Abstract：
:Chemotherapy is still a major challenge for in vivo drug targeting to macrophages. Toxicity remains the major obstacle for the most potent drugs already known in the therapy of leishmaniasis. Thus, new drugs and new delivery systems are sought. By using different vesicular delivery modes e.g. liposomes, niosomes, microspheres and nanoparticles, attempts have been made to deliver an indigenous antileishmanial compound, quercetin, to treat experimental leishmaniasis in the hamster model so as to increase its efficacy as well as to reduce the toxicity. At equivalent quercetin concentration, the nanocapsulated quercetin was found to be the most potent in reducing the parasite burden in the spleen as well as in reducing hepatotoxcity and renaltoxicity compared to free drug or drug in other vesicular forms. An inverse relationship between the efficacy and the size of the vesicles was established. Such a drug vehicle formulation especially in the nanocapsulated form may be considered for clinical trials.
journal_name
J Drug Targetjournal_title
Journal of drug targetingauthors
Sarkar S,Mandal S,Sinha J,Mukhopadhyay S,Das N,Basu MKdoi
10.1080/106118021000072681keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
573-8issue
8eissn
1061-186Xissn
1029-2330journal_volume
10pub_type
杂志文章abstract：:To identify an agent with specific activity against B-lineage leukaemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanised anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-liposomes). These liposomes were specially designed to recognise and kill B-LSC...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/1061186X.2017.1339193
更新日期：2018-01-01 00:00:00
abstract：:beta-Glucuronidase (GUSB) is a lysosomal enzyme that could be developed as a brain therapy for Type VII Mucopolysaccharidosis. However, GUSB does not cross the blood-brain barrier (BBB). To enable BBB transport of the enzyme, human GUSB was re-engineered as a fusion protein with the chimeric monoclonal antibody (MAb) ...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611860903353362
更新日期：2010-04-01 00:00:00
abstract：:Interactions between phosphatidylcholine (PC) or phosphatidylserine (PS) liposomes and human umbilical vein endothelial cells (HUVEC) or human promyelocytic leukemia cells (HL60) were investigated. Pyramine encapsulating or rhodamine incorporating small unilamellar liposomes with mean diameters around 80 nm (demonstra...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611860008997910
更新日期：2000-01-01 00:00:00
abstract：:Tumour microenvironment provides the 'soil' for tumour growth. Besides tumour cells, there are also numbers of stromal cells, extracellular matrix and other components in the tumour microenvironment. In the past years, kinds of ligands and markers specifically high-expressed on the surface of the tumour stromal cells ...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/1061186X.2020.1744157
更新日期：2020-08-01 00:00:00
abstract：:There are much said about Pieter Cullis in this special volume honoring him. He was the pioneer to study the role of hexagonal HII phase in membrane fusion and the one who applied this concept for the design of lipid nanoparticles. He was also the first to utilize remote loading techniques for the delivery of amphipat...
journal_title：Journal of drug targeting
pub_type： 传,历史文章,杂志文章
doi：10.3109/1061186X.2016.1172590
更新日期：2016-11-01 00:00:00
abstract：:Influenza, mainly caused by influenza virus, is becoming one of the major concerns in the world. Limitation in vaccines necessitates the urgent development of new therapeutic options against this virus. In the present study, we designed small interfering RNA (siRNA) targeting overlapping gene of PB1 and PB1-F2 gene of...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860802473048
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:The objective of this work was to examine the application of catechins-containing phospholipids-based ultrasonic microbubbles (PUM) in ultrasound-induced delivery. METHODS:Catechins-containing PUM were prepared by dissolving lyophilized PUM powder in catechins solution. Morphologic characteristics of catechi...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860802475696
更新日期：2008-12-01 00:00:00
abstract：INTRODUCTION:Growing interest in the application of nanotechnology to treat lymphatic filariasis (LF) implies that the imminent medical arsenal of this interesting technology is attractive for health authorities. Currently, they are completely dependent on friendly oral mass drug (anti-filarials) administration to elim...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.3109/1061186X.2013.832766
更新日期：2014-01-01 00:00:00
abstract：:The aim of the present study was to evaluate the transfer of N-acetyl-p-aminobenzoic acid (AcPABA) across the rat term placenta and the rat small intestine and to compare it with that of its parent drug p-aminobenzoic acid (PABA). Umbilical perfusion of the rat term placenta was used to determine the materno-fetal tra...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611869808995875
更新日期：1998-01-01 00:00:00
abstract：:The biodistribution of orally and intravenously administered archaeosomes in mice was compared to that of archaeosomes containing either coenzyme Q10 (archaeosome-CoQ10), polyethylene glycol (archaeosome-PEG), or PEG plus CoQ10 (archaeosome-PEG-CoQ10). The archaeosome formulations were prepared by a reverse-phase evap...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611869909085521
更新日期：2000-01-01 00:00:00
abstract：:Local tissue toxicity, systemic toxicity and platinum pharmacokinetics were evaluated in 6 normal healthy beagle dogs injected subcutaneously with two formulations of a polylactide biodegradable polymer (Atrigel) system containing cisplatin. Dogs were injected 4 times at 30 day intervals at platinum dosages of 70, 105...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611869808997866
更新日期：1998-01-01 00:00:00
abstract：:The purpose of this research is to develop ligand-targeted plasmid based gene delivery systems for gene transfer to tumor endothelium. Cell adhesion assays were used to test the peptide inhibition of human endothelial cell adsorption to vitronectin-treated tissue culture plates. A series of RGD containing peptides wer...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860410001724468
更新日期：2004-05-01 00:00:00
abstract：:The human body has adapted to defend against the aggressive biological or chemical agents. As a result, the defence mechanisms of the human body became barriers for the drug delivery. Theoretically, any problem that prevents a drug from reaching its site of action is considered to be a barrier to drug delivery. The ai...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611860903398099
更新日期：2010-05-01 00:00:00
abstract：:Human epidermal growth factor receptor 2 (HER2) expression has been shown to be increased in several types of human tumours. In this study, for the imaging of HER2-related tumours, a modified RNA aptamer with HER2-specific targeting was labelled with (99m)Tc, by using hydrazino nicotinamide (HYNIC) as the chelator in ...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/1061186X.2013.839688
更新日期：2014-02-01 00:00:00
abstract：:Tissue factor (TF) is aberrantly expressed on tumor vascular endothelial cells (VECs) and on cancer cells in many malignant tumors, but not on normal VECs, making it a promising target for cancer therapy. As a transmembrane receptor for coagulation factor VIIa (fVIIa), TF forms a high-affinity complex with its cognate...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860801890093
更新日期：2008-04-01 00:00:00
abstract：:Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels have attracted interest as carriers for proteins/peptides and anticancer drugs ...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.1080/1061186X.2017.1326123
更新日期：2017-09-01 00:00:00
abstract：:Resveratrol is a promising neuroprotective agent against neurodegenerative disorders such as Alzheimer's disease. Resveratrol-loaded transferosomes and nanoemulsions were developed and labelled with gold nanoparticles (GNPs). The water maze test was utilised to identify the effect on spatial memory recovery. The treat...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/1061186X.2019.1608553
更新日期：2019-12-01 00:00:00
abstract：:Previous studies indicated the potential of zinc protoporphyrin (ZnPP) as an antitumor agent targeting to the tumor survival factor heme oxygenase-1, and/or for photodynamic therapy (PDT). In this study, to achieve tumor-targeted delivery, styrene-maleic acid-copolymer conjugated ZnPP (SMA-ZnPP) was synthesized via am...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/1061186X.2015.1077851
更新日期：2016-01-01 00:00:00
abstract：:An aqueous dispersion of self-organized phospholipid tubules has been utilized as the template for silica-deposited nanotubules (approximately 0.5 microm thick and >10 microm long) by a sol-gel method. The formation of the hybrid tubules was mechanistically investigated by controlled sol-gel reaction. The incorporatio...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860802295581
更新日期：2008-11-01 00:00:00
abstract：:Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 thymidine kinase gene (HSV-tk) delivery by retrovirus-producing cells and DNA/liposome complexes for the treatment...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611860008996854
更新日期：2000-01-01 00:00:00
abstract：:The COVID-19 pandemic is caused by the severe acute-respiratory-syndrome-coronavirus-2 that uses ACE2 as its receptor. Drugs that raise serum/tissue ACE2 levels include ACE inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs) that are commonly used in patients with hypertension, cardiovascular disease and/or...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.1080/1061186X.2020.1797754
更新日期：2020-08-01 00:00:00
abstract：:Considering limitations of conventional insulin therapies, the present study characterizes usefulness of novel mucoadhesive multivesicular liposomes as a mucoadhesive sustained release carrier of insulin via nasal and ocular routes, thus attempts to develop non-invasive carrier system for the controlled release of bio...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860701453653
更新日期：2007-07-01 00:00:00
abstract：:We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the twenty-first century. Multiple drug resistance and nonspecific drug targeting of the m...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.1080/1061186X.2017.1291645
更新日期：2017-08-01 00:00:00
abstract：:Microparticles-adsorbed insulin and zinc insulin (PenfilN) were molded to self-dissolving micropiles (SDMPs) with chondroitin sulfate as the base for the percutaneous administration of insulin. Porous silicon dioxide (Sylysia 320, 440 and 730) and porous calcium silicate (FloriteRE) were used as microparticles. As a r...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860701349794
更新日期：2007-06-01 00:00:00
abstract：:The effects of concentration, amperage and duration on the antidiuretic response induced by iontophoretic delivery of desmopressin acetate (DDAVP) were examined using a diabetes insipidus model in rats. A higher current density brought about a larger and longer antidiuretic response. Prolonged iontophoretic duration c...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611869509015918
更新日期：1995-01-01 00:00:00
abstract：:The aim of the present study was to develop a polymeric delivery system for water-insoluble drug oridonin. Amphiphilic block copolymers, poly(epsilon-caprolactone)-poly(ethylene glycol)-poly (epsilon-caprolactone) (PCL-PEO-PCL), were synthesized by ring-opening polymerization of caprolactone initiated by the hydroxyl ...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860802200938
更新日期：2008-07-01 00:00:00
abstract：:Germ-free (GF) animals lack a colonic microflora like that seen in conventional (CV) animals. Bacterial presence plays a role in the development of glycoproteins in the gastrointestinal (GI) tract; the absence of a microbiota has been seen to suppress the production of certain glycoproteins and glycolipids. Binding pa...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611860108997920
更新日期：2001-04-01 00:00:00
abstract：:Cyclodextrins (CDs) are macrocyclic oligosaccharides composed of α(1,4)-linked glucopyranose subunits. These molecules possess a cage-like supramolecular structure, comparable with the structures of crown ethers, cryptands, spherands, cyclophanes, or calixarenes. However, it took 50 years to establish the molecular st...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.3109/10611861003622552
更新日期：2010-11-01 00:00:00
abstract：:Gene transfer offers a potential way to correct local and systemic protein deficiency disorders by using genes as drugs, so called gene therapeutics. Salivary glands present an interesting target site for gene therapeutic applications. Herein, we review proofs of concept achieved for salivary glands with in vivo anima...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.3109/10611860108998782
更新日期：2001-01-01 00:00:00
abstract：:The aim of this study was to evaluate the pharmacokinetics (PK), tissue distribution, and the specific drug targeting of cefpiramide sodium-loaded liposomes (CPMS-Lips) compared with cefpiramide sodium solution (CPMS-Sol) in mice. CPMS-Lips were prepared by reverse phase evaporation method. In the PK and biodistributi...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611861003667607
更新日期：2011-01-01 00:00:00
