听力与言语-语言病理学

行为科学

医学伦理学

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  • Histone deacetylase 9 inhibition upregulates microRNA-92a to repress the progression of intracranial aneurysm via silencing Bcl-2-like protein 11.

    abstract:OBJECTIVE:Histone deacetylases (HDACs) have been revealed to be involved in cerebrovascular diseases, while the role of HDAC9 in intracranial aneurysm (IA) remains seldom studied. We aim to explore the role of the HDAC9/microRNA-92a (miR-92a)/Bcl-2-like protein 11 (BCL2L11) axis in IA progression. METHODS:Expression o...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2021.1878365

    authors: Cai Y,Huang D,Ma W,Wang M,Qin Q,Jiang Z,Liu M

    更新日期:2021-01-22 00:00:00

  • Virulence-attenuated Salmonella engineered to secrete immunomodulators reduce tumour growth and increase survival in an autochthonous mouse model of breast cancer.

    abstract::The ultimate goal of bacterial based cancer therapy is to achieve non-toxic penetration and colonisation of the tumour microenvironment. To overcome this efficacy-limiting toxicity of anticancer immunotherapy, we have tested a therapy comprised of systemic delivery of a vascular disrupting agent to induce intratumoral...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2020.1850739

    authors: Augustin LB,Milbauer L,Hastings SE,Leonard AS,Saltzman DA,Schottel JL

    更新日期:2020-12-21 00:00:00

  • Pharmacotherapy in COVID-19 patients: a review of ACE2-raising drugs and their clinical safety.

    abstract::The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs) that are commonly used in patients with hypertension, cardiovascular disease and/or...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2020.1797754

    authors: Akhtar S,Benter IF,Danjuma MI,Doi SAR,Hasan SS,Habib AM

    更新日期:2020-08-01 00:00:00

  • Therapeutic drugs and drug delivery systems targeting stromal cells for cancer therapy: a review.

    abstract::Tumour microenvironment provides the 'soil' for tumour growth. Besides tumour cells, there are also numbers of stromal cells, extracellular matrix and other components in the tumour microenvironment. In the past years, kinds of ligands and markers specifically high-expressed on the surface of the tumour stromal cells ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2020.1744157

    authors: Li Z,Zheng Z,Li C,Li Z,Wu J,Zhang B

    更新日期:2020-08-01 00:00:00

  • Stability issues and approaches to stabilised nanoparticles based drug delivery system.

    abstract::Nanoparticles form the fundamental building blocks for many exciting applications in various scientific disciplines due to its unique features such as large surface to mass ratio, targeting potential, ability to adsorbed and carry other compound which makes them suitable for biomedical applications. However, the probl...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2020.1722137

    authors: Sultana S,Alzahrani N,Alzahrani R,Alshamrani W,Aloufi W,Ali A,Najib S,Siddiqui NA

    更新日期:2020-06-01 00:00:00

  • Sulpiride gastro-retentive floating microsponges; analytical study, in vitro optimization and in vivo characterization.

    abstract::Sulpiride (SUL), anti-dopaminergic drug, has a specific site for absorption located in the upper portion of the gastrointestinal tract hence, its oral delivery represents a challenge regarding SUL absorption and bioavailability. So, a gastro-retentive oral platform of SUL was developed to increase its gastric residenc...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2019.1663526

    authors: Younis MA,El-Zahry MR,Tallat MA,Tawfeek HM

    更新日期:2020-04-01 00:00:00

  • Gold nanoparticles potentiates N-acetylcysteine effects on neurochemicals alterations in rats after polymicrobial sepsis.

    abstract::Herein, we report the effect of gold nanoparticles (AuNP) and n-acetylcysteine (NAC) isolated or in association as important anti-inflammatory and antioxidant compounds on brain dysfunction in septic rats. Male Wistar rats after sham operation or caecal ligation and perforation (CLP) were treated with subcutaneously i...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2019.1678168

    authors: Petronilho F,Tenfen L,Della Giustina A,Joaquim L,Novochadlo M,de Oliveira Junior AN,Bagio E,Goldim MPS,de Carli RJ,Bonfante SRSA,Metzker KLL,Muttini S,Dos Santos TM,de Oliveira MP,Engel NA,Rezin GT,Kanis LA,Barichello T

    更新日期:2020-04-01 00:00:00

  • Role of therapeutic agents on repolarisation of tumour-associated macrophage to halt lung cancer progression.

    abstract::Tumour-associated macrophages (TAMs) represent as much as 50% of the solid mass in different types of human solid tumours including lung, breast, ovarian and pancreatic adenocarcinomas. The tumour microenvironment (TME) plays an important role in the polarisation of macrophages into the M1 phenotype, which is tumour-s...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2019.1648478

    authors: Aldawsari HM,Gorain B,Alhakamy NA,Md S

    更新日期:2020-02-01 00:00:00

  • Cascade catalytic nanoplatform for enhanced starvation and sonodynamic therapy.

    abstract::Background: Sonodynamic therapy (SDT) has emerged as an alternative to the traditional treatments of cancer. However, the oxygen consumption induced by SDT and glucose oxidase (GOx) mediated starvation therapy would worsen the hypoxic tumor environment, which further impeded therapeutic efficacy. Purpose: To develop a...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2019.1641507

    authors: Zhang Y,Wang H,Jia X,Du S,Yin Y,Zhang X

    更新日期:2020-02-01 00:00:00

  • Brain targeting of resveratrol through intranasal lipid vesicles labelled with gold nanoparticles: in vivo evaluation and bioaccumulation investigation using computed tomography and histopathological examination.

    abstract::Resveratrol is a promising neuroprotective agent against neurodegenerative disorders such as Alzheimer's disease. Resveratrol-loaded transferosomes and nanoemulsions were developed and labelled with gold nanoparticles (GNPs). The water maze test was utilised to identify the effect on spatial memory recovery. The treat...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2019.1608553

    authors: Salem HF,Kharshoum RM,Abou-Taleb HA,Naguib DM

    更新日期:2019-12-01 00:00:00

  • Low-intensity light-induced paclitaxel release from lipid-based nano-delivery systems.

    abstract::Light-induced drug release has been explored as a strategy for externally modulating the release of drug from delivery systems. This study reports the development of a solid lipid nanoparticulate system (SLN) for paclitaxel (PTX), where photosensitizer-mediated oxidation of lipids was used as a mechanism for controlli...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2019.1571066

    authors: Meerovich I,Nichols MG,Dash AK

    更新日期:2019-11-01 00:00:00

  • Application of titanium dioxide (TiO2) nanoparticles in cancer therapies.

    abstract::Cancer is one of the most common diseases all over the world; many people suffer from diverse types of cancer. However, currently there is no exact cure or therapy developed for cancer. On the other hand, nanoparticles are defined as microscopic particles that have dimensions less than 100 nm and they are known for th...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2018.1527338

    authors: Çeşmeli S,Biray Avci C

    更新日期:2019-08-01 00:00:00

  • siRNA: an alternative treatment for diabetes and associated conditions.

    abstract::Diabetes is a condition that is not completely treatable but life of a diabetic patient can be smoothed by preventing or delaying the associate conditions like diabetic retinopathy, nephropathy, impaired wound healing process, etc. Apart from conventional methods to regulate diabetic condition, new techniques using si...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2018.1476518

    authors: Shende P,Patel C

    更新日期:2019-02-01 00:00:00

  • Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex.

    abstract::Cationic liposomes composed of dialkyl cationic lipid such as 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) can efficiently deliver siRNA to the lungs following the intravenous injection of cationic liposome/siRNA complexes (lipoplexes). In this study, we examined the effect of cationic lipid of cationic liposomes ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2018.1502775

    authors: Hattori Y,Nakamura M,Takeuchi N,Tamaki K,Shimizu S,Yoshiike Y,Taguchi M,Ohno H,Ozaki KI,Onishi H

    更新日期:2019-02-01 00:00:00

  • Nanocapsules embedded in microparticles for enhanced oral bioavailability and efficacy of Lopinavir as an anti-AIDS drug.

    abstract::Lopinavir (LPV), an efficient drug for HIV infection treatment, was incorporated into biodegradable PLGA nanocapsules (NCs) embedded in microparticles (MCPs) using the spray-drying technique in an attempt to bypass the P-gp efflux and protect the drug from CYP3A pre-systemic metabolism without ritonavir (RTV). SEM obs...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2018.1552275

    authors: Nassar T,Rohald A,Naraykin N,Barasch D,Amsalem O,Prabhu P,Kotler M,Benita S

    更新日期:2019-01-01 00:00:00

  • Graphene-based nanocomposites: synthesis and their theranostic applications.

    abstract::Graphene, the mother of all carbon materials, has unlocked a new era of biomedical nanomaterials due to its exceptional biocompatibility, physicochemical and mechanical properties. It is a single atom thick, nanosized, two-dimensional structure and provides high surface area with adjustable surface chemistry to form h...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2018.1437920

    authors: Madni A,Noreen S,Maqbool I,Rehman F,Batool A,Kashif PM,Rehman M,Tahir N,Khan MI

    更新日期:2018-12-01 00:00:00

  • Targeting oxidative stress through antioxidants in diabetes mellitus.

    abstract::The myriad of complications associated with diabetes is closely linked with the generation of reactive species or free radicals leading to oxidative and nitrosative stress. Increased oxidative stress is an important cause and result of diabetes and it is thought to underlie the cellular changes that lead to diabetic c...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2017.1419478

    authors: Thakur P,Kumar A,Kumar A

    更新日期:2018-11-01 00:00:00

  • Local drug delivery in the urinary tract: current challenges and opportunities.

    abstract::Drug delivery is an important consideration in disease treatment. There are many opportunities for novel methods and technologies to hold promising roles in overcoming traditional obstacles. Delivery systems functionalised to boast synergistic antimicrobial effects, specific targeting, and enhanced bioavailability all...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2017.1419356

    authors: Mittal R,Pan DR,Parrish JM,Huang EH,Yang Y,Patel AP,Malhotra AK,Mittal J,Chhibber S,Harjai K

    更新日期:2018-09-01 00:00:00

  • Recent advances in metal nanoparticles in cancer therapy.

    abstract::Metal nanoparticles (NPs) may have the potential to overcome problems related to conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in cancer therapy providing better targeting, gene silencing and drug delivery. Functionalised metal NPs with targeting ligands offer a better control of...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2017.1400553

    authors: Sharma A,Goyal AK,Rath G

    更新日期:2018-09-01 00:00:00

  • The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation.

    abstract::Therapeutic peptides are conventionally administered via subcutaneous injection. Chitosan-based nanoparticles are gaining increased attention for their ability to serve as a carrier for oral delivery of peptides and vaccination. They offered superior biocompatibiltiy, controlled drug release profile and facilitated ga...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2017.1400552

    authors: Wong CY,Al-Salami H,Dass CR

    更新日期:2018-08-01 00:00:00

  • Recent advances in targeted delivery of tissue plasminogen activator for enhanced thrombolysis in ischaemic stroke.

    abstract::Tissue plasminogen activator (tPA) is the only FDA approved medical treatment for the ischaemic stroke. However, it associates with some inevitable limitations, including: short therapeutic window, extremely short half-life and low penetration in large clots. Systemic administration may lead to complications such as h...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2017.1365874

    authors: Zamanlu M,Farhoudi M,Eskandani M,Mahmoudi J,Barar J,Rafi M,Omidi Y

    更新日期:2018-02-01 00:00:00

  • Neuroprotective effects of a biodegradable poly(lactic-co-glycolic acid)-ginsenoside Rg3 nanoformulation: a potential nanotherapy for Alzheimer's disease?

    abstract::It is well established that overproduction and accumulation of the β-amyloid (Aβ) peptide 1-42 (Aβ(1-42)) is a trigger of the pathological cascade in Alzheimer's disease (AD) that manifests as cognitive impairment. Ginsenoside Rg3 is an important constituent of ginseng, plays an essential role in memory and improved c...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2017.1354002

    authors: Aalinkeel R,Kutscher HL,Singh A,Cwiklinski K,Khechen N,Schwartz SA,Prasad PN,Mahajan SD

    更新日期:2018-02-01 00:00:00

  • Topical delivery of TRPsiRNA-loaded solid lipid nanoparticles confer reduced pain sensation via TRPV1 silencing, in rats.

    abstract::Present work describes a novel composition for encapsulating TRPsiRNA (TRPV1-targeting siRNA) within lipid-matrix (4:1::glyceryl behnate:stearic acid) of SLNs, using suitably modified cold high-pressure homogenisation technique. Optimisation of the method and composition conducted using calf-thymus DNA (ctDNA), to avo...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2017.1350857

    authors: Sharma G,Chopra K,Puri S,Bishnoi M,Rishi P,Kaur IP

    更新日期:2018-02-01 00:00:00

  • Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.

    abstract::Local treatment of middle ear (ME) disease currently requires surgical penetration of the tympanic membrane (TM). We previously discovered 12-mer peptides that are actively transported across the intact TM, a process that could be used for non-invasive drug delivery into the ME. To optimise transport and provide furth...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2017.1347791

    authors: Kurabi A,Schaerer D,Chang L,Pak K,Ryan AF

    更新日期:2018-02-01 00:00:00

  • Organ-based drug delivery.

    abstract::The phenomenal advances in pharmaceutical sciences over the last few decades have led to the development of new therapeutics like peptides, proteins, RNAs, DNAs and highly potent small molecules. Fruitful applications of these therapeutics have been challenged by several anatomical and physiological barriers that limi...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2018.1437919

    authors: Alsaggar M,Liu D

    更新日期:2018-01-01 00:00:00

  • The targeting effect of Hm2E8b-NCTD-liposomes on B-lineage leukaemia stem cells is associated with the HLF-SLUG axis.

    abstract::To identify an agent with specific activity against B-lineage leukaemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanised anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-liposomes). These liposomes were specially designed to recognise and kill B-LSC...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2017.1339193

    authors: Zhang J,Shen D,Jia M,Zhao H,Tang Y

    更新日期:2018-01-01 00:00:00

  • The application of polysaccharide-based nanogels in peptides/proteins and anticancer drugs delivery.

    abstract::Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels have attracted interest as carriers for proteins/peptides and anticancer drugs ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2017.1326123

    authors: Zhang L,Pan J,Dong S,Li Z

    更新日期:2017-09-01 00:00:00

  • Malaria treatment using novel nano-based drug delivery systems.

    abstract::We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the twenty-first century. Multiple drug resistance and nonspecific drug targeting of the m...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2017.1291645

    authors: Baruah UK,Gowthamarajan K,Vanka R,Karri VVSR,Selvaraj K,Jojo GM

    更新日期:2017-08-01 00:00:00

  • α-Tocopherol as functional excipient for resveratrol and coenzyme Q10-loaded SNEDDS for improved bioavailability and prophylaxis of breast cancer.

    abstract::The present study evaluates the prophylactic efficacy of α-tocopherol (α-TOH), resveratrol (RES), and coenzyme Q10 (CoQ10) co-loaded self-nanoemulsifying drug delivery system (α-TOH-RES-CoQ10 SNEDDS) in 7,12-Dimethylbenz[a]anthracene (DMBA) induced breast cancer model. SNEDDS formulation components were rationally sel...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2017.1298603

    authors: Jain S,Garg T,Kushwah V,Thanki K,Agrawal AK,Dora CP

    更新日期:2017-07-01 00:00:00

  • Effects of cell penetrating Notch inhibitory peptide conjugated to elastin-like polypeptide on glioblastoma cells.

    abstract::Notch pathway was found to be activated in most glioblastomas (GBMs), underlining the importance of Notch in formation and recurrence of GBM. In this study, a Notch inhibitory peptide, dominant negative MAML (dnMAML), was conjugated to elastin-like polypeptide (ELP) for tumor targeted delivery. ELP is a thermally resp...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2017.1289537

    authors: Opačak-Bernardi T,Ryu JS,Raucher D

    更新日期:2017-07-01 00:00:00

  • The potential use of rabies virus glycoprotein-derived peptides to facilitate drug delivery into the central nervous system: a mini review.

    abstract::Rabies virus glycoprotein (RVG), a 505 amino acid type-1 glycoprotein, is responsible for the neurotrophic nature of the rabies virus infection. Despite varying reports in the literature as to which receptor is ultimately responsible for interaction of RVG with the nervous system, there is a strong argument for major ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2016.1223676

    authors: Huey R,Hawthorne S,McCarron P

    更新日期:2017-06-01 00:00:00

  • Single-walled carbon nanotube-loaded doxorubicin and Gd-DTPA for targeted drug delivery and magnetic resonance imaging.

    abstract::An aspargine-glycine-arginine (NGR) peptide modified single-walled carbon nanotubes (SWCNTs) system, developed by a simple non-covalent approach, could be loaded with the anticancer drug doxorubicin (DOX) and magnetic resonance imaging (MRI) contrast agent gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). This...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2016.1221958

    authors: Yan C,Chen C,Hou L,Zhang H,Che Y,Qi Y,Zhang X,Cheng J,Zhang Z

    更新日期:2017-02-01 00:00:00

  • Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route?

    abstract::The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy and is defined to a large part by the many and complex cellular biological and biochemical barriers such that a construct must traverse. It is shown here that model dextrin conjugates are able to pass through...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2017.1378660

    authors: Powell A,Caterson B,Hughes C,Paul A,James C,Hopkins S,Mansour O,Griffiths P

    更新日期:2017-01-01 00:00:00

  • The anti-tumor effect of folate-targeted liposome microbubbles loaded with oridonin as ultrasound-triggered tumor-targeted therapeutic carrier system.

    abstract::In this study, folate receptor (FR) targeted liposome microbubbles loaded with oridonin (ORI) (F-LMB-ORI), liposome loaded with ORI (L-ORI) and liposome microbubbles loaded with ORI (LMB-ORI) were prepared. In vitro release properties, cellular uptake and cytotoxicity in HepG-2 cells as well as in vivo antitumor effec...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2016.1200588

    authors: Wang C,Li W,Hu B

    更新日期:2017-01-01 00:00:00

  • Green fluorescent protein (GFP): is seeing believing and is that enough?

    abstract::Intracellular compartmentalisation is a significant barrier to the successful nucleocytosolic delivery of biologics. The endocytic system has been shown to be responsible for compartmentalisation, providing an entry point, and trigger(s) for the activation of drug delivery systems. Consequently, many of the technologi...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.1080/1061186X.2017.1358725

    authors: Shorter SA,Pettit MW,Dyer PDR,Coakley Youngs E,Gorringe-Pattrick MAM,El-Daher S,Richardson S

    更新日期:2017-01-01 00:00:00

  • Factors influencing the nuclear targeting ability of nuclear localization signals.

    abstract::A nuclear localization signal (NLS) is a short amino acid sequence derived from eukaryotic nuclear proteins and viral proteins. Many NLS peptides can efficiently mediate the intranucleus transport of cargo molecules, so they have been widely used for non-viral gene transfer and shown potential ability to improve nucle...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审

    doi:10.1080/1061186X.2016.1184273

    authors: Sun Y,Xian L,Xing H,Yu J,Yang Z,Yang T,Yang L,Ding P

    更新日期:2016-12-01 00:00:00

  • Pieter Cullis: an outstanding lipid biophysicist, drug delivery scientist, educator, and entrepreneur.

    abstract::There are much said about Pieter Cullis in this special volume honoring him. He was the pioneer to study the role of hexagonal HII phase in membrane fusion and the one who applied this concept for the design of lipid nanoparticles. He was also the first to utilize remote loading techniques for the delivery of amphipat...

    journal_title:Journal of drug targeting

    pub_type: 传,历史文章,杂志文章

    doi:10.3109/1061186X.2016.1172590

    authors: Huang L,Miao L

    更新日期:2016-11-01 00:00:00

  • Lactose-modified DNA tile nanostructures as drug carriers.

    abstract:BACKGROUND:DNA hybridization allows the preparation of nanoscale DNA structures with desired shape and size. DNA structures using simple base pairing can be used for the delivery of drug molecules into the cells. Since DNA carries multiple negative charges, their cellular uptake efficiency is low. Thus, the modificatio...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.3109/1061186X.2016.1144059

    authors: Akkus Sut P,Tunc CU,Culha M

    更新日期:2016-09-01 00:00:00

  • Anti-tumor effect of ultrasound-induced Nordy-loaded microbubbles destruction.

    abstract:BACKGROUND:Synthesized dl-Nordihydroguaiaretic acid (dl-NGDA or "Nordy") can inhibit the growth of malignant human tumors, especially the tumor angiogenesis. However, its liposoluble nature limits its in vivo efficacy in the hydrosoluble circulation of human. PURPOSE:We tried to use the ultrasonic microbubble as the c...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.3109/1061186X.2016.1144058

    authors: Hua X,Ding J,Li R,Zhang Y,Huang Z,Guo Y,Chen Q

    更新日期:2016-09-01 00:00:00

  • Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones.

    abstract::Necrosis avid agents (NAAs) can be used for diagnose of necrosis-related diseases, evaluation of therapeutic responses and targeted therapeutics of tumor. In order to probe into the effects of molecular skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones, four dianthrone com...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章

    doi:10.3109/1061186X.2015.1113541

    authors: Zhang D,Jiang C,Yang S,Gao M,Huang D,Wang X,Shao H,Feng Y,Sun Z,Ni Y,Zhang J,Yin Z

    更新日期:2016-01-01 00:00:00

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