Expression of the iron-activated nspA and secY genes in Neisseria meningitidis group B by Fur-dependent and -independent mechanisms.

Abstract:

:Our whole-genome microarray studies of Neisseria meningitidis MC58 previously identified a set of 153 genes whose transcription was activated during growth in iron. In this study, Fur-mediated regulation of the iron-activated nspA gene was confirmed, whereas iron-activated regulation of the secY gene was demonstrated to be Fur independent. Analysis of the Fur binding sequences in the nspA gene and an additional iron-activated and Fur-regulated gene identified a hexameric (G/T)ATAAT unit in the operator regions of these genes similar to that observed in Fur- and iron-repressed genes. These studies indicate that the expression of the iron-activated nspA and secY genes in N. meningitidis occur by Fur-dependent and -independent mechanisms, respectively.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Shaik YB,Grogan S,Davey M,Sebastian S,Goswami S,Szmigielski B,Genco CA

doi

10.1128/JB.01638-06

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

663-9

issue

2

eissn

0021-9193

issn

1098-5530

pii

JB.01638-06

journal_volume

189

pub_type

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