Abstract：
:Tumour-associated macrophages (TAMs) represent as much as 50% of the solid mass in different types of human solid tumours including lung, breast, ovarian and pancreatic adenocarcinomas. The tumour microenvironment (TME) plays an important role in the polarisation of macrophages into the M1 phenotype, which is tumour-suppressive, or M2 phenotype, which is tumour promoting. Preclinical and clinical evidences suggest that TAMs are predominantly of the M2 phenotype that supports immune suppression, tumour growth, angiogenesis, metastasis and therapeutic resistance. Hence, significant attention has been focussed on the development of strategies for the modification of TAMs to halt lung cancer progression. The promotion of repolarisation from the M2 to the M1 subtype, or the prevention of M2 polarisation of TAMs in the stromal environment is potential approaches to reduce progression and metastasis of lung cancer. The focus of this article is an introduction to the development and evaluation of therapeutic agents that may halt lung cancer progression via the manipulation of macrophage polarisation. This article will address recent advances in the therapeutic efficacy of nanomedicine exploiting surface functionalisation of nanoparticles and will also consider future perspectives.
journal_name
J Drug Targetjournal_title
Journal of drug targetingauthors
Aldawsari HM,Gorain B,Alhakamy NA,Md Sdoi
10.1080/1061186X.2019.1648478subject
Has Abstractpub_date
2020-02-01 00:00:00pages
166-175issue
2eissn
1061-186Xissn
1029-2330journal_volume
28pub_type
杂志文章abstract：:Liposomal encapsulation of doxorubicin (DXR) improves tumor accumulation and reduces adverse effects. One possible strategy for further optimization of this delivery technology would be to design the liposome carrier to release its content within the tumor tissue in response to specific stimuli such as ultrasound (US)...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/1061186X.2010.551401
更新日期：2011-09-01 00:00:00
abstract：:Tissue plasminogen activator (tPA) is the only FDA approved medical treatment for the ischaemic stroke. However, it associates with some inevitable limitations, including: short therapeutic window, extremely short half-life and low penetration in large clots. Systemic administration may lead to complications such as h...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.1080/1061186X.2017.1365874
更新日期：2018-02-01 00:00:00
abstract：:Gene augmentation has been the paradigm in the majority of gene therapy protocols but in recent years the potential of repairing the mutated gene in situ by targeted gene correction has become a reality. In fact, targeted gene repair has many advantages over conventional replacement strategies, notably the possibility...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.1080/10611860290016739
更新日期：2002-03-01 00:00:00
abstract：:Polynucleotides are anionic macromolecules which are expected to transfer into the targeted cells through specific uptake mechanisms. So, we developed polynucleotides coating complexes of plasmid DNA (pDNA) and polyethylenimine (PEI) for a secure and efficient gene delivery system and evaluated their usefulness. Polya...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/1061186X.2014.950665
更新日期：2015-01-01 00:00:00
abstract：:A novel concept in drug delivery discussed here, takes advantage of certain properties of the drug "containers" cyclodextrins and liposomes to combine them into a single system thus circumventing problems associated with both systems. The concept, entailing entrapment of water-soluble cyclodextrin-drug inclusion compl...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.3109/10611869408996821
更新日期：1994-01-01 00:00:00
abstract：:Liposomes have been prepared from dipalmitoylphosphatidylcholine (DPPC), cholesterol (Chol) and dimethyldioctadecylammonium bromide (DDAB). The cationic vesicles adsorb to biofilms of the skin-associated bacteria Staphylococcus epidermidis, which have a negative charge. Encapsulation of the antibacterial drug vancomyc...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611869609015975
更新日期：1996-01-01 00:00:00
abstract：:Light-induced drug release has been explored as a strategy for externally modulating the release of drug from delivery systems. This study reports the development of a solid lipid nanoparticulate system (SLN) for paclitaxel (PTX), where photosensitizer-mediated oxidation of lipids was used as a mechanism for controlli...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/1061186X.2019.1571066
更新日期：2019-11-01 00:00:00
abstract：:In this review, we emphasize the efforts on the development of radiolabeled nanoparticles (NPs) for cancer treatment, i.e. theranostic tools based on nanotechnology and nuclear medicine. Currently, radionuclide therapy remains to be an important treatment option. The ionizing radiation from radionuclides (not provided...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.3109/1061186X.2014.988216
更新日期：2015-04-01 00:00:00
abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers containing doxorubicin and galactosamine have been developed to target the hepatocyte galactose receptor with the aim of organ-specific chemotherapy of primary and metastatic liver disease. Previous biodistribution studies in rats and mice have used tyrosinamide inco...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611869308996068
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Treatment of late stage cancers has proven to be a very difficult task. Targeted therapy and combinatory drug administration may be the solution. PURPOSE:The study was performed to evaluate the therapeutic efficacy of PEG-PE micelles, co-loaded with curcumin (CUR) and doxorubicin (DOX), and targeted with an...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/1061186X.2013.840639
更新日期：2013-12-01 00:00:00
abstract：:DNA nanoparticles (DNA NPs), which self-assemble from DNA plasmids and poly-L-lysine (pLL)-polyethylene glycol (PEG) block copolymers, transfect several cell types in vitro and in vivo with minimal toxicity and immune response. To further enhance the gene transfer efficiency of DNA NP and control its tropism, we estab...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/1061186X.2012.712128
更新日期：2012-09-01 00:00:00
abstract：:It is well established that overproduction and accumulation of the β-amyloid (Aβ) peptide 1-42 (Aβ(1-42)) is a trigger of the pathological cascade in Alzheimer's disease (AD) that manifests as cognitive impairment. Ginsenoside Rg3 is an important constituent of ginseng, plays an essential role in memory and improved c...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/1061186X.2017.1354002
更新日期：2018-02-01 00:00:00
abstract：:Chloramphenicol-loaded (CHL) poly-d,l-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) were prepared by emulsification solvent evaporation technique either by using polyvinyl alcohol (PVA) as emulsion stabilizer or polysorbate-80 (PS-80) as surfactant and characterised by transmission electron microscopy, zeta-poten...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860801899300
更新日期：2008-05-01 00:00:00
abstract：:Diabetes is a condition that is not completely treatable but life of a diabetic patient can be smoothed by preventing or delaying the associate conditions like diabetic retinopathy, nephropathy, impaired wound healing process, etc. Apart from conventional methods to regulate diabetic condition, new techniques using si...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.1080/1061186X.2018.1476518
更新日期：2019-02-01 00:00:00
abstract：:Liposomes have been prepared loaded with DNA (plasmid encoding for the green fluorescent protein, GFP) and additionally modified with TATp and PEG, with PEG being attached to the liposome surface via both pH-sensitive hydrazone and non-pH-sensitive bonds. The pGFP-loaded liposomal preparations have been administered i...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860701498203
更新日期：2007-08-01 00:00:00
abstract：:Cyclodextrins (CDs) are macrocyclic oligosaccharides composed of α(1,4)-linked glucopyranose subunits. These molecules possess a cage-like supramolecular structure, comparable with the structures of crown ethers, cryptands, spherands, cyclophanes, or calixarenes. However, it took 50 years to establish the molecular st...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.3109/10611861003622552
更新日期：2010-11-01 00:00:00
abstract：:The phenomenal advances in pharmaceutical sciences over the last few decades have led to the development of new therapeutics like peptides, proteins, RNAs, DNAs and highly potent small molecules. Fruitful applications of these therapeutics have been challenged by several anatomical and physiological barriers that limi...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.1080/1061186X.2018.1437919
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:The objective of this work was to examine the application of catechins-containing phospholipids-based ultrasonic microbubbles (PUM) in ultrasound-induced delivery. METHODS:Catechins-containing PUM were prepared by dissolving lyophilized PUM powder in catechins solution. Morphologic characteristics of catechi...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860802475696
更新日期：2008-12-01 00:00:00
abstract：:The human papillomavirus type-16 (HPV-16) E7 protein is considered a major viral oncoprotein involved in cervical cancer (CxCa) and a potential candidate for the development of a vaccine against this neoplasia. Here, two lactic acid bacteria (the model one Lactococcus lactis and a probiotic one Lactobacillus plantarum...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/10611860400024219
更新日期：2005-02-01 00:00:00
abstract：:There are much said about Pieter Cullis in this special volume honoring him. He was the pioneer to study the role of hexagonal HII phase in membrane fusion and the one who applied this concept for the design of lipid nanoparticles. He was also the first to utilize remote loading techniques for the delivery of amphipat...
journal_title：Journal of drug targeting
pub_type： 传,历史文章,杂志文章
doi：10.3109/1061186X.2016.1172590
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:To evaluate the internalization and subcellular fate of AS1411 aptamer (for glioma targeting) and TGN peptide (for blood-brain barrier targeting)-modified nanoparticles (AsTNPs), which was important for optimizing targeted delivery systems and realizing the potential toxicity to cells. METHODS:Organelles were ...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/1061186X.2014.886038
更新日期：2014-06-01 00:00:00
abstract：:Gelatin microspheres (ms) and gelatin/BSA (bovine serum albumin) or gelatin/alginate ms were prepared by encapsulating fluorescein isothiocyanate (FITC) labeled dextran or interferon alpha (IFN-alpha). Ms were obtained by an emulsion-solvent-extraction method. Gelatin and gelatin/BSA ms were obtained by treating water...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611869908996851
更新日期：1999-01-01 00:00:00
abstract：:Despite the advantages of drug delivery through skin, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept known as microneedle was introduced and could be used to pierce effectively to deliver drugs us...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611860903115274
更新日期：2010-01-01 00:00:00
abstract：:Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 thymidine kinase gene (HSV-tk) delivery by retrovirus-producing cells and DNA/liposome complexes for the treatment...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611860008996854
更新日期：2000-01-01 00:00:00
abstract：:Interactions between phosphatidylcholine (PC) or phosphatidylserine (PS) liposomes and human umbilical vein endothelial cells (HUVEC) or human promyelocytic leukemia cells (HL60) were investigated. Pyramine encapsulating or rhodamine incorporating small unilamellar liposomes with mean diameters around 80 nm (demonstra...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611860008997910
更新日期：2000-01-01 00:00:00
abstract：:Nanoparticles have shown great promise in the treatment of cancer, with a demonstrated potential in targeted drug delivery. Among a myriad of nanocarriers that have been recently developed, dendrimers have attracted a great deal of scientific interests due to their unique chemical and structural properties that allow ...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.3109/1061186X.2015.1052077
更新日期：2015-01-01 00:00:00
abstract：:The use of liposomes in the treatment of severe infections is under investigation. Classical liposomes which localize in cells of the mononuclear phagocyte system (MPS) can be exploited in two ways. First for targeting of macrophage modulators such as muramyl peptides or IFN-gamma, to stimulate the cells of the MPS to...
journal_title：Journal of drug targeting
pub_type： 杂志文章,评审
doi：10.3109/10611869408996811
更新日期：1994-01-01 00:00:00
abstract：:Background: Sonodynamic therapy (SDT) has emerged as an alternative to the traditional treatments of cancer. However, the oxygen consumption induced by SDT and glucose oxidase (GOx) mediated starvation therapy would worsen the hypoxic tumor environment, which further impeded therapeutic efficacy. Purpose: To develop a...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.1080/1061186X.2019.1641507
更新日期：2020-02-01 00:00:00
abstract：:Radiolabeled cytochrome c (Cyt c), either as a free protein or as cell penetrating peptide (CPP)-conjugates, was tested for cellular uptake and nuclear transport in Human embryonic kidney 293 (HEK293) cells and HeLa cells. Conjugation of Cyt c with either the amphipathic peptide model amphipathic peptide (MAP) or the ...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/1061186X.2011.649481
更新日期：2012-05-01 00:00:00
abstract：:The objective of this study was to investigate the factors for enhancing the susceptibility of cancer cells to chemotherapeutic drug by ultrasound microbubbles. Ultrasound (US) combined with phospholipid-based microbubbles (MB) was used to enhance the susceptibility of colon cancer cell line SWD-620 to anticancer drug...
journal_title：Journal of drug targeting
pub_type： 杂志文章
doi：10.3109/10611860903434043
更新日期：2010-07-01 00:00:00
