Phospholipids-based ultrasonic microbubbles for catechins encapsulation and ultrasound-triggered release.

abstract：:The objective of this study was to estimate the colon-specific delivery of [Asu1,7]-eel calcitonin (ECT) using chitosan capsules in rats. The intestinal absorption of ECT was evaluated by measuring the plasma calcium levels after oral administration of the chitosan capsules containing ECT and different combinations of...

journal_title：Journal of drug targeting

authors： Fetih G,Fausia H,Okada N,Fujita T,Attia M,Yamamoto A

更新日期：2006-04-01 00:00:00

abstract：:Acyclovir is an antiviral agent and it has been particularly used for the treatment of herpes simplex infections. The treatment of infection in the oral cavity is often difficult, because of insufficient drug concentration in saliva when acyclovir is administered via the oral route in conventional tablet form for syst...

journal_title：Journal of drug targeting

authors： Değim T,Eğlen B,Ocak O

更新日期：2006-01-01 00:00:00

abstract：:We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the twenty-first century. Multiple drug resistance and nonspecific drug targeting of the m...

journal_title：Journal of drug targeting

authors： Baruah UK,Gowthamarajan K,Vanka R,Karri VVSR,Selvaraj K,Jojo GM

更新日期：2017-08-01 00:00:00

abstract：:The present work describes the potential for using lectin-conjugated gliadin nanoparticles as a means of locating and anchoring a drug delivery system on the carbohydrate receptors of Helicobacter pylori (H. pylori). Gliadin nanoparticles (GNP) bearing acetohydroxamic acid (AHA) were prepared by a desolvation method. ...

journal_title：Journal of drug targeting

authors： Umamaheshwari RB,Jain NK

更新日期：2003-08-01 00:00:00

abstract：:Tissue factor (TF) is aberrantly expressed on tumor vascular endothelial cells (VECs) and on cancer cells in many malignant tumors, but not on normal VECs, making it a promising target for cancer therapy. As a transmembrane receptor for coagulation factor VIIa (fVIIa), TF forms a high-affinity complex with its cognate...

journal_title：Journal of drug targeting

authors： Shoji M,Sun A,Kisiel W,Lu YJ,Shim H,McCarey BE,Nichols C,Parker ET,Pohl J,Mosley CA,Alizadeh AR,Liotta DC,Snyder JP

更新日期：2008-04-01 00:00:00

abstract：:Oleanolic acid (OA) is a pentacyclic triterpenoid found in various plant species. Triterpenoid compounds have been shown to inhibit tumor proliferation and to induce apoptosis in cancer cells. We synthesized an OA derivative and evaluated its inhibitory effects on cell proliferation in human colon cancer. Radioisotope...

journal_title：Journal of drug targeting

authors： Kim SM,Jeong IH,Yim MS,Chae MK,Kim HN,Kim DK,Kang CM,Choe YS,Lee C,Ryu EK

更新日期：2014-10-07 00:00:00

abstract：:We hypothesized that immunoliposomes (ILs) constructed using Fab' from the humanized anti-EGFR monoclonal antibody, EMD72000, can provide efficient intracellular drug delivery in EGFR-overexpressing colorectal tumor cells.ILs were constructed modularly with various MAb fragments, including Fab' from EMD72000 (matuzuma...

journal_title：Journal of drug targeting

authors： Mamot C,Ritschard R,Küng W,Park JW,Herrmann R,Rochlitz CF

更新日期：2006-05-01 00:00:00

abstract：:Germ-free (GF) animals lack a colonic microflora like that seen in conventional (CV) animals. Bacterial presence plays a role in the development of glycoproteins in the gastrointestinal (GI) tract; the absence of a microbiota has been seen to suppress the production of certain glycoproteins and glycolipids. Binding pa...

journal_title：Journal of drug targeting

authors： Wróblewski S,Ríhová B,Rossmann P,Hudcovicz T,Reháková Z,Kopecková P,Kopecek J

更新日期：2001-04-01 00:00:00

abstract：:Recent studies have demonstrated that the carboxyterminal third domain of alpha-fetoprotein (AFP-CD) binds with various ligands and receptors. Reports within the last decade have established that AFP-CD contains a large fragment of amino acids that interact with several different receptor types. Using computer softwar...

journal_title：Journal of drug targeting

authors： Mizejewski GJ

更新日期：2015-01-01 00:00:00

abstract：:The human body has adapted to defend against the aggressive biological or chemical agents. As a result, the defence mechanisms of the human body became barriers for the drug delivery. Theoretically, any problem that prevents a drug from reaching its site of action is considered to be a barrier to drug delivery. The ai...

journal_title：Journal of drug targeting

authors： Jătariu AN,Popa M,Peptu CA

更新日期：2010-05-01 00:00:00

abstract：:Recent research into the complex and varied components of rheumatoid arthritis (RA) is leading to the development of more effective targets for pharmaceutical approach than even before. Current treatment of RA frequently includes the use of nonsteroidal anti-inflammatory drugs, such as Diclofenac sodium (DFNa) in spit...

journal_title：Journal of drug targeting

authors： Türker S,Erdoğan S,Ozer YA,Bilgili H,Deveci S

更新日期：2008-01-01 00:00:00

abstract：:Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 thymidine kinase gene (HSV-tk) delivery by retrovirus-producing cells and DNA/liposome complexes for the treatment...

journal_title：Journal of drug targeting

authors： Princen F,Lechanteur C,Lopez M,Gielen J,Bours V,Merville MP

更新日期：2000-01-01 00:00:00

abstract：:In order to confirm the efficacy of ciprofloxacin (CPFX) incorporated into liposomes (CPFX-liposomes) for treatment of respiratory intracellular parasite infections, the influence of particle size on drug delivery to rat alveolar macrophages (AMs) following pulmonary administration of CPFX-liposomes was investigated. ...

journal_title：Journal of drug targeting

authors： Chono S,Tanino T,Seki T,Morimoto K

更新日期：2006-09-01 00:00:00

abstract：:An oral vaccine formulation comprised of starch microparticles with conjugated antigens is being developed. In this report we have examined the uptake of such microparticles by the intestinal mucosa and examined whether the conjugated antigen can influence the uptake. Two model antigens were used: recombinant cholera ...

journal_title：Journal of drug targeting

authors： Larhed A,Stertman L,Edvardsson E,Sjöholm I

更新日期：2004-06-01 00:00:00

abstract：:siRNA therapeutics has developed rapidly and already there are clinical trials ongoing or planned; however, the delivery of siRNA into cells, tissues or organs remains to be a major obstacle. Lipid-based vectors hold the most promising position among non-viral vectors, as they have a similar structure to cell or organ...

journal_title：Journal of drug targeting

authors： Zhang S,Zhi D,Huang L

更新日期：2012-11-01 00:00:00

abstract：:Local tissue toxicity, systemic toxicity and platinum pharmacokinetics were evaluated in 6 normal healthy beagle dogs injected subcutaneously with two formulations of a polylactide biodegradable polymer (Atrigel) system containing cisplatin. Dogs were injected 4 times at 30 day intervals at platinum dosages of 70, 105...

journal_title：Journal of drug targeting

authors： Dernell WS,Straw RC,Withrow SJ,Powers BE,Fujita SM,Yewey GS,Joseph KF,Dunn RL,Whitman SL,Southard GL

更新日期：1998-01-01 00:00:00

abstract：:Organic anion-transporting polypeptides (OATPs) encoded by the SLCO genes constitute an important transporter superfamily that mediates transmembrane transport of various clinical drugs and endogenous nutrients. Eleven human OATPs with different transport functions are expressed in various tissues. Bile acids, steroid...

journal_title：Journal of drug targeting

authors： Liu T,Li Q

更新日期：2014-01-01 00:00:00

abstract：:We have previously reported that the transfection efficiency of laminin-derived AG73-peptide labeled polyethyleneglycol-modified liposomes (AG73-PEG liposomes) was enhanced by echo-contrast gas entrapping PEG liposomes (Bubble liposomes, BLs) and ultrasound (US) exposure by improving endosomal escape. However, it has ...

journal_title：Journal of drug targeting

authors： Omata D,Negishi Y,Hagiwara S,Yamamura S,Endo-Takahashi Y,Suzuki R,Maruyama K,Aramaki Y

更新日期：2012-05-01 00:00:00

abstract：:Cytokine inhibiting drugs are much more effective when delivered intracellularly to phagocytic cells in the microencapsulated form. Dexamethasone is a powerful inhibitor of TNF-α cytokine through inhibition of NF-κB which is a gene regulator of multiple pro-inflammatory cytokines. We have determined the effect of micr...

journal_title：Journal of drug targeting

authors： Uddin MN,Siddiq A,Oettinger CW,D'Souza MJ

更新日期：2011-11-01 00:00:00

abstract：:This study was designed to exploit the ability of Peyer's patch M cells to recognize antigen-antibody complexes in the targeted delivery of a model antigen for the induction of mucosal immunity. Sensitized liposomes consisted of an entrapped model antigen, ovalbumin (OVA), and coated with unrelated antigen-antibody co...

journal_title：Journal of drug targeting

authors： Velez CN,Tonkonogy SL,Lichtman SN,Cho MJ

更新日期：1997-01-01 00:00:00

abstract：:There are much said about Pieter Cullis in this special volume honoring him. He was the pioneer to study the role of hexagonal HII phase in membrane fusion and the one who applied this concept for the design of lipid nanoparticles. He was also the first to utilize remote loading techniques for the delivery of amphipat...

journal_title：Journal of drug targeting

authors： Huang L,Miao L

更新日期：2016-11-01 00:00:00

abstract：:A promising strategy to carry genetic material to brain cells either in vitro or in vivo is using the LDL receptor (LDLr) on blood-brain barrier. LDLr naturally help to low density lipoproteins (LDL(S)) transporting across the BBB by endocytosis. Here we present the idea of using the LDLr-mediated pathway for transpor...

journal_title：Journal of drug targeting

authors： Mousazadeh M,Palizban A,Salehi R,Salehi M

更新日期：2007-04-01 00:00:00

abstract：:Microparticles and nanoparticles used in drug delivery frequently depend on their movement in confined spaces such as cells. Liposomes containing small numbers of 1-µm diameter polystyrene particles were used to study the dynamics of their movement within the confined space of the liposome interior. The analysis of th...

journal_title：Journal of drug targeting

authors： Al-Obaidi H,Nasseri B,Florence AT

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Multifunctional gold nanospheres (MGNs)-loaded with docetaxel (MGN@DTX) were prepared and evaluated for therapeutic efficacy in nude mice bearing human prostate cancer xenografts. METHODS:MGNs were prepared from PEGylated hollow gold nanospheres (HGNs) coated with folic acid and DTPTT chelate. Then, the eff...

journal_title：Journal of drug targeting

authors： Shen Y,Ma Z,Chen F,Dong Q,Hu Q,Bai L,Chen J

更新日期：2015-01-01 00:00:00

abstract：:Developing a highly effective and lung-targeted local drug delivery carrier with low irritancy may be critical for improving treatment of lung cancer. Using soluble excipients as microspheres (MS) matrix, respirable MS embedding chitosan-coated poly(d,l-lactide-co-glycolide) nanoparticles (CNP-MS) for 2-methoxyestradi...

journal_title：Journal of drug targeting

authors： Guo X,Zhang X,Ye L,Zhang Y,Ding R,Hao Y,Zhao Y,Zhang Z,Zhang Y

更新日期：2014-06-01 00:00:00

abstract：:Nanoparticles form the fundamental building blocks for many exciting applications in various scientific disciplines due to its unique features such as large surface to mass ratio, targeting potential, ability to adsorbed and carry other compound which makes them suitable for biomedical applications. However, the probl...

journal_title：Journal of drug targeting

authors： Sultana S,Alzahrani N,Alzahrani R,Alshamrani W,Aloufi W,Ali A,Najib S,Siddiqui NA

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Synthesized dl-Nordihydroguaiaretic acid (dl-NGDA or "Nordy") can inhibit the growth of malignant human tumors, especially the tumor angiogenesis. However, its liposoluble nature limits its in vivo efficacy in the hydrosoluble circulation of human. PURPOSE:We tried to use the ultrasonic microbubble as the c...

journal_title：Journal of drug targeting

authors： Hua X,Ding J,Li R,Zhang Y,Huang Z,Guo Y,Chen Q

更新日期：2016-09-01 00:00:00

abstract：:The transport of 125I-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings. Translocation of the particles into the blood stream was examined by means of monitoring the radiolabel associated with the particles. Particles were detected in the...

journal_title：Journal of drug targeting

authors： Brooking J,Davis SS,Illum L

更新日期：2001-01-01 00:00:00

abstract：:beta-Glucuronidase (GUSB) is a lysosomal enzyme that could be developed as a brain therapy for Type VII Mucopolysaccharidosis. However, GUSB does not cross the blood-brain barrier (BBB). To enable BBB transport of the enzyme, human GUSB was re-engineered as a fusion protein with the chimeric monoclonal antibody (MAb) ...

journal_title：Journal of drug targeting

authors： Boado RJ,Pardridge WM

更新日期：2010-04-01 00:00:00

abstract：:Influenza, mainly caused by influenza virus, is becoming one of the major concerns in the world. Limitation in vaccines necessitates the urgent development of new therapeutic options against this virus. In the present study, we designed small interfering RNA (siRNA) targeting overlapping gene of PB1 and PB1-F2 gene of...

journal_title：Journal of drug targeting

authors： Cheng C,Yao L,Chen A,Jia R,Huan L,Guo J,Bo H,Shu Y,Zhang Z

更新日期：2009-02-01 00:00:00