Muco-adhesive multivesicular liposomes as an effective carrier for transmucosal insulin delivery.

abstract：:The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs) that are commonly used in patients with hypertension, cardiovascular disease and/or...

journal_title：Journal of drug targeting

authors： Akhtar S,Benter IF,Danjuma MI,Doi SAR,Hasan SS,Habib AM

更新日期：2020-08-01 00:00:00

abstract：:A biophysical model was developed, using Ascaris suum as a model gastrointestinal nematode, to provide quantitative perspectives into the microenvironmental pH within the water-filled, porous, negatively charged cuticle matrix of gastrointestinal nematodes. The central features of the model include (a) the constant ra...

journal_title：Journal of drug targeting

authors： Sims SM,Ho NF,Magas LT,Geary TG,Barsuhn CL,Thompson DP

更新日期：1994-01-01 00:00:00

abstract：:Diabetes is a condition that is not completely treatable but life of a diabetic patient can be smoothed by preventing or delaying the associate conditions like diabetic retinopathy, nephropathy, impaired wound healing process, etc. Apart from conventional methods to regulate diabetic condition, new techniques using si...

journal_title：Journal of drug targeting

authors： Shende P,Patel C

更新日期：2019-02-01 00:00:00

abstract：:Drug efflux by the membrane transporter P-glycoprotein (P-gp) plays a key role in multidrug resistance (MDR). In order to bypass P-gp, thus overcoming MDR, a hybrid peptide comprising a cell penetrating peptide (Tat) and a drug binding motif (DBM) has been developed to noncovalently bind and deliver doxorubicin (Dox) ...

journal_title：Journal of drug targeting

authors： Zheng Z,Aojula H,Clarke D

更新日期：2010-07-01 00:00:00

abstract：:The transport of 125I-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings. Translocation of the particles into the blood stream was examined by means of monitoring the radiolabel associated with the particles. Particles were detected in the...

journal_title：Journal of drug targeting

authors： Brooking J,Davis SS,Illum L

更新日期：2001-01-01 00:00:00

abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers containing doxorubicin and galactosamine have been developed to target the hepatocyte galactose receptor with the aim of organ-specific chemotherapy of primary and metastatic liver disease. Previous biodistribution studies in rats and mice have used tyrosinamide inco...

journal_title：Journal of drug targeting

authors： Pimm MV,Perkins AC,Duncan R,Ulbrich K

更新日期：1993-01-01 00:00:00

abstract：:The present study evaluates the prophylactic efficacy of α-tocopherol (α-TOH), resveratrol (RES), and coenzyme Q10 (CoQ10) co-loaded self-nanoemulsifying drug delivery system (α-TOH-RES-CoQ10 SNEDDS) in 7,12-Dimethylbenz[a]anthracene (DMBA) induced breast cancer model. SNEDDS formulation components were rationally sel...

journal_title：Journal of drug targeting

authors： Jain S,Garg T,Kushwah V,Thanki K,Agrawal AK,Dora CP

更新日期：2017-07-01 00:00:00

abstract：:Gene transfer offers a potential way to correct local and systemic protein deficiency disorders by using genes as drugs, so called gene therapeutics. Salivary glands present an interesting target site for gene therapeutic applications. Herein, we review proofs of concept achieved for salivary glands with in vivo anima...

journal_title：Journal of drug targeting

authors： Hoque AT,Yamano S,Baccaglini L,Baum BJ

更新日期：2001-01-01 00:00:00

abstract：:In this review, we emphasize the efforts on the development of radiolabeled nanoparticles (NPs) for cancer treatment, i.e. theranostic tools based on nanotechnology and nuclear medicine. Currently, radionuclide therapy remains to be an important treatment option. The ionizing radiation from radionuclides (not provided...

journal_title：Journal of drug targeting

authors： Enrique MA,Mariana OR,Mirshojaei SF,Ahmadi A

更新日期：2015-04-01 00:00:00

abstract：:Anionic, cationic, and neutral liposomes were constructed to contain IL-2 in order to evaluate their affinity to a cervical cancer cell line (INBL) and to determine whether they can present IL-2 on their external surface. When these liposomes were co-cultured with INBL, the anionic liposomes were the only ones found t...

journal_title：Journal of drug targeting

authors： Corona-Ortega T,Rangel-Corona R,Hernández-Jiménez M,Baeza I,Ibáñez M,Weiss-Steider B

更新日期：2009-08-01 00:00:00

abstract：:A novel concept in drug delivery discussed here, takes advantage of certain properties of the drug "containers" cyclodextrins and liposomes to combine them into a single system thus circumventing problems associated with both systems. The concept, entailing entrapment of water-soluble cyclodextrin-drug inclusion compl...

journal_title：Journal of drug targeting

authors： McCormack B,Gregoriadis G

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:High expression of glucagon-like peptide-1 receptor (GLP-1R) in insulinoma supplies a potential drug target for tumor imaging. Exendin-4 can specifically bind to GLP-1R as an agonist and its analogs are extensively used in receptor imaging studies. PURPOSE:A new GLP-1R imaging agent, [(18)F]AlF-NOTA-MAL-Cys...

journal_title：Journal of drug targeting

authors： Xu Q,Zhu C,Xu Y,Pan D,Liu P,Yang R,Wang L,Chen F,Sun X,Luo S,Yang M

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The objective of this work was to examine the application of catechins-containing phospholipids-based ultrasonic microbubbles (PUM) in ultrasound-induced delivery. METHODS:Catechins-containing PUM were prepared by dissolving lyophilized PUM powder in catechins solution. Morphologic characteristics of catechi...

journal_title：Journal of drug targeting

authors： Lu CT,Zhao YZ

更新日期：2008-12-01 00:00:00

abstract：:Increased generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a variety of diseases such as cardiovascular diseases and cancer. NADPH oxidase (Nox), a multicomponent enzyme, has been identified as one of the key sources of ROS. Nox4, one of the seven members of Nox family (Nox1, Nox2...

journal_title：Journal of drug targeting

authors： Guo S,Chen X

更新日期：2015-12-01 00:00:00

abstract：:The aim of the present study was to evaluate the transfer of N-acetyl-p-aminobenzoic acid (AcPABA) across the rat term placenta and the rat small intestine and to compare it with that of its parent drug p-aminobenzoic acid (PABA). Umbilical perfusion of the rat term placenta was used to determine the materno-fetal tra...

journal_title：Journal of drug targeting

authors： Staud F,Fendrich Z,Hartl J,Jindrova O,Láznícek M

更新日期：1998-01-01 00:00:00

abstract：:Lopinavir (LPV), an efficient drug for HIV infection treatment, was incorporated into biodegradable PLGA nanocapsules (NCs) embedded in microparticles (MCPs) using the spray-drying technique in an attempt to bypass the P-gp efflux and protect the drug from CYP3A pre-systemic metabolism without ritonavir (RTV). SEM obs...

journal_title：Journal of drug targeting

authors： Nassar T,Rohald A,Naraykin N,Barasch D,Amsalem O,Prabhu P,Kotler M,Benita S

更新日期：2019-01-01 00:00:00

abstract：:Tissue factor (TF) is aberrantly expressed on tumor vascular endothelial cells (VECs) and on cancer cells in many malignant tumors, but not on normal VECs, making it a promising target for cancer therapy. As a transmembrane receptor for coagulation factor VIIa (fVIIa), TF forms a high-affinity complex with its cognate...

journal_title：Journal of drug targeting

authors： Shoji M,Sun A,Kisiel W,Lu YJ,Shim H,McCarey BE,Nichols C,Parker ET,Pohl J,Mosley CA,Alizadeh AR,Liotta DC,Snyder JP

更新日期：2008-04-01 00:00:00

abstract：:We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the twenty-first century. Multiple drug resistance and nonspecific drug targeting of the m...

journal_title：Journal of drug targeting

authors： Baruah UK,Gowthamarajan K,Vanka R,Karri VVSR,Selvaraj K,Jojo GM

更新日期：2017-08-01 00:00:00

abstract：:The nerve growth factor (NGF) is essential for the survival of both peripheral ganglion cells and central cholinergic neurons in the basal forebrain. The accelerated loss of central cholinergic neurons during Alzheimer's disease may be a determinant cause of dementia, and this observation may suggest a possible therap...

journal_title：Journal of drug targeting

authors： Kurakhmaeva KB,Djindjikhashvili IA,Petrov VE,Balabanyan VU,Voronina TA,Trofimov SS,Kreuter J,Gelperina S,Begley D,Alyautdin RN

更新日期：2009-09-01 00:00:00

abstract：:Resveratrol is a promising neuroprotective agent against neurodegenerative disorders such as Alzheimer's disease. Resveratrol-loaded transferosomes and nanoemulsions were developed and labelled with gold nanoparticles (GNPs). The water maze test was utilised to identify the effect on spatial memory recovery. The treat...

journal_title：Journal of drug targeting

authors： Salem HF,Kharshoum RM,Abou-Taleb HA,Naguib DM

更新日期：2019-12-01 00:00:00

abstract：:Background: Sonodynamic therapy (SDT) has emerged as an alternative to the traditional treatments of cancer. However, the oxygen consumption induced by SDT and glucose oxidase (GOx) mediated starvation therapy would worsen the hypoxic tumor environment, which further impeded therapeutic efficacy. Purpose: To develop a...

journal_title：Journal of drug targeting

authors： Zhang Y,Wang H,Jia X,Du S,Yin Y,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:The effects of concentration, amperage and duration on the antidiuretic response induced by iontophoretic delivery of desmopressin acetate (DDAVP) were examined using a diabetes insipidus model in rats. A higher current density brought about a larger and longer antidiuretic response. Prolonged iontophoretic duration c...

journal_title：Journal of drug targeting

authors： Nakakura M,Terajima M,Kato Y,Hayakawa E,Ito K,Kuroda T

更新日期：1995-01-01 00:00:00

abstract：:Gelatin microspheres (ms) and gelatin/BSA (bovine serum albumin) or gelatin/alginate ms were prepared by encapsulating fluorescein isothiocyanate (FITC) labeled dextran or interferon alpha (IFN-alpha). Ms were obtained by an emulsion-solvent-extraction method. Gelatin and gelatin/BSA ms were obtained by treating water...

journal_title：Journal of drug targeting

authors： Yoshikawa Y,Komuta Y,Nishihara T,Itoh Y,Yoshikawa H,Takada K

更新日期：1999-01-01 00:00:00

abstract：:Gene delivery systems face the problem not only of the route toward the cell and tissues in question, but also of the molecularly crowded environment of both the cytoplasm and the nucleus itself. One of the physical barriers in the cytoplasm for diffusing nanoparticles is an actin network. Here, we describe the findin...

journal_title：Journal of drug targeting

authors： Ruenraroengsak P,Florence AT

更新日期：2010-12-01 00:00:00

abstract：:To identify an agent with specific activity against B-lineage leukaemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanised anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-liposomes). These liposomes were specially designed to recognise and kill B-LSC...

journal_title：Journal of drug targeting

authors： Zhang J,Shen D,Jia M,Zhao H,Tang Y

更新日期：2018-01-01 00:00:00

abstract：:An in vivo study has been performed in order to determine the influence of amphotericin B (AMB) molecular organization on the toxicity and activity of this drug in the treatment of experimental visceral leishmaniasis. Three formulations with similar composition but different drug molecular self-association in aqueous ...

journal_title：Journal of drug targeting

authors： Sánchez-Brunete JA,Dea MA,Rama S,Bolás F,Alunda JM,Torrado-Santiago S,Torrado JJ

更新日期：2004-01-01 00:00:00

abstract：:Submicron sized hydrophobic and hydrophilic albumin microspheres (MS) were prepared using a chemical crosslinking technique. Spermine was linked to the surface of the hydrophilic MS. The degree of hydrophobicity for these three types of MS was investigated using a novel technique of sedimentation volume. The surface t...

journal_title：Journal of drug targeting

authors： Shafi ZB,Martin GP,Olliff CJ,James SL

更新日期：1995-01-01 00:00:00

abstract：:Metal nanoparticles (NPs) may have the potential to overcome problems related to conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in cancer therapy providing better targeting, gene silencing and drug delivery. Functionalised metal NPs with targeting ligands offer a better control of...

journal_title：Journal of drug targeting

authors： Sharma A,Goyal AK,Rath G

更新日期：2018-09-01 00:00:00

abstract：:Surface architecture of pharmaceutical nanocarriers (using polymeric micelles as an example) and the length of the spacer group through which specific ligand is attached to the carrier surface determine the interaction of ligand-bearing nanocarrier with cells. We have prepared surface-modified polyethyleneglycol-phosp...

journal_title：Journal of drug targeting

authors： Sawant RR,Sawant RM,Kale AA,Torchilin VP

更新日期：2008-08-01 00:00:00

abstract：:Local treatment of middle ear (ME) disease currently requires surgical penetration of the tympanic membrane (TM). We previously discovered 12-mer peptides that are actively transported across the intact TM, a process that could be used for non-invasive drug delivery into the ME. To optimise transport and provide furth...

journal_title：Journal of drug targeting

authors： Kurabi A,Schaerer D,Chang L,Pak K,Ryan AF

更新日期：2018-02-01 00:00:00