Radiation sensitivity of Haemophilus influenzae: a composite response.

Abstract:

:The survival of ultraviolet (UV)-irradiated cultures of Haemophilus influenzae Rd is determined by at least two responses: (i) excision-repair ability and (ii) UV-induced cell lysis. An UV-resistant mutant, BC200, has the same capabilities as the wild type, Rd, for excising dimers but does not exhibit lysis. Lytic response is dose-dependent. Relative to the wild type, a lower dose of UV causes lysis of a UV-sensitive mutant, BC100, which is incapable of excising thymine dimers. A lytic protein is present in cultures undergoing lysis. Synthesis of this protein is initiated 45 to 60 min after irradiation. Lysis appears to be due to derepression of a defective prophage which codes for an endolysin-like lytic enzyme.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Barnhart BJ,Cox SH

doi

10.1128/JB.103.1.9-15.1970

subject

Has Abstract

pub_date

1970-07-01 00:00:00

pages

9-15

issue

1

eissn

0021-9193

issn

1098-5530

journal_volume

103

pub_type

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