Colon-specific delivery and enhanced colonic absorption of [Asu(1,7)]-eel calcitonin using chitosan capsules containing various additives in rats.

abstract：:The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy and is defined to a large part by the many and complex cellular biological and biochemical barriers such that a construct must traverse. It is shown here that model dextrin conjugates are able to pass through...

journal_title：Journal of drug targeting

authors： Powell A,Caterson B,Hughes C,Paul A,James C,Hopkins S,Mansour O,Griffiths P

更新日期：2017-01-01 00:00:00

abstract：:Based on the organotropic characteristics of bile acids towards the liver and the intestine, two novel compounds of the Bamet family, containing at least one bile acid moiety bound to platinum(II), have been synthesized and their cytostatic effect compared to their ability to become accumulated in tumor cells of hepat...

journal_title：Journal of drug targeting

authors： Larena MG,Martinez-Diez MC,Macias RI,Dominguez MF,Serrano MA,Marin JJ

更新日期：2002-08-01 00:00:00

abstract：:Interactions between phosphatidylcholine (PC) or phosphatidylserine (PS) liposomes and human umbilical vein endothelial cells (HUVEC) or human promyelocytic leukemia cells (HL60) were investigated. Pyramine encapsulating or rhodamine incorporating small unilamellar liposomes with mean diameters around 80 nm (demonstra...

journal_title：Journal of drug targeting

authors： Papadimitriou E,Antimisiaris SG

更新日期：2000-01-01 00:00:00

abstract：:Supramolecules since ages have been characterised as self-associating systems emanating the properties directly related to the mode of molecular association. Similar to supramolecules, liquid crystals may also be considered as an associated system. The liquid crystals are defined as the state of matter with the charac...

journal_title：Journal of drug targeting

authors： Jaitely V,Vyas SP

更新日期：1999-01-01 00:00:00

abstract：:The high-molecular-weight soluble aggregates of Fab fragments of murine antibodies against cardiac myosin were prepared as a potential long-circulating and low immunogenic pharmaceutical carriers by conjugation of thiolated Fab and Fab modified with succinimidyl 3-(2-pyridyldithio)propionate. The clearance time and bi...

journal_title：Journal of drug targeting

authors： Dalkara S,Petrov A,Trubetskoy VS,Khaw BA,Torchilin VP

更新日期：1998-01-01 00:00:00

abstract：:We hypothesized that immunoliposomes (ILs) constructed using Fab' from the humanized anti-EGFR monoclonal antibody, EMD72000, can provide efficient intracellular drug delivery in EGFR-overexpressing colorectal tumor cells.ILs were constructed modularly with various MAb fragments, including Fab' from EMD72000 (matuzuma...

journal_title：Journal of drug targeting

authors： Mamot C,Ritschard R,Küng W,Park JW,Herrmann R,Rochlitz CF

更新日期：2006-05-01 00:00:00

abstract：:The present study evaluates the prophylactic efficacy of α-tocopherol (α-TOH), resveratrol (RES), and coenzyme Q10 (CoQ10) co-loaded self-nanoemulsifying drug delivery system (α-TOH-RES-CoQ10 SNEDDS) in 7,12-Dimethylbenz[a]anthracene (DMBA) induced breast cancer model. SNEDDS formulation components were rationally sel...

journal_title：Journal of drug targeting

authors： Jain S,Garg T,Kushwah V,Thanki K,Agrawal AK,Dora CP

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:Peptide antibiotics as new therapeutic agents are becoming a popular option to investigate due to their broad bacterial target selectivity and limited resistance problems. Although attractive, these new drug candidates have several limitations including low potency and delivery issues which face all peptid...

journal_title：Journal of drug targeting

authors： Zhang C,Yadava P,Sun J,Hughes JA

更新日期：2006-11-01 00:00:00

abstract：:Glioma is one of the most commonly occurring malignant brain tumours which need proper treatment strategy. The current therapies for treating glioma like surgical resection, radiotherapy, and chemotherapy have failed in achieving satisfactory results and this forms a rationale for the development of novel drug deliver...

journal_title：Journal of drug targeting

authors： Krishnamoorthy B,Karanam V,Chellan VR,Siram K,Natarajan TS,Gregory M

更新日期：2014-07-01 00:00:00

abstract：:As a percutaneous sustained-release preparation, insulin micropiles (MPs) were prepared with biodegradable polymers poly(lactic acid) (PLA), poly(ϵ-caprolactone) (PCL) and poly(lactic-co-glycolic acid) (PLGA) as the base. The obtained PLA, PCL, and PLGA MPs of which the insulin:polymer ratio was 1:2 were administered ...

journal_title：Journal of drug targeting

authors： Fukushima K,Ito Y,Ishihata M,Sugioka N,Takada K

更新日期：2011-04-01 00:00:00

abstract：:A new drug-targeting system for CD13(+) tumors has been developed, based on ultrasound-sensitive nanobubbles (NBs) and cell-permeable peptides (CPPs). Here, the CPP-doxorubicin conjugate (CPP-DOX) was entrapped in the asparagine-glycine-arginine (NGR) peptide modified NB (CPP-DOX/NGR-NB) and the penetration of CPP-DOX...

journal_title：Journal of drug targeting

authors： Lin W,Xie X,Deng J,Liu H,Chen Y,Fu X,Liu H,Yang Y

更新日期：2016-01-01 00:00:00

abstract：:The goal of this study was to develop a systemically non-toxic and stable circulation based passive targeting system for efficient anticancer treatment. Gelatin-doxorubicin (GD) and PEGylated gelatin-doxorubicin (PGD) nanoparticles were designed and their feasibilities as an anti-cancer drug were evaluated. The sizes ...

journal_title：Journal of drug targeting

authors： Lee GY,Park K,Nam JH,Kim SY,Byun Y

更新日期：2006-12-01 00:00:00

abstract：:The ultimate goal of bacterial based cancer therapy is to achieve non-toxic penetration and colonisation of the tumour microenvironment. To overcome this efficacy-limiting toxicity of anticancer immunotherapy, we have tested a therapy comprised of systemic delivery of a vascular disrupting agent to induce intratumoral...

journal_title：Journal of drug targeting

authors： Augustin LB,Milbauer L,Hastings SE,Leonard AS,Saltzman DA,Schottel JL

更新日期：2020-12-21 00:00:00

abstract：:Influenza, mainly caused by influenza virus, is becoming one of the major concerns in the world. Limitation in vaccines necessitates the urgent development of new therapeutic options against this virus. In the present study, we designed small interfering RNA (siRNA) targeting overlapping gene of PB1 and PB1-F2 gene of...

journal_title：Journal of drug targeting

authors： Cheng C,Yao L,Chen A,Jia R,Huan L,Guo J,Bo H,Shu Y,Zhang Z

更新日期：2009-02-01 00:00:00

abstract：:Recent research into the complex and varied components of rheumatoid arthritis (RA) is leading to the development of more effective targets for pharmaceutical approach than even before. Current treatment of RA frequently includes the use of nonsteroidal anti-inflammatory drugs, such as Diclofenac sodium (DFNa) in spit...

journal_title：Journal of drug targeting

authors： Türker S,Erdoğan S,Ozer YA,Bilgili H,Deveci S

更新日期：2008-01-01 00:00:00

abstract：:An in vivo study has been performed in order to determine the influence of amphotericin B (AMB) molecular organization on the toxicity and activity of this drug in the treatment of experimental visceral leishmaniasis. Three formulations with similar composition but different drug molecular self-association in aqueous ...

journal_title：Journal of drug targeting

authors： Sánchez-Brunete JA,Dea MA,Rama S,Bolás F,Alunda JM,Torrado-Santiago S,Torrado JJ

更新日期：2004-01-01 00:00:00

abstract：:The objective of this study is to develop and evaluate gastroretentive particulate delivery systems using Riboflavin-5'-monophosphate sodium salt dihydrate (RF5'PNa) as model drug. Poly(acrylic acid)-cysteine and chitosan-4-thiobuthylamidine were evaluated and compared as anionic and cationic polymers for gastroretent...

journal_title：Journal of drug targeting

authors： Senyigit ZA,Vetter A,Guneri T,Bernkop-Schnürch A

更新日期：2010-06-01 00:00:00

abstract：:Diabetes is a condition that is not completely treatable but life of a diabetic patient can be smoothed by preventing or delaying the associate conditions like diabetic retinopathy, nephropathy, impaired wound healing process, etc. Apart from conventional methods to regulate diabetic condition, new techniques using si...

journal_title：Journal of drug targeting

authors： Shende P,Patel C

更新日期：2019-02-01 00:00:00

abstract：:Biphenylylacetic acid (BPAA) was linked to the free hydroxyl group of 2,6-di-O-methyl-beta-Cyclodextrin (DM-beta-CyD) through an ester linkage to obtain the site specific release of the drug to the colon. The conjugate at 1:1 mole ratio was separated from the reaction mixture by semipreparative reverse-phase HPLC and ...

journal_title：Journal of drug targeting

authors： Ventura CA,Paolino D,Pedotti S,Pistarà V,Corsaro A,Puglisi G

更新日期：2003-05-01 00:00:00

abstract：:Most therapeutic agents are delivered orally. Consequently, the major classes of therapeutically useful chemicals are partially lipophilic, small molecular weight compounds. They have reasonable permeability coefficient values across cell membranes, including those of intestinal epithelia and vascular endothelia. In c...

journal_title：Journal of drug targeting

authors： Baird AW,Campion DP,O'Brien L,Brayden DJ

更新日期：2004-02-01 00:00:00

abstract：:The aim of this study was to evaluate the pharmacokinetics (PK), tissue distribution, and the specific drug targeting of cefpiramide sodium-loaded liposomes (CPMS-Lips) compared with cefpiramide sodium solution (CPMS-Sol) in mice. CPMS-Lips were prepared by reverse phase evaporation method. In the PK and biodistributi...

journal_title：Journal of drug targeting

authors： Sun Q,Shi M,Shao W,Shi Y,Xi Y,Huang G

更新日期：2011-01-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) is the only FDA approved medical treatment for the ischaemic stroke. However, it associates with some inevitable limitations, including: short therapeutic window, extremely short half-life and low penetration in large clots. Systemic administration may lead to complications such as h...

journal_title：Journal of drug targeting

authors： Zamanlu M,Farhoudi M,Eskandani M,Mahmoudi J,Barar J,Rafi M,Omidi Y

更新日期：2018-02-01 00:00:00

abstract：:Recent studies have shown that drugs that are normally unable to cross the blood-brain barrier (BBB) following intravenous injection can be transported across this barrier by binding to poly(butyl cyanoacrylate) nanoparticles and coating with polysorbate 80. However, the mechanism of this transport so far was not know...

journal_title：Journal of drug targeting

authors： Kreuter J,Shamenkov D,Petrov V,Ramge P,Cychutek K,Koch-Brandt C,Alyautdin R

更新日期：2002-06-01 00:00:00

abstract：:Improved delivery of macromolecular drugs to solid tumor is known as the enhanced permeability and retention (EPR) effect of macromolecular drugs and lipids. We report here that a prostaglandin I2 (PGI2) analogue induces enhancement of tumor-selective drug delivery, while it decreases tumor blood flow, in a rat tumor ...

journal_title：Journal of drug targeting

authors： Tanaka S,Akaike T,Wu J,Fang J,Sawa T,Ogawa M,Beppu T,Maeda H

更新日期：2003-01-01 00:00:00

abstract：:Therapeutic peptides are conventionally administered via subcutaneous injection. Chitosan-based nanoparticles are gaining increased attention for their ability to serve as a carrier for oral delivery of peptides and vaccination. They offered superior biocompatibiltiy, controlled drug release profile and facilitated ga...

journal_title：Journal of drug targeting

authors： Wong CY,Al-Salami H,Dass CR

更新日期：2018-08-01 00:00:00

abstract：:Germ-free (GF) animals lack a colonic microflora like that seen in conventional (CV) animals. Bacterial presence plays a role in the development of glycoproteins in the gastrointestinal (GI) tract; the absence of a microbiota has been seen to suppress the production of certain glycoproteins and glycolipids. Binding pa...

journal_title：Journal of drug targeting

authors： Wróblewski S,Ríhová B,Rossmann P,Hudcovicz T,Reháková Z,Kopecková P,Kopecek J

更新日期：2001-04-01 00:00:00

abstract：:Chemotherapy is still a major challenge for in vivo drug targeting to macrophages. Toxicity remains the major obstacle for the most potent drugs already known in the therapy of leishmaniasis. Thus, new drugs and new delivery systems are sought. By using different vesicular delivery modes e.g. liposomes, niosomes, micr...

journal_title：Journal of drug targeting

authors： Sarkar S,Mandal S,Sinha J,Mukhopadhyay S,Das N,Basu MK

更新日期：2002-12-01 00:00:00

abstract：:Intracellular compartmentalisation is a significant barrier to the successful nucleocytosolic delivery of biologics. The endocytic system has been shown to be responsible for compartmentalisation, providing an entry point, and trigger(s) for the activation of drug delivery systems. Consequently, many of the technologi...

journal_title：Journal of drug targeting

authors： Shorter SA,Pettit MW,Dyer PDR,Coakley Youngs E,Gorringe-Pattrick MAM,El-Daher S,Richardson S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The polycationic nanopeptide RKKRRQRRR is a fragment of HIV-Tat protein known to be a transfection enhancer. Such factors control the transfection efficiency of plasmid DNA complexed with tat peptide. However, their actions are poorly understood. METHODS AND RESULTS:Several cell lines and primary cells were...

journal_title：Journal of drug targeting

authors： Hellgren I,Gorman J,Sylvén C

更新日期：2004-01-01 00:00:00

abstract：:I125 radiolabelled HSA (HSA-I125) was utilised as a probe to quantify protein adsorption onto polystyrene (PS) and Poloxamine 908 coated PS (PS-908) particles. Upon ageing of the HSA-I125 a dramatic increase in the amount of protein adsorbed onto the two particle systems was observed. This phenomenon was not due to la...

journal_title：Journal of drug targeting

authors： Armstrong TI,Illum L

更新日期：1997-01-01 00:00:00