MAP-mediated nuclear delivery of a cargo protein.

abstract：:Drug systems targeting tumor cells using basic fibroblast growth factor (bFGF) have been widely reported. In this study, the peptide KRTGQYKLC (bFGFp), containing cysteine at the carboxyl termination of the bFGF-derived peptide, was applied as a novel ligand targeting tumor cells. bFGFp was conjugated with bovine seru...

journal_title：Journal of drug targeting

authors： Terada T,Mizobata M,Kawakami S,Yabe Y,Yamashita F,Hashida M

更新日期：2006-09-01 00:00:00

abstract：:It is well established that overproduction and accumulation of the β-amyloid (Aβ) peptide 1-42 (Aβ(1-42)) is a trigger of the pathological cascade in Alzheimer's disease (AD) that manifests as cognitive impairment. Ginsenoside Rg3 is an important constituent of ginseng, plays an essential role in memory and improved c...

journal_title：Journal of drug targeting

authors： Aalinkeel R,Kutscher HL,Singh A,Cwiklinski K,Khechen N,Schwartz SA,Prasad PN,Mahajan SD

更新日期：2018-02-01 00:00:00

abstract：:Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 thymidine kinase gene (HSV-tk) delivery by retrovirus-producing cells and DNA/liposome complexes for the treatment...

journal_title：Journal of drug targeting

authors： Princen F,Lechanteur C,Lopez M,Gielen J,Bours V,Merville MP

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Treatment of late stage cancers has proven to be a very difficult task. Targeted therapy and combinatory drug administration may be the solution. PURPOSE:The study was performed to evaluate the therapeutic efficacy of PEG-PE micelles, co-loaded with curcumin (CUR) and doxorubicin (DOX), and targeted with an...

journal_title：Journal of drug targeting

authors： Abouzeid AH,Patel NR,Rachman IM,Senn S,Torchilin VP

更新日期：2013-12-01 00:00:00

abstract：:Local tissue toxicity, systemic toxicity and platinum pharmacokinetics were evaluated in 6 normal healthy beagle dogs injected subcutaneously with two formulations of a polylactide biodegradable polymer (Atrigel) system containing cisplatin. Dogs were injected 4 times at 30 day intervals at platinum dosages of 70, 105...

journal_title：Journal of drug targeting

authors： Dernell WS,Straw RC,Withrow SJ,Powers BE,Fujita SM,Yewey GS,Joseph KF,Dunn RL,Whitman SL,Southard GL

更新日期：1998-01-01 00:00:00

abstract：:Nanostructured lipid carrier (NLC) is second generation smarter drug carrier system having solid matrix at room temperature. This carrier system is made up of physiological, biodegradable and biocompatible lipid materials and surfactants and is accepted by regulatory authorities for application in different drug deliv...

journal_title：Journal of drug targeting

authors： Iqbal MA,Md S,Sahni JK,Baboota S,Dang S,Ali J

更新日期：2012-12-01 00:00:00

abstract：:Recent studies have shown that drugs that are normally unable to cross the blood-brain barrier (BBB) following intravenous injection can be transported across this barrier by binding to poly(butyl cyanoacrylate) nanoparticles and coating with polysorbate 80. However, the mechanism of this transport so far was not know...

journal_title：Journal of drug targeting

authors： Kreuter J,Shamenkov D,Petrov V,Ramge P,Cychutek K,Koch-Brandt C,Alyautdin R

更新日期：2002-06-01 00:00:00

abstract：:Glioma is one of the most commonly occurring malignant brain tumours which need proper treatment strategy. The current therapies for treating glioma like surgical resection, radiotherapy, and chemotherapy have failed in achieving satisfactory results and this forms a rationale for the development of novel drug deliver...

journal_title：Journal of drug targeting

authors： Krishnamoorthy B,Karanam V,Chellan VR,Siram K,Natarajan TS,Gregory M

更新日期：2014-07-01 00:00:00

abstract：:The present work describes the potential for using lectin-conjugated gliadin nanoparticles as a means of locating and anchoring a drug delivery system on the carbohydrate receptors of Helicobacter pylori (H. pylori). Gliadin nanoparticles (GNP) bearing acetohydroxamic acid (AHA) were prepared by a desolvation method. ...

journal_title：Journal of drug targeting

authors： Umamaheshwari RB,Jain NK

更新日期：2003-08-01 00:00:00

abstract：:A simple method for the separation of polyalkylcyanoacrylate nanoparticles was developed using polyisohexylcyanoacrylate (PIHCA) as a model. Fluorescein isothiocyanate dextran 70 was used to label the nanoparticles. Ultracentrifugation onto a performed sucrose gradient allowed the easy elimination of the dextran and o...

journal_title：Journal of drug targeting

authors： Pinto-Alphandary H,Balland O,Couvreur P

更新日期：1995-01-01 00:00:00

abstract：:Nanoparticles form the fundamental building blocks for many exciting applications in various scientific disciplines due to its unique features such as large surface to mass ratio, targeting potential, ability to adsorbed and carry other compound which makes them suitable for biomedical applications. However, the probl...

journal_title：Journal of drug targeting

authors： Sultana S,Alzahrani N,Alzahrani R,Alshamrani W,Aloufi W,Ali A,Najib S,Siddiqui NA

更新日期：2020-06-01 00:00:00

abstract：:Liposomes have been prepared from dipalmitoylphosphatidylcholine (DPPC), cholesterol (Chol) and dimethyldioctadecylammonium bromide (DDAB). The cationic vesicles adsorb to biofilms of the skin-associated bacteria Staphylococcus epidermidis, which have a negative charge. Encapsulation of the antibacterial drug vancomyc...

journal_title：Journal of drug targeting

authors： Sanderson NM,Jones MN

更新日期：1996-01-01 00:00:00

abstract：:Liposomal encapsulation of doxorubicin (DXR) improves tumor accumulation and reduces adverse effects. One possible strategy for further optimization of this delivery technology would be to design the liposome carrier to release its content within the tumor tissue in response to specific stimuli such as ultrasound (US)...

journal_title：Journal of drug targeting

authors： Hagtvet E,Evjen TJ,Olsen DR,Fossheim SL,Nilssen EA

更新日期：2011-09-01 00:00:00

abstract：:The phenomenal advances in pharmaceutical sciences over the last few decades have led to the development of new therapeutics like peptides, proteins, RNAs, DNAs and highly potent small molecules. Fruitful applications of these therapeutics have been challenged by several anatomical and physiological barriers that limi...

journal_title：Journal of drug targeting

authors： Alsaggar M,Liu D

更新日期：2018-01-01 00:00:00

abstract：:We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the twenty-first century. Multiple drug resistance and nonspecific drug targeting of the m...

journal_title：Journal of drug targeting

authors： Baruah UK,Gowthamarajan K,Vanka R,Karri VVSR,Selvaraj K,Jojo GM

更新日期：2017-08-01 00:00:00

abstract：:An aspargine-glycine-arginine (NGR) peptide modified single-walled carbon nanotubes (SWCNTs) system, developed by a simple non-covalent approach, could be loaded with the anticancer drug doxorubicin (DOX) and magnetic resonance imaging (MRI) contrast agent gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). This...

journal_title：Journal of drug targeting

authors： Yan C,Chen C,Hou L,Zhang H,Che Y,Qi Y,Zhang X,Cheng J,Zhang Z

更新日期：2017-02-01 00:00:00

abstract：:Sulpiride (SUL), anti-dopaminergic drug, has a specific site for absorption located in the upper portion of the gastrointestinal tract hence, its oral delivery represents a challenge regarding SUL absorption and bioavailability. So, a gastro-retentive oral platform of SUL was developed to increase its gastric residenc...

journal_title：Journal of drug targeting

authors： Younis MA,El-Zahry MR,Tallat MA,Tawfeek HM

更新日期：2020-04-01 00:00:00

abstract：:The biodistribution of orally and intravenously administered archaeosomes in mice was compared to that of archaeosomes containing either coenzyme Q10 (archaeosome-CoQ10), polyethylene glycol (archaeosome-PEG), or PEG plus CoQ10 (archaeosome-PEG-CoQ10). The archaeosome formulations were prepared by a reverse-phase evap...

journal_title：Journal of drug targeting

authors： Omri A,Makabi-Panzu B,Agnew BJ,Sprott GD,Patel GB

更新日期：2000-01-01 00:00:00

abstract：:Considering limitations of conventional insulin therapies, the present study characterizes usefulness of novel mucoadhesive multivesicular liposomes as a mucoadhesive sustained release carrier of insulin via nasal and ocular routes, thus attempts to develop non-invasive carrier system for the controlled release of bio...

journal_title：Journal of drug targeting

authors： Jain AK,Chalasani KB,Khar RK,Ahmed FJ,Diwan PV

更新日期：2007-07-01 00:00:00

abstract：:Metal nanoparticles (NPs) may have the potential to overcome problems related to conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in cancer therapy providing better targeting, gene silencing and drug delivery. Functionalised metal NPs with targeting ligands offer a better control of...

journal_title：Journal of drug targeting

authors： Sharma A,Goyal AK,Rath G

更新日期：2018-09-01 00:00:00

abstract：:The objective of this study was to investigate the factors for enhancing the susceptibility of cancer cells to chemotherapeutic drug by ultrasound microbubbles. Ultrasound (US) combined with phospholipid-based microbubbles (MB) was used to enhance the susceptibility of colon cancer cell line SWD-620 to anticancer drug...

journal_title：Journal of drug targeting

authors： Zhao YZ,Gao HS,Zhou ZC,Tang QQ,Lu CT,Jin Z,Tian JL,Xu YY,Tian XQ,Wang L,Kong FL,Li XK,Huang PT,He HL,Wu Y

更新日期：2010-07-01 00:00:00

abstract：:Graphene, the mother of all carbon materials, has unlocked a new era of biomedical nanomaterials due to its exceptional biocompatibility, physicochemical and mechanical properties. It is a single atom thick, nanosized, two-dimensional structure and provides high surface area with adjustable surface chemistry to form h...

journal_title：Journal of drug targeting

authors： Madni A,Noreen S,Maqbool I,Rehman F,Batool A,Kashif PM,Rehman M,Tahir N,Khan MI

更新日期：2018-12-01 00:00:00

abstract：:Cationic liposomes composed of dialkyl cationic lipid such as 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) can efficiently deliver siRNA to the lungs following the intravenous injection of cationic liposome/siRNA complexes (lipoplexes). In this study, we examined the effect of cationic lipid of cationic liposomes ...

journal_title：Journal of drug targeting

authors： Hattori Y,Nakamura M,Takeuchi N,Tamaki K,Shimizu S,Yoshiike Y,Taguchi M,Ohno H,Ozaki KI,Onishi H

更新日期：2019-02-01 00:00:00

abstract：:A nuclear localization signal (NLS) is a short amino acid sequence derived from eukaryotic nuclear proteins and viral proteins. Many NLS peptides can efficiently mediate the intranucleus transport of cargo molecules, so they have been widely used for non-viral gene transfer and shown potential ability to improve nucle...

journal_title：Journal of drug targeting

authors： Sun Y,Xian L,Xing H,Yu J,Yang Z,Yang T,Yang L,Ding P

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:The objective of this work was to examine the application of catechins-containing phospholipids-based ultrasonic microbubbles (PUM) in ultrasound-induced delivery. METHODS:Catechins-containing PUM were prepared by dissolving lyophilized PUM powder in catechins solution. Morphologic characteristics of catechi...

journal_title：Journal of drug targeting

authors： Lu CT,Zhao YZ

更新日期：2008-12-01 00:00:00

abstract：:The purpose of this research is to develop ligand-targeted plasmid based gene delivery systems for gene transfer to tumor endothelium. Cell adhesion assays were used to test the peptide inhibition of human endothelial cell adsorption to vitronectin-treated tissue culture plates. A series of RGD containing peptides wer...

journal_title：Journal of drug targeting

authors： Anwer K,Kao G,Rolland A,Driessen WH,Sullivan SM

更新日期：2004-05-01 00:00:00

abstract：:Chemotherapy is still a major challenge for in vivo drug targeting to macrophages. Toxicity remains the major obstacle for the most potent drugs already known in the therapy of leishmaniasis. Thus, new drugs and new delivery systems are sought. By using different vesicular delivery modes e.g. liposomes, niosomes, micr...

journal_title：Journal of drug targeting

authors： Sarkar S,Mandal S,Sinha J,Mukhopadhyay S,Das N,Basu MK

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:An octreotide-conjugated polyamidoamine (PAMAM) dendrimer was synthesized and employed as nanocarriers of methotrexate (MTX), for targeting to the somatostatin receptors over-expressed tumor cells. METHODS:PAMAM-PEG-octreotide (PPO) and PAMAM-PEG (PPG) were synthesized and characterized. The cellular uptake of...

journal_title：Journal of drug targeting

authors： Peng J,Qi X,Chen Y,Ma N,Zhang Z,Xing J,Zhu X,Li Z,Wu Z

更新日期：2014-06-01 00:00:00

abstract：:A higher encapsulation rate was obtained using the dehydration-rehydration method compared with the reverse-phase evaporation technique in negative multilamellar vesicles with amikacin (AMK) (45% versus 15%; P < 0.05) and teicoplanin (TCP) (34% versus 25%; P < 0.05). The addition of 250 mM sucrose to AMK- or TCP-conta...

journal_title：Journal of drug targeting

authors： Ravaoarinoro M,Toma E,Agbaba O,Morisset R

更新日期：1993-01-01 00:00:00

abstract：:Cancer is one of the most common diseases all over the world; many people suffer from diverse types of cancer. However, currently there is no exact cure or therapy developed for cancer. On the other hand, nanoparticles are defined as microscopic particles that have dimensions less than 100 nm and they are known for th...

journal_title：Journal of drug targeting

authors： Çeşmeli S,Biray Avci C

更新日期：2019-08-01 00:00:00