proliferation and to induce apoptosis in cancer cells. We synthesized an OA derivative and evaluated its inhibitory effects on cell proliferation in human colon cancer. Radioisotope...

journal_title：Journal of drug targeting

authors： Kim SM,Jeong IH,Yim MS,Chae MK,Kim HN,Kim DK,Kang CM,Choe YS,Lee C,Ryu EK

更新日期：2014-10-07 00:00:00

abstract：:Diabetes is a condition that is not completely treatable but life of a diabetic patient can be smoothed by preventing or delaying the associate conditions like diabetic retinopathy, nephropathy, impaired wound healing process, etc. Apart from conventional methods to regulate diabetic condition, new techniques using si...

journal_title：Journal of drug targeting

authors： Shende P,Patel C

更新日期：2019-02-01 00:00:00

abstract：:The nerve growth factor (NGF) is essential for the survival of both peripheral ganglion cells and central cholinergic neurons in the basal forebrain. The accelerated loss of central cholinergic neurons during Alzheimer's disease may be a determinant cause of dementia, and this observation may suggest a possible therap...

journal_title：Journal of drug targeting

authors： Kurakhmaeva KB,Djindjikhashvili IA,Petrov VE,Balabanyan VU,Voronina TA,Trofimov SS,Kreuter J,Gelperina S,Begley D,Alyautdin RN

更新日期：2009-09-01 00:00:00

abstract：:We hypothesized that immunoliposomes (ILs) constructed using Fab' from the humanized anti-EGFR monoclonal antibody, EMD72000, can provide efficient intracellular drug delivery in EGFR-overexpressing colorectal tumor cells.ILs were constructed modularly with various MAb fragments, including Fab' from EMD72000 (matuzuma...

journal_title：Journal of drug targeting

authors： Mamot C,Ritschard R,Küng W,Park JW,Herrmann R,Rochlitz CF

更新日期：2006-05-01 00:00:00

abstract：:Liposomes have been prepared from dipalmitoylphosphatidylcholine (DPPC), cholesterol (Chol) and dimethyldioctadecylammonium bromide (DDAB). The cationic vesicles adsorb to biofilms of the skin-associated bacteria Staphylococcus epidermidis, which have a negative charge. Encapsulation of the antibacterial drug vancomyc...

journal_title：Journal of drug targeting

authors： Sanderson NM,Jones MN

更新日期：1996-01-01 00:00:00

abstract：:The present work describes the potential for using lectin-conjugated gliadin nanoparticles as a means of locating and anchoring a drug delivery system on the carbohydrate receptors of Helicobacter pylori (H. pylori). Gliadin nanoparticles (GNP) bearing acetohydroxamic acid (AHA) were prepared by a desolvation method. ...

journal_title：Journal of drug targeting

authors： Umamaheshwari RB,Jain NK

更新日期：2003-08-01 00:00:00

abstract：:Herein, we report the effect of gold nanoparticles (AuNP) and n-acetylcysteine (NAC) isolated or in association as important anti-inflammatory and antioxidant compounds on brain dysfunction in septic rats. Male Wistar rats after sham operation or caecal ligation and perforation (CLP) were treated with subcutaneously i...

journal_title：Journal of drug targeting

authors： Petronilho F,Tenfen L,Della Giustina A,Joaquim L,Novochadlo M,de Oliveira Junior AN,Bagio E,Goldim MPS,de Carli RJ,Bonfante SRSA,Metzker KLL,Muttini S,Dos Santos TM,de Oliveira MP,Engel NA,Rezin GT,Kanis LA,Barichello T

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To evaluate the internalization and subcellular fate of AS1411 aptamer (for glioma targeting) and TGN peptide (for blood-brain barrier targeting)-modified nanoparticles (AsTNPs), which was important for optimizing targeted delivery systems and realizing the potential toxicity to cells. METHODS:Organelles were ...

journal_title：Journal of drug targeting

authors： Gao H,Yang Z,Zhang S,Pang Z,Jiang X

更新日期：2014-06-01 00:00:00

abstract：:We have developed a new method to evaluate the transfer of macromolecular drugs to intrapulmonary lymph nodes in rats after intrapulmonary administration. By using this method, we observed that the transfer of fluorescein isothiocyanate dextrans (FDs) to the intrapulmonary lymph nodes was markedly higher than that to ...

journal_title：Journal of drug targeting

authors： Hanatani K,Takada K,Yoshida N,Nakasuji M,Morishita Y,Yasako K,Fujita T,Yamamoto A,Muranishi S

更新日期：1995-01-01 00:00:00

abstract：:The goal of this study was to develop a systemically non-toxic and stable circulation based passive targeting system for efficient anticancer treatment. Gelatin-doxorubicin (GD) and PEGylated gelatin-doxorubicin (PGD) nanoparticles were designed and their feasibilities as an anti-cancer drug were evaluated. The sizes ...

journal_title：Journal of drug targeting

authors： Lee GY,Park K,Nam JH,Kim SY,Byun Y

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:The objective of this work was to examine the application of catechins-containing phospholipids-based ultrasonic microbubbles (PUM) in ultrasound-induced delivery. METHODS:Catechins-containing PUM were prepared by dissolving lyophilized PUM powder in catechins solution. Morphologic characteristics of catechi...

journal_title：Journal of drug targeting

authors： Lu CT,Zhao YZ

更新日期：2008-12-01 00:00:00

abstract：:Recent studies have demonstrated that the carboxyterminal third domain of alpha-fetoprotein (AFP-CD) binds with various ligands and receptors. Reports within the last decade have established that AFP-CD contains a large fragment of amino acids that interact with several different receptor types. Using computer softwar...

journal_title：Journal of drug targeting

authors： Mizejewski GJ

更新日期：2015-01-01 00:00:00

abstract：:Cancer is one of the most common diseases all over the world; many people suffer from diverse types of cancer. However, currently there is no exact cure or therapy developed for cancer. On the other hand, nanoparticles are defined as microscopic particles that have dimensions less than 100 nm and they are known for th...

journal_title：Journal of drug targeting

authors： Çeşmeli S,Biray Avci C

更新日期：2019-08-01 00:00:00

abstract：:Biphenylylacetic acid (BPAA) was linked to the free hydroxyl group of 2,6-di-O-methyl-beta-Cyclodextrin (DM-beta-CyD) through an ester linkage to obtain the site specific release of the drug to the colon. The conjugate at 1:1 mole ratio was separated from the reaction mixture by semipreparative reverse-phase HPLC and ...

journal_title：Journal of drug targeting

authors： Ventura CA,Paolino D,Pedotti S,Pistarà V,Corsaro A,Puglisi G

更新日期：2003-05-01 00:00:00

abstract：:There are much said about Pieter Cullis in this special volume honoring him. He was the pioneer to study the role of hexagonal HII phase in membrane fusion and the one who applied this concept for the design of lipid nanoparticles. He was also the first to utilize remote loading techniques for the delivery of amphipat...

journal_title：Journal of drug targeting

authors： Huang L,Miao L

更新日期：2016-11-01 00:00:00

abstract：:Nanoparticles have shown great promise in the treatment of cancer, with a demonstrated potential in targeted drug delivery. Among a myriad of nanocarriers that have been recently developed, dendrimers have attracted a great deal of scientific interests due to their unique chemical and structural properties that allow ...

journal_title：Journal of drug targeting

authors： Bugno J,Hsu HJ,Hong S

更新日期：2015-01-01 00:00:00

abstract：:Microparticles and nanoparticles used in drug delivery frequently depend on their movement in confined spaces such as cells. Liposomes containing small numbers of 1-µm diameter polystyrene particles were used to study the dynamics of their movement within the confined space of the liposome interior. The analysis of th...

journal_title：Journal of drug targeting

authors： Al-Obaidi H,Nasseri B,Florence AT

更新日期：2010-12-01 00:00:00

abstract：:Increased generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a variety of diseases such as cardiovascular diseases and cancer. NADPH oxidase (Nox), a multicomponent enzyme, has been identified as one of the key sources of ROS. Nox4, one of the seven members of Nox family (Nox1, Nox2...

journal_title：Journal of drug targeting

authors： Guo S,Chen X

更新日期：2015-12-01 00:00:00

abstract：:HEK cells were transfected with the GFP gene using various vectors: naked DNA, lipofectamine, and both PLGA and P(FASA) plasmid-loaded nanospheres. All methods were assessed alone and with the use of chloroquine, a lysosomal enzyme inhibitor. Transfection efficiencies were determined and compared at various times post...

journal_title：Journal of drug targeting

authors： Sandor M,Mehta S,Harris J,Thanos C,Weston P,Marshall J,Mathiowitz E

更新日期：2002-09-01 00:00:00

abstract：:The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy and is defined to a large part by the many and complex cellular biological and biochemical barriers such that a construct must traverse. It is shown here that model dextrin conjugates are able to pass through...

journal_title：Journal of drug targeting

authors： Powell A,Caterson B,Hughes C,Paul A,James C,Hopkins S,Mansour O,Griffiths P

更新日期：2017-01-01 00:00:00

abstract：:Germ-free (GF) animals lack a colonic microflora like that seen in conventional (CV) animals. Bacterial presence plays a role in the development of glycoproteins in the gastrointestinal (GI) tract; the absence of a microbiota has been seen to suppress the production of certain glycoproteins and glycolipids. Binding pa...

journal_title：Journal of drug targeting

authors： Wróblewski S,Ríhová B,Rossmann P,Hudcovicz T,Reháková Z,Kopecková P,Kopecek J

更新日期：2001-04-01 00:00:00

abstract：:Glioma is one of the most commonly occurring malignant brain tumours which need proper treatment strategy. The current therapies for treating glioma like surgical resection, radiotherapy, and chemotherapy have failed in achieving satisfactory results and this forms a rationale for the development of novel drug deliver...

journal_title：Journal of drug targeting

authors： Krishnamoorthy B,Karanam V,Chellan VR,Siram K,Natarajan TS,Gregory M

更新日期：2014-07-01 00:00:00

abstract：:Most therapeutic agents are delivered orally. Consequently, the major classes of therapeutically useful chemicals are partially lipophilic, small molecular weight compounds. They have reasonable permeability coefficient values across cell membranes, including those of intestinal epithelia and vascular endothelia. In c...

journal_title：Journal of drug targeting

authors： Baird AW,Campion DP,O'Brien L,Brayden DJ

更新日期：2004-02-01 00:00:00