α-Tocopherol as functional excipient for resveratrol and coenzyme Q10-loaded SNEDDS for improved bioavailability and prophylaxis of breast cancer.

abstract：:The aim of the present study was to develop a polymeric delivery system for water-insoluble drug oridonin. Amphiphilic block copolymers, poly(epsilon-caprolactone)-poly(ethylene glycol)-poly (epsilon-caprolactone) (PCL-PEO-PCL), were synthesized by ring-opening polymerization of caprolactone initiated by the hydroxyl ...

journal_title：Journal of drug targeting

authors： Feng N,Wu P,Li Q,Mei Y,Shi S,Yu J,Xu J,Liu Y,Wang Y

更新日期：2008-07-01 00:00:00

abstract：:Radiolabeled cytochrome c (Cyt c), either as a free protein or as cell penetrating peptide (CPP)-conjugates, was tested for cellular uptake and nuclear transport in Human embryonic kidney 293 (HEK293) cells and HeLa cells. Conjugation of Cyt c with either the amphipathic peptide model amphipathic peptide (MAP) or the ...

journal_title：Journal of drug targeting

authors： Kenien R,Zaro JL,Shen WC

更新日期：2012-05-01 00:00:00

abstract：:Graphene, the mother of all carbon materials, has unlocked a new era of biomedical nanomaterials due to its exceptional biocompatibility, physicochemical and mechanical properties. It is a single atom thick, nanosized, two-dimensional structure and provides high surface area with adjustable surface chemistry to form h...

journal_title：Journal of drug targeting

authors： Madni A,Noreen S,Maqbool I,Rehman F,Batool A,Kashif PM,Rehman M,Tahir N,Khan MI

更新日期：2018-12-01 00:00:00

abstract：:Radiolabelled poly(methylmethacrylate) (PMMA) nanoparticles were coated with rat serum albumin (RSA), serum and inactivated serum, to examine the influence of these blood components on the body distribution of a model colloidal drug carrier. The particles were incubated overnight at 37 degrees C either in a 1% solutio...

journal_title：Journal of drug targeting

authors： Borchard G,Kreuter J

更新日期：1993-01-01 00:00:00

abstract：:Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels have attracted interest as carriers for proteins/peptides and anticancer drugs ...

journal_title：Journal of drug targeting

authors： Zhang L,Pan J,Dong S,Li Z

更新日期：2017-09-01 00:00:00

abstract：:Acyclovir is an antiviral agent and it has been particularly used for the treatment of herpes simplex infections. The treatment of infection in the oral cavity is often difficult, because of insufficient drug concentration in saliva when acyclovir is administered via the oral route in conventional tablet form for syst...

journal_title：Journal of drug targeting

authors： Değim T,Eğlen B,Ocak O

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Peptide antibiotics as new therapeutic agents are becoming a popular option to investigate due to their broad bacterial target selectivity and limited resistance problems. Although attractive, these new drug candidates have several limitations including low potency and delivery issues which face all peptid...

journal_title：Journal of drug targeting

authors： Zhang C,Yadava P,Sun J,Hughes JA

更新日期：2006-11-01 00:00:00

abstract：:Archaeal ether glycerolipid vesicles (archaeosomes) efficiently deliver exogenous antigen for induction of humoral and cell-mediated immunity. Because induction of CD8 cytotoxic T cells is critical for protective vaccination against tumors, we compared the ability of various archaeosome lipid compositions to evoke a s...

journal_title：Journal of drug targeting

authors： Krishnan L,Dennis Sprott G,Institute for Biological Sciences, National Research Council of Canada.

更新日期：2003-01-01 00:00:00

abstract：:Gene augmentation has been the paradigm in the majority of gene therapy protocols but in recent years the potential of repairing the mutated gene in situ by targeted gene correction has become a reality. In fact, targeted gene repair has many advantages over conventional replacement strategies, notably the possibility...

journal_title：Journal of drug targeting

authors： Richardson P,Thoma C,Kren BT,Steer CJ

更新日期：2002-03-01 00:00:00

abstract：:Liposomes have been prepared loaded with DNA (plasmid encoding for the green fluorescent protein, GFP) and additionally modified with TATp and PEG, with PEG being attached to the liposome surface via both pH-sensitive hydrazone and non-pH-sensitive bonds. The pGFP-loaded liposomal preparations have been administered i...

journal_title：Journal of drug targeting

authors： Kale AA,Torchilin VP

更新日期：2007-08-01 00:00:00

abstract：:Intravenous targeting of anticancer agents should improve both efficacy and therapeutic index. However, rational design of targeting constructs requires detailed definition of receptor targets and must take account of polarised tissue architecture that may restrict access to chosen receptors from the bloodstream. Bact...

journal_title：Journal of drug targeting

authors： Maruta F,Akita N,Nakayama J,Miyagawa S,Ismail T,Rowlands DC,Kerr DJ,Fisher KD,Seymour LW,Parker AL

更新日期：2007-05-01 00:00:00

abstract：:I125 radiolabelled HSA (HSA-I125) was utilised as a probe to quantify protein adsorption onto polystyrene (PS) and Poloxamine 908 coated PS (PS-908) particles. Upon ageing of the HSA-I125 a dramatic increase in the amount of protein adsorbed onto the two particle systems was observed. This phenomenon was not due to la...

journal_title：Journal of drug targeting

authors： Armstrong TI,Illum L

更新日期：1997-01-01 00:00:00

abstract：:To identify an agent with specific activity against B-lineage leukaemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanised anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-liposomes). These liposomes were specially designed to recognise and kill B-LSC...

journal_title：Journal of drug targeting

authors： Zhang J,Shen D,Jia M,Zhao H,Tang Y

更新日期：2018-01-01 00:00:00

abstract：:The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs) that are commonly used in patients with hypertension, cardiovascular disease and/or...

journal_title：Journal of drug targeting

authors： Akhtar S,Benter IF,Danjuma MI,Doi SAR,Hasan SS,Habib AM

更新日期：2020-08-01 00:00:00

abstract：:There are much said about Pieter Cullis in this special volume honoring him. He was the pioneer to study the role of hexagonal HII phase in membrane fusion and the one who applied this concept for the design of lipid nanoparticles. He was also the first to utilize remote loading techniques for the delivery of amphipat...

journal_title：Journal of drug targeting

authors： Huang L,Miao L

更新日期：2016-11-01 00:00:00

abstract：:A new drug-targeting system for CD13(+) tumors has been developed, based on ultrasound-sensitive nanobubbles (NBs) and cell-permeable peptides (CPPs). Here, the CPP-doxorubicin conjugate (CPP-DOX) was entrapped in the asparagine-glycine-arginine (NGR) peptide modified NB (CPP-DOX/NGR-NB) and the penetration of CPP-DOX...

journal_title：Journal of drug targeting

authors： Lin W,Xie X,Deng J,Liu H,Chen Y,Fu X,Liu H,Yang Y

更新日期：2016-01-01 00:00:00

abstract：:The human body has adapted to defend against the aggressive biological or chemical agents. As a result, the defence mechanisms of the human body became barriers for the drug delivery. Theoretically, any problem that prevents a drug from reaching its site of action is considered to be a barrier to drug delivery. The ai...

journal_title：Journal of drug targeting

authors： Jătariu AN,Popa M,Peptu CA

更新日期：2010-05-01 00:00:00

abstract：:Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 thymidine kinase gene (HSV-tk) delivery by retrovirus-producing cells and DNA/liposome complexes for the treatment...

journal_title：Journal of drug targeting

authors： Princen F,Lechanteur C,Lopez M,Gielen J,Bours V,Merville MP

更新日期：2000-01-01 00:00:00

abstract：:An aqueous dispersion of self-organized phospholipid tubules has been utilized as the template for silica-deposited nanotubules (approximately 0.5 microm thick and >10 microm long) by a sol-gel method. The formation of the hybrid tubules was mechanistically investigated by controlled sol-gel reaction. The incorporatio...

journal_title：Journal of drug targeting

authors： Kim I,Park YH,Rey DA,Batt CA

更新日期：2008-11-01 00:00:00

abstract：:In order to confirm the efficacy of ciprofloxacin (CPFX) incorporated into liposomes (CPFX-liposomes) for treatment of respiratory intracellular parasite infections, the influence of particle size on drug delivery to rat alveolar macrophages (AMs) following pulmonary administration of CPFX-liposomes was investigated. ...

journal_title：Journal of drug targeting

authors： Chono S,Tanino T,Seki T,Morimoto K

更新日期：2006-09-01 00:00:00

abstract：:The nerve growth factor (NGF) is essential for the survival of both peripheral ganglion cells and central cholinergic neurons in the basal forebrain. The accelerated loss of central cholinergic neurons during Alzheimer's disease may be a determinant cause of dementia, and this observation may suggest a possible therap...

journal_title：Journal of drug targeting

authors： Kurakhmaeva KB,Djindjikhashvili IA,Petrov VE,Balabanyan VU,Voronina TA,Trofimov SS,Kreuter J,Gelperina S,Begley D,Alyautdin RN

更新日期：2009-09-01 00:00:00

abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers containing doxorubicin and galactosamine have been developed to target the hepatocyte galactose receptor with the aim of organ-specific chemotherapy of primary and metastatic liver disease. Previous biodistribution studies in rats and mice have used tyrosinamide inco...

journal_title：Journal of drug targeting

authors： Pimm MV,Perkins AC,Duncan R,Ulbrich K

更新日期：1993-01-01 00:00:00

abstract：:The myriad of complications associated with diabetes is closely linked with the generation of reactive species or free radicals leading to oxidative and nitrosative stress. Increased oxidative stress is an important cause and result of diabetes and it is thought to underlie the cellular changes that lead to diabetic c...

journal_title：Journal of drug targeting

authors： Thakur P,Kumar A,Kumar A

更新日期：2018-11-01 00:00:00

abstract：:Dendrimers, spherical or quasi-spherical synthetic polymers in the nano-size range, have found useful applications as prospective carriers in drug and gene delivery. The investigation of dendrimer uptake by cells has been previously achieved by the incorporation of a fluorescent dye to the dendrimer either by chemical...

journal_title：Journal of drug targeting

authors： Al-Jamal KT,Ruenraroengsak P,Hartell N,Florence AT

更新日期：2006-07-01 00:00:00

abstract：:In this review, we emphasize the efforts on the development of radiolabeled nanoparticles (NPs) for cancer treatment, i.e. theranostic tools based on nanotechnology and nuclear medicine. Currently, radionuclide therapy remains to be an important treatment option. The ionizing radiation from radionuclides (not provided...

journal_title：Journal of drug targeting

authors： Enrique MA,Mariana OR,Mirshojaei SF,Ahmadi A

更新日期：2015-04-01 00:00:00

abstract：:Influenza, mainly caused by influenza virus, is becoming one of the major concerns in the world. Limitation in vaccines necessitates the urgent development of new therapeutic options against this virus. In the present study, we designed small interfering RNA (siRNA) targeting overlapping gene of PB1 and PB1-F2 gene of...

journal_title：Journal of drug targeting

authors： Cheng C,Yao L,Chen A,Jia R,Huan L,Guo J,Bo H,Shu Y,Zhang Z

更新日期：2009-02-01 00:00:00

abstract：:Cytokine inhibiting drugs are much more effective when delivered intracellularly to phagocytic cells in the microencapsulated form. Dexamethasone is a powerful inhibitor of TNF-α cytokine through inhibition of NF-κB which is a gene regulator of multiple pro-inflammatory cytokines. We have determined the effect of micr...

journal_title：Journal of drug targeting

authors： Uddin MN,Siddiq A,Oettinger CW,D'Souza MJ

更新日期：2011-11-01 00:00:00

abstract：:Local treatment of middle ear (ME) disease currently requires surgical penetration of the tympanic membrane (TM). We previously discovered 12-mer peptides that are actively transported across the intact TM, a process that could be used for non-invasive drug delivery into the ME. To optimise transport and provide furth...

journal_title：Journal of drug targeting

authors： Kurabi A,Schaerer D,Chang L,Pak K,Ryan AF

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To evaluate the internalization and subcellular fate of AS1411 aptamer (for glioma targeting) and TGN peptide (for blood-brain barrier targeting)-modified nanoparticles (AsTNPs), which was important for optimizing targeted delivery systems and realizing the potential toxicity to cells. METHODS:Organelles were ...

journal_title：Journal of drug targeting

authors： Gao H,Yang Z,Zhang S,Pang Z,Jiang X

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Synthesized dl-Nordihydroguaiaretic acid (dl-NGDA or "Nordy") can inhibit the growth of malignant human tumors, especially the tumor angiogenesis. However, its liposoluble nature limits its in vivo efficacy in the hydrosoluble circulation of human. PURPOSE:We tried to use the ultrasonic microbubble as the c...

journal_title：Journal of drug targeting

authors： Hua X,Ding J,Li R,Zhang Y,Huang Z,Guo Y,Chen Q

更新日期：2016-09-01 00:00:00