Application of titanium dioxide (TiO2) nanoparticles in cancer therapies.


:Cancer is one of the most common diseases all over the world; many people suffer from diverse types of cancer. However, currently there is no exact cure or therapy developed for cancer. On the other hand, nanoparticles are defined as microscopic particles that have dimensions less than 100 nm and they are known for their usage in health sciences and medicine, however a few harmful effects on different animal cells. Therefore, researchers began to use nanoparticles for cancer therapies and to develop new methods for much more effective therapies. Nanoparticles in cancer studies are commonly used in photodynamic therapy (PDT) and sonodynamic therapy (SDT) as a sensitising agent, in computed tomography imaging (CT) and radiation therapy as an enhancement agent, in dual-mode image contrast and enhancement therapy as an image contrast agent. Titanium dioxide nanoparticles (TiO2 NPs) are known as commonly used nanoparticles in medical applications and hence in cancer studies. They are used in PDT, SDT and drug delivery systems. As cancer continues to affect people, new therapeutics and therapies will be developed and nanotechnology for this aim will be an important approach for the researchers.


J Drug Target


Çeşmeli S,Biray Avci C




Has Abstract


2019-08-01 00:00:00












  • Factors influencing the nuclear targeting ability of nuclear localization signals.

    abstract::A nuclear localization signal (NLS) is a short amino acid sequence derived from eukaryotic nuclear proteins and viral proteins. Many NLS peptides can efficiently mediate the intranucleus transport of cargo molecules, so they have been widely used for non-viral gene transfer and shown potential ability to improve nucle...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Sun Y,Xian L,Xing H,Yu J,Yang Z,Yang T,Yang L,Ding P

    更新日期:2016-12-01 00:00:00

  • Apparent interaction of dimethyl sulfoxide with cisplatin released from polymer delivery devices injected subcutaneously in dogs.

    abstract::Local tissue toxicity, systemic toxicity and platinum pharmacokinetics were evaluated in 6 normal healthy beagle dogs injected subcutaneously with two formulations of a polylactide biodegradable polymer (Atrigel) system containing cisplatin. Dogs were injected 4 times at 30 day intervals at platinum dosages of 70, 105...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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    更新日期:1998-01-01 00:00:00

  • Oral delivery of pathogens from the intestine to the nervous system.

    abstract::Most therapeutic agents are delivered orally. Consequently, the major classes of therapeutically useful chemicals are partially lipophilic, small molecular weight compounds. They have reasonable permeability coefficient values across cell membranes, including those of intestinal epithelia and vascular endothelia. In c...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Baird AW,Campion DP,O'Brien L,Brayden DJ

    更新日期:2004-02-01 00:00:00

  • Pharmacotherapy in COVID-19 patients: a review of ACE2-raising drugs and their clinical safety.

    abstract::The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs) that are commonly used in patients with hypertension, cardiovascular disease and/or...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Akhtar S,Benter IF,Danjuma MI,Doi SAR,Hasan SS,Habib AM

    更新日期:2020-08-01 00:00:00

  • Sustained-release self-dissolving micropiles for percutaneous absorption of insulin in mice.

    abstract::Microparticles-adsorbed insulin and zinc insulin (PenfilN) were molded to self-dissolving micropiles (SDMPs) with chondroitin sulfate as the base for the percutaneous administration of insulin. Porous silicon dioxide (Sylysia 320, 440 and 730) and porous calcium silicate (FloriteRE) were used as microparticles. As a r...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Ito Y,Hagiwara E,Saeki A,Sugioka N,Takada K

    更新日期:2007-06-01 00:00:00

  • Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route?

    abstract::The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy and is defined to a large part by the many and complex cellular biological and biochemical barriers such that a construct must traverse. It is shown here that model dextrin conjugates are able to pass through...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Powell A,Caterson B,Hughes C,Paul A,James C,Hopkins S,Mansour O,Griffiths P

    更新日期:2017-01-01 00:00:00

  • Characterization of oleanolic acid derivative for colon cancer targeting with positron emission tomography.

    abstract::Oleanolic acid (OA) is a pentacyclic triterpenoid found in various plant species. Triterpenoid compounds have been shown to inhibit tumor proliferation and to induce apoptosis in cancer cells. We synthesized an OA derivative and evaluated its inhibitory effects on cell proliferation in human colon cancer. Radioisotope...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Kim SM,Jeong IH,Yim MS,Chae MK,Kim HN,Kim DK,Kang CM,Choe YS,Lee C,Ryu EK

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  • Transfection by polyethyleneimine-coated microspheres.

    abstract:UNLABELLED:Polyethyleneimine (PEI) can be used as a DNA delivery mechanism in cell culture and in vivo. Cells can be transfected by using surface-bound PEI, as well as by PEI/DNA microparticles. In the present experiments we extended these observations by preparing microspheres with covalently attached PEI. Blends of p...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Manuel WS,Zheng JI,Hornsby PJ

    更新日期:2001-01-01 00:00:00

  • Sensitized liposomes as an antigen delivery system for the stimulation of mucosal immunity.

    abstract::This study was designed to exploit the ability of Peyer's patch M cells to recognize antigen-antibody complexes in the targeted delivery of a model antigen for the induction of mucosal immunity. Sensitized liposomes consisted of an entrapped model antigen, ovalbumin (OVA), and coated with unrelated antigen-antibody co...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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  • Reduction of doxorubicin resistance in P-glycoprotein overexpressing cells by hybrid cell-penetrating and drug-binding peptide.

    abstract::Drug efflux by the membrane transporter P-glycoprotein (P-gp) plays a key role in multidrug resistance (MDR). In order to bypass P-gp, thus overcoming MDR, a hybrid peptide comprising a cell penetrating peptide (Tat) and a drug binding motif (DBM) has been developed to noncovalently bind and deliver doxorubicin (Dox) ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Zheng Z,Aojula H,Clarke D

    更新日期:2010-07-01 00:00:00

  • Local drug delivery in the urinary tract: current challenges and opportunities.

    abstract::Drug delivery is an important consideration in disease treatment. There are many opportunities for novel methods and technologies to hold promising roles in overcoming traditional obstacles. Delivery systems functionalised to boast synergistic antimicrobial effects, specific targeting, and enhanced bioavailability all...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


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  • The human Nox4: gene, structure, physiological function and pathological significance.

    abstract::Increased generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a variety of diseases such as cardiovascular diseases and cancer. NADPH oxidase (Nox), a multicomponent enzyme, has been identified as one of the key sources of ROS. Nox4, one of the seven members of Nox family (Nox1, Nox2...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Guo S,Chen X

    更新日期:2015-12-01 00:00:00

  • Nanocapsules embedded in microparticles for enhanced oral bioavailability and efficacy of Lopinavir as an anti-AIDS drug.

    abstract::Lopinavir (LPV), an efficient drug for HIV infection treatment, was incorporated into biodegradable PLGA nanocapsules (NCs) embedded in microparticles (MCPs) using the spray-drying technique in an attempt to bypass the P-gp efflux and protect the drug from CYP3A pre-systemic metabolism without ritonavir (RTV). SEM obs...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Nassar T,Rohald A,Naraykin N,Barasch D,Amsalem O,Prabhu P,Kotler M,Benita S

    更新日期:2019-01-01 00:00:00

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    abstract::The nerve growth factor (NGF) is essential for the survival of both peripheral ganglion cells and central cholinergic neurons in the basal forebrain. The accelerated loss of central cholinergic neurons during Alzheimer's disease may be a determinant cause of dementia, and this observation may suggest a possible therap...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Kurakhmaeva KB,Djindjikhashvili IA,Petrov VE,Balabanyan VU,Voronina TA,Trofimov SS,Kreuter J,Gelperina S,Begley D,Alyautdin RN

    更新日期:2009-09-01 00:00:00

  • Potentiation of pro-inflammatory cytokine suppression and survival by microencapsulated dexamethasone in the treatment of experimental sepsis.

    abstract::Cytokine inhibiting drugs are much more effective when delivered intracellularly to phagocytic cells in the microencapsulated form. Dexamethasone is a powerful inhibitor of TNF-α cytokine through inhibition of NF-κB which is a gene regulator of multiple pro-inflammatory cytokines. We have determined the effect of micr...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Uddin MN,Siddiq A,Oettinger CW,D'Souza MJ

    更新日期:2011-11-01 00:00:00

  • Recent advances in metal nanoparticles in cancer therapy.

    abstract::Metal nanoparticles (NPs) may have the potential to overcome problems related to conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in cancer therapy providing better targeting, gene silencing and drug delivery. Functionalised metal NPs with targeting ligands offer a better control of...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Sharma A,Goyal AK,Rath G

    更新日期:2018-09-01 00:00:00

  • Interactions of PC/Chol and PS/Chol liposomes with human cells in vitro.

    abstract::Interactions between phosphatidylcholine (PC) or phosphatidylserine (PS) liposomes and human umbilical vein endothelial cells (HUVEC) or human promyelocytic leukemia cells (HL60) were investigated. Pyramine encapsulating or rhodamine incorporating small unilamellar liposomes with mean diameters around 80 nm (demonstra...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Papadimitriou E,Antimisiaris SG

    更新日期:2000-01-01 00:00:00

  • Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices.

    abstract::This study assesses a protective effect of a mitochondria-targeted antioxidant SkQT1 (a mixture of 10-(6'-toluquinonyl) decyltriphenylphosphonium and 10-(5'-toluquinonyl) decyltriphenylphosphonium in proportion of 1.4:1), using an open focal trauma model of the rat brain sensorimotor cortex and a model of amyloid-beta...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Genrikhs EE,Stelmashook EV,Popova OV,Kapay NA,Korshunova GA,Sumbatyan NV,Skrebitsky VG,Skulachev VP,Isaev NK

    更新日期:2015-05-01 00:00:00

  • siRNA: an alternative treatment for diabetes and associated conditions.

    abstract::Diabetes is a condition that is not completely treatable but life of a diabetic patient can be smoothed by preventing or delaying the associate conditions like diabetic retinopathy, nephropathy, impaired wound healing process, etc. Apart from conventional methods to regulate diabetic condition, new techniques using si...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Shende P,Patel C

    更新日期:2019-02-01 00:00:00

  • The application of polysaccharide-based nanogels in peptides/proteins and anticancer drugs delivery.

    abstract::Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels have attracted interest as carriers for proteins/peptides and anticancer drugs ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Zhang L,Pan J,Dong S,Li Z

    更新日期:2017-09-01 00:00:00

  • Using salivary glands as a tissue target for gene therapeutics.

    abstract::Gene transfer offers a potential way to correct local and systemic protein deficiency disorders by using genes as drugs, so called gene therapeutics. Salivary glands present an interesting target site for gene therapeutic applications. Herein, we review proofs of concept achieved for salivary glands with in vivo anima...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Hoque AT,Yamano S,Baccaglini L,Baum BJ

    更新日期:2001-01-01 00:00:00

  • Entrapment of cyclodextrin-drug complexes into liposomes: potential advantages in drug delivery.

    abstract::A novel concept in drug delivery discussed here, takes advantage of certain properties of the drug "containers" cyclodextrins and liposomes to combine them into a single system thus circumventing problems associated with both systems. The concept, entailing entrapment of water-soluble cyclodextrin-drug inclusion compl...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: McCormack B,Gregoriadis G

    更新日期:1994-01-01 00:00:00

  • A sustained release dosage form of acyclovir for buccal application: an experimental study in dogs.

    abstract::Acyclovir is an antiviral agent and it has been particularly used for the treatment of herpes simplex infections. The treatment of infection in the oral cavity is often difficult, because of insufficient drug concentration in saliva when acyclovir is administered via the oral route in conventional tablet form for syst...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Değim T,Eğlen B,Ocak O

    更新日期:2006-01-01 00:00:00

  • The targeting effect of Hm2E8b-NCTD-liposomes on B-lineage leukaemia stem cells is associated with the HLF-SLUG axis.

    abstract::To identify an agent with specific activity against B-lineage leukaemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanised anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-liposomes). These liposomes were specially designed to recognise and kill B-LSC...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Zhang J,Shen D,Jia M,Zhao H,Tang Y

    更新日期:2018-01-01 00:00:00

  • Polymersomes as an effective drug delivery system for glioma--a review.

    abstract::Glioma is one of the most commonly occurring malignant brain tumours which need proper treatment strategy. The current therapies for treating glioma like surgical resection, radiotherapy, and chemotherapy have failed in achieving satisfactory results and this forms a rationale for the development of novel drug deliver...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Krishnamoorthy B,Karanam V,Chellan VR,Siram K,Natarajan TS,Gregory M

    更新日期:2014-07-01 00:00:00

  • Effect of applying modes of the polymer microneedle-roller on the permeation of L-ascorbic acid in rats.

    abstract::Despite the advantages of drug delivery through skin, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept known as microneedle was introduced and could be used to pierce effectively to deliver drugs us...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: You SK,Noh YW,Park HH,Han M,Lee SS,Shin SC,Cho CW

    更新日期:2010-01-01 00:00:00

  • Organic anion-transporting polypeptides: a novel approach for cancer therapy.

    abstract::Organic anion-transporting polypeptides (OATPs) encoded by the SLCO genes constitute an important transporter superfamily that mediates transmembrane transport of various clinical drugs and endogenous nutrients. Eleven human OATPs with different transport functions are expressed in various tissues. Bile acids, steroid...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Liu T,Li Q

    更新日期:2014-01-01 00:00:00

  • Chloramphenicol-incorporated poly lactide-co-glycolide (PLGA) nanoparticles: formulation, characterization, technetium-99m labeling and biodistribution studies.

    abstract::Chloramphenicol-loaded (CHL) poly-d,l-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) were prepared by emulsification solvent evaporation technique either by using polyvinyl alcohol (PVA) as emulsion stabilizer or polysorbate-80 (PS-80) as surfactant and characterised by transmission electron microscopy, zeta-poten...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Halder KK,Mandal B,Debnath MC,Bera H,Ghosh LK,Gupta BK

    更新日期:2008-05-01 00:00:00

  • Topical delivery of TRPsiRNA-loaded solid lipid nanoparticles confer reduced pain sensation via TRPV1 silencing, in rats.

    abstract::Present work describes a novel composition for encapsulating TRPsiRNA (TRPV1-targeting siRNA) within lipid-matrix (4:1::glyceryl behnate:stearic acid) of SLNs, using suitably modified cold high-pressure homogenisation technique. Optimisation of the method and composition conducted using calf-thymus DNA (ctDNA), to avo...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Sharma G,Chopra K,Puri S,Bishnoi M,Rishi P,Kaur IP

    更新日期:2018-02-01 00:00:00