The application of polysaccharide-based nanogels in peptides/proteins and anticancer drugs delivery.

abstract：:Anionic, cationic, and neutral liposomes were constructed to contain IL-2 in order to evaluate their affinity to a cervical cancer cell line (INBL) and to determine whether they can present IL-2 on their external surface. When these liposomes were co-cultured with INBL, the anionic liposomes were the only ones found t...

journal_title：Journal of drug targeting

authors： Corona-Ortega T,Rangel-Corona R,Hernández-Jiménez M,Baeza I,Ibáñez M,Weiss-Steider B

更新日期：2009-08-01 00:00:00

abstract：:An aspargine-glycine-arginine (NGR) peptide modified single-walled carbon nanotubes (SWCNTs) system, developed by a simple non-covalent approach, could be loaded with the anticancer drug doxorubicin (DOX) and magnetic resonance imaging (MRI) contrast agent gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). This...

journal_title：Journal of drug targeting

authors： Yan C,Chen C,Hou L,Zhang H,Che Y,Qi Y,Zhang X,Cheng J,Zhang Z

更新日期：2017-02-01 00:00:00

abstract：:We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the twenty-first century. Multiple drug resistance and nonspecific drug targeting of the m...

journal_title：Journal of drug targeting

authors： Baruah UK,Gowthamarajan K,Vanka R,Karri VVSR,Selvaraj K,Jojo GM

更新日期：2017-08-01 00:00:00

abstract：:The present study evaluates the prophylactic efficacy of α-tocopherol (α-TOH), resveratrol (RES), and coenzyme Q10 (CoQ10) co-loaded self-nanoemulsifying drug delivery system (α-TOH-RES-CoQ10 SNEDDS) in 7,12-Dimethylbenz[a]anthracene (DMBA) induced breast cancer model. SNEDDS formulation components were rationally sel...

journal_title：Journal of drug targeting

authors： Jain S,Garg T,Kushwah V,Thanki K,Agrawal AK,Dora CP

更新日期：2017-07-01 00:00:00

abstract：:DNA nanoparticles (DNA NPs), which self-assemble from DNA plasmids and poly-L-lysine (pLL)-polyethylene glycol (PEG) block copolymers, transfect several cell types in vitro and in vivo with minimal toxicity and immune response. To further enhance the gene transfer efficiency of DNA NP and control its tropism, we estab...

journal_title：Journal of drug targeting

authors： Sun W,Fletcher D,van Heeckeren RC,Davis PB

更新日期：2012-09-01 00:00:00

abstract：:An aqueous dispersion of self-organized phospholipid tubules has been utilized as the template for silica-deposited nanotubules (approximately 0.5 microm thick and >10 microm long) by a sol-gel method. The formation of the hybrid tubules was mechanistically investigated by controlled sol-gel reaction. The incorporatio...

journal_title：Journal of drug targeting

authors： Kim I,Park YH,Rey DA,Batt CA

更新日期：2008-11-01 00:00:00

abstract：:Considering limitations of conventional insulin therapies, the present study characterizes usefulness of novel mucoadhesive multivesicular liposomes as a mucoadhesive sustained release carrier of insulin via nasal and ocular routes, thus attempts to develop non-invasive carrier system for the controlled release of bio...

journal_title：Journal of drug targeting

authors： Jain AK,Chalasani KB,Khar RK,Ahmed FJ,Diwan PV

更新日期：2007-07-01 00:00:00

abstract：:A targeted delivery system for inflammatory bowel diseases, chitosan-Ca-alginate microparticles efficiently loaded with budesonide (BDS), were designed using one-step spray-drying process. They were eudragit-coated and examined for in vivo efficacy. Experimental colitis was induced by rectal instillation of 2,4,6-trin...

journal_title：Journal of drug targeting

authors： Crcarevska MS,Dodov MG,Petrusevska G,Gjorgoski I,Goracinova K

更新日期：2009-12-01 00:00:00

abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers containing doxorubicin and galactosamine have been developed to target the hepatocyte galactose receptor with the aim of organ-specific chemotherapy of primary and metastatic liver disease. Previous biodistribution studies in rats and mice have used tyrosinamide inco...

journal_title：Journal of drug targeting

authors： Pimm MV,Perkins AC,Duncan R,Ulbrich K

更新日期：1993-01-01 00:00:00

abstract：:To identify an agent with specific activity against B-lineage leukaemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanised anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-liposomes). These liposomes were specially designed to recognise and kill B-LSC...

journal_title：Journal of drug targeting

authors： Zhang J,Shen D,Jia M,Zhao H,Tang Y

更新日期：2018-01-01 00:00:00

abstract：:We have developed a new method to evaluate the transfer of macromolecular drugs to intrapulmonary lymph nodes in rats after intrapulmonary administration. By using this method, we observed that the transfer of fluorescein isothiocyanate dextrans (FDs) to the intrapulmonary lymph nodes was markedly higher than that to ...

journal_title：Journal of drug targeting

authors： Hanatani K,Takada K,Yoshida N,Nakasuji M,Morishita Y,Yasako K,Fujita T,Yamamoto A,Muranishi S

更新日期：1995-01-01 00:00:00

abstract：:Mitochondria are one type of the major organelles in the cell, participating in a variety of important physiological and biochemical processes, such as tricarboxylic acid cycle, fatty acid metabolism and oxidative phosphorylation. Meanwhile, it also happens to be the key regulator of apoptosis by triggering the comple...

journal_title：Journal of drug targeting

authors： Chen ZP,Li M,Zhang LJ,He JY,Wu L,Xiao YY,Duan JA,Cai T,Li WD

更新日期：2016-01-01 00:00:00

abstract：:Cell-penetrating peptides (CPPs) are efficient vehicles to transport bioactive molecules into the cells. Despite numerous studies the exact mechanism by which CPPs facilitate delivery of cargo to its intracellular target is still debated. The current work presents methods that can be used for tracking CPP/pDNA complex...

journal_title：Journal of drug targeting

authors： Pärnaste L,Arukuusk P,Zagato E,Braeckmans K,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：:Archaeal ether glycerolipid vesicles (archaeosomes) efficiently deliver exogenous antigen for induction of humoral and cell-mediated immunity. Because induction of CD8 cytotoxic T cells is critical for protective vaccination against tumors, we compared the ability of various archaeosome lipid compositions to evoke a s...

journal_title：Journal of drug targeting

authors： Krishnan L,Dennis Sprott G,Institute for Biological Sciences, National Research Council of Canada.

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The polycationic nanopeptide RKKRRQRRR is a fragment of HIV-Tat protein known to be a transfection enhancer. Such factors control the transfection efficiency of plasmid DNA complexed with tat peptide. However, their actions are poorly understood. METHODS AND RESULTS:Several cell lines and primary cells were...

journal_title：Journal of drug targeting

authors： Hellgren I,Gorman J,Sylvén C

更新日期：2004-01-01 00:00:00

abstract：:Previous studies indicated the potential of zinc protoporphyrin (ZnPP) as an antitumor agent targeting to the tumor survival factor heme oxygenase-1, and/or for photodynamic therapy (PDT). In this study, to achieve tumor-targeted delivery, styrene-maleic acid-copolymer conjugated ZnPP (SMA-ZnPP) was synthesized via am...

journal_title：Journal of drug targeting

authors： Fang J,Tsukigawa K,Liao L,Yin H,Eguchi K,Maeda H

更新日期：2016-01-01 00:00:00

abstract：:The phenomenal advances in pharmaceutical sciences over the last few decades have led to the development of new therapeutics like peptides, proteins, RNAs, DNAs and highly potent small molecules. Fruitful applications of these therapeutics have been challenged by several anatomical and physiological barriers that limi...

journal_title：Journal of drug targeting

authors： Alsaggar M,Liu D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Nanoparticles with controlled physical properties have been widely used for controlled release applications. In addition to shape, the anisotropic nature of the particles can be an important design criterion to ensure selective surface modification or independent release of combinations of drugs. PURPOSE:El...

journal_title：Journal of drug targeting

authors： Rahmani S,Villa CH,Dishman AF,Grabowski ME,Pan DC,Durmaz H,Misra AC,Colón-Meléndez L,Solomon MJ,Muzykantov VR,Lahann J

更新日期：2015-01-01 00:00:00

abstract：:Necrosis avid agents (NAAs) can be used for diagnose of necrosis-related diseases, evaluation of therapeutic responses and targeted therapeutics of tumor. In order to probe into the effects of molecular skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones, four dianthrone com...

journal_title：Journal of drug targeting

authors： Zhang D,Jiang C,Yang S,Gao M,Huang D,Wang X,Shao H,Feng Y,Sun Z,Ni Y,Zhang J,Yin Z

更新日期：2016-01-01 00:00:00

abstract：:A higher encapsulation rate was obtained using the dehydration-rehydration method compared with the reverse-phase evaporation technique in negative multilamellar vesicles with amikacin (AMK) (45% versus 15%; P < 0.05) and teicoplanin (TCP) (34% versus 25%; P < 0.05). The addition of 250 mM sucrose to AMK- or TCP-conta...

journal_title：Journal of drug targeting

authors： Ravaoarinoro M,Toma E,Agbaba O,Morisset R

更新日期：1993-01-01 00:00:00

abstract：:Influenza, mainly caused by influenza virus, is becoming one of the major concerns in the world. Limitation in vaccines necessitates the urgent development of new therapeutic options against this virus. In the present study, we designed small interfering RNA (siRNA) targeting overlapping gene of PB1 and PB1-F2 gene of...

journal_title：Journal of drug targeting

authors： Cheng C,Yao L,Chen A,Jia R,Huan L,Guo J,Bo H,Shu Y,Zhang Z

更新日期：2009-02-01 00:00:00

abstract：:The present work describes the potential for using lectin-conjugated gliadin nanoparticles as a means of locating and anchoring a drug delivery system on the carbohydrate receptors of Helicobacter pylori (H. pylori). Gliadin nanoparticles (GNP) bearing acetohydroxamic acid (AHA) were prepared by a desolvation method. ...

journal_title：Journal of drug targeting

authors： Umamaheshwari RB,Jain NK

更新日期：2003-08-01 00:00:00

abstract：:Liposomes have been prepared loaded with DNA (plasmid encoding for the green fluorescent protein, GFP) and additionally modified with TATp and PEG, with PEG being attached to the liposome surface via both pH-sensitive hydrazone and non-pH-sensitive bonds. The pGFP-loaded liposomal preparations have been administered i...

journal_title：Journal of drug targeting

authors： Kale AA,Torchilin VP

更新日期：2007-08-01 00:00:00

abstract：:Rabies virus glycoprotein (RVG), a 505 amino acid type-1 glycoprotein, is responsible for the neurotrophic nature of the rabies virus infection. Despite varying reports in the literature as to which receptor is ultimately responsible for interaction of RVG with the nervous system, there is a strong argument for major ...

journal_title：Journal of drug targeting

authors： Huey R,Hawthorne S,McCarron P

更新日期：2017-06-01 00:00:00

abstract：:Recent studies have demonstrated that the carboxyterminal third domain of alpha-fetoprotein (AFP-CD) binds with various ligands and receptors. Reports within the last decade have established that AFP-CD contains a large fragment of amino acids that interact with several different receptor types. Using computer softwar...

journal_title：Journal of drug targeting

authors： Mizejewski GJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:High expression of glucagon-like peptide-1 receptor (GLP-1R) in insulinoma supplies a potential drug target for tumor imaging. Exendin-4 can specifically bind to GLP-1R as an agonist and its analogs are extensively used in receptor imaging studies. PURPOSE:A new GLP-1R imaging agent, [(18)F]AlF-NOTA-MAL-Cys...

journal_title：Journal of drug targeting

authors： Xu Q,Zhu C,Xu Y,Pan D,Liu P,Yang R,Wang L,Chen F,Sun X,Luo S,Yang M

更新日期：2015-01-01 00:00:00

abstract：:Germ-free (GF) animals lack a colonic microflora like that seen in conventional (CV) animals. Bacterial presence plays a role in the development of glycoproteins in the gastrointestinal (GI) tract; the absence of a microbiota has been seen to suppress the production of certain glycoproteins and glycolipids. Binding pa...

journal_title：Journal of drug targeting

authors： Wróblewski S,Ríhová B,Rossmann P,Hudcovicz T,Reháková Z,Kopecková P,Kopecek J

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:To evaluate the internalization and subcellular fate of AS1411 aptamer (for glioma targeting) and TGN peptide (for blood-brain barrier targeting)-modified nanoparticles (AsTNPs), which was important for optimizing targeted delivery systems and realizing the potential toxicity to cells. METHODS:Organelles were ...

journal_title：Journal of drug targeting

authors： Gao H,Yang Z,Zhang S,Pang Z,Jiang X

更新日期：2014-06-01 00:00:00

abstract：:A simple method for the separation of polyalkylcyanoacrylate nanoparticles was developed using polyisohexylcyanoacrylate (PIHCA) as a model. Fluorescein isothiocyanate dextran 70 was used to label the nanoparticles. Ultracentrifugation onto a performed sucrose gradient allowed the easy elimination of the dextran and o...

journal_title：Journal of drug targeting

authors： Pinto-Alphandary H,Balland O,Couvreur P

更新日期：1995-01-01 00:00:00

abstract：:A nuclear localization signal (NLS) is a short amino acid sequence derived from eukaryotic nuclear proteins and viral proteins. Many NLS peptides can efficiently mediate the intranucleus transport of cargo molecules, so they have been widely used for non-viral gene transfer and shown potential ability to improve nucle...

journal_title：Journal of drug targeting

authors： Sun Y,Xian L,Xing H,Yu J,Yang Z,Yang T,Yang L,Ding P

更新日期：2016-12-01 00:00:00