Abstract:
:The myriad of complications associated with diabetes is closely linked with the generation of reactive species or free radicals leading to oxidative and nitrosative stress. Increased oxidative stress is an important cause and result of diabetes and it is thought to underlie the cellular changes that lead to diabetic complications. The whole cause and effect form a vicious circle, underlying many layers of potential therapeutics in its research. In this regards, this review outlines the briefs about the correlation of type 2 diabetes and oxidative (or nitrosative) stress and also compiles the potentiality of various antioxidants that are being or can be used for alleviating the oxidative stress. Since the complications are like a knit matrix of numerous deteriorating mechanisms, a single antioxidant therapeutic approach cannot be an answer. Therefore, it is important to develop new fixed-dose combinations of effective antioxidants that target key reactive oxygen (or nitrogen)-producing sources, mimic endogenous antioxidants and scavenge the reactive species generated balancing the pro and antioxidant cycle. This review focuses on the preclinical and clinical trial data with therapeutic antioxidants in type 2 diabetes along with a brief focus on success and failures of antioxidant-based therapy.
journal_name
J Drug Targetjournal_title
Journal of drug targetingauthors
Thakur P,Kumar A,Kumar Adoi
10.1080/1061186X.2017.1419478subject
Has Abstractpub_date
2018-11-01 00:00:00pages
766-776issue
9eissn
1061-186Xissn
1029-2330journal_volume
26pub_type
杂志文章,评审abstract:INTRODUCTION:Peptide antibiotics as new therapeutic agents are becoming a popular option to investigate due to their broad bacterial target selectivity and limited resistance problems. Although attractive, these new drug candidates have several limitations including low potency and delivery issues which face all peptid...
journal_title:Journal of drug targeting
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doi:10.1080/10611860600907767
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abstract::Based on the organotropic characteristics of bile acids towards the liver and the intestine, two novel compounds of the Bamet family, containing at least one bile acid moiety bound to platinum(II), have been synthesized and their cytostatic effect compared to their ability to become accumulated in tumor cells of hepat...
journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
pub_type: 杂志文章
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journal_title:Journal of drug targeting
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doi:10.3109/1061186X.2015.1077851
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journal_title:Journal of drug targeting
pub_type: 杂志文章
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journal_title:Journal of drug targeting
pub_type: 杂志文章,评审
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journal_title:Journal of drug targeting
pub_type: 杂志文章
doi:10.3109/1061186X.2015.1018910
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journal_title:Journal of drug targeting
pub_type: 杂志文章
doi:10.1080/10611860701453653
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journal_title:Journal of drug targeting
pub_type: 杂志文章
doi:10.3109/1061186X.2012.660162
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journal_title:Journal of drug targeting
pub_type: 杂志文章
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journal_title:Journal of drug targeting
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
abstract::A simple method for the separation of polyalkylcyanoacrylate nanoparticles was developed using polyisohexylcyanoacrylate (PIHCA) as a model. Fluorescein isothiocyanate dextran 70 was used to label the nanoparticles. Ultracentrifugation onto a performed sucrose gradient allowed the easy elimination of the dextran and o...
journal_title:Journal of drug targeting
pub_type: 杂志文章
doi:10.3109/10611869509059216
更新日期:1995-01-01 00:00:00
abstract::Present work describes a novel composition for encapsulating TRPsiRNA (TRPV1-targeting siRNA) within lipid-matrix (4:1::glyceryl behnate:stearic acid) of SLNs, using suitably modified cold high-pressure homogenisation technique. Optimisation of the method and composition conducted using calf-thymus DNA (ctDNA), to avo...
journal_title:Journal of drug targeting
pub_type: 杂志文章
doi:10.1080/1061186X.2017.1350857
更新日期:2018-02-01 00:00:00
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journal_title:Journal of drug targeting
pub_type: 杂志文章,评审
doi:10.1080/10611860600968967
更新日期:2007-01-01 00:00:00
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journal_title:Journal of drug targeting
pub_type: 杂志文章
doi:10.1080/1061186X.2019.1571066
更新日期:2019-11-01 00:00:00
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journal_title:Journal of drug targeting
pub_type: 杂志文章
doi:10.3109/1061186X.2016.1144059
更新日期:2016-09-01 00:00:00
abstract::A polymeric gene carrier was developed to deliver vascular endothelial growth factor (VEGF) small interfering RNA (siRNA) for prostate cancer cells in a target-specific manner. Prostate cancer-binding peptide (PCP) was conjugated with polyethylenimine (PEI) via a poly(ethylene glycol) (PEG) linker (PEI-PEG-PCP). The P...
journal_title:Journal of drug targeting
pub_type: 杂志文章
doi:10.1080/10611860902767232
更新日期:2009-05-01 00:00:00
abstract::We hypothesized that immunoliposomes (ILs) constructed using Fab' from the humanized anti-EGFR monoclonal antibody, EMD72000, can provide efficient intracellular drug delivery in EGFR-overexpressing colorectal tumor cells.ILs were constructed modularly with various MAb fragments, including Fab' from EMD72000 (matuzuma...
journal_title:Journal of drug targeting
pub_type: 杂志文章
doi:10.1080/10611860600691049
更新日期:2006-05-01 00:00:00
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journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
pub_type: 杂志文章,评审
doi:10.3109/10611869408996811
更新日期:1994-01-01 00:00:00
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journal_title:Journal of drug targeting
pub_type: 杂志文章,评审
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journal_title:Journal of drug targeting
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更新日期:2007-08-01 00:00:00
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journal_title:Journal of drug targeting
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更新日期:2017-07-01 00:00:00
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journal_title:Journal of drug targeting
pub_type: 杂志文章
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journal_title:Journal of drug targeting
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abstract::The purpose of this research is to develop ligand-targeted plasmid based gene delivery systems for gene transfer to tumor endothelium. Cell adhesion assays were used to test the peptide inhibition of human endothelial cell adsorption to vitronectin-treated tissue culture plates. A series of RGD containing peptides wer...
journal_title:Journal of drug targeting
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abstract::Toxoplasmic encephalitis (TE) is the most common clinical manifestation of reactivated infection with Toxoplasma gondii in immunocompromised patients that is lethal if untreated. The combination of pyrimethamine plus sulfadiazine or clindamycin is the standard therapy for the treatment of TE, but these combinations ar...
journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Journal of drug targeting
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