Design of a Pep-1 peptide-modified liposomal nanocarrier system for intracellular drug delivery: Conformational characterization and cellular uptake evaluation.

abstract：:The use of liposomes in the treatment of severe infections is under investigation. Classical liposomes which localize in cells of the mononuclear phagocyte system (MPS) can be exploited in two ways. First for targeting of macrophage modulators such as muramyl peptides or IFN-gamma, to stimulate the cells of the MPS to...

journal_title：Journal of drug targeting

authors： Bakker-Woudenberg IA,Storm G,Woodle MC

更新日期：1994-01-01 00:00:00

abstract：:Drug efflux by the membrane transporter P-glycoprotein (P-gp) plays a key role in multidrug resistance (MDR). In order to bypass P-gp, thus overcoming MDR, a hybrid peptide comprising a cell penetrating peptide (Tat) and a drug binding motif (DBM) has been developed to noncovalently bind and deliver doxorubicin (Dox) ...

journal_title：Journal of drug targeting

authors： Zheng Z,Aojula H,Clarke D

更新日期：2010-07-01 00:00:00

abstract：:Drug systems targeting tumor cells using basic fibroblast growth factor (bFGF) have been widely reported. In this study, the peptide KRTGQYKLC (bFGFp), containing cysteine at the carboxyl termination of the bFGF-derived peptide, was applied as a novel ligand targeting tumor cells. bFGFp was conjugated with bovine seru...

journal_title：Journal of drug targeting

authors： Terada T,Mizobata M,Kawakami S,Yabe Y,Yamashita F,Hashida M

更新日期：2006-09-01 00:00:00

abstract：:Acyclovir is an antiviral agent and it has been particularly used for the treatment of herpes simplex infections. The treatment of infection in the oral cavity is often difficult, because of insufficient drug concentration in saliva when acyclovir is administered via the oral route in conventional tablet form for syst...

journal_title：Journal of drug targeting

authors： Değim T,Eğlen B,Ocak O

更新日期：2006-01-01 00:00:00

abstract：:Recent studies have shown that drugs that are normally unable to cross the blood-brain barrier (BBB) following intravenous injection can be transported across this barrier by binding to poly(butyl cyanoacrylate) nanoparticles and coating with polysorbate 80. However, the mechanism of this transport so far was not know...

journal_title：Journal of drug targeting

authors： Kreuter J,Shamenkov D,Petrov V,Ramge P,Cychutek K,Koch-Brandt C,Alyautdin R

更新日期：2002-06-01 00:00:00

abstract：INTRODUCTION:Peptide antibiotics as new therapeutic agents are becoming a popular option to investigate due to their broad bacterial target selectivity and limited resistance problems. Although attractive, these new drug candidates have several limitations including low potency and delivery issues which face all peptid...

journal_title：Journal of drug targeting

authors： Zhang C,Yadava P,Sun J,Hughes JA

更新日期：2006-11-01 00:00:00

abstract：:Microparticles-adsorbed insulin and zinc insulin (PenfilN) were molded to self-dissolving micropiles (SDMPs) with chondroitin sulfate as the base for the percutaneous administration of insulin. Porous silicon dioxide (Sylysia 320, 440 and 730) and porous calcium silicate (FloriteRE) were used as microparticles. As a r...

journal_title：Journal of drug targeting

authors： Ito Y,Hagiwara E,Saeki A,Sugioka N,Takada K

更新日期：2007-06-01 00:00:00

abstract：:Cell-penetrating peptides (CPPs) are efficient vehicles to transport bioactive molecules into the cells. Despite numerous studies the exact mechanism by which CPPs facilitate delivery of cargo to its intracellular target is still debated. The current work presents methods that can be used for tracking CPP/pDNA complex...

journal_title：Journal of drug targeting

authors： Pärnaste L,Arukuusk P,Zagato E,Braeckmans K,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Synthesized dl-Nordihydroguaiaretic acid (dl-NGDA or "Nordy") can inhibit the growth of malignant human tumors, especially the tumor angiogenesis. However, its liposoluble nature limits its in vivo efficacy in the hydrosoluble circulation of human. PURPOSE:We tried to use the ultrasonic microbubble as the c...

journal_title：Journal of drug targeting

authors： Hua X,Ding J,Li R,Zhang Y,Huang Z,Guo Y,Chen Q

更新日期：2016-09-01 00:00:00

abstract：:DNA nanoparticles (DNA NPs), which self-assemble from DNA plasmids and poly-L-lysine (pLL)-polyethylene glycol (PEG) block copolymers, transfect several cell types in vitro and in vivo with minimal toxicity and immune response. To further enhance the gene transfer efficiency of DNA NP and control its tropism, we estab...

journal_title：Journal of drug targeting

authors： Sun W,Fletcher D,van Heeckeren RC,Davis PB

更新日期：2012-09-01 00:00:00

abstract：:The human papillomavirus type-16 (HPV-16) E7 protein is considered a major viral oncoprotein involved in cervical cancer (CxCa) and a potential candidate for the development of a vaccine against this neoplasia. Here, two lactic acid bacteria (the model one Lactococcus lactis and a probiotic one Lactobacillus plantarum...

journal_title：Journal of drug targeting

authors： Cortes-Perez NG,Azevedo V,Alcocer-González JM,Rodriguez-Padilla C,Tamez-Guerra RS,Corthier G,Gruss A,Langella P,Bermúdez-Humarán LG

更新日期：2005-02-01 00:00:00

abstract：:Microparticles and nanoparticles used in drug delivery frequently depend on their movement in confined spaces such as cells. Liposomes containing small numbers of 1-µm diameter polystyrene particles were used to study the dynamics of their movement within the confined space of the liposome interior. The analysis of th...

journal_title：Journal of drug targeting

authors： Al-Obaidi H,Nasseri B,Florence AT

更新日期：2010-12-01 00:00:00

abstract：:Anionic, cationic, and neutral liposomes were constructed to contain IL-2 in order to evaluate their affinity to a cervical cancer cell line (INBL) and to determine whether they can present IL-2 on their external surface. When these liposomes were co-cultured with INBL, the anionic liposomes were the only ones found t...

journal_title：Journal of drug targeting

authors： Corona-Ortega T,Rangel-Corona R,Hernández-Jiménez M,Baeza I,Ibáñez M,Weiss-Steider B

更新日期：2009-08-01 00:00:00

abstract：:Previous studies indicated the potential of zinc protoporphyrin (ZnPP) as an antitumor agent targeting to the tumor survival factor heme oxygenase-1, and/or for photodynamic therapy (PDT). In this study, to achieve tumor-targeted delivery, styrene-maleic acid-copolymer conjugated ZnPP (SMA-ZnPP) was synthesized via am...

journal_title：Journal of drug targeting

authors： Fang J,Tsukigawa K,Liao L,Yin H,Eguchi K,Maeda H

更新日期：2016-01-01 00:00:00

abstract：:The effects of concentration, amperage and duration on the antidiuretic response induced by iontophoretic delivery of desmopressin acetate (DDAVP) were examined using a diabetes insipidus model in rats. A higher current density brought about a larger and longer antidiuretic response. Prolonged iontophoretic duration c...

journal_title：Journal of drug targeting

authors： Nakakura M,Terajima M,Kato Y,Hayakawa E,Ito K,Kuroda T

更新日期：1995-01-01 00:00:00

abstract：:Doxorubicin (DXR) was encapsulated in long-circulating liposomes, composed of ganglioside GM1 (GM1)/distearoylphosphatidylcholine (DSPC)/cholesterol (CH) (0.13:1:1 in molar ratio) and sized to approximately 100 nm in mean diameter, with 98% entrapping efficiency by the transmembrane pH gradient method. Free DXR, DXR-D...

journal_title：Journal of drug targeting

authors： Unezaki S,Maruyama K,Ishida O,Takahashi N,Iwatsuru M

更新日期：1993-01-01 00:00:00

abstract：:Developing a highly effective and lung-targeted local drug delivery carrier with low irritancy may be critical for improving treatment of lung cancer. Using soluble excipients as microspheres (MS) matrix, respirable MS embedding chitosan-coated poly(d,l-lactide-co-glycolide) nanoparticles (CNP-MS) for 2-methoxyestradi...

journal_title：Journal of drug targeting

authors： Guo X,Zhang X,Ye L,Zhang Y,Ding R,Hao Y,Zhao Y,Zhang Z,Zhang Y

更新日期：2014-06-01 00:00:00

abstract：:The ultimate goal of bacterial based cancer therapy is to achieve non-toxic penetration and colonisation of the tumour microenvironment. To overcome this efficacy-limiting toxicity of anticancer immunotherapy, we have tested a therapy comprised of systemic delivery of a vascular disrupting agent to induce intratumoral...

journal_title：Journal of drug targeting

authors： Augustin LB,Milbauer L,Hastings SE,Leonard AS,Saltzman DA,Schottel JL

更新日期：2020-12-21 00:00:00

abstract：:Recent studies have demonstrated that the carboxyterminal third domain of alpha-fetoprotein (AFP-CD) binds with various ligands and receptors. Reports within the last decade have established that AFP-CD contains a large fragment of amino acids that interact with several different receptor types. Using computer softwar...

journal_title：Journal of drug targeting

authors： Mizejewski GJ

更新日期：2015-01-01 00:00:00

abstract：:Tumour microenvironment provides the 'soil' for tumour growth. Besides tumour cells, there are also numbers of stromal cells, extracellular matrix and other components in the tumour microenvironment. In the past years, kinds of ligands and markers specifically high-expressed on the surface of the tumour stromal cells ...

journal_title：Journal of drug targeting

authors： Li Z,Zheng Z,Li C,Li Z,Wu J,Zhang B

更新日期：2020-08-01 00:00:00

abstract：:The human body has adapted to defend against the aggressive biological or chemical agents. As a result, the defence mechanisms of the human body became barriers for the drug delivery. Theoretically, any problem that prevents a drug from reaching its site of action is considered to be a barrier to drug delivery. The ai...

journal_title：Journal of drug targeting

authors： Jătariu AN,Popa M,Peptu CA

更新日期：2010-05-01 00:00:00

abstract：:Pathophysiological molecules in the extracellular environment offer excellent targets that can be exploited for designing drug targeting systems. Matrix metalloproteases (MMPs) are a family of extracellular proteolytic enzymes that are characterized by their overexpression or overactivity in several pathologies. Over ...

journal_title：Journal of drug targeting

authors： Vartak DG,Gemeinhart RA

更新日期：2007-01-01 00:00:00

abstract：:Polyethylene glycol-modified GoldMag nanoparticles (PGMNs) were synthesized and characterized by several analysis including transmission electron microscopy, dynamic light scattering, Fourier transform infrared spectroscopy, and vibrating sample magnetometer. Here, we showed that the composite nanoparticles have a sat...

journal_title：Journal of drug targeting

authors： Chao X,Guo L,Zhao Y,Hua K,Peng M,Chen C,Cui Y

更新日期：2011-04-01 00:00:00

abstract：UNLABELLED:Polyethyleneimine (PEI) can be used as a DNA delivery mechanism in cell culture and in vivo. Cells can be transfected by using surface-bound PEI, as well as by PEI/DNA microparticles. In the present experiments we extended these observations by preparing microspheres with covalently attached PEI. Blends of p...

journal_title：Journal of drug targeting

authors： Manuel WS,Zheng JI,Hornsby PJ

更新日期：2001-01-01 00:00:00

abstract：:Necrosis avid agents (NAAs) can be used for diagnose of necrosis-related diseases, evaluation of therapeutic responses and targeted therapeutics of tumor. In order to probe into the effects of molecular skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones, four dianthrone com...

journal_title：Journal of drug targeting

authors： Zhang D,Jiang C,Yang S,Gao M,Huang D,Wang X,Shao H,Feng Y,Sun Z,Ni Y,Zhang J,Yin Z

更新日期：2016-01-01 00:00:00

abstract：:In this review, we emphasize the efforts on the development of radiolabeled nanoparticles (NPs) for cancer treatment, i.e. theranostic tools based on nanotechnology and nuclear medicine. Currently, radionuclide therapy remains to be an important treatment option. The ionizing radiation from radionuclides (not provided...

journal_title：Journal of drug targeting

authors： Enrique MA,Mariana OR,Mirshojaei SF,Ahmadi A

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:High expression of glucagon-like peptide-1 receptor (GLP-1R) in insulinoma supplies a potential drug target for tumor imaging. Exendin-4 can specifically bind to GLP-1R as an agonist and its analogs are extensively used in receptor imaging studies. PURPOSE:A new GLP-1R imaging agent, [(18)F]AlF-NOTA-MAL-Cys...

journal_title：Journal of drug targeting

authors： Xu Q,Zhu C,Xu Y,Pan D,Liu P,Yang R,Wang L,Chen F,Sun X,Luo S,Yang M

更新日期：2015-01-01 00:00:00

abstract：:I125 radiolabelled HSA (HSA-I125) was utilised as a probe to quantify protein adsorption onto polystyrene (PS) and Poloxamine 908 coated PS (PS-908) particles. Upon ageing of the HSA-I125 a dramatic increase in the amount of protein adsorbed onto the two particle systems was observed. This phenomenon was not due to la...

journal_title：Journal of drug targeting

authors： Armstrong TI,Illum L

更新日期：1997-01-01 00:00:00

abstract：:A general mathematical model involving partition coefficient, molecular weight and hydrogen bonding is used to correlate the structures and permeability of various organic compounds through the toad urinary bladder and human red blood cell (RBC) membranes. Log Per (permeability) is correlated with log Po/w (partition ...

journal_title：Journal of drug targeting

authors： Ren S,Das A,Lien EJ

更新日期：1996-01-01 00:00:00

abstract：:A biophysical model was developed, using Ascaris suum as a model gastrointestinal nematode, to provide quantitative perspectives into the microenvironmental pH within the water-filled, porous, negatively charged cuticle matrix of gastrointestinal nematodes. The central features of the model include (a) the constant ra...

journal_title：Journal of drug targeting

authors： Sims SM,Ho NF,Magas LT,Geary TG,Barsuhn CL,Thompson DP

更新日期：1994-01-01 00:00:00