EGFR-targeted immunoliposomes derived from the monoclonal antibody EMD72000 mediate specific and efficient drug delivery to a variety of colorectal cancer cells.

abstract：:Cationic liposomes composed of dialkyl cationic lipid such as 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) can efficiently deliver siRNA to the lungs following the intravenous injection of cationic liposome/siRNA complexes (lipoplexes). In this study, we examined the effect of cationic lipid of cationic liposomes ...

journal_title：Journal of drug targeting

authors： Hattori Y,Nakamura M,Takeuchi N,Tamaki K,Shimizu S,Yoshiike Y,Taguchi M,Ohno H,Ozaki KI,Onishi H

更新日期：2019-02-01 00:00:00

abstract：:Insulin and dexamethasone were encapsulated in poly(lactic-co-glycolic acid) (PLGA) microspheres to induce adipogenesis for potential applications in soft tissue reconstruction. Release kinetics and bioactivity of the drugs were examined. Surface morphology and diameter of the PLGA microspheres was evaluated using sca...

journal_title：Journal of drug targeting

authors： Rubin JP,DeFail A,Rajendran N,Marra KG

更新日期：2009-04-01 00:00:00

abstract：:In order to facilitate the intracellular delivery of macromolecules, Pep-1 peptide-modified liposomal (Pep1-Lipo) nanocarriers were designed and examined for their in vitro cell translocation capability. Pep-1 peptides were coupled via thiol-maleimide linkage to small unilamellar vesicles composed of phosphatidylcholi...

journal_title：Journal of drug targeting

authors： Kang MJ,Kim BG,Eum JY,Park SH,Choi SE,An JJ,Jang SH,Eum WS,Lee J,Lee MW,Kang K,Oh CH,Choi SY,Choi YW

更新日期：2011-08-01 00:00:00

abstract：:Graphene, the mother of all carbon materials, has unlocked a new era of biomedical nanomaterials due to its exceptional biocompatibility, physicochemical and mechanical properties. It is a single atom thick, nanosized, two-dimensional structure and provides high surface area with adjustable surface chemistry to form h...

journal_title：Journal of drug targeting

authors： Madni A,Noreen S,Maqbool I,Rehman F,Batool A,Kashif PM,Rehman M,Tahir N,Khan MI

更新日期：2018-12-01 00:00:00

abstract：:The objective of this study was to estimate the colon-specific delivery of [Asu1,7]-eel calcitonin (ECT) using chitosan capsules in rats. The intestinal absorption of ECT was evaluated by measuring the plasma calcium levels after oral administration of the chitosan capsules containing ECT and different combinations of...

journal_title：Journal of drug targeting

authors： Fetih G,Fausia H,Okada N,Fujita T,Attia M,Yamamoto A

更新日期：2006-04-01 00:00:00

abstract：:We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the twenty-first century. Multiple drug resistance and nonspecific drug targeting of the m...

journal_title：Journal of drug targeting

authors： Baruah UK,Gowthamarajan K,Vanka R,Karri VVSR,Selvaraj K,Jojo GM

更新日期：2017-08-01 00:00:00

abstract：UNLABELLED:Polyethyleneimine (PEI) can be used as a DNA delivery mechanism in cell culture and in vivo. Cells can be transfected by using surface-bound PEI, as well as by PEI/DNA microparticles. In the present experiments we extended these observations by preparing microspheres with covalently attached PEI. Blends of p...

journal_title：Journal of drug targeting

authors： Manuel WS,Zheng JI,Hornsby PJ

更新日期：2001-01-01 00:00:00

abstract：:Toxoplasmic encephalitis (TE) is the most common clinical manifestation of reactivated infection with Toxoplasma gondii in immunocompromised patients that is lethal if untreated. The combination of pyrimethamine plus sulfadiazine or clindamycin is the standard therapy for the treatment of TE, but these combinations ar...

journal_title：Journal of drug targeting

authors： Shubar HM,Lachenmaier S,Heimesaat MM,Lohman U,Mauludin R,Mueller RH,Fitzner R,Borner K,Liesenfeld O

更新日期：2011-02-01 00:00:00

abstract：:Lopinavir (LPV), an efficient drug for HIV infection treatment, was incorporated into biodegradable PLGA nanocapsules (NCs) embedded in microparticles (MCPs) using the spray-drying technique in an attempt to bypass the P-gp efflux and protect the drug from CYP3A pre-systemic metabolism without ritonavir (RTV). SEM obs...

journal_title：Journal of drug targeting

authors： Nassar T,Rohald A,Naraykin N,Barasch D,Amsalem O,Prabhu P,Kotler M,Benita S

更新日期：2019-01-01 00:00:00

abstract：:A simple method for the separation of polyalkylcyanoacrylate nanoparticles was developed using polyisohexylcyanoacrylate (PIHCA) as a model. Fluorescein isothiocyanate dextran 70 was used to label the nanoparticles. Ultracentrifugation onto a performed sucrose gradient allowed the easy elimination of the dextran and o...

journal_title：Journal of drug targeting

authors： Pinto-Alphandary H,Balland O,Couvreur P

更新日期：1995-01-01 00:00:00

abstract：:Radiolabelled poly(methylmethacrylate) (PMMA) nanoparticles were coated with rat serum albumin (RSA), serum and inactivated serum, to examine the influence of these blood components on the body distribution of a model colloidal drug carrier. The particles were incubated overnight at 37 degrees C either in a 1% solutio...

journal_title：Journal of drug targeting

authors： Borchard G,Kreuter J

更新日期：1993-01-01 00:00:00

abstract：:beta-Glucuronidase (GUSB) is a lysosomal enzyme that could be developed as a brain therapy for Type VII Mucopolysaccharidosis. However, GUSB does not cross the blood-brain barrier (BBB). To enable BBB transport of the enzyme, human GUSB was re-engineered as a fusion protein with the chimeric monoclonal antibody (MAb) ...

journal_title：Journal of drug targeting

authors： Boado RJ,Pardridge WM

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:DNA hybridization allows the preparation of nanoscale DNA structures with desired shape and size. DNA structures using simple base pairing can be used for the delivery of drug molecules into the cells. Since DNA carries multiple negative charges, their cellular uptake efficiency is low. Thus, the modificatio...

journal_title：Journal of drug targeting

authors： Akkus Sut P,Tunc CU,Culha M

更新日期：2016-09-01 00:00:00

abstract：:DNA nanoparticles (DNA NPs), which self-assemble from DNA plasmids and poly-L-lysine (pLL)-polyethylene glycol (PEG) block copolymers, transfect several cell types in vitro and in vivo with minimal toxicity and immune response. To further enhance the gene transfer efficiency of DNA NP and control its tropism, we estab...

journal_title：Journal of drug targeting

authors： Sun W,Fletcher D,van Heeckeren RC,Davis PB

更新日期：2012-09-01 00:00:00

abstract：:Finding adequate carriers for proteins/peptides and anticancer drugs delivery has become an urgent need, owing to the growing number of therapeutic macromolecules and the increasing amount of cancer incidence. Polysaccharide-based nanogels have attracted interest as carriers for proteins/peptides and anticancer drugs ...

journal_title：Journal of drug targeting

authors： Zhang L,Pan J,Dong S,Li Z

更新日期：2017-09-01 00:00:00

abstract：:An in vivo study has been performed in order to determine the influence of amphotericin B (AMB) molecular organization on the toxicity and activity of this drug in the treatment of experimental visceral leishmaniasis. Three formulations with similar composition but different drug molecular self-association in aqueous ...

journal_title：Journal of drug targeting

authors： Sánchez-Brunete JA,Dea MA,Rama S,Bolás F,Alunda JM,Torrado-Santiago S,Torrado JJ

更新日期：2004-01-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) expression has been shown to be increased in several types of human tumours. In this study, for the imaging of HER2-related tumours, a modified RNA aptamer with HER2-specific targeting was labelled with (99m)Tc, by using hydrazino nicotinamide (HYNIC) as the chelator in ...

journal_title：Journal of drug targeting

authors： Varmira K,Hosseinimehr SJ,Noaparast Z,Abedi SM

更新日期：2014-02-01 00:00:00

abstract：:Previous studies indicated the potential of zinc protoporphyrin (ZnPP) as an antitumor agent targeting to the tumor survival factor heme oxygenase-1, and/or for photodynamic therapy (PDT). In this study, to achieve tumor-targeted delivery, styrene-maleic acid-copolymer conjugated ZnPP (SMA-ZnPP) was synthesized via am...

journal_title：Journal of drug targeting

authors： Fang J,Tsukigawa K,Liao L,Yin H,Eguchi K,Maeda H

更新日期：2016-01-01 00:00:00

abstract：:Pathophysiological molecules in the extracellular environment offer excellent targets that can be exploited for designing drug targeting systems. Matrix metalloproteases (MMPs) are a family of extracellular proteolytic enzymes that are characterized by their overexpression or overactivity in several pathologies. Over ...

journal_title：Journal of drug targeting

authors： Vartak DG,Gemeinhart RA

更新日期：2007-01-01 00:00:00

abstract：:Gelatin microspheres (ms) and gelatin/BSA (bovine serum albumin) or gelatin/alginate ms were prepared by encapsulating fluorescein isothiocyanate (FITC) labeled dextran or interferon alpha (IFN-alpha). Ms were obtained by an emulsion-solvent-extraction method. Gelatin and gelatin/BSA ms were obtained by treating water...

journal_title：Journal of drug targeting

authors： Yoshikawa Y,Komuta Y,Nishihara T,Itoh Y,Yoshikawa H,Takada K

更新日期：1999-01-01 00:00:00

abstract：:Anionic, cationic, and neutral liposomes were constructed to contain IL-2 in order to evaluate their affinity to a cervical cancer cell line (INBL) and to determine whether they can present IL-2 on their external surface. When these liposomes were co-cultured with INBL, the anionic liposomes were the only ones found t...

journal_title：Journal of drug targeting

authors： Corona-Ortega T,Rangel-Corona R,Hernández-Jiménez M,Baeza I,Ibáñez M,Weiss-Steider B

更新日期：2009-08-01 00:00:00

abstract：:Tissue factor (TF) is aberrantly expressed on tumor vascular endothelial cells (VECs) and on cancer cells in many malignant tumors, but not on normal VECs, making it a promising target for cancer therapy. As a transmembrane receptor for coagulation factor VIIa (fVIIa), TF forms a high-affinity complex with its cognate...

journal_title：Journal of drug targeting

authors： Shoji M,Sun A,Kisiel W,Lu YJ,Shim H,McCarey BE,Nichols C,Parker ET,Pohl J,Mosley CA,Alizadeh AR,Liotta DC,Snyder JP

更新日期：2008-04-01 00:00:00

abstract：:In this study, folate receptor (FR) targeted liposome microbubbles loaded with oridonin (ORI) (F-LMB-ORI), liposome loaded with ORI (L-ORI) and liposome microbubbles loaded with ORI (LMB-ORI) were prepared. In vitro release properties, cellular uptake and cytotoxicity in HepG-2 cells as well as in vivo antitumor effec...

journal_title：Journal of drug targeting

authors： Wang C,Li W,Hu B

更新日期：2017-01-01 00:00:00

abstract：:Cytokine inhibiting drugs are much more effective when delivered intracellularly to phagocytic cells in the microencapsulated form. Dexamethasone is a powerful inhibitor of TNF-α cytokine through inhibition of NF-κB which is a gene regulator of multiple pro-inflammatory cytokines. We have determined the effect of micr...

journal_title：Journal of drug targeting

authors： Uddin MN,Siddiq A,Oettinger CW,D'Souza MJ

更新日期：2011-11-01 00:00:00

abstract：:Nanostructured lipid carrier (NLC) is second generation smarter drug carrier system having solid matrix at room temperature. This carrier system is made up of physiological, biodegradable and biocompatible lipid materials and surfactants and is accepted by regulatory authorities for application in different drug deliv...

journal_title：Journal of drug targeting

authors： Iqbal MA,Md S,Sahni JK,Baboota S,Dang S,Ali J

更新日期：2012-12-01 00:00:00

abstract：:Cell-penetrating peptides (CPPs) are efficient vehicles to transport bioactive molecules into the cells. Despite numerous studies the exact mechanism by which CPPs facilitate delivery of cargo to its intracellular target is still debated. The current work presents methods that can be used for tracking CPP/pDNA complex...

journal_title：Journal of drug targeting

authors： Pärnaste L,Arukuusk P,Zagato E,Braeckmans K,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：:Highly lipophilic antitumor agent, palmitoyl rhizoxin (RS-1541), was incorporated into stable lipid emulsions about 100-1000nm in mean diameter consisting of triglyceride ODO and surfactant HCO-60. The pharmacokinetics of RS-1541 were studied after i.v. injection in mice, rats, rabbits, and dogs. Dog showed characteri...

journal_title：Journal of drug targeting

authors： Kurihara A,Shibayama Y,Kasuya A,Ikeda M,Hisaoka M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Nanoparticles with controlled physical properties have been widely used for controlled release applications. In addition to shape, the anisotropic nature of the particles can be an important design criterion to ensure selective surface modification or independent release of combinations of drugs. PURPOSE:El...

journal_title：Journal of drug targeting

authors： Rahmani S,Villa CH,Dishman AF,Grabowski ME,Pan DC,Durmaz H,Misra AC,Colón-Meléndez L,Solomon MJ,Muzykantov VR,Lahann J

更新日期：2015-01-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) is the only FDA approved medical treatment for the ischaemic stroke. However, it associates with some inevitable limitations, including: short therapeutic window, extremely short half-life and low penetration in large clots. Systemic administration may lead to complications such as h...

journal_title：Journal of drug targeting

authors： Zamanlu M,Farhoudi M,Eskandani M,Mahmoudi J,Barar J,Rafi M,Omidi Y

更新日期：2018-02-01 00:00:00

abstract：:Herein, we report the effect of gold nanoparticles (AuNP) and n-acetylcysteine (NAC) isolated or in association as important anti-inflammatory and antioxidant compounds on brain dysfunction in septic rats. Male Wistar rats after sham operation or caecal ligation and perforation (CLP) were treated with subcutaneously i...

journal_title：Journal of drug targeting

authors： Petronilho F,Tenfen L,Della Giustina A,Joaquim L,Novochadlo M,de Oliveira Junior AN,Bagio E,Goldim MPS,de Carli RJ,Bonfante SRSA,Metzker KLL,Muttini S,Dos Santos TM,de Oliveira MP,Engel NA,Rezin GT,Kanis LA,Barichello T

更新日期：2020-04-01 00:00:00