The application of polysaccharide-based nanogels in peptides/proteins and anticancer drugs delivery.


:Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels have attracted interest as carriers for proteins/peptides and anticancer drugs because of their characteristic properties like biodegradability, biocompatibility, stimuli-responsive behaviour, softness and swelling to help achieve a controlled, triggered response at the target site. In addition, the groups of the polysaccharide backbone are able to be modified to develop functional nanogels. Some polysaccharides have the intrinsic ability to recognise specific cell types, allowing the design of targeted drug delivery systems through receptor-mediated endocytosis. This review is aimed at describing and exploring the potential of polysaccharides that are used in nanogels which can help to deliver proteins/peptides and anticancer drugs.


J Drug Target


Zhang L,Pan J,Dong S,Li Z




Has Abstract


2017-09-01 00:00:00












  • A gene delivery approach for antimicrobials: expression of defensins.

    abstract:INTRODUCTION:Peptide antibiotics as new therapeutic agents are becoming a popular option to investigate due to their broad bacterial target selectivity and limited resistance problems. Although attractive, these new drug candidates have several limitations including low potency and delivery issues which face all peptid...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Zhang C,Yadava P,Sun J,Hughes JA

    更新日期:2006-11-01 00:00:00

  • Liposomes in the treatment of infections.

    abstract::The use of liposomes in the treatment of severe infections is under investigation. Classical liposomes which localize in cells of the mononuclear phagocyte system (MPS) can be exploited in two ways. First for targeting of macrophage modulators such as muramyl peptides or IFN-gamma, to stimulate the cells of the MPS to...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


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  • Development of a novel drug delivery system, time-controlled explosion system (TES). IV. In vivo drug release behavior.

    abstract::Time-Controlled Explosion System (TES) has the time-controlled drug release property with a pre-designed lag time. The drug release from the system is initiated by destruction of the membrane. In this study, metoprolol tartrate was used as a model drug. After five types of TES with different in vitro lag times were or...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Ueda S,Ibuki R,Kawamura A,Murata S,Takahashi T,Kimura S,Hata T

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  • Influence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofloxacin incorporated into liposomes.

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    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Chono S,Tanino T,Seki T,Morimoto K

    更新日期:2006-09-01 00:00:00

  • A new method to isolate polyalkylcyanoacrylate nanoparticle preparations.

    abstract::A simple method for the separation of polyalkylcyanoacrylate nanoparticles was developed using polyisohexylcyanoacrylate (PIHCA) as a model. Fluorescein isothiocyanate dextran 70 was used to label the nanoparticles. Ultracentrifugation onto a performed sucrose gradient allowed the easy elimination of the dextran and o...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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  • Characterization of oleanolic acid derivative for colon cancer targeting with positron emission tomography.

    abstract::Oleanolic acid (OA) is a pentacyclic triterpenoid found in various plant species. Triterpenoid compounds have been shown to inhibit tumor proliferation and to induce apoptosis in cancer cells. We synthesized an OA derivative and evaluated its inhibitory effects on cell proliferation in human colon cancer. Radioisotope...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Kim SM,Jeong IH,Yim MS,Chae MK,Kim HN,Kim DK,Kang CM,Choe YS,Lee C,Ryu EK

    更新日期:2014-10-07 00:00:00

  • Transfection of HEK cells via DNA-loaded PLGA and P(FASA) nanospheres.

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    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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  • Non-covalent ligand conjugation to biotinylated DNA nanoparticles using TAT peptide genetically fused to monovalent streptavidin.

    abstract::DNA nanoparticles (DNA NPs), which self-assemble from DNA plasmids and poly-L-lysine (pLL)-polyethylene glycol (PEG) block copolymers, transfect several cell types in vitro and in vivo with minimal toxicity and immune response. To further enhance the gene transfer efficiency of DNA NP and control its tropism, we estab...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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    更新日期:2012-09-01 00:00:00

  • Effect of applying modes of the polymer microneedle-roller on the permeation of L-ascorbic acid in rats.

    abstract::Despite the advantages of drug delivery through skin, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept known as microneedle was introduced and could be used to pierce effectively to deliver drugs us...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: You SK,Noh YW,Park HH,Han M,Lee SS,Shin SC,Cho CW

    更新日期:2010-01-01 00:00:00

  • Organ-based drug delivery.

    abstract::The phenomenal advances in pharmaceutical sciences over the last few decades have led to the development of new therapeutics like peptides, proteins, RNAs, DNAs and highly potent small molecules. Fruitful applications of these therapeutics have been challenged by several anatomical and physiological barriers that limi...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Alsaggar M,Liu D

    更新日期:2018-01-01 00:00:00

  • Efficient entrapment of amikacin and teicoplanin in liposomes.

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    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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  • Polymersomes as an effective drug delivery system for glioma--a review.

    abstract::Glioma is one of the most commonly occurring malignant brain tumours which need proper treatment strategy. The current therapies for treating glioma like surgical resection, radiotherapy, and chemotherapy have failed in achieving satisfactory results and this forms a rationale for the development of novel drug deliver...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Krishnamoorthy B,Karanam V,Chellan VR,Siram K,Natarajan TS,Gregory M

    更新日期:2014-07-01 00:00:00

  • SDS-coated atovaquone nanosuspensions show improved therapeutic efficacy against experimental acquired and reactivated toxoplasmosis by improving passage of gastrointestinal and blood-brain barriers.

    abstract::Toxoplasmic encephalitis (TE) is the most common clinical manifestation of reactivated infection with Toxoplasma gondii in immunocompromised patients that is lethal if untreated. The combination of pyrimethamine plus sulfadiazine or clindamycin is the standard therapy for the treatment of TE, but these combinations ar...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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    更新日期:2011-02-01 00:00:00

  • Design of a Pep-1 peptide-modified liposomal nanocarrier system for intracellular drug delivery: Conformational characterization and cellular uptake evaluation.

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    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Kang MJ,Kim BG,Eum JY,Park SH,Choi SE,An JJ,Jang SH,Eum WS,Lee J,Lee MW,Kang K,Oh CH,Choi SY,Choi YW

    更新日期:2011-08-01 00:00:00

  • Anti-tumor effect of ultrasound-induced Nordy-loaded microbubbles destruction.

    abstract:BACKGROUND:Synthesized dl-Nordihydroguaiaretic acid (dl-NGDA or "Nordy") can inhibit the growth of malignant human tumors, especially the tumor angiogenesis. However, its liposoluble nature limits its in vivo efficacy in the hydrosoluble circulation of human. PURPOSE:We tried to use the ultrasonic microbubble as the c...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Hua X,Ding J,Li R,Zhang Y,Huang Z,Guo Y,Chen Q

    更新日期:2016-09-01 00:00:00

  • Enhanced efficacy of diclofenac sodium-loaded lipogelosome formulation in intra-articular treatment of rheumatoid arthritis.

    abstract::Recent research into the complex and varied components of rheumatoid arthritis (RA) is leading to the development of more effective targets for pharmaceutical approach than even before. Current treatment of RA frequently includes the use of nonsteroidal anti-inflammatory drugs, such as Diclofenac sodium (DFNa) in spit...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Türker S,Erdoğan S,Ozer YA,Bilgili H,Deveci S

    更新日期:2008-01-01 00:00:00

  • Secure and effective gene delivery system of plasmid DNA coated by polynucleotide.

    abstract::Polynucleotides are anionic macromolecules which are expected to transfer into the targeted cells through specific uptake mechanisms. So, we developed polynucleotides coating complexes of plasmid DNA (pDNA) and polyethylenimine (PEI) for a secure and efficient gene delivery system and evaluated their usefulness. Polya...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Kodama Y,Ohkubo C,Kurosaki T,Egashira K,Sato K,Fumoto S,Nishida K,Higuchi N,Kitahara T,Nakamura T,Sasaki H

    更新日期:2015-01-01 00:00:00

  • Colon-specific delivery and enhanced colonic absorption of [Asu(1,7)]-eel calcitonin using chitosan capsules containing various additives in rats.

    abstract::The objective of this study was to estimate the colon-specific delivery of [Asu1,7]-eel calcitonin (ECT) using chitosan capsules in rats. The intestinal absorption of ECT was evaluated by measuring the plasma calcium levels after oral administration of the chitosan capsules containing ECT and different combinations of...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


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    更新日期:2006-04-01 00:00:00

  • Chloramphenicol-incorporated poly lactide-co-glycolide (PLGA) nanoparticles: formulation, characterization, technetium-99m labeling and biodistribution studies.

    abstract::Chloramphenicol-loaded (CHL) poly-d,l-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) were prepared by emulsification solvent evaporation technique either by using polyvinyl alcohol (PVA) as emulsion stabilizer or polysorbate-80 (PS-80) as surfactant and characterised by transmission electron microscopy, zeta-poten...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Halder KK,Mandal B,Debnath MC,Bera H,Ghosh LK,Gupta BK

    更新日期:2008-05-01 00:00:00

  • Liposomes and niosomes as potential carriers for dermal delivery of minoxidil.

    abstract::The aim of this work was to formulate minoxidil loaded liposome and niosome formulations to improve skin drug delivery. Multilamellar liposomes were prepared using soy phosphatidylcholine at different purity degrees (Phospholipon 90, 90% purity, soy lecithin (SL), 75% purity) and cholesterol (Chol), whereas niosomes w...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Mura S,Pirot F,Manconi M,Falson F,Fadda AM

    更新日期:2007-02-01 00:00:00

  • Transport of nanoparticles across the rat nasal mucosa.

    abstract::The transport of 125I-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings. Translocation of the particles into the blood stream was examined by means of monitoring the radiolabel associated with the particles. Particles were detected in the...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Brooking J,Davis SS,Illum L

    更新日期:2001-01-01 00:00:00

  • Entrapment of cyclodextrin-drug complexes into liposomes: potential advantages in drug delivery.

    abstract::A novel concept in drug delivery discussed here, takes advantage of certain properties of the drug "containers" cyclodextrins and liposomes to combine them into a single system thus circumventing problems associated with both systems. The concept, entailing entrapment of water-soluble cyclodextrin-drug inclusion compl...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: McCormack B,Gregoriadis G

    更新日期:1994-01-01 00:00:00

  • Preliminary evaluation of [18F]AlF-NOTA-MAL-Cys39-exendin-4 in insulinoma with PET.

    abstract:BACKGROUND:High expression of glucagon-like peptide-1 receptor (GLP-1R) in insulinoma supplies a potential drug target for tumor imaging. Exendin-4 can specifically bind to GLP-1R as an agonist and its analogs are extensively used in receptor imaging studies. PURPOSE:A new GLP-1R imaging agent, [(18)F]AlF-NOTA-MAL-Cys...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Xu Q,Zhu C,Xu Y,Pan D,Liu P,Yang R,Wang L,Chen F,Sun X,Luo S,Yang M

    更新日期:2015-01-01 00:00:00

  • Differences in the adsorption behaviour of poly(ethylene oxide) copolymers onto model polystyrene nanoparticles assessed by isothermal titration microcalorimetry correspond to the biological differences.

    abstract::The adsorption behaviour of a tetrafunctional copolymer of poly (ethylene oxide)-poly (propylene oxide) ethylene diamine (commercially available as Poloxamine 908) and a diblock copolymer of poly (lactic acid)-poly (ethylene oxide) (PLA/PEG 2:5) onto a model colloidal drug carrier (156 nm sized polystyrene latex) is d...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Stolnik S,Heald CR,Garnett MG,Illum L,Davis SS

    更新日期:2005-09-01 00:00:00

  • The potential use of rabies virus glycoprotein-derived peptides to facilitate drug delivery into the central nervous system: a mini review.

    abstract::Rabies virus glycoprotein (RVG), a 505 amino acid type-1 glycoprotein, is responsible for the neurotrophic nature of the rabies virus infection. Despite varying reports in the literature as to which receptor is ultimately responsible for interaction of RVG with the nervous system, there is a strong argument for major ...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章,评审


    authors: Huey R,Hawthorne S,McCarron P

    更新日期:2017-06-01 00:00:00

  • Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.

    abstract::Local treatment of middle ear (ME) disease currently requires surgical penetration of the tympanic membrane (TM). We previously discovered 12-mer peptides that are actively transported across the intact TM, a process that could be used for non-invasive drug delivery into the ME. To optimise transport and provide furth...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Kurabi A,Schaerer D,Chang L,Pak K,Ryan AF

    更新日期:2018-02-01 00:00:00

  • Low-intensity light-induced paclitaxel release from lipid-based nano-delivery systems.

    abstract::Light-induced drug release has been explored as a strategy for externally modulating the release of drug from delivery systems. This study reports the development of a solid lipid nanoparticulate system (SLN) for paclitaxel (PTX), where photosensitizer-mediated oxidation of lipids was used as a mechanism for controlli...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Meerovich I,Nichols MG,Dash AK

    更新日期:2019-11-01 00:00:00

  • Celecoxib incorporated chitosan microspheres: in vitro and in vivo evaluation.

    abstract::Recently, considerable interest has been focussed on the use of biodegradable polymers for specialized applications such as controlled release of drug formulations; meanwhile, microsphere drug delivery systems using various kinds of biodegradable polymers have been studied extensively during the past two decades. In t...

    journal_title:Journal of drug targeting

    pub_type: 杂志文章


    authors: Thakkar H,Sharma RK,Mishra AK,Chuttani K,Murthy RS

    更新日期:2004-01-01 00:00:00