Recent advances in targeted delivery of tissue plasminogen activator for enhanced thrombolysis in ischaemic stroke.

abstract：:We have previously reported that the transfection efficiency of laminin-derived AG73-peptide labeled polyethyleneglycol-modified liposomes (AG73-PEG liposomes) was enhanced by echo-contrast gas entrapping PEG liposomes (Bubble liposomes, BLs) and ultrasound (US) exposure by improving endosomal escape. However, it has ...

journal_title：Journal of drug targeting

authors： Omata D,Negishi Y,Hagiwara S,Yamamura S,Endo-Takahashi Y,Suzuki R,Maruyama K,Aramaki Y

更新日期：2012-05-01 00:00:00

abstract：:Pathophysiological molecules in the extracellular environment offer excellent targets that can be exploited for designing drug targeting systems. Matrix metalloproteases (MMPs) are a family of extracellular proteolytic enzymes that are characterized by their overexpression or overactivity in several pathologies. Over ...

journal_title：Journal of drug targeting

authors： Vartak DG,Gemeinhart RA

更新日期：2007-01-01 00:00:00

abstract：:Cancer is one of the most common diseases all over the world; many people suffer from diverse types of cancer. However, currently there is no exact cure or therapy developed for cancer. On the other hand, nanoparticles are defined as microscopic particles that have dimensions less than 100 nm and they are known for th...

journal_title：Journal of drug targeting

authors： Çeşmeli S,Biray Avci C

更新日期：2019-08-01 00:00:00

abstract：:Cyclodextrins (CDs) are macrocyclic oligosaccharides composed of α(1,4)-linked glucopyranose subunits. These molecules possess a cage-like supramolecular structure, comparable with the structures of crown ethers, cryptands, spherands, cyclophanes, or calixarenes. However, it took 50 years to establish the molecular st...

journal_title：Journal of drug targeting

authors： Laza-Knoerr AL,Gref R,Couvreur P

更新日期：2010-11-01 00:00:00

abstract：:Nanoparticles form the fundamental building blocks for many exciting applications in various scientific disciplines due to its unique features such as large surface to mass ratio, targeting potential, ability to adsorbed and carry other compound which makes them suitable for biomedical applications. However, the probl...

journal_title：Journal of drug targeting

authors： Sultana S,Alzahrani N,Alzahrani R,Alshamrani W,Aloufi W,Ali A,Najib S,Siddiqui NA

更新日期：2020-06-01 00:00:00

abstract：:Despite the advantages of drug delivery through skin, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept known as microneedle was introduced and could be used to pierce effectively to deliver drugs us...

journal_title：Journal of drug targeting

authors： You SK,Noh YW,Park HH,Han M,Lee SS,Shin SC,Cho CW

更新日期：2010-01-01 00:00:00

abstract：:A novel concept in drug delivery discussed here, takes advantage of certain properties of the drug "containers" cyclodextrins and liposomes to combine them into a single system thus circumventing problems associated with both systems. The concept, entailing entrapment of water-soluble cyclodextrin-drug inclusion compl...

journal_title：Journal of drug targeting

authors： McCormack B,Gregoriadis G

更新日期：1994-01-01 00:00:00

abstract：:Notch pathway was found to be activated in most glioblastomas (GBMs), underlining the importance of Notch in formation and recurrence of GBM. In this study, a Notch inhibitory peptide, dominant negative MAML (dnMAML), was conjugated to elastin-like polypeptide (ELP) for tumor targeted delivery. ELP is a thermally resp...

journal_title：Journal of drug targeting

authors： Opačak-Bernardi T,Ryu JS,Raucher D

更新日期：2017-07-01 00:00:00

abstract：:The myriad of complications associated with diabetes is closely linked with the generation of reactive species or free radicals leading to oxidative and nitrosative stress. Increased oxidative stress is an important cause and result of diabetes and it is thought to underlie the cellular changes that lead to diabetic c...

journal_title：Journal of drug targeting

authors： Thakur P,Kumar A,Kumar A

更新日期：2018-11-01 00:00:00

abstract：:Recent research into the complex and varied components of rheumatoid arthritis (RA) is leading to the development of more effective targets for pharmaceutical approach than even before. Current treatment of RA frequently includes the use of nonsteroidal anti-inflammatory drugs, such as Diclofenac sodium (DFNa) in spit...

journal_title：Journal of drug targeting

authors： Türker S,Erdoğan S,Ozer YA,Bilgili H,Deveci S

更新日期：2008-01-01 00:00:00

abstract：:The human body has adapted to defend against the aggressive biological or chemical agents. As a result, the defence mechanisms of the human body became barriers for the drug delivery. Theoretically, any problem that prevents a drug from reaching its site of action is considered to be a barrier to drug delivery. The ai...

journal_title：Journal of drug targeting

authors： Jătariu AN,Popa M,Peptu CA

更新日期：2010-05-01 00:00:00

abstract：:beta-Glucuronidase (GUSB) is a lysosomal enzyme that could be developed as a brain therapy for Type VII Mucopolysaccharidosis. However, GUSB does not cross the blood-brain barrier (BBB). To enable BBB transport of the enzyme, human GUSB was re-engineered as a fusion protein with the chimeric monoclonal antibody (MAb) ...

journal_title：Journal of drug targeting

authors： Boado RJ,Pardridge WM

更新日期：2010-04-01 00:00:00

abstract：:A simple method for the separation of polyalkylcyanoacrylate nanoparticles was developed using polyisohexylcyanoacrylate (PIHCA) as a model. Fluorescein isothiocyanate dextran 70 was used to label the nanoparticles. Ultracentrifugation onto a performed sucrose gradient allowed the easy elimination of the dextran and o...

journal_title：Journal of drug targeting

authors： Pinto-Alphandary H,Balland O,Couvreur P

更新日期：1995-01-01 00:00:00

abstract：:Gene transfer offers a potential way to correct local and systemic protein deficiency disorders by using genes as drugs, so called gene therapeutics. Salivary glands present an interesting target site for gene therapeutic applications. Herein, we review proofs of concept achieved for salivary glands with in vivo anima...

journal_title：Journal of drug targeting

authors： Hoque AT,Yamano S,Baccaglini L,Baum BJ

更新日期：2001-01-01 00:00:00

abstract：:Submicron sized hydrophobic and hydrophilic albumin microspheres (MS) were prepared using a chemical crosslinking technique. Spermine was linked to the surface of the hydrophilic MS. The degree of hydrophobicity for these three types of MS was investigated using a novel technique of sedimentation volume. The surface t...

journal_title：Journal of drug targeting

authors： Shafi ZB,Martin GP,Olliff CJ,James SL

更新日期：1995-01-01 00:00:00

abstract：:The objective of this study was to investigate the factors for enhancing the susceptibility of cancer cells to chemotherapeutic drug by ultrasound microbubbles. Ultrasound (US) combined with phospholipid-based microbubbles (MB) was used to enhance the susceptibility of colon cancer cell line SWD-620 to anticancer drug...

journal_title：Journal of drug targeting

authors： Zhao YZ,Gao HS,Zhou ZC,Tang QQ,Lu CT,Jin Z,Tian JL,Xu YY,Tian XQ,Wang L,Kong FL,Li XK,Huang PT,He HL,Wu Y

更新日期：2010-07-01 00:00:00

abstract：:Liposomes have been prepared loaded with DNA (plasmid encoding for the green fluorescent protein, GFP) and additionally modified with TATp and PEG, with PEG being attached to the liposome surface via both pH-sensitive hydrazone and non-pH-sensitive bonds. The pGFP-loaded liposomal preparations have been administered i...

journal_title：Journal of drug targeting

authors： Kale AA,Torchilin VP

更新日期：2007-08-01 00:00:00

abstract：:A biophysical model was developed, using Ascaris suum as a model gastrointestinal nematode, to provide quantitative perspectives into the microenvironmental pH within the water-filled, porous, negatively charged cuticle matrix of gastrointestinal nematodes. The central features of the model include (a) the constant ra...

journal_title：Journal of drug targeting

authors： Sims SM,Ho NF,Magas LT,Geary TG,Barsuhn CL,Thompson DP

更新日期：1994-01-01 00:00:00

abstract：:The high-molecular-weight soluble aggregates of Fab fragments of murine antibodies against cardiac myosin were prepared as a potential long-circulating and low immunogenic pharmaceutical carriers by conjugation of thiolated Fab and Fab modified with succinimidyl 3-(2-pyridyldithio)propionate. The clearance time and bi...

journal_title：Journal of drug targeting

authors： Dalkara S,Petrov A,Trubetskoy VS,Khaw BA,Torchilin VP

更新日期：1998-01-01 00:00:00

abstract：:To identify an agent with specific activity against B-lineage leukaemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanised anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-liposomes). These liposomes were specially designed to recognise and kill B-LSC...

journal_title：Journal of drug targeting

authors： Zhang J,Shen D,Jia M,Zhao H,Tang Y

更新日期：2018-01-01 00:00:00

abstract：:Oleanolic acid (OA) is a pentacyclic triterpenoid found in various plant species. Triterpenoid compounds have been shown to inhibit tumor proliferation and to induce apoptosis in cancer cells. We synthesized an OA derivative and evaluated its inhibitory effects on cell proliferation in human colon cancer. Radioisotope...

journal_title：Journal of drug targeting

authors： Kim SM,Jeong IH,Yim MS,Chae MK,Kim HN,Kim DK,Kang CM,Choe YS,Lee C,Ryu EK

更新日期：2014-10-07 00:00:00

abstract：:This study was designed to exploit the ability of Peyer's patch M cells to recognize antigen-antibody complexes in the targeted delivery of a model antigen for the induction of mucosal immunity. Sensitized liposomes consisted of an entrapped model antigen, ovalbumin (OVA), and coated with unrelated antigen-antibody co...

journal_title：Journal of drug targeting

authors： Velez CN,Tonkonogy SL,Lichtman SN,Cho MJ

更新日期：1997-01-01 00:00:00

abstract：:The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs) that are commonly used in patients with hypertension, cardiovascular disease and/or...

journal_title：Journal of drug targeting

authors： Akhtar S,Benter IF,Danjuma MI,Doi SAR,Hasan SS,Habib AM

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:High expression of glucagon-like peptide-1 receptor (GLP-1R) in insulinoma supplies a potential drug target for tumor imaging. Exendin-4 can specifically bind to GLP-1R as an agonist and its analogs are extensively used in receptor imaging studies. PURPOSE:A new GLP-1R imaging agent, [(18)F]AlF-NOTA-MAL-Cys...

journal_title：Journal of drug targeting

authors： Xu Q,Zhu C,Xu Y,Pan D,Liu P,Yang R,Wang L,Chen F,Sun X,Luo S,Yang M

更新日期：2015-01-01 00:00:00

abstract：:Microparticles-adsorbed insulin and zinc insulin (PenfilN) were molded to self-dissolving micropiles (SDMPs) with chondroitin sulfate as the base for the percutaneous administration of insulin. Porous silicon dioxide (Sylysia 320, 440 and 730) and porous calcium silicate (FloriteRE) were used as microparticles. As a r...

journal_title：Journal of drug targeting

authors： Ito Y,Hagiwara E,Saeki A,Sugioka N,Takada K

更新日期：2007-06-01 00:00:00

abstract：:Highly lipophilic antitumor agent, palmitoyl rhizoxin (RS-1541), was incorporated into stable lipid emulsions about 100-1000nm in mean diameter consisting of triglyceride ODO and surfactant HCO-60. The pharmacokinetics of RS-1541 were studied after i.v. injection in mice, rats, rabbits, and dogs. Dog showed characteri...

journal_title：Journal of drug targeting

authors： Kurihara A,Shibayama Y,Kasuya A,Ikeda M,Hisaoka M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Nanoparticles with controlled physical properties have been widely used for controlled release applications. In addition to shape, the anisotropic nature of the particles can be an important design criterion to ensure selective surface modification or independent release of combinations of drugs. PURPOSE:El...

journal_title：Journal of drug targeting

authors： Rahmani S,Villa CH,Dishman AF,Grabowski ME,Pan DC,Durmaz H,Misra AC,Colón-Meléndez L,Solomon MJ,Muzykantov VR,Lahann J

更新日期：2015-01-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) expression has been shown to be increased in several types of human tumours. In this study, for the imaging of HER2-related tumours, a modified RNA aptamer with HER2-specific targeting was labelled with (99m)Tc, by using hydrazino nicotinamide (HYNIC) as the chelator in ...

journal_title：Journal of drug targeting

authors： Varmira K,Hosseinimehr SJ,Noaparast Z,Abedi SM

更新日期：2014-02-01 00:00:00

abstract：:Intracellular compartmentalisation is a significant barrier to the successful nucleocytosolic delivery of biologics. The endocytic system has been shown to be responsible for compartmentalisation, providing an entry point, and trigger(s) for the activation of drug delivery systems. Consequently, many of the technologi...

journal_title：Journal of drug targeting

authors： Shorter SA,Pettit MW,Dyer PDR,Coakley Youngs E,Gorringe-Pattrick MAM,El-Daher S,Richardson S

更新日期：2017-01-01 00:00:00

abstract：:The aim of this work was to formulate minoxidil loaded liposome and niosome formulations to improve skin drug delivery. Multilamellar liposomes were prepared using soy phosphatidylcholine at different purity degrees (Phospholipon 90, 90% purity, soy lecithin (SL), 75% purity) and cholesterol (Chol), whereas niosomes w...

journal_title：Journal of drug targeting

authors： Mura S,Pirot F,Manconi M,Falson F,Fadda AM

更新日期：2007-02-01 00:00:00