Abstract:
:The biodistribution of orally and intravenously administered archaeosomes in mice was compared to that of archaeosomes containing either coenzyme Q10 (archaeosome-CoQ10), polyethylene glycol (archaeosome-PEG), or PEG plus CoQ10 (archaeosome-PEG-CoQ10). The archaeosome formulations were prepared by a reverse-phase evaporation method using the total polar lipids from the archaeobacterium Methanosarcina mazei. In the case of oral gavage, the most striking observation was that a significantly (p < 0.05) higher concentration (42.28+/-4.17%) of administered dose was found in the stomach content 3 h after administration of unmodified archaeosomes, as compared to that of archaeosome-CoQ10 (16.98+/-2.48%) and archaeosome-PEG-CoQ10 (5.8 +/-4.05"/ vesicles. This correlated with an increased uptake, notably of the archaeosome-PEG-CoQ 0 vesicles.,into liver and spleen; however, no more than 7% of the administered dose was found in liver, spleen and blood at any time point studied. In the case of intravenous administration, a significantly higher percentage of injected dose of unmodified archaeosomes was found in the liver (66.4 +/-.92%) and spleen (11.445+/-.68%) at 48 h, compared to archaeosome-CoQ10, archaeosome-PEG, and archaeosome-PEG-CoQ10 vesicles. The combination of PEG and CoQ10 significantly prolonged the circulation of archaeosomes in the blood, but after 48 h the amount of the vesicle marker in blood had declined to only about 0.5% of administered dose. These data indicate that the biodistribution of archaeosome formulations given orally or intravenously can be altered significantly by incorporating PEG or CoQ 10, alone or in combination, and these vesicles have the potential to act as a carrier for therapeutics and vaccines.
journal_name
J Drug Targetjournal_title
Journal of drug targetingauthors
Omri A,Makabi-Panzu B,Agnew BJ,Sprott GD,Patel GBdoi
10.3109/10611869909085521keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
383-92issue
5eissn
1061-186Xissn
1029-2330journal_volume
7pub_type
杂志文章abstract::A general mathematical model involving partition coefficient, molecular weight and hydrogen bonding is used to correlate the structures and permeability of various organic compounds through the toad urinary bladder and human red blood cell (RBC) membranes. Log Per (permeability) is correlated with log Po/w (partition ...
journal_title:Journal of drug targeting
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doi:10.3109/10611869609046268
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journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
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abstract::Nanoparticles have shown great promise in the treatment of cancer, with a demonstrated potential in targeted drug delivery. Among a myriad of nanocarriers that have been recently developed, dendrimers have attracted a great deal of scientific interests due to their unique chemical and structural properties that allow ...
journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
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doi:10.3109/10611869708995854
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journal_title:Journal of drug targeting
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doi:10.1080/1061186021000038373
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abstract::Cancer is one of the most common diseases all over the world; many people suffer from diverse types of cancer. However, currently there is no exact cure or therapy developed for cancer. On the other hand, nanoparticles are defined as microscopic particles that have dimensions less than 100 nm and they are known for th...
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journal_title:Journal of drug targeting
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journal_title:Journal of drug targeting
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doi:10.3109/1061186X.2012.712128
更新日期:2012-09-01 00:00:00
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journal_title:Journal of drug targeting
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doi:10.3109/10611869908996839
更新日期:1999-01-01 00:00:00
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journal_title:Journal of drug targeting
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doi:10.3109/10611869609015975
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journal_title:Journal of drug targeting
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doi:10.1080/10611860701195510
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journal_title:Journal of drug targeting
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doi:10.1080/10611860310001647771
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