Recent advances in metal nanoparticles in cancer therapy.

abstract：:Cancer is one of the most common diseases all over the world; many people suffer from diverse types of cancer. However, currently there is no exact cure or therapy developed for cancer. On the other hand, nanoparticles are defined as microscopic particles that have dimensions less than 100 nm and they are known for th...

journal_title：Journal of drug targeting

authors： Çeşmeli S,Biray Avci C

更新日期：2019-08-01 00:00:00

abstract：:Intracellular compartmentalisation is a significant barrier to the successful nucleocytosolic delivery of biologics. The endocytic system has been shown to be responsible for compartmentalisation, providing an entry point, and trigger(s) for the activation of drug delivery systems. Consequently, many of the technologi...

journal_title：Journal of drug targeting

authors： Shorter SA,Pettit MW,Dyer PDR,Coakley Youngs E,Gorringe-Pattrick MAM,El-Daher S,Richardson S

更新日期：2017-01-01 00:00:00

abstract：:An oral vaccine formulation comprised of starch microparticles with conjugated antigens is being developed. In this report we have examined the uptake of such microparticles by the intestinal mucosa and examined whether the conjugated antigen can influence the uptake. Two model antigens were used: recombinant cholera ...

journal_title：Journal of drug targeting

authors： Larhed A,Stertman L,Edvardsson E,Sjöholm I

更新日期：2004-06-01 00:00:00

abstract：:Influenza, mainly caused by influenza virus, is becoming one of the major concerns in the world. Limitation in vaccines necessitates the urgent development of new therapeutic options against this virus. In the present study, we designed small interfering RNA (siRNA) targeting overlapping gene of PB1 and PB1-F2 gene of...

journal_title：Journal of drug targeting

authors： Cheng C,Yao L,Chen A,Jia R,Huan L,Guo J,Bo H,Shu Y,Zhang Z

更新日期：2009-02-01 00:00:00

abstract：:Cytokine inhibiting drugs are much more effective when delivered intracellularly to phagocytic cells in the microencapsulated form. Dexamethasone is a powerful inhibitor of TNF-α cytokine through inhibition of NF-κB which is a gene regulator of multiple pro-inflammatory cytokines. We have determined the effect of micr...

journal_title：Journal of drug targeting

authors： Uddin MN,Siddiq A,Oettinger CW,D'Souza MJ

更新日期：2011-11-01 00:00:00

abstract：:To design a novel cytospecific photosensitizer for photodynamic antitumor therapy, a fullerene (C(60)) was chemically modified with pullulan which is a water-soluble polysaccharide with a high affinity for asialoglycoprotein receptors. Ethylene diamine was introduced to the terminal aldehyde groups of pullulan by the ...

journal_title：Journal of drug targeting

authors： Liu J,Tabata Y

更新日期：2010-09-01 00:00:00

abstract：:Interactions between phosphatidylcholine (PC) or phosphatidylserine (PS) liposomes and human umbilical vein endothelial cells (HUVEC) or human promyelocytic leukemia cells (HL60) were investigated. Pyramine encapsulating or rhodamine incorporating small unilamellar liposomes with mean diameters around 80 nm (demonstra...

journal_title：Journal of drug targeting

authors： Papadimitriou E,Antimisiaris SG

更新日期：2000-01-01 00:00:00

abstract：:A novel concept in drug delivery discussed here, takes advantage of certain properties of the drug "containers" cyclodextrins and liposomes to combine them into a single system thus circumventing problems associated with both systems. The concept, entailing entrapment of water-soluble cyclodextrin-drug inclusion compl...

journal_title：Journal of drug targeting

authors： McCormack B,Gregoriadis G

更新日期：1994-01-01 00:00:00

abstract：:Recently, considerable interest has been focussed on the use of biodegradable polymers for specialized applications such as controlled release of drug formulations; meanwhile, microsphere drug delivery systems using various kinds of biodegradable polymers have been studied extensively during the past two decades. In t...

journal_title：Journal of drug targeting

authors： Thakkar H,Sharma RK,Mishra AK,Chuttani K,Murthy RS

更新日期：2004-01-01 00:00:00

abstract：:Therapeutic peptides are conventionally administered via subcutaneous injection. Chitosan-based nanoparticles are gaining increased attention for their ability to serve as a carrier for oral delivery of peptides and vaccination. They offered superior biocompatibiltiy, controlled drug release profile and facilitated ga...

journal_title：Journal of drug targeting

authors： Wong CY,Al-Salami H,Dass CR

更新日期：2018-08-01 00:00:00

abstract：:The objective of this study was to estimate the colon-specific delivery of [Asu1,7]-eel calcitonin (ECT) using chitosan capsules in rats. The intestinal absorption of ECT was evaluated by measuring the plasma calcium levels after oral administration of the chitosan capsules containing ECT and different combinations of...

journal_title：Journal of drug targeting

authors： Fetih G,Fausia H,Okada N,Fujita T,Attia M,Yamamoto A

更新日期：2006-04-01 00:00:00

abstract：:Supramolecules since ages have been characterised as self-associating systems emanating the properties directly related to the mode of molecular association. Similar to supramolecules, liquid crystals may also be considered as an associated system. The liquid crystals are defined as the state of matter with the charac...

journal_title：Journal of drug targeting

authors： Jaitely V,Vyas SP

更新日期：1999-01-01 00:00:00

abstract：:Poly(D,L-lactic-co-glycolic) acid (PLGA) microspheres containing plasmid DNA encoding the firefly luciferase gene were prepared using the water-in-oil-in-water (w/o/w) double emulsion and solvent evaporation method. In this study, we investigated the effects of three process parameters on DNA microencapsulation: (1) e...

journal_title：Journal of drug targeting

authors： Hsu YY,Hao T,Hedley ML

更新日期：1999-12-01 00:00:00

abstract：:The use of liposomes in the treatment of severe infections is under investigation. Classical liposomes which localize in cells of the mononuclear phagocyte system (MPS) can be exploited in two ways. First for targeting of macrophage modulators such as muramyl peptides or IFN-gamma, to stimulate the cells of the MPS to...

journal_title：Journal of drug targeting

authors： Bakker-Woudenberg IA,Storm G,Woodle MC

更新日期：1994-01-01 00:00:00

abstract：:Microparticles and nanoparticles used in drug delivery frequently depend on their movement in confined spaces such as cells. Liposomes containing small numbers of 1-µm diameter polystyrene particles were used to study the dynamics of their movement within the confined space of the liposome interior. The analysis of th...

journal_title：Journal of drug targeting

authors： Al-Obaidi H,Nasseri B,Florence AT

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Growing interest in the application of nanotechnology to treat lymphatic filariasis (LF) implies that the imminent medical arsenal of this interesting technology is attractive for health authorities. Currently, they are completely dependent on friendly oral mass drug (anti-filarials) administration to elim...

journal_title：Journal of drug targeting

authors： Ali M,Afzal M,Kaushik U,Bhattacharya SM,Ahmad FJ,Dinda AK

更新日期：2014-01-01 00:00:00

abstract：:Lopinavir (LPV), an efficient drug for HIV infection treatment, was incorporated into biodegradable PLGA nanocapsules (NCs) embedded in microparticles (MCPs) using the spray-drying technique in an attempt to bypass the P-gp efflux and protect the drug from CYP3A pre-systemic metabolism without ritonavir (RTV). SEM obs...

journal_title：Journal of drug targeting

authors： Nassar T,Rohald A,Naraykin N,Barasch D,Amsalem O,Prabhu P,Kotler M,Benita S

更新日期：2019-01-01 00:00:00

abstract：:The purpose of this study is to develop novel intestinal-specific insulin delivery systems with pH-sensitive swelling and drug release properties. The glucose-6-acrylate-1,2,3,4-tetraacetate (GATA) monomer was prepared under mild conditions. Cubane-1,4-dicarboxylic acid linked to two 2-hydroxyethyl methacrylate groups...

journal_title：Journal of drug targeting

authors： Mahkam M

更新日期：2009-01-01 00:00:00

abstract：:Herein, we report the effect of gold nanoparticles (AuNP) and n-acetylcysteine (NAC) isolated or in association as important anti-inflammatory and antioxidant compounds on brain dysfunction in septic rats. Male Wistar rats after sham operation or caecal ligation and perforation (CLP) were treated with subcutaneously i...

journal_title：Journal of drug targeting

authors： Petronilho F,Tenfen L,Della Giustina A,Joaquim L,Novochadlo M,de Oliveira Junior AN,Bagio E,Goldim MPS,de Carli RJ,Bonfante SRSA,Metzker KLL,Muttini S,Dos Santos TM,de Oliveira MP,Engel NA,Rezin GT,Kanis LA,Barichello T

更新日期：2020-04-01 00:00:00

abstract：:Local tissue toxicity, systemic toxicity and platinum pharmacokinetics were evaluated in 6 normal healthy beagle dogs injected subcutaneously with two formulations of a polylactide biodegradable polymer (Atrigel) system containing cisplatin. Dogs were injected 4 times at 30 day intervals at platinum dosages of 70, 105...

journal_title：Journal of drug targeting

authors： Dernell WS,Straw RC,Withrow SJ,Powers BE,Fujita SM,Yewey GS,Joseph KF,Dunn RL,Whitman SL,Southard GL

更新日期：1998-01-01 00:00:00

abstract：:We have developed a new method to evaluate the transfer of macromolecular drugs to intrapulmonary lymph nodes in rats after intrapulmonary administration. By using this method, we observed that the transfer of fluorescein isothiocyanate dextrans (FDs) to the intrapulmonary lymph nodes was markedly higher than that to ...

journal_title：Journal of drug targeting

authors： Hanatani K,Takada K,Yoshida N,Nakasuji M,Morishita Y,Yasako K,Fujita T,Yamamoto A,Muranishi S

更新日期：1995-01-01 00:00:00

abstract：:Submicron sized hydrophobic and hydrophilic albumin microspheres (MS) were prepared using a chemical crosslinking technique. Spermine was linked to the surface of the hydrophilic MS. The degree of hydrophobicity for these three types of MS was investigated using a novel technique of sedimentation volume. The surface t...

journal_title：Journal of drug targeting

authors： Shafi ZB,Martin GP,Olliff CJ,James SL

更新日期：1995-01-01 00:00:00

abstract：:An aqueous dispersion of self-organized phospholipid tubules has been utilized as the template for silica-deposited nanotubules (approximately 0.5 microm thick and >10 microm long) by a sol-gel method. The formation of the hybrid tubules was mechanistically investigated by controlled sol-gel reaction. The incorporatio...

journal_title：Journal of drug targeting

authors： Kim I,Park YH,Rey DA,Batt CA

更新日期：2008-11-01 00:00:00

abstract：:Gene augmentation has been the paradigm in the majority of gene therapy protocols but in recent years the potential of repairing the mutated gene in situ by targeted gene correction has become a reality. In fact, targeted gene repair has many advantages over conventional replacement strategies, notably the possibility...

journal_title：Journal of drug targeting

authors： Richardson P,Thoma C,Kren BT,Steer CJ

更新日期：2002-03-01 00:00:00

abstract：:Aim was to develop and optimize multiunit gastro-retentive floating beads (FBs) intended for localized and prolonged release of ginger for treating gastric ulcers. Protective effect of ginger extract (GE) against ulcer is well documented, but therapeutic use is compromised due to poor bioavailability and physicochemic...

journal_title：Journal of drug targeting

authors： Kumar Singh P,Pal Kaur I

更新日期：2011-11-01 00:00:00

abstract：:Cell-penetrating peptides (CPPs) are efficient vehicles to transport bioactive molecules into the cells. Despite numerous studies the exact mechanism by which CPPs facilitate delivery of cargo to its intracellular target is still debated. The current work presents methods that can be used for tracking CPP/pDNA complex...

journal_title：Journal of drug targeting

authors： Pärnaste L,Arukuusk P,Zagato E,Braeckmans K,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：:Gene transfer offers a potential way to correct local and systemic protein deficiency disorders by using genes as drugs, so called gene therapeutics. Salivary glands present an interesting target site for gene therapeutic applications. Herein, we review proofs of concept achieved for salivary glands with in vivo anima...

journal_title：Journal of drug targeting

authors： Hoque AT,Yamano S,Baccaglini L,Baum BJ

更新日期：2001-01-01 00:00:00

abstract：:Developing a highly effective and lung-targeted local drug delivery carrier with low irritancy may be critical for improving treatment of lung cancer. Using soluble excipients as microspheres (MS) matrix, respirable MS embedding chitosan-coated poly(d,l-lactide-co-glycolide) nanoparticles (CNP-MS) for 2-methoxyestradi...

journal_title：Journal of drug targeting

authors： Guo X,Zhang X,Ye L,Zhang Y,Ding R,Hao Y,Zhao Y,Zhang Z,Zhang Y

更新日期：2014-06-01 00:00:00

abstract：:The present work describes the potential for using lectin-conjugated gliadin nanoparticles as a means of locating and anchoring a drug delivery system on the carbohydrate receptors of Helicobacter pylori (H. pylori). Gliadin nanoparticles (GNP) bearing acetohydroxamic acid (AHA) were prepared by a desolvation method. ...

journal_title：Journal of drug targeting

authors： Umamaheshwari RB,Jain NK

更新日期：2003-08-01 00:00:00

abstract：:beta-Glucuronidase (GUSB) is a lysosomal enzyme that could be developed as a brain therapy for Type VII Mucopolysaccharidosis. However, GUSB does not cross the blood-brain barrier (BBB). To enable BBB transport of the enzyme, human GUSB was re-engineered as a fusion protein with the chimeric monoclonal antibody (MAb) ...

journal_title：Journal of drug targeting

authors： Boado RJ,Pardridge WM

更新日期：2010-04-01 00:00:00