Similar efficiency of DNA-liposome complexes and retrovirus-producing cells for HSV-tk suicide gene therapy of peritoneal carcinomatosis.

abstract：:Dendrimers, spherical or quasi-spherical synthetic polymers in the nano-size range, have found useful applications as prospective carriers in drug and gene delivery. The investigation of dendrimer uptake by cells has been previously achieved by the incorporation of a fluorescent dye to the dendrimer either by chemical...

journal_title：Journal of drug targeting

authors： Al-Jamal KT,Ruenraroengsak P,Hartell N,Florence AT

更新日期：2006-07-01 00:00:00

abstract：:Drug systems targeting tumor cells using basic fibroblast growth factor (bFGF) have been widely reported. In this study, the peptide KRTGQYKLC (bFGFp), containing cysteine at the carboxyl termination of the bFGF-derived peptide, was applied as a novel ligand targeting tumor cells. bFGFp was conjugated with bovine seru...

journal_title：Journal of drug targeting

authors： Terada T,Mizobata M,Kawakami S,Yabe Y,Yamashita F,Hashida M

更新日期：2006-09-01 00:00:00

abstract：:Local treatment of middle ear (ME) disease currently requires surgical penetration of the tympanic membrane (TM). We previously discovered 12-mer peptides that are actively transported across the intact TM, a process that could be used for non-invasive drug delivery into the ME. To optimise transport and provide furth...

journal_title：Journal of drug targeting

authors： Kurabi A,Schaerer D,Chang L,Pak K,Ryan AF

更新日期：2018-02-01 00:00:00

abstract：:The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy and is defined to a large part by the many and complex cellular biological and biochemical barriers such that a construct must traverse. It is shown here that model dextrin conjugates are able to pass through...

journal_title：Journal of drug targeting

authors： Powell A,Caterson B,Hughes C,Paul A,James C,Hopkins S,Mansour O,Griffiths P

更新日期：2017-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the transfer of N-acetyl-p-aminobenzoic acid (AcPABA) across the rat term placenta and the rat small intestine and to compare it with that of its parent drug p-aminobenzoic acid (PABA). Umbilical perfusion of the rat term placenta was used to determine the materno-fetal tra...

journal_title：Journal of drug targeting

authors： Staud F,Fendrich Z,Hartl J,Jindrova O,Láznícek M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Multifunctional gold nanospheres (MGNs)-loaded with docetaxel (MGN@DTX) were prepared and evaluated for therapeutic efficacy in nude mice bearing human prostate cancer xenografts. METHODS:MGNs were prepared from PEGylated hollow gold nanospheres (HGNs) coated with folic acid and DTPTT chelate. Then, the eff...

journal_title：Journal of drug targeting

authors： Shen Y,Ma Z,Chen F,Dong Q,Hu Q,Bai L,Chen J

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The objective of this work was to examine the application of catechins-containing phospholipids-based ultrasonic microbubbles (PUM) in ultrasound-induced delivery. METHODS:Catechins-containing PUM were prepared by dissolving lyophilized PUM powder in catechins solution. Morphologic characteristics of catechi...

journal_title：Journal of drug targeting

authors： Lu CT,Zhao YZ

更新日期：2008-12-01 00:00:00

abstract：:Anionic, cationic, and neutral liposomes were constructed to contain IL-2 in order to evaluate their affinity to a cervical cancer cell line (INBL) and to determine whether they can present IL-2 on their external surface. When these liposomes were co-cultured with INBL, the anionic liposomes were the only ones found t...

journal_title：Journal of drug targeting

authors： Corona-Ortega T,Rangel-Corona R,Hernández-Jiménez M,Baeza I,Ibáñez M,Weiss-Steider B

更新日期：2009-08-01 00:00:00

abstract：:The aim of this work was to formulate minoxidil loaded liposome and niosome formulations to improve skin drug delivery. Multilamellar liposomes were prepared using soy phosphatidylcholine at different purity degrees (Phospholipon 90, 90% purity, soy lecithin (SL), 75% purity) and cholesterol (Chol), whereas niosomes w...

journal_title：Journal of drug targeting

authors： Mura S,Pirot F,Manconi M,Falson F,Fadda AM

更新日期：2007-02-01 00:00:00

abstract：:Tumour-associated macrophages (TAMs) represent as much as 50% of the solid mass in different types of human solid tumours including lung, breast, ovarian and pancreatic adenocarcinomas. The tumour microenvironment (TME) plays an important role in the polarisation of macrophages into the M1 phenotype, which is tumour-s...

journal_title：Journal of drug targeting

authors： Aldawsari HM,Gorain B,Alhakamy NA,Md S

更新日期：2020-02-01 00:00:00

abstract：:To identify an agent with specific activity against B-lineage leukaemia stem cells (B-LSCs), we generated norcantharidin (NCTD)-encapsulated liposomes modified with a novel humanised anti-human CD19 monoclonal antibody, Hm2E8b (Hm2E8b-NCTD-liposomes). These liposomes were specially designed to recognise and kill B-LSC...

journal_title：Journal of drug targeting

authors： Zhang J,Shen D,Jia M,Zhao H,Tang Y

更新日期：2018-01-01 00:00:00

abstract：:In order to facilitate the intracellular delivery of macromolecules, Pep-1 peptide-modified liposomal (Pep1-Lipo) nanocarriers were designed and examined for their in vitro cell translocation capability. Pep-1 peptides were coupled via thiol-maleimide linkage to small unilamellar vesicles composed of phosphatidylcholi...

journal_title：Journal of drug targeting

authors： Kang MJ,Kim BG,Eum JY,Park SH,Choi SE,An JJ,Jang SH,Eum WS,Lee J,Lee MW,Kang K,Oh CH,Choi SY,Choi YW

更新日期：2011-08-01 00:00:00

abstract：:Radiolabelled poly(methylmethacrylate) (PMMA) nanoparticles were coated with rat serum albumin (RSA), serum and inactivated serum, to examine the influence of these blood components on the body distribution of a model colloidal drug carrier. The particles were incubated overnight at 37 degrees C either in a 1% solutio...

journal_title：Journal of drug targeting

authors： Borchard G,Kreuter J

更新日期：1993-01-01 00:00:00

abstract：:Aim was to develop and optimize multiunit gastro-retentive floating beads (FBs) intended for localized and prolonged release of ginger for treating gastric ulcers. Protective effect of ginger extract (GE) against ulcer is well documented, but therapeutic use is compromised due to poor bioavailability and physicochemic...

journal_title：Journal of drug targeting

authors： Kumar Singh P,Pal Kaur I

更新日期：2011-11-01 00:00:00

abstract：:A general mathematical model involving partition coefficient, molecular weight and hydrogen bonding is used to correlate the structures and permeability of various organic compounds through the toad urinary bladder and human red blood cell (RBC) membranes. Log Per (permeability) is correlated with log Po/w (partition ...

journal_title：Journal of drug targeting

authors： Ren S,Das A,Lien EJ

更新日期：1996-01-01 00:00:00

abstract：:Cytokine inhibiting drugs are much more effective when delivered intracellularly to phagocytic cells in the microencapsulated form. Dexamethasone is a powerful inhibitor of TNF-α cytokine through inhibition of NF-κB which is a gene regulator of multiple pro-inflammatory cytokines. We have determined the effect of micr...

journal_title：Journal of drug targeting

authors： Uddin MN,Siddiq A,Oettinger CW,D'Souza MJ

更新日期：2011-11-01 00:00:00

abstract：:Local tissue toxicity, systemic toxicity and platinum pharmacokinetics were evaluated in 6 normal healthy beagle dogs injected subcutaneously with two formulations of a polylactide biodegradable polymer (Atrigel) system containing cisplatin. Dogs were injected 4 times at 30 day intervals at platinum dosages of 70, 105...

journal_title：Journal of drug targeting

authors： Dernell WS,Straw RC,Withrow SJ,Powers BE,Fujita SM,Yewey GS,Joseph KF,Dunn RL,Whitman SL,Southard GL

更新日期：1998-01-01 00:00:00

abstract：:Most therapeutic agents are delivered orally. Consequently, the major classes of therapeutically useful chemicals are partially lipophilic, small molecular weight compounds. They have reasonable permeability coefficient values across cell membranes, including those of intestinal epithelia and vascular endothelia. In c...

journal_title：Journal of drug targeting

authors： Baird AW,Campion DP,O'Brien L,Brayden DJ

更新日期：2004-02-01 00:00:00

abstract：:Chloramphenicol-loaded (CHL) poly-d,l-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) were prepared by emulsification solvent evaporation technique either by using polyvinyl alcohol (PVA) as emulsion stabilizer or polysorbate-80 (PS-80) as surfactant and characterised by transmission electron microscopy, zeta-poten...

journal_title：Journal of drug targeting

authors： Halder KK,Mandal B,Debnath MC,Bera H,Ghosh LK,Gupta BK

更新日期：2008-05-01 00:00:00

abstract：:The objective of this study was to estimate the colon-specific delivery of [Asu1,7]-eel calcitonin (ECT) using chitosan capsules in rats. The intestinal absorption of ECT was evaluated by measuring the plasma calcium levels after oral administration of the chitosan capsules containing ECT and different combinations of...

journal_title：Journal of drug targeting

authors： Fetih G,Fausia H,Okada N,Fujita T,Attia M,Yamamoto A

更新日期：2006-04-01 00:00:00

abstract：:An oral vaccine formulation comprised of starch microparticles with conjugated antigens is being developed. In this report we have examined the uptake of such microparticles by the intestinal mucosa and examined whether the conjugated antigen can influence the uptake. Two model antigens were used: recombinant cholera ...

journal_title：Journal of drug targeting

authors： Larhed A,Stertman L,Edvardsson E,Sjöholm I

更新日期：2004-06-01 00:00:00

abstract：:There are much said about Pieter Cullis in this special volume honoring him. He was the pioneer to study the role of hexagonal HII phase in membrane fusion and the one who applied this concept for the design of lipid nanoparticles. He was also the first to utilize remote loading techniques for the delivery of amphipat...

journal_title：Journal of drug targeting

authors： Huang L,Miao L

更新日期：2016-11-01 00:00:00

abstract：:The objective of this study was to investigate the factors for enhancing the susceptibility of cancer cells to chemotherapeutic drug by ultrasound microbubbles. Ultrasound (US) combined with phospholipid-based microbubbles (MB) was used to enhance the susceptibility of colon cancer cell line SWD-620 to anticancer drug...

journal_title：Journal of drug targeting

authors： Zhao YZ,Gao HS,Zhou ZC,Tang QQ,Lu CT,Jin Z,Tian JL,Xu YY,Tian XQ,Wang L,Kong FL,Li XK,Huang PT,He HL,Wu Y

更新日期：2010-07-01 00:00:00

abstract：:Intracellular compartmentalisation is a significant barrier to the successful nucleocytosolic delivery of biologics. The endocytic system has been shown to be responsible for compartmentalisation, providing an entry point, and trigger(s) for the activation of drug delivery systems. Consequently, many of the technologi...

journal_title：Journal of drug targeting

authors： Shorter SA,Pettit MW,Dyer PDR,Coakley Youngs E,Gorringe-Pattrick MAM,El-Daher S,Richardson S

更新日期：2017-01-01 00:00:00

abstract：:Interactions between phosphatidylcholine (PC) or phosphatidylserine (PS) liposomes and human umbilical vein endothelial cells (HUVEC) or human promyelocytic leukemia cells (HL60) were investigated. Pyramine encapsulating or rhodamine incorporating small unilamellar liposomes with mean diameters around 80 nm (demonstra...

journal_title：Journal of drug targeting

authors： Papadimitriou E,Antimisiaris SG

更新日期：2000-01-01 00:00:00

abstract：:A higher encapsulation rate was obtained using the dehydration-rehydration method compared with the reverse-phase evaporation technique in negative multilamellar vesicles with amikacin (AMK) (45% versus 15%; P < 0.05) and teicoplanin (TCP) (34% versus 25%; P < 0.05). The addition of 250 mM sucrose to AMK- or TCP-conta...

journal_title：Journal of drug targeting

authors： Ravaoarinoro M,Toma E,Agbaba O,Morisset R

更新日期：1993-01-01 00:00:00

abstract：:Chemotherapy is still a major challenge for in vivo drug targeting to macrophages. Toxicity remains the major obstacle for the most potent drugs already known in the therapy of leishmaniasis. Thus, new drugs and new delivery systems are sought. By using different vesicular delivery modes e.g. liposomes, niosomes, micr...

journal_title：Journal of drug targeting

authors： Sarkar S,Mandal S,Sinha J,Mukhopadhyay S,Das N,Basu MK

更新日期：2002-12-01 00:00:00

abstract：:Microparticles-adsorbed insulin and zinc insulin (PenfilN) were molded to self-dissolving micropiles (SDMPs) with chondroitin sulfate as the base for the percutaneous administration of insulin. Porous silicon dioxide (Sylysia 320, 440 and 730) and porous calcium silicate (FloriteRE) were used as microparticles. As a r...

journal_title：Journal of drug targeting

authors： Ito Y,Hagiwara E,Saeki A,Sugioka N,Takada K

更新日期：2007-06-01 00:00:00

abstract：:The purpose of this study is to develop novel intestinal-specific insulin delivery systems with pH-sensitive swelling and drug release properties. The glucose-6-acrylate-1,2,3,4-tetraacetate (GATA) monomer was prepared under mild conditions. Cubane-1,4-dicarboxylic acid linked to two 2-hydroxyethyl methacrylate groups...

journal_title：Journal of drug targeting

authors： Mahkam M

更新日期：2009-01-01 00:00:00

abstract：:The aim of this study was to evaluate the pharmacokinetics (PK), tissue distribution, and the specific drug targeting of cefpiramide sodium-loaded liposomes (CPMS-Lips) compared with cefpiramide sodium solution (CPMS-Sol) in mice. CPMS-Lips were prepared by reverse phase evaporation method. In the PK and biodistributi...

journal_title：Journal of drug targeting

authors： Sun Q,Shi M,Shao W,Shi Y,Xi Y,Huang G

更新日期：2011-01-01 00:00:00