Ultrasound enhancement of in vitro transfection of plasmid DNA by a cationized gelatin.

abstract：:Microparticles-adsorbed insulin and zinc insulin (PenfilN) were molded to self-dissolving micropiles (SDMPs) with chondroitin sulfate as the base for the percutaneous administration of insulin. Porous silicon dioxide (Sylysia 320, 440 and 730) and porous calcium silicate (FloriteRE) were used as microparticles. As a r...

journal_title：Journal of drug targeting

authors： Ito Y,Hagiwara E,Saeki A,Sugioka N,Takada K

更新日期：2007-06-01 00:00:00

abstract：:Gene transfer offers a potential way to correct local and systemic protein deficiency disorders by using genes as drugs, so called gene therapeutics. Salivary glands present an interesting target site for gene therapeutic applications. Herein, we review proofs of concept achieved for salivary glands with in vivo anima...

journal_title：Journal of drug targeting

authors： Hoque AT,Yamano S,Baccaglini L,Baum BJ

更新日期：2001-01-01 00:00:00

abstract：:DNA nanoparticles (DNA NPs), which self-assemble from DNA plasmids and poly-L-lysine (pLL)-polyethylene glycol (PEG) block copolymers, transfect several cell types in vitro and in vivo with minimal toxicity and immune response. To further enhance the gene transfer efficiency of DNA NP and control its tropism, we estab...

journal_title：Journal of drug targeting

authors： Sun W,Fletcher D,van Heeckeren RC,Davis PB

更新日期：2012-09-01 00:00:00

abstract：:Submicron sized hydrophobic and hydrophilic albumin microspheres (MS) were prepared using a chemical crosslinking technique. Spermine was linked to the surface of the hydrophilic MS. The degree of hydrophobicity for these three types of MS was investigated using a novel technique of sedimentation volume. The surface t...

journal_title：Journal of drug targeting

authors： Shafi ZB,Martin GP,Olliff CJ,James SL

更新日期：1995-01-01 00:00:00

abstract：:The aim of this study was to evaluate the pharmacokinetics (PK), tissue distribution, and the specific drug targeting of cefpiramide sodium-loaded liposomes (CPMS-Lips) compared with cefpiramide sodium solution (CPMS-Sol) in mice. CPMS-Lips were prepared by reverse phase evaporation method. In the PK and biodistributi...

journal_title：Journal of drug targeting

authors： Sun Q,Shi M,Shao W,Shi Y,Xi Y,Huang G

更新日期：2011-01-01 00:00:00

abstract：:Microparticles and nanoparticles used in drug delivery frequently depend on their movement in confined spaces such as cells. Liposomes containing small numbers of 1-µm diameter polystyrene particles were used to study the dynamics of their movement within the confined space of the liposome interior. The analysis of th...

journal_title：Journal of drug targeting

authors： Al-Obaidi H,Nasseri B,Florence AT

更新日期：2010-12-01 00:00:00

abstract：:Sulpiride (SUL), anti-dopaminergic drug, has a specific site for absorption located in the upper portion of the gastrointestinal tract hence, its oral delivery represents a challenge regarding SUL absorption and bioavailability. So, a gastro-retentive oral platform of SUL was developed to increase its gastric residenc...

journal_title：Journal of drug targeting

authors： Younis MA,El-Zahry MR,Tallat MA,Tawfeek HM

更新日期：2020-04-01 00:00:00

abstract：:Developing a highly effective and lung-targeted local drug delivery carrier with low irritancy may be critical for improving treatment of lung cancer. Using soluble excipients as microspheres (MS) matrix, respirable MS embedding chitosan-coated poly(d,l-lactide-co-glycolide) nanoparticles (CNP-MS) for 2-methoxyestradi...

journal_title：Journal of drug targeting

authors： Guo X,Zhang X,Ye L,Zhang Y,Ding R,Hao Y,Zhao Y,Zhang Z,Zhang Y

更新日期：2014-06-01 00:00:00

abstract：:Liposomal encapsulation of doxorubicin (DXR) improves tumor accumulation and reduces adverse effects. One possible strategy for further optimization of this delivery technology would be to design the liposome carrier to release its content within the tumor tissue in response to specific stimuli such as ultrasound (US)...

journal_title：Journal of drug targeting

authors： Hagtvet E,Evjen TJ,Olsen DR,Fossheim SL,Nilssen EA

更新日期：2011-09-01 00:00:00

abstract：:A promising strategy to carry genetic material to brain cells either in vitro or in vivo is using the LDL receptor (LDLr) on blood-brain barrier. LDLr naturally help to low density lipoproteins (LDL(S)) transporting across the BBB by endocytosis. Here we present the idea of using the LDLr-mediated pathway for transpor...

journal_title：Journal of drug targeting

authors： Mousazadeh M,Palizban A,Salehi R,Salehi M

更新日期：2007-04-01 00:00:00

abstract：:The human body has adapted to defend against the aggressive biological or chemical agents. As a result, the defence mechanisms of the human body became barriers for the drug delivery. Theoretically, any problem that prevents a drug from reaching its site of action is considered to be a barrier to drug delivery. The ai...

journal_title：Journal of drug targeting

authors： Jătariu AN,Popa M,Peptu CA

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Treatment of late stage cancers has proven to be a very difficult task. Targeted therapy and combinatory drug administration may be the solution. PURPOSE:The study was performed to evaluate the therapeutic efficacy of PEG-PE micelles, co-loaded with curcumin (CUR) and doxorubicin (DOX), and targeted with an...

journal_title：Journal of drug targeting

authors： Abouzeid AH,Patel NR,Rachman IM,Senn S,Torchilin VP

更新日期：2013-12-01 00:00:00

abstract：:Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 thymidine kinase gene (HSV-tk) delivery by retrovirus-producing cells and DNA/liposome complexes for the treatment...

journal_title：Journal of drug targeting

authors： Princen F,Lechanteur C,Lopez M,Gielen J,Bours V,Merville MP

更新日期：2000-01-01 00:00:00

abstract：:Polyethylene glycol-modified GoldMag nanoparticles (PGMNs) were synthesized and characterized by several analysis including transmission electron microscopy, dynamic light scattering, Fourier transform infrared spectroscopy, and vibrating sample magnetometer. Here, we showed that the composite nanoparticles have a sat...

journal_title：Journal of drug targeting

authors： Chao X,Guo L,Zhao Y,Hua K,Peng M,Chen C,Cui Y

更新日期：2011-04-01 00:00:00

abstract：:The present investigation was aimed at targeting indinavir, a protease inhibitor to cells of mononuclear phagocyte system (MPS) via mannosylated liposomes. β-d-1-thiomannopyranoside residues were covalently coupled with dimyristoyl phosphatidylethanolamine (DMPE) to generate mannosylated-DMPE (Man-DMPE) conjugate whic...

journal_title：Journal of drug targeting

authors： Dubey V,Nahar M,Mishra D,Mishra P,Jain NK

更新日期：2011-05-01 00:00:00

abstract：:Cancer is one of the most common diseases all over the world; many people suffer from diverse types of cancer. However, currently there is no exact cure or therapy developed for cancer. On the other hand, nanoparticles are defined as microscopic particles that have dimensions less than 100 nm and they are known for th...

journal_title：Journal of drug targeting

authors： Çeşmeli S,Biray Avci C

更新日期：2019-08-01 00:00:00

abstract：:Archaeal ether glycerolipid vesicles (archaeosomes) efficiently deliver exogenous antigen for induction of humoral and cell-mediated immunity. Because induction of CD8 cytotoxic T cells is critical for protective vaccination against tumors, we compared the ability of various archaeosome lipid compositions to evoke a s...

journal_title：Journal of drug targeting

authors： Krishnan L,Dennis Sprott G,Institute for Biological Sciences, National Research Council of Canada.

更新日期：2003-01-01 00:00:00

abstract：:Herein, we report the effect of gold nanoparticles (AuNP) and n-acetylcysteine (NAC) isolated or in association as important anti-inflammatory and antioxidant compounds on brain dysfunction in septic rats. Male Wistar rats after sham operation or caecal ligation and perforation (CLP) were treated with subcutaneously i...

journal_title：Journal of drug targeting

authors： Petronilho F,Tenfen L,Della Giustina A,Joaquim L,Novochadlo M,de Oliveira Junior AN,Bagio E,Goldim MPS,de Carli RJ,Bonfante SRSA,Metzker KLL,Muttini S,Dos Santos TM,de Oliveira MP,Engel NA,Rezin GT,Kanis LA,Barichello T

更新日期：2020-04-01 00:00:00

abstract：:Doxorubicin (DXR) was encapsulated in long-circulating liposomes, composed of ganglioside GM1 (GM1)/distearoylphosphatidylcholine (DSPC)/cholesterol (CH) (0.13:1:1 in molar ratio) and sized to approximately 100 nm in mean diameter, with 98% entrapping efficiency by the transmembrane pH gradient method. Free DXR, DXR-D...

journal_title：Journal of drug targeting

authors： Unezaki S,Maruyama K,Ishida O,Takahashi N,Iwatsuru M

更新日期：1993-01-01 00:00:00

abstract：:Graphene, the mother of all carbon materials, has unlocked a new era of biomedical nanomaterials due to its exceptional biocompatibility, physicochemical and mechanical properties. It is a single atom thick, nanosized, two-dimensional structure and provides high surface area with adjustable surface chemistry to form h...

journal_title：Journal of drug targeting

authors： Madni A,Noreen S,Maqbool I,Rehman F,Batool A,Kashif PM,Rehman M,Tahir N,Khan MI

更新日期：2018-12-01 00:00:00

abstract：:A biophysical model was developed, using Ascaris suum as a model gastrointestinal nematode, to provide quantitative perspectives into the microenvironmental pH within the water-filled, porous, negatively charged cuticle matrix of gastrointestinal nematodes. The central features of the model include (a) the constant ra...

journal_title：Journal of drug targeting

authors： Sims SM,Ho NF,Magas LT,Geary TG,Barsuhn CL,Thompson DP

更新日期：1994-01-01 00:00:00

abstract：:Anionic, cationic, and neutral liposomes were constructed to contain IL-2 in order to evaluate their affinity to a cervical cancer cell line (INBL) and to determine whether they can present IL-2 on their external surface. When these liposomes were co-cultured with INBL, the anionic liposomes were the only ones found t...

journal_title：Journal of drug targeting

authors： Corona-Ortega T,Rangel-Corona R,Hernández-Jiménez M,Baeza I,Ibáñez M,Weiss-Steider B

更新日期：2009-08-01 00:00:00

abstract：:Solid tumors such as breast cancer have historically provided many challenges to anti-cancer therapy. Therapeutic hurdles to drug penetration in solid tumors include heterogeneous vascular supply and high interstitial pressures within tumor tissue, particularly in necrotic zones, lower pH and presence of leaky vascula...

journal_title：Journal of drug targeting

authors： Sharma G,Anabousi S,Ehrhardt C,Ravi Kumar MN

更新日期：2006-06-01 00:00:00

abstract：:Phage display technology has been widely used for developing tumor-targeting agents. Most of the efforts were directed towards identifying phage-displayed ligands against cancer-relevant purified targets and cancer cell lines. Whole cell screening procedures typically use a relatively large sample size and are not ide...

journal_title：Journal of drug targeting

authors： Shukla GS,Krag DN

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Histone deacetylases (HDACs) have been revealed to be involved in cerebrovascular diseases, while the role of HDAC9 in intracranial aneurysm (IA) remains seldom studied. We aim to explore the role of the HDAC9/microRNA-92a (miR-92a)/Bcl-2-like protein 11 (BCL2L11) axis in IA progression. METHODS:Expression o...

journal_title：Journal of drug targeting

authors： Cai Y,Huang D,Ma W,Wang M,Qin Q,Jiang Z,Liu M

更新日期：2021-01-22 00:00:00

abstract：:A general mathematical model involving partition coefficient, molecular weight and hydrogen bonding is used to correlate the structures and permeability of various organic compounds through the toad urinary bladder and human red blood cell (RBC) membranes. Log Per (permeability) is correlated with log Po/w (partition ...

journal_title：Journal of drug targeting

authors： Ren S,Das A,Lien EJ

更新日期：1996-01-01 00:00:00

abstract：:Liposomes have been prepared from dipalmitoylphosphatidylcholine (DPPC), cholesterol (Chol) and dimethyldioctadecylammonium bromide (DDAB). The cationic vesicles adsorb to biofilms of the skin-associated bacteria Staphylococcus epidermidis, which have a negative charge. Encapsulation of the antibacterial drug vancomyc...

journal_title：Journal of drug targeting

authors： Sanderson NM,Jones MN

更新日期：1996-01-01 00:00:00

abstract：:Cell-penetrating peptides (CPPs) are efficient vehicles to transport bioactive molecules into the cells. Despite numerous studies the exact mechanism by which CPPs facilitate delivery of cargo to its intracellular target is still debated. The current work presents methods that can be used for tracking CPP/pDNA complex...

journal_title：Journal of drug targeting

authors： Pärnaste L,Arukuusk P,Zagato E,Braeckmans K,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) is the only FDA approved medical treatment for the ischaemic stroke. However, it associates with some inevitable limitations, including: short therapeutic window, extremely short half-life and low penetration in large clots. Systemic administration may lead to complications such as h...

journal_title：Journal of drug targeting

authors： Zamanlu M,Farhoudi M,Eskandani M,Mahmoudi J,Barar J,Rafi M,Omidi Y

更新日期：2018-02-01 00:00:00

abstract：:Most therapeutic agents are delivered orally. Consequently, the major classes of therapeutically useful chemicals are partially lipophilic, small molecular weight compounds. They have reasonable permeability coefficient values across cell membranes, including those of intestinal epithelia and vascular endothelia. In c...

journal_title：Journal of drug targeting

authors： Baird AW,Campion DP,O'Brien L,Brayden DJ

更新日期：2004-02-01 00:00:00