Application of titanium dioxide (TiO2) nanoparticles in cancer therapies.

abstract：:Biphenylylacetic acid (BPAA) was linked to the free hydroxyl group of 2,6-di-O-methyl-beta-Cyclodextrin (DM-beta-CyD) through an ester linkage to obtain the site specific release of the drug to the colon. The conjugate at 1:1 mole ratio was separated from the reaction mixture by semipreparative reverse-phase HPLC and ...

journal_title：Journal of drug targeting

authors： Ventura CA,Paolino D,Pedotti S,Pistarà V,Corsaro A,Puglisi G

更新日期：2003-05-01 00:00:00

abstract：:The objective of this study is to develop and evaluate gastroretentive particulate delivery systems using Riboflavin-5'-monophosphate sodium salt dihydrate (RF5'PNa) as model drug. Poly(acrylic acid)-cysteine and chitosan-4-thiobuthylamidine were evaluated and compared as anionic and cationic polymers for gastroretent...

journal_title：Journal of drug targeting

authors： Senyigit ZA,Vetter A,Guneri T,Bernkop-Schnürch A

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:An octreotide-conjugated polyamidoamine (PAMAM) dendrimer was synthesized and employed as nanocarriers of methotrexate (MTX), for targeting to the somatostatin receptors over-expressed tumor cells. METHODS:PAMAM-PEG-octreotide (PPO) and PAMAM-PEG (PPG) were synthesized and characterized. The cellular uptake of...

journal_title：Journal of drug targeting

authors： Peng J,Qi X,Chen Y,Ma N,Zhang Z,Xing J,Zhu X,Li Z,Wu Z

更新日期：2014-06-01 00:00:00

abstract：:A higher encapsulation rate was obtained using the dehydration-rehydration method compared with the reverse-phase evaporation technique in negative multilamellar vesicles with amikacin (AMK) (45% versus 15%; P < 0.05) and teicoplanin (TCP) (34% versus 25%; P < 0.05). The addition of 250 mM sucrose to AMK- or TCP-conta...

journal_title：Journal of drug targeting

authors： Ravaoarinoro M,Toma E,Agbaba O,Morisset R

更新日期：1993-01-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) expression has been shown to be increased in several types of human tumours. In this study, for the imaging of HER2-related tumours, a modified RNA aptamer with HER2-specific targeting was labelled with (99m)Tc, by using hydrazino nicotinamide (HYNIC) as the chelator in ...

journal_title：Journal of drug targeting

authors： Varmira K,Hosseinimehr SJ,Noaparast Z,Abedi SM

更新日期：2014-02-01 00:00:00

abstract：:Archaeal ether glycerolipid vesicles (archaeosomes) efficiently deliver exogenous antigen for induction of humoral and cell-mediated immunity. Because induction of CD8 cytotoxic T cells is critical for protective vaccination against tumors, we compared the ability of various archaeosome lipid compositions to evoke a s...

journal_title：Journal of drug targeting

authors： Krishnan L,Dennis Sprott G,Institute for Biological Sciences, National Research Council of Canada.

更新日期：2003-01-01 00:00:00

abstract：:Nanostructured lipid carrier (NLC) is second generation smarter drug carrier system having solid matrix at room temperature. This carrier system is made up of physiological, biodegradable and biocompatible lipid materials and surfactants and is accepted by regulatory authorities for application in different drug deliv...

journal_title：Journal of drug targeting

authors： Iqbal MA,Md S,Sahni JK,Baboota S,Dang S,Ali J

更新日期：2012-12-01 00:00:00

abstract：:Metal nanoparticles (NPs) may have the potential to overcome problems related to conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in cancer therapy providing better targeting, gene silencing and drug delivery. Functionalised metal NPs with targeting ligands offer a better control of...

journal_title：Journal of drug targeting

authors： Sharma A,Goyal AK,Rath G

更新日期：2018-09-01 00:00:00

abstract：:The transport of 125I-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings. Translocation of the particles into the blood stream was examined by means of monitoring the radiolabel associated with the particles. Particles were detected in the...

journal_title：Journal of drug targeting

authors： Brooking J,Davis SS,Illum L

更新日期：2001-01-01 00:00:00

abstract：:To design a novel cytospecific photosensitizer for photodynamic antitumor therapy, a fullerene (C(60)) was chemically modified with pullulan which is a water-soluble polysaccharide with a high affinity for asialoglycoprotein receptors. Ethylene diamine was introduced to the terminal aldehyde groups of pullulan by the ...

journal_title：Journal of drug targeting

authors： Liu J,Tabata Y

更新日期：2010-09-01 00:00:00

abstract：:A promising strategy to carry genetic material to brain cells either in vitro or in vivo is using the LDL receptor (LDLr) on blood-brain barrier. LDLr naturally help to low density lipoproteins (LDL(S)) transporting across the BBB by endocytosis. Here we present the idea of using the LDLr-mediated pathway for transpor...

journal_title：Journal of drug targeting

authors： Mousazadeh M,Palizban A,Salehi R,Salehi M

更新日期：2007-04-01 00:00:00

abstract：:Previous studies indicated the potential of zinc protoporphyrin (ZnPP) as an antitumor agent targeting to the tumor survival factor heme oxygenase-1, and/or for photodynamic therapy (PDT). In this study, to achieve tumor-targeted delivery, styrene-maleic acid-copolymer conjugated ZnPP (SMA-ZnPP) was synthesized via am...

journal_title：Journal of drug targeting

authors： Fang J,Tsukigawa K,Liao L,Yin H,Eguchi K,Maeda H

更新日期：2016-01-01 00:00:00

abstract：:A general mathematical model involving partition coefficient, molecular weight and hydrogen bonding is used to correlate the structures and permeability of various organic compounds through the toad urinary bladder and human red blood cell (RBC) membranes. Log Per (permeability) is correlated with log Po/w (partition ...

journal_title：Journal of drug targeting

authors： Ren S,Das A,Lien EJ

更新日期：1996-01-01 00:00:00

abstract：:An aqueous dispersion of self-organized phospholipid tubules has been utilized as the template for silica-deposited nanotubules (approximately 0.5 microm thick and >10 microm long) by a sol-gel method. The formation of the hybrid tubules was mechanistically investigated by controlled sol-gel reaction. The incorporatio...

journal_title：Journal of drug targeting

authors： Kim I,Park YH,Rey DA,Batt CA

更新日期：2008-11-01 00:00:00

abstract：:Gene transfer offers a potential way to correct local and systemic protein deficiency disorders by using genes as drugs, so called gene therapeutics. Salivary glands present an interesting target site for gene therapeutic applications. Herein, we review proofs of concept achieved for salivary glands with in vivo anima...

journal_title：Journal of drug targeting

authors： Hoque AT,Yamano S,Baccaglini L,Baum BJ

更新日期：2001-01-01 00:00:00

abstract：:Gene delivery systems face the problem not only of the route toward the cell and tissues in question, but also of the molecularly crowded environment of both the cytoplasm and the nucleus itself. One of the physical barriers in the cytoplasm for diffusing nanoparticles is an actin network. Here, we describe the findin...

journal_title：Journal of drug targeting

authors： Ruenraroengsak P,Florence AT

更新日期：2010-12-01 00:00:00

abstract：:The aim of the present study was to develop a polymeric delivery system for water-insoluble drug oridonin. Amphiphilic block copolymers, poly(epsilon-caprolactone)-poly(ethylene glycol)-poly (epsilon-caprolactone) (PCL-PEO-PCL), were synthesized by ring-opening polymerization of caprolactone initiated by the hydroxyl ...

journal_title：Journal of drug targeting

authors： Feng N,Wu P,Li Q,Mei Y,Shi S,Yu J,Xu J,Liu Y,Wang Y

更新日期：2008-07-01 00:00:00

abstract：:As a percutaneous sustained-release preparation, insulin micropiles (MPs) were prepared with biodegradable polymers poly(lactic acid) (PLA), poly(ϵ-caprolactone) (PCL) and poly(lactic-co-glycolic acid) (PLGA) as the base. The obtained PLA, PCL, and PLGA MPs of which the insulin:polymer ratio was 1:2 were administered ...

journal_title：Journal of drug targeting

authors： Fukushima K,Ito Y,Ishihata M,Sugioka N,Takada K

更新日期：2011-04-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) is the only FDA approved medical treatment for the ischaemic stroke. However, it associates with some inevitable limitations, including: short therapeutic window, extremely short half-life and low penetration in large clots. Systemic administration may lead to complications such as h...

journal_title：Journal of drug targeting

authors： Zamanlu M,Farhoudi M,Eskandani M,Mahmoudi J,Barar J,Rafi M,Omidi Y

更新日期：2018-02-01 00:00:00

abstract：:Polyethylene glycol-modified GoldMag nanoparticles (PGMNs) were synthesized and characterized by several analysis including transmission electron microscopy, dynamic light scattering, Fourier transform infrared spectroscopy, and vibrating sample magnetometer. Here, we showed that the composite nanoparticles have a sat...

journal_title：Journal of drug targeting

authors： Chao X,Guo L,Zhao Y,Hua K,Peng M,Chen C,Cui Y

更新日期：2011-04-01 00:00:00

abstract：:Intravenous targeting of anticancer agents should improve both efficacy and therapeutic index. However, rational design of targeting constructs requires detailed definition of receptor targets and must take account of polarised tissue architecture that may restrict access to chosen receptors from the bloodstream. Bact...

journal_title：Journal of drug targeting

authors： Maruta F,Akita N,Nakayama J,Miyagawa S,Ismail T,Rowlands DC,Kerr DJ,Fisher KD,Seymour LW,Parker AL

更新日期：2007-05-01 00:00:00

abstract：:Submicron sized hydrophobic and hydrophilic albumin microspheres (MS) were prepared using a chemical crosslinking technique. Spermine was linked to the surface of the hydrophilic MS. The degree of hydrophobicity for these three types of MS was investigated using a novel technique of sedimentation volume. The surface t...

journal_title：Journal of drug targeting

authors： Shafi ZB,Martin GP,Olliff CJ,James SL

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:Peptide antibiotics as new therapeutic agents are becoming a popular option to investigate due to their broad bacterial target selectivity and limited resistance problems. Although attractive, these new drug candidates have several limitations including low potency and delivery issues which face all peptid...

journal_title：Journal of drug targeting

authors： Zhang C,Yadava P,Sun J,Hughes JA

更新日期：2006-11-01 00:00:00

abstract：:Considering limitations of conventional insulin therapies, the present study characterizes usefulness of novel mucoadhesive multivesicular liposomes as a mucoadhesive sustained release carrier of insulin via nasal and ocular routes, thus attempts to develop non-invasive carrier system for the controlled release of bio...

journal_title：Journal of drug targeting

authors： Jain AK,Chalasani KB,Khar RK,Ahmed FJ,Diwan PV

更新日期：2007-07-01 00:00:00

abstract：:I125 radiolabelled HSA (HSA-I125) was utilised as a probe to quantify protein adsorption onto polystyrene (PS) and Poloxamine 908 coated PS (PS-908) particles. Upon ageing of the HSA-I125 a dramatic increase in the amount of protein adsorbed onto the two particle systems was observed. This phenomenon was not due to la...

journal_title：Journal of drug targeting

authors： Armstrong TI,Illum L

更新日期：1997-01-01 00:00:00

abstract：:In order to confirm the efficacy of ciprofloxacin (CPFX) incorporated into liposomes (CPFX-liposomes) for treatment of respiratory intracellular parasite infections, the influence of particle size on drug delivery to rat alveolar macrophages (AMs) following pulmonary administration of CPFX-liposomes was investigated. ...

journal_title：Journal of drug targeting

authors： Chono S,Tanino T,Seki T,Morimoto K

更新日期：2006-09-01 00:00:00

abstract：:Cytokine inhibiting drugs are much more effective when delivered intracellularly to phagocytic cells in the microencapsulated form. Dexamethasone is a powerful inhibitor of TNF-α cytokine through inhibition of NF-κB which is a gene regulator of multiple pro-inflammatory cytokines. We have determined the effect of micr...

journal_title：Journal of drug targeting

authors： Uddin MN,Siddiq A,Oettinger CW,D'Souza MJ

更新日期：2011-11-01 00:00:00

abstract：:Micro-needle arrays increase skin permeability by forming channels through the outer physical barrier, without stimulating pain receptors populating the underlying dermis. It was postulated that micro-needle arrays could facilitate transfer of DNA to human skin epidermis for cutaneous gene therapy applications. Platin...

journal_title：Journal of drug targeting

authors： Birchall J,Coulman S,Pearton M,Allender C,Brain K,Anstey A,Gateley C,Wilke N,Morrissey A

更新日期：2005-08-01 00:00:00

abstract：:The goal of this study was to develop a systemically non-toxic and stable circulation based passive targeting system for efficient anticancer treatment. Gelatin-doxorubicin (GD) and PEGylated gelatin-doxorubicin (PGD) nanoparticles were designed and their feasibilities as an anti-cancer drug were evaluated. The sizes ...

journal_title：Journal of drug targeting

authors： Lee GY,Park K,Nam JH,Kim SY,Byun Y

更新日期：2006-12-01 00:00:00

abstract：:Polynucleotides are anionic macromolecules which are expected to transfer into the targeted cells through specific uptake mechanisms. So, we developed polynucleotides coating complexes of plasmid DNA (pDNA) and polyethylenimine (PEI) for a secure and efficient gene delivery system and evaluated their usefulness. Polya...

journal_title：Journal of drug targeting

authors： Kodama Y,Ohkubo C,Kurosaki T,Egashira K,Sato K,Fumoto S,Nishida K,Higuchi N,Kitahara T,Nakamura T,Sasaki H

更新日期：2015-01-01 00:00:00