Celecoxib incorporated chitosan microspheres: in vitro and in vivo evaluation.

Abstract:

:Recently, considerable interest has been focussed on the use of biodegradable polymers for specialized applications such as controlled release of drug formulations; meanwhile, microsphere drug delivery systems using various kinds of biodegradable polymers have been studied extensively during the past two decades. In the present investigation, it was aimed to prepare microsphere formulations of celecoxib using a natural polymer, chitosan as a carrier for intra-articular administration to extend the retention of the drug in the knee joint. Microsphere formulations were evaluated in vitro for particle size, entrapment efficiency, surface morphology and in vitro drug release. For in vivo studies, (99m)Technetium- labeled glutathione was used as a radiopharmaceutical to demonstrate arthritic lesions by gamma scintigraphy. Evaluation of arthritic lesions post therapy in rats showed a significant difference (P < 0.005) in the group treated with celecoxib solution compared to the group treated with celecoxib loaded chitosan microspheres.

journal_name

J Drug Target

authors

Thakkar H,Sharma RK,Mishra AK,Chuttani K,Murthy RS

doi

10.1080/10611860400010630

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

549-57

issue

9-10

eissn

1061-186X

issn

1029-2330

pii

QJ0WM6NV6JTKK87R

journal_volume

12

pub_type

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