QSAR analysis of membrane permeability to organic compounds.

abstract：:The effects of concentration, amperage and duration on the antidiuretic response induced by iontophoretic delivery of desmopressin acetate (DDAVP) were examined using a diabetes insipidus model in rats. A higher current density brought about a larger and longer antidiuretic response. Prolonged iontophoretic duration c...

journal_title：Journal of drug targeting

authors： Nakakura M,Terajima M,Kato Y,Hayakawa E,Ito K,Kuroda T

更新日期：1995-01-01 00:00:00

abstract：:Cytokine inhibiting drugs are much more effective when delivered intracellularly to phagocytic cells in the microencapsulated form. Dexamethasone is a powerful inhibitor of TNF-α cytokine through inhibition of NF-κB which is a gene regulator of multiple pro-inflammatory cytokines. We have determined the effect of micr...

journal_title：Journal of drug targeting

authors： Uddin MN,Siddiq A,Oettinger CW,D'Souza MJ

更新日期：2011-11-01 00:00:00

abstract：:Tissue factor (TF) is aberrantly expressed on tumor vascular endothelial cells (VECs) and on cancer cells in many malignant tumors, but not on normal VECs, making it a promising target for cancer therapy. As a transmembrane receptor for coagulation factor VIIa (fVIIa), TF forms a high-affinity complex with its cognate...

journal_title：Journal of drug targeting

authors： Shoji M,Sun A,Kisiel W,Lu YJ,Shim H,McCarey BE,Nichols C,Parker ET,Pohl J,Mosley CA,Alizadeh AR,Liotta DC,Snyder JP

更新日期：2008-04-01 00:00:00

abstract：:Considering limitations of conventional insulin therapies, the present study characterizes usefulness of novel mucoadhesive multivesicular liposomes as a mucoadhesive sustained release carrier of insulin via nasal and ocular routes, thus attempts to develop non-invasive carrier system for the controlled release of bio...

journal_title：Journal of drug targeting

authors： Jain AK,Chalasani KB,Khar RK,Ahmed FJ,Diwan PV

更新日期：2007-07-01 00:00:00

abstract：:Nanoparticles have shown great promise in the treatment of cancer, with a demonstrated potential in targeted drug delivery. Among a myriad of nanocarriers that have been recently developed, dendrimers have attracted a great deal of scientific interests due to their unique chemical and structural properties that allow ...

journal_title：Journal of drug targeting

authors： Bugno J,Hsu HJ,Hong S

更新日期：2015-01-01 00:00:00

abstract：:The use of liposomes in the treatment of severe infections is under investigation. Classical liposomes which localize in cells of the mononuclear phagocyte system (MPS) can be exploited in two ways. First for targeting of macrophage modulators such as muramyl peptides or IFN-gamma, to stimulate the cells of the MPS to...

journal_title：Journal of drug targeting

authors： Bakker-Woudenberg IA,Storm G,Woodle MC

更新日期：1994-01-01 00:00:00

abstract：:Pathophysiological molecules in the extracellular environment offer excellent targets that can be exploited for designing drug targeting systems. Matrix metalloproteases (MMPs) are a family of extracellular proteolytic enzymes that are characterized by their overexpression or overactivity in several pathologies. Over ...

journal_title：Journal of drug targeting

authors： Vartak DG,Gemeinhart RA

更新日期：2007-01-01 00:00:00

abstract：:Present work describes a novel composition for encapsulating TRPsiRNA (TRPV1-targeting siRNA) within lipid-matrix (4:1::glyceryl behnate:stearic acid) of SLNs, using suitably modified cold high-pressure homogenisation technique. Optimisation of the method and composition conducted using calf-thymus DNA (ctDNA), to avo...

journal_title：Journal of drug targeting

authors： Sharma G,Chopra K,Puri S,Bishnoi M,Rishi P,Kaur IP

更新日期：2018-02-01 00:00:00

abstract：:An aqueous dispersion of self-organized phospholipid tubules has been utilized as the template for silica-deposited nanotubules (approximately 0.5 microm thick and >10 microm long) by a sol-gel method. The formation of the hybrid tubules was mechanistically investigated by controlled sol-gel reaction. The incorporatio...

journal_title：Journal of drug targeting

authors： Kim I,Park YH,Rey DA,Batt CA

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:The objective of this work was to examine the application of catechins-containing phospholipids-based ultrasonic microbubbles (PUM) in ultrasound-induced delivery. METHODS:Catechins-containing PUM were prepared by dissolving lyophilized PUM powder in catechins solution. Morphologic characteristics of catechi...

journal_title：Journal of drug targeting

authors： Lu CT,Zhao YZ

更新日期：2008-12-01 00:00:00

abstract：:The purpose of this research is to develop ligand-targeted plasmid based gene delivery systems for gene transfer to tumor endothelium. Cell adhesion assays were used to test the peptide inhibition of human endothelial cell adsorption to vitronectin-treated tissue culture plates. A series of RGD containing peptides wer...

journal_title：Journal of drug targeting

authors： Anwer K,Kao G,Rolland A,Driessen WH,Sullivan SM

更新日期：2004-05-01 00:00:00

abstract：:The transport of 125I-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings. Translocation of the particles into the blood stream was examined by means of monitoring the radiolabel associated with the particles. Particles were detected in the...

journal_title：Journal of drug targeting

authors： Brooking J,Davis SS,Illum L

更新日期：2001-01-01 00:00:00

abstract：:Most therapeutic agents are delivered orally. Consequently, the major classes of therapeutically useful chemicals are partially lipophilic, small molecular weight compounds. They have reasonable permeability coefficient values across cell membranes, including those of intestinal epithelia and vascular endothelia. In c...

journal_title：Journal of drug targeting

authors： Baird AW,Campion DP,O'Brien L,Brayden DJ

更新日期：2004-02-01 00:00:00

abstract：:Polynucleotides are anionic macromolecules which are expected to transfer into the targeted cells through specific uptake mechanisms. So, we developed polynucleotides coating complexes of plasmid DNA (pDNA) and polyethylenimine (PEI) for a secure and efficient gene delivery system and evaluated their usefulness. Polya...

journal_title：Journal of drug targeting

authors： Kodama Y,Ohkubo C,Kurosaki T,Egashira K,Sato K,Fumoto S,Nishida K,Higuchi N,Kitahara T,Nakamura T,Sasaki H

更新日期：2015-01-01 00:00:00

abstract：:Rabies virus glycoprotein (RVG), a 505 amino acid type-1 glycoprotein, is responsible for the neurotrophic nature of the rabies virus infection. Despite varying reports in the literature as to which receptor is ultimately responsible for interaction of RVG with the nervous system, there is a strong argument for major ...

journal_title：Journal of drug targeting

authors： Huey R,Hawthorne S,McCarron P

更新日期：2017-06-01 00:00:00

abstract：:Recent studies have demonstrated that the carboxyterminal third domain of alpha-fetoprotein (AFP-CD) binds with various ligands and receptors. Reports within the last decade have established that AFP-CD contains a large fragment of amino acids that interact with several different receptor types. Using computer softwar...

journal_title：Journal of drug targeting

authors： Mizejewski GJ

更新日期：2015-01-01 00:00:00

abstract：:Light-induced drug release has been explored as a strategy for externally modulating the release of drug from delivery systems. This study reports the development of a solid lipid nanoparticulate system (SLN) for paclitaxel (PTX), where photosensitizer-mediated oxidation of lipids was used as a mechanism for controlli...

journal_title：Journal of drug targeting

authors： Meerovich I,Nichols MG,Dash AK

更新日期：2019-11-01 00:00:00

abstract：:Radiolabelled poly(methylmethacrylate) (PMMA) nanoparticles were coated with rat serum albumin (RSA), serum and inactivated serum, to examine the influence of these blood components on the body distribution of a model colloidal drug carrier. The particles were incubated overnight at 37 degrees C either in a 1% solutio...

journal_title：Journal of drug targeting

authors： Borchard G,Kreuter J

更新日期：1993-01-01 00:00:00

abstract：:Liposomes have been prepared from dipalmitoylphosphatidylcholine (DPPC), cholesterol (Chol) and dimethyldioctadecylammonium bromide (DDAB). The cationic vesicles adsorb to biofilms of the skin-associated bacteria Staphylococcus epidermidis, which have a negative charge. Encapsulation of the antibacterial drug vancomyc...

journal_title：Journal of drug targeting

authors： Sanderson NM,Jones MN

更新日期：1996-01-01 00:00:00

abstract：:To identify an agent with specific activity against B-lineage leukaemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanised anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-liposomes). These liposomes were specially designed to recognise and kill B-LSC...

journal_title：Journal of drug targeting

authors： Zhang J,Shen D,Jia M,Zhao H,Tang Y

更新日期：2018-01-01 00:00:00

abstract：:A higher encapsulation rate was obtained using the dehydration-rehydration method compared with the reverse-phase evaporation technique in negative multilamellar vesicles with amikacin (AMK) (45% versus 15%; P < 0.05) and teicoplanin (TCP) (34% versus 25%; P < 0.05). The addition of 250 mM sucrose to AMK- or TCP-conta...

journal_title：Journal of drug targeting

authors： Ravaoarinoro M,Toma E,Agbaba O,Morisset R

更新日期：1993-01-01 00:00:00

abstract：:The myriad of complications associated with diabetes is closely linked with the generation of reactive species or free radicals leading to oxidative and nitrosative stress. Increased oxidative stress is an important cause and result of diabetes and it is thought to underlie the cellular changes that lead to diabetic c...

journal_title：Journal of drug targeting

authors： Thakur P,Kumar A,Kumar A

更新日期：2018-11-01 00:00:00

abstract：:Submicron sized hydrophobic and hydrophilic albumin microspheres (MS) were prepared using a chemical crosslinking technique. Spermine was linked to the surface of the hydrophilic MS. The degree of hydrophobicity for these three types of MS was investigated using a novel technique of sedimentation volume. The surface t...

journal_title：Journal of drug targeting

authors： Shafi ZB,Martin GP,Olliff CJ,James SL

更新日期：1995-01-01 00:00:00

abstract：:An oral vaccine formulation comprised of starch microparticles with conjugated antigens is being developed. In this report we have examined the uptake of such microparticles by the intestinal mucosa and examined whether the conjugated antigen can influence the uptake. Two model antigens were used: recombinant cholera ...

journal_title：Journal of drug targeting

authors： Larhed A,Stertman L,Edvardsson E,Sjöholm I

更新日期：2004-06-01 00:00:00

abstract：:Nanostructured lipid carrier (NLC) is second generation smarter drug carrier system having solid matrix at room temperature. This carrier system is made up of physiological, biodegradable and biocompatible lipid materials and surfactants and is accepted by regulatory authorities for application in different drug deliv...

journal_title：Journal of drug targeting

authors： Iqbal MA,Md S,Sahni JK,Baboota S,Dang S,Ali J

更新日期：2012-12-01 00:00:00

abstract：:The purpose of this study is to develop novel intestinal-specific insulin delivery systems with pH-sensitive swelling and drug release properties. The glucose-6-acrylate-1,2,3,4-tetraacetate (GATA) monomer was prepared under mild conditions. Cubane-1,4-dicarboxylic acid linked to two 2-hydroxyethyl methacrylate groups...

journal_title：Journal of drug targeting

authors： Mahkam M

更新日期：2009-01-01 00:00:00

abstract：:I125 radiolabelled HSA (HSA-I125) was utilised as a probe to quantify protein adsorption onto polystyrene (PS) and Poloxamine 908 coated PS (PS-908) particles. Upon ageing of the HSA-I125 a dramatic increase in the amount of protein adsorbed onto the two particle systems was observed. This phenomenon was not due to la...

journal_title：Journal of drug targeting

authors： Armstrong TI,Illum L

更新日期：1997-01-01 00:00:00

abstract：:The ultimate goal of bacterial based cancer therapy is to achieve non-toxic penetration and colonisation of the tumour microenvironment. To overcome this efficacy-limiting toxicity of anticancer immunotherapy, we have tested a therapy comprised of systemic delivery of a vascular disrupting agent to induce intratumoral...

journal_title：Journal of drug targeting

authors： Augustin LB,Milbauer L,Hastings SE,Leonard AS,Saltzman DA,Schottel JL

更新日期：2020-12-21 00:00:00

abstract：:A new drug-targeting system for CD13(+) tumors has been developed, based on ultrasound-sensitive nanobubbles (NBs) and cell-permeable peptides (CPPs). Here, the CPP-doxorubicin conjugate (CPP-DOX) was entrapped in the asparagine-glycine-arginine (NGR) peptide modified NB (CPP-DOX/NGR-NB) and the penetration of CPP-DOX...

journal_title：Journal of drug targeting

authors： Lin W,Xie X,Deng J,Liu H,Chen Y,Fu X,Liu H,Yang Y

更新日期：2016-01-01 00:00:00

abstract：:The adsorption behaviour of a tetrafunctional copolymer of poly (ethylene oxide)-poly (propylene oxide) ethylene diamine (commercially available as Poloxamine 908) and a diblock copolymer of poly (lactic acid)-poly (ethylene oxide) (PLA/PEG 2:5) onto a model colloidal drug carrier (156 nm sized polystyrene latex) is d...

journal_title：Journal of drug targeting

authors： Stolnik S,Heald CR,Garnett MG,Illum L,Davis SS

更新日期：2005-09-01 00:00:00