Application of titanium dioxide (TiO2) nanoparticles in cancer therapies.


:Cancer is one of the most common diseases all over the world; many people suffer from diverse types of cancer. However, currently there is no exact cure or therapy developed for cancer. On the other hand, nanoparticles are defined as microscopic particles that have dimensions less than 100 nm and they are known for their usage in health sciences and medicine, however a few harmful effects on different animal cells. Therefore, researchers began to use nanoparticles for cancer therapies and to develop new methods for much more effective therapies. Nanoparticles in cancer studies are commonly used in photodynamic therapy (PDT) and sonodynamic therapy (SDT) as a sensitising agent, in computed tomography imaging (CT) and radiation therapy as an enhancement agent, in dual-mode image contrast and enhancement therapy as an image contrast agent. Titanium dioxide nanoparticles (TiO2 NPs) are known as commonly used nanoparticles in medical applications and hence in cancer studies. They are used in PDT, SDT and drug delivery systems. As cancer continues to affect people, new therapeutics and therapies will be developed and nanotechnology for this aim will be an important approach for the researchers.


J Drug Target


Çeşmeli S,Biray Avci C




Has Abstract


2019-08-01 00:00:00












  • Entrapment of cyclodextrin-drug complexes into liposomes: potential advantages in drug delivery.

    abstract::A novel concept in drug delivery discussed here, takes advantage of certain properties of the drug "containers" cyclodextrins and liposomes to combine them into a single system thus circumventing problems associated with both systems. The concept, entailing entrapment of water-soluble cyclodextrin-drug inclusion compl...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: McCormack B,Gregoriadis G

    更新日期:1994-01-01 00:00:00

  • Design of a Pep-1 peptide-modified liposomal nanocarrier system for intracellular drug delivery: Conformational characterization and cellular uptake evaluation.

    abstract::In order to facilitate the intracellular delivery of macromolecules, Pep-1 peptide-modified liposomal (Pep1-Lipo) nanocarriers were designed and examined for their in vitro cell translocation capability. Pep-1 peptides were coupled via thiol-maleimide linkage to small unilamellar vesicles composed of phosphatidylcholi...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Kang MJ,Kim BG,Eum JY,Park SH,Choi SE,An JJ,Jang SH,Eum WS,Lee J,Lee MW,Kang K,Oh CH,Choi SY,Choi YW

    更新日期:2011-08-01 00:00:00

  • Preparation and evaluation of once-a-day injectable microspheres of interferon alpha in rats.

    abstract::Gelatin microspheres (ms) and gelatin/BSA (bovine serum albumin) or gelatin/alginate ms were prepared by encapsulating fluorescein isothiocyanate (FITC) labeled dextran or interferon alpha (IFN-alpha). Ms were obtained by an emulsion-solvent-extraction method. Gelatin and gelatin/BSA ms were obtained by treating water...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Yoshikawa Y,Komuta Y,Nishihara T,Itoh Y,Yoshikawa H,Takada K

    更新日期:1999-01-01 00:00:00

  • Methods to follow intracellular trafficking of cell-penetrating peptides.

    abstract::Cell-penetrating peptides (CPPs) are efficient vehicles to transport bioactive molecules into the cells. Despite numerous studies the exact mechanism by which CPPs facilitate delivery of cargo to its intracellular target is still debated. The current work presents methods that can be used for tracking CPP/pDNA complex...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Pärnaste L,Arukuusk P,Zagato E,Braeckmans K,Langel Ü

    更新日期:2016-01-01 00:00:00

  • Pharmacokinetics and targeting property of TFu-loaded liposomes with different sizes after intravenous and oral administration.

    abstract::The purpose of the study was to develop the liposomal formulations of TFu for oral and intravenous (i.v.) administration, clarify the biodistribution characteristics and in vivo pharmacokinetic behaviors of TFu-loaded liposomes. Four TFu-loaded liposomes of different sizes were prepared and characterized. The pharmaco...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Sun W,Zou W,Huang G,Li A,Zhang N

    更新日期:2008-06-01 00:00:00

  • Peptide-mediated gene transfer of cationic lipid/plasmid DNA complexes to endothelial cells.

    abstract::The purpose of this research is to develop ligand-targeted plasmid based gene delivery systems for gene transfer to tumor endothelium. Cell adhesion assays were used to test the peptide inhibition of human endothelial cell adsorption to vitronectin-treated tissue culture plates. A series of RGD containing peptides wer...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Anwer K,Kao G,Rolland A,Driessen WH,Sullivan SM

    更新日期:2004-05-01 00:00:00

  • Characterization of cationic liposomes having IL-2 expressed on their external surface, and their affinity to cervical cancer cells expressing the IL-2 receptor.

    abstract::Anionic, cationic, and neutral liposomes were constructed to contain IL-2 in order to evaluate their affinity to a cervical cancer cell line (INBL) and to determine whether they can present IL-2 on their external surface. When these liposomes were co-cultured with INBL, the anionic liposomes were the only ones found t...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Corona-Ortega T,Rangel-Corona R,Hernández-Jiménez M,Baeza I,Ibáñez M,Weiss-Steider B

    更新日期:2009-08-01 00:00:00

  • Molecular weight-dependent lymphatic transfer of fluorescein isothiocyanate-labeled dextrans after intrapulmonary administration and effects of various absorption enhancers on the lymphatic transfer of drugs in rats.

    abstract::We have developed a new method to evaluate the transfer of macromolecular drugs to intrapulmonary lymph nodes in rats after intrapulmonary administration. By using this method, we observed that the transfer of fluorescein isothiocyanate dextrans (FDs) to the intrapulmonary lymph nodes was markedly higher than that to ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Hanatani K,Takada K,Yoshida N,Nakasuji M,Morishita Y,Yasako K,Fujita T,Yamamoto A,Muranishi S

    更新日期:1995-01-01 00:00:00

  • Influence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofloxacin incorporated into liposomes.

    abstract::In order to confirm the efficacy of ciprofloxacin (CPFX) incorporated into liposomes (CPFX-liposomes) for treatment of respiratory intracellular parasite infections, the influence of particle size on drug delivery to rat alveolar macrophages (AMs) following pulmonary administration of CPFX-liposomes was investigated. ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Chono S,Tanino T,Seki T,Morimoto K

    更新日期:2006-09-01 00:00:00

  • Enhanced tumor targeting of doxorubicin by ganglioside GM1-bearing long-circulating liposomes.

    abstract::Doxorubicin (DXR) was encapsulated in long-circulating liposomes, composed of ganglioside GM1 (GM1)/distearoylphosphatidylcholine (DSPC)/cholesterol (CH) (0.13:1:1 in molar ratio) and sized to approximately 100 nm in mean diameter, with 98% entrapping efficiency by the transmembrane pH gradient method. Free DXR, DXR-D...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Unezaki S,Maruyama K,Ishida O,Takahashi N,Iwatsuru M

    更新日期:1993-01-01 00:00:00

  • α-Tocopherol as functional excipient for resveratrol and coenzyme Q10-loaded SNEDDS for improved bioavailability and prophylaxis of breast cancer.

    abstract::The present study evaluates the prophylactic efficacy of α-tocopherol (α-TOH), resveratrol (RES), and coenzyme Q10 (CoQ10) co-loaded self-nanoemulsifying drug delivery system (α-TOH-RES-CoQ10 SNEDDS) in 7,12-Dimethylbenz[a]anthracene (DMBA) induced breast cancer model. SNEDDS formulation components were rationally sel...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Jain S,Garg T,Kushwah V,Thanki K,Agrawal AK,Dora CP

    更新日期:2017-07-01 00:00:00

  • EGFR-targeted immunoliposomes derived from the monoclonal antibody EMD72000 mediate specific and efficient drug delivery to a variety of colorectal cancer cells.

    abstract::We hypothesized that immunoliposomes (ILs) constructed using Fab' from the humanized anti-EGFR monoclonal antibody, EMD72000, can provide efficient intracellular drug delivery in EGFR-overexpressing colorectal tumor cells.ILs were constructed modularly with various MAb fragments, including Fab' from EMD72000 (matuzuma...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Mamot C,Ritschard R,Küng W,Park JW,Herrmann R,Rochlitz CF

    更新日期:2006-05-01 00:00:00

  • Inhibitory effect of small interfering RNA specific for a novel candidate target in PB1 gene of influenza A virus.

    abstract::Influenza, mainly caused by influenza virus, is becoming one of the major concerns in the world. Limitation in vaccines necessitates the urgent development of new therapeutic options against this virus. In the present study, we designed small interfering RNA (siRNA) targeting overlapping gene of PB1 and PB1-F2 gene of...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Cheng C,Yao L,Chen A,Jia R,Huan L,Guo J,Bo H,Shu Y,Zhang Z

    更新日期:2009-02-01 00:00:00

  • Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa.

    abstract::Tissue factor (TF) is aberrantly expressed on tumor vascular endothelial cells (VECs) and on cancer cells in many malignant tumors, but not on normal VECs, making it a promising target for cancer therapy. As a transmembrane receptor for coagulation factor VIIa (fVIIa), TF forms a high-affinity complex with its cognate...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Shoji M,Sun A,Kisiel W,Lu YJ,Shim H,McCarey BE,Nichols C,Parker ET,Pohl J,Mosley CA,Alizadeh AR,Liotta DC,Snyder JP

    更新日期:2008-04-01 00:00:00

  • Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex.

    abstract::Cationic liposomes composed of dialkyl cationic lipid such as 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) can efficiently deliver siRNA to the lungs following the intravenous injection of cationic liposome/siRNA complexes (lipoplexes). In this study, we examined the effect of cationic lipid of cationic liposomes ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Hattori Y,Nakamura M,Takeuchi N,Tamaki K,Shimizu S,Yoshiike Y,Taguchi M,Ohno H,Ozaki KI,Onishi H

    更新日期:2019-02-01 00:00:00

  • Human serum albumin as a probe for surface conditioning--a study of the ageing effect.

    abstract::I125 radiolabelled HSA (HSA-I125) was utilised as a probe to quantify protein adsorption onto polystyrene (PS) and Poloxamine 908 coated PS (PS-908) particles. Upon ageing of the HSA-I125 a dramatic increase in the amount of protein adsorbed onto the two particle systems was observed. This phenomenon was not due to la...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Armstrong TI,Illum L

    更新日期:1997-01-01 00:00:00

  • Comparison of process parameters for microencapsulation of plasmid DNA in poly(D,L-lactic-co-glycolic) acid microspheres.

    abstract::Poly(D,L-lactic-co-glycolic) acid (PLGA) microspheres containing plasmid DNA encoding the firefly luciferase gene were prepared using the water-in-oil-in-water (w/o/w) double emulsion and solvent evaporation method. In this study, we investigated the effects of three process parameters on DNA microencapsulation: (1) e...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Hsu YY,Hao T,Hedley ML

    更新日期:1999-12-01 00:00:00

  • Dynamics of microparticles inside lipid vesicles: movement in confined spaces.

    abstract::Microparticles and nanoparticles used in drug delivery frequently depend on their movement in confined spaces such as cells. Liposomes containing small numbers of 1-µm diameter polystyrene particles were used to study the dynamics of their movement within the confined space of the liposome interior. The analysis of th...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Al-Obaidi H,Nasseri B,Florence AT

    更新日期:2010-12-01 00:00:00

  • Ultrasound enhancement of in vitro transfection of plasmid DNA by a cationized gelatin.

    abstract::In vitro transfection efficiency of a plasmid DNA for rat gastric mucosal (RGM)-1 cells was enhanced by ultrasound (US) irradiation. Ethylenediamine was introduced to the carboxyl groups of gelatin to prepare a cationized gelatin as the vector of plasmid DNA encoding luciferase. An electrophoresis experiment revealed ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,收录出版


    authors: Hosseinkhani H,Aoyama T,Ogawa O,Tabata Y

    更新日期:2002-05-01 00:00:00

  • Local drug delivery in the urinary tract: current challenges and opportunities.

    abstract::Drug delivery is an important consideration in disease treatment. There are many opportunities for novel methods and technologies to hold promising roles in overcoming traditional obstacles. Delivery systems functionalised to boast synergistic antimicrobial effects, specific targeting, and enhanced bioavailability all...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Mittal R,Pan DR,Parrish JM,Huang EH,Yang Y,Patel AP,Malhotra AK,Mittal J,Chhibber S,Harjai K

    更新日期:2018-09-01 00:00:00

  • Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.

    abstract::Recent studies have shown that drugs that are normally unable to cross the blood-brain barrier (BBB) following intravenous injection can be transported across this barrier by binding to poly(butyl cyanoacrylate) nanoparticles and coating with polysorbate 80. However, the mechanism of this transport so far was not know...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Kreuter J,Shamenkov D,Petrov V,Ramge P,Cychutek K,Koch-Brandt C,Alyautdin R

    更新日期:2002-06-01 00:00:00

  • Organic anion-transporting polypeptides: a novel approach for cancer therapy.

    abstract::Organic anion-transporting polypeptides (OATPs) encoded by the SLCO genes constitute an important transporter superfamily that mediates transmembrane transport of various clinical drugs and endogenous nutrients. Eleven human OATPs with different transport functions are expressed in various tissues. Bile acids, steroid...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Liu T,Li Q

    更新日期:2014-01-01 00:00:00

  • Effect of applying modes of the polymer microneedle-roller on the permeation of L-ascorbic acid in rats.

    abstract::Despite the advantages of drug delivery through skin, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept known as microneedle was introduced and could be used to pierce effectively to deliver drugs us...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: You SK,Noh YW,Park HH,Han M,Lee SS,Shin SC,Cho CW

    更新日期:2010-01-01 00:00:00

  • Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones.

    abstract::Necrosis avid agents (NAAs) can be used for diagnose of necrosis-related diseases, evaluation of therapeutic responses and targeted therapeutics of tumor. In order to probe into the effects of molecular skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones, four dianthrone com...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Zhang D,Jiang C,Yang S,Gao M,Huang D,Wang X,Shao H,Feng Y,Sun Z,Ni Y,Zhang J,Yin Z

    更新日期:2016-01-01 00:00:00

  • Strategies for hepatic gene correction.

    abstract::Gene augmentation has been the paradigm in the majority of gene therapy protocols but in recent years the potential of repairing the mutated gene in situ by targeted gene correction has become a reality. In fact, targeted gene repair has many advantages over conventional replacement strategies, notably the possibility...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Richardson P,Thoma C,Kren BT,Steer CJ

    更新日期:2002-03-01 00:00:00

  • Insulin micropiles comprising biodegradable polymers for production of a long-term hypoglycemic effect.

    abstract::As a percutaneous sustained-release preparation, insulin micropiles (MPs) were prepared with biodegradable polymers poly(lactic acid) (PLA), poly(ϵ-caprolactone) (PCL) and poly(lactic-co-glycolic acid) (PLGA) as the base. The obtained PLA, PCL, and PLGA MPs of which the insulin:polymer ratio was 1:2 were administered ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Fukushima K,Ito Y,Ishihata M,Sugioka N,Takada K

    更新日期:2011-04-01 00:00:00

  • Celecoxib incorporated chitosan microspheres: in vitro and in vivo evaluation.

    abstract::Recently, considerable interest has been focussed on the use of biodegradable polymers for specialized applications such as controlled release of drug formulations; meanwhile, microsphere drug delivery systems using various kinds of biodegradable polymers have been studied extensively during the past two decades. In t...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Thakkar H,Sharma RK,Mishra AK,Chuttani K,Murthy RS

    更新日期:2004-01-01 00:00:00

  • The anti-tumor effect of folate-targeted liposome microbubbles loaded with oridonin as ultrasound-triggered tumor-targeted therapeutic carrier system.

    abstract::In this study, folate receptor (FR) targeted liposome microbubbles loaded with oridonin (ORI) (F-LMB-ORI), liposome loaded with ORI (L-ORI) and liposome microbubbles loaded with ORI (LMB-ORI) were prepared. In vitro release properties, cellular uptake and cytotoxicity in HepG-2 cells as well as in vivo antitumor effec...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Wang C,Li W,Hu B

    更新日期:2017-01-01 00:00:00

  • Multifunctional radiolabeled nanoparticles: strategies and novel classification of radiopharmaceuticals for cancer treatment.

    abstract::In this review, we emphasize the efforts on the development of radiolabeled nanoparticles (NPs) for cancer treatment, i.e. theranostic tools based on nanotechnology and nuclear medicine. Currently, radionuclide therapy remains to be an important treatment option. The ionizing radiation from radionuclides (not provided...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Enrique MA,Mariana OR,Mirshojaei SF,Ahmadi A

    更新日期:2015-04-01 00:00:00

  • New terpolymers as hydrogels for oral protein delivery application.

    abstract::The purpose of this study is to develop novel intestinal-specific insulin delivery systems with pH-sensitive swelling and drug release properties. The glucose-6-acrylate-1,2,3,4-tetraacetate (GATA) monomer was prepared under mild conditions. Cubane-1,4-dicarboxylic acid linked to two 2-hydroxyethyl methacrylate groups...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Mahkam M

    更新日期:2009-01-01 00:00:00