Starch microparticles as oral vaccine adjuvant: antigen-dependent uptake in mouse intestinal mucosa.

abstract：:I125 radiolabelled HSA (HSA-I125) was utilised as a probe to quantify protein adsorption onto polystyrene (PS) and Poloxamine 908 coated PS (PS-908) particles. Upon ageing of the HSA-I125 a dramatic increase in the amount of protein adsorbed onto the two particle systems was observed. This phenomenon was not due to la...

journal_title：Journal of drug targeting

authors： Armstrong TI,Illum L

更新日期：1997-01-01 00:00:00

abstract：:Increased generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a variety of diseases such as cardiovascular diseases and cancer. NADPH oxidase (Nox), a multicomponent enzyme, has been identified as one of the key sources of ROS. Nox4, one of the seven members of Nox family (Nox1, Nox2...

journal_title：Journal of drug targeting

authors： Guo S,Chen X

更新日期：2015-12-01 00:00:00

abstract：:Micro-needle arrays increase skin permeability by forming channels through the outer physical barrier, without stimulating pain receptors populating the underlying dermis. It was postulated that micro-needle arrays could facilitate transfer of DNA to human skin epidermis for cutaneous gene therapy applications. Platin...

journal_title：Journal of drug targeting

authors： Birchall J,Coulman S,Pearton M,Allender C,Brain K,Anstey A,Gateley C,Wilke N,Morrissey A

更新日期：2005-08-01 00:00:00

abstract：:Germ-free (GF) animals lack a colonic microflora like that seen in conventional (CV) animals. Bacterial presence plays a role in the development of glycoproteins in the gastrointestinal (GI) tract; the absence of a microbiota has been seen to suppress the production of certain glycoproteins and glycolipids. Binding pa...

journal_title：Journal of drug targeting

authors： Wróblewski S,Ríhová B,Rossmann P,Hudcovicz T,Reháková Z,Kopecková P,Kopecek J

更新日期：2001-04-01 00:00:00

abstract：:Nanoparticles form the fundamental building blocks for many exciting applications in various scientific disciplines due to its unique features such as large surface to mass ratio, targeting potential, ability to adsorbed and carry other compound which makes them suitable for biomedical applications. However, the probl...

journal_title：Journal of drug targeting

authors： Sultana S,Alzahrani N,Alzahrani R,Alshamrani W,Aloufi W,Ali A,Najib S,Siddiqui NA

更新日期：2020-06-01 00:00:00

abstract：:Phage display technology has been widely used for developing tumor-targeting agents. Most of the efforts were directed towards identifying phage-displayed ligands against cancer-relevant purified targets and cancer cell lines. Whole cell screening procedures typically use a relatively large sample size and are not ide...

journal_title：Journal of drug targeting

authors： Shukla GS,Krag DN

更新日期：2005-01-01 00:00:00

abstract：:Drug systems targeting tumor cells using basic fibroblast growth factor (bFGF) have been widely reported. In this study, the peptide KRTGQYKLC (bFGFp), containing cysteine at the carboxyl termination of the bFGF-derived peptide, was applied as a novel ligand targeting tumor cells. bFGFp was conjugated with bovine seru...

journal_title：Journal of drug targeting

authors： Terada T,Mizobata M,Kawakami S,Yabe Y,Yamashita F,Hashida M

更新日期：2006-09-01 00:00:00

abstract：:Pathophysiological molecules in the extracellular environment offer excellent targets that can be exploited for designing drug targeting systems. Matrix metalloproteases (MMPs) are a family of extracellular proteolytic enzymes that are characterized by their overexpression or overactivity in several pathologies. Over ...

journal_title：Journal of drug targeting

authors： Vartak DG,Gemeinhart RA

更新日期：2007-01-01 00:00:00

abstract：:Tumour microenvironment provides the 'soil' for tumour growth. Besides tumour cells, there are also numbers of stromal cells, extracellular matrix and other components in the tumour microenvironment. In the past years, kinds of ligands and markers specifically high-expressed on the surface of the tumour stromal cells ...

journal_title：Journal of drug targeting

authors： Li Z,Zheng Z,Li C,Li Z,Wu J,Zhang B

更新日期：2020-08-01 00:00:00

abstract：:A novel concept in drug delivery discussed here, takes advantage of certain properties of the drug "containers" cyclodextrins and liposomes to combine them into a single system thus circumventing problems associated with both systems. The concept, entailing entrapment of water-soluble cyclodextrin-drug inclusion compl...

journal_title：Journal of drug targeting

authors： McCormack B,Gregoriadis G

更新日期：1994-01-01 00:00:00

abstract：:Gene transfer offers a potential way to correct local and systemic protein deficiency disorders by using genes as drugs, so called gene therapeutics. Salivary glands present an interesting target site for gene therapeutic applications. Herein, we review proofs of concept achieved for salivary glands with in vivo anima...

journal_title：Journal of drug targeting

authors： Hoque AT,Yamano S,Baccaglini L,Baum BJ

更新日期：2001-01-01 00:00:00

abstract：:The human papillomavirus type-16 (HPV-16) E7 protein is considered a major viral oncoprotein involved in cervical cancer (CxCa) and a potential candidate for the development of a vaccine against this neoplasia. Here, two lactic acid bacteria (the model one Lactococcus lactis and a probiotic one Lactobacillus plantarum...

journal_title：Journal of drug targeting

authors： Cortes-Perez NG,Azevedo V,Alcocer-González JM,Rodriguez-Padilla C,Tamez-Guerra RS,Corthier G,Gruss A,Langella P,Bermúdez-Humarán LG

更新日期：2005-02-01 00:00:00

abstract：:Chemotherapy is still a major challenge for in vivo drug targeting to macrophages. Toxicity remains the major obstacle for the most potent drugs already known in the therapy of leishmaniasis. Thus, new drugs and new delivery systems are sought. By using different vesicular delivery modes e.g. liposomes, niosomes, micr...

journal_title：Journal of drug targeting

authors： Sarkar S,Mandal S,Sinha J,Mukhopadhyay S,Das N,Basu MK

更新日期：2002-12-01 00:00:00

abstract：:In order to facilitate the intracellular delivery of macromolecules, Pep-1 peptide-modified liposomal (Pep1-Lipo) nanocarriers were designed and examined for their in vitro cell translocation capability. Pep-1 peptides were coupled via thiol-maleimide linkage to small unilamellar vesicles composed of phosphatidylcholi...

journal_title：Journal of drug targeting

authors： Kang MJ,Kim BG,Eum JY,Park SH,Choi SE,An JJ,Jang SH,Eum WS,Lee J,Lee MW,Kang K,Oh CH,Choi SY,Choi YW

更新日期：2011-08-01 00:00:00

abstract：:Lopinavir (LPV), an efficient drug for HIV infection treatment, was incorporated into biodegradable PLGA nanocapsules (NCs) embedded in microparticles (MCPs) using the spray-drying technique in an attempt to bypass the P-gp efflux and protect the drug from CYP3A pre-systemic metabolism without ritonavir (RTV). SEM obs...

journal_title：Journal of drug targeting

authors： Nassar T,Rohald A,Naraykin N,Barasch D,Amsalem O,Prabhu P,Kotler M,Benita S

更新日期：2019-01-01 00:00:00

abstract：:In this review, we emphasize the efforts on the development of radiolabeled nanoparticles (NPs) for cancer treatment, i.e. theranostic tools based on nanotechnology and nuclear medicine. Currently, radionuclide therapy remains to be an important treatment option. The ionizing radiation from radionuclides (not provided...

journal_title：Journal of drug targeting

authors： Enrique MA,Mariana OR,Mirshojaei SF,Ahmadi A

更新日期：2015-04-01 00:00:00

abstract：:Recent studies have shown that drugs that are normally unable to cross the blood-brain barrier (BBB) following intravenous injection can be transported across this barrier by binding to poly(butyl cyanoacrylate) nanoparticles and coating with polysorbate 80. However, the mechanism of this transport so far was not know...

journal_title：Journal of drug targeting

authors： Kreuter J,Shamenkov D,Petrov V,Ramge P,Cychutek K,Koch-Brandt C,Alyautdin R

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:The objective of this work was to examine the application of catechins-containing phospholipids-based ultrasonic microbubbles (PUM) in ultrasound-induced delivery. METHODS:Catechins-containing PUM were prepared by dissolving lyophilized PUM powder in catechins solution. Morphologic characteristics of catechi...

journal_title：Journal of drug targeting

authors： Lu CT,Zhao YZ

更新日期：2008-12-01 00:00:00

abstract：:The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs) that are commonly used in patients with hypertension, cardiovascular disease and/or...

journal_title：Journal of drug targeting

authors： Akhtar S,Benter IF,Danjuma MI,Doi SAR,Hasan SS,Habib AM

更新日期：2020-08-01 00:00:00

abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers containing doxorubicin and galactosamine have been developed to target the hepatocyte galactose receptor with the aim of organ-specific chemotherapy of primary and metastatic liver disease. Previous biodistribution studies in rats and mice have used tyrosinamide inco...

journal_title：Journal of drug targeting

authors： Pimm MV,Perkins AC,Duncan R,Ulbrich K

更新日期：1993-01-01 00:00:00

abstract：:In vitro transfection efficiency of a plasmid DNA for rat gastric mucosal (RGM)-1 cells was enhanced by ultrasound (US) irradiation. Ethylenediamine was introduced to the carboxyl groups of gelatin to prepare a cationized gelatin as the vector of plasmid DNA encoding luciferase. An electrophoresis experiment revealed ...

journal_title：Journal of drug targeting

authors： Hosseinkhani H,Aoyama T,Ogawa O,Tabata Y

更新日期：2002-05-01 00:00:00

abstract：:Targeting of anti-tumor drugs to the urinary bladder for the treatment of bladder carcinoma may be useful, since these agents generally have a low degree of urinary excretion and are highly toxic elsewhere in the body. The anti-tumor drug doxorubicin was coupled to the low-molecular weight protein lysozyme via the aci...

journal_title：Journal of drug targeting

authors： Haas M,Moolenaar F,Elsinga A,Van der Wouden EA,de Jong PE,Meijer DK,de Zeeuw D

更新日期：2002-02-01 00:00:00

abstract：:The myriad of complications associated with diabetes is closely linked with the generation of reactive species or free radicals leading to oxidative and nitrosative stress. Increased oxidative stress is an important cause and result of diabetes and it is thought to underlie the cellular changes that lead to diabetic c...

journal_title：Journal of drug targeting

authors： Thakur P,Kumar A,Kumar A

更新日期：2018-11-01 00:00:00

abstract：:Sulpiride (SUL), anti-dopaminergic drug, has a specific site for absorption located in the upper portion of the gastrointestinal tract hence, its oral delivery represents a challenge regarding SUL absorption and bioavailability. So, a gastro-retentive oral platform of SUL was developed to increase its gastric residenc...

journal_title：Journal of drug targeting

authors： Younis MA,El-Zahry MR,Tallat MA,Tawfeek HM

更新日期：2020-04-01 00:00:00

abstract：:Microparticles and nanoparticles used in drug delivery frequently depend on their movement in confined spaces such as cells. Liposomes containing small numbers of 1-µm diameter polystyrene particles were used to study the dynamics of their movement within the confined space of the liposome interior. The analysis of th...

journal_title：Journal of drug targeting

authors： Al-Obaidi H,Nasseri B,Florence AT

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:High expression of glucagon-like peptide-1 receptor (GLP-1R) in insulinoma supplies a potential drug target for tumor imaging. Exendin-4 can specifically bind to GLP-1R as an agonist and its analogs are extensively used in receptor imaging studies. PURPOSE:A new GLP-1R imaging agent, [(18)F]AlF-NOTA-MAL-Cys...

journal_title：Journal of drug targeting

authors： Xu Q,Zhu C,Xu Y,Pan D,Liu P,Yang R,Wang L,Chen F,Sun X,Luo S,Yang M

更新日期：2015-01-01 00:00:00

abstract：:Most therapeutic agents are delivered orally. Consequently, the major classes of therapeutically useful chemicals are partially lipophilic, small molecular weight compounds. They have reasonable permeability coefficient values across cell membranes, including those of intestinal epithelia and vascular endothelia. In c...

journal_title：Journal of drug targeting

authors： Baird AW,Campion DP,O'Brien L,Brayden DJ

更新日期：2004-02-01 00:00:00

abstract：:beta-Glucuronidase (GUSB) is a lysosomal enzyme that could be developed as a brain therapy for Type VII Mucopolysaccharidosis. However, GUSB does not cross the blood-brain barrier (BBB). To enable BBB transport of the enzyme, human GUSB was re-engineered as a fusion protein with the chimeric monoclonal antibody (MAb) ...

journal_title：Journal of drug targeting

authors： Boado RJ,Pardridge WM

更新日期：2010-04-01 00:00:00

abstract：:We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the twenty-first century. Multiple drug resistance and nonspecific drug targeting of the m...

journal_title：Journal of drug targeting

authors： Baruah UK,Gowthamarajan K,Vanka R,Karri VVSR,Selvaraj K,Jojo GM

更新日期：2017-08-01 00:00:00

abstract：:Cationic liposomes composed of dialkyl cationic lipid such as 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) can efficiently deliver siRNA to the lungs following the intravenous injection of cationic liposome/siRNA complexes (lipoplexes). In this study, we examined the effect of cationic lipid of cationic liposomes ...

journal_title：Journal of drug targeting

authors： Hattori Y,Nakamura M,Takeuchi N,Tamaki K,Shimizu S,Yoshiike Y,Taguchi M,Ohno H,Ozaki KI,Onishi H

更新日期：2019-02-01 00:00:00