The application of polysaccharide-based nanogels in peptides/proteins and anticancer drugs delivery.

Abstract:

:Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels have attracted interest as carriers for proteins/peptides and anticancer drugs because of their characteristic properties like biodegradability, biocompatibility, stimuli-responsive behaviour, softness and swelling to help achieve a controlled, triggered response at the target site. In addition, the groups of the polysaccharide backbone are able to be modified to develop functional nanogels. Some polysaccharides have the intrinsic ability to recognise specific cell types, allowing the design of targeted drug delivery systems through receptor-mediated endocytosis. This review is aimed at describing and exploring the potential of polysaccharides that are used in nanogels which can help to deliver proteins/peptides and anticancer drugs.

journal_name

J Drug Target

authors

Zhang L,Pan J,Dong S,Li Z

doi

10.1080/1061186X.2017.1326123

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

673-684

issue

8

eissn

1061-186X

issn

1029-2330

journal_volume

25

pub_type

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