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Exhaled nasal nitric oxide output is reduced in humans at night during the sleep period.

Abstract：

:The physiologic function of nasal nitric oxide (NO) release is unknown. In prior experiments, topical NG-nitro-L-arginine methyl ester (L-NAME) on nasal mucosa reduced exhaled nasal NO output and caused daytime sleepiness. We hypothesized that nasal NO output is reduced at night during the sleep period. We measured exhaled nasal NO concentration and minute ventilation and calculated nasal NO output in humans over 24 h. Daytime awake NO output was greater than NO output at night during sleep or transient wakefulness. Exhaled NO concentration decreased during sleep along with minute ventilation. A daytime voluntary reduction in minute ventilation also decreased nasal NO output but exhaled NO concentration increased. Nasal NO output was not changed by body position. We conclude that exhaled nasal NO output is decreased at night due to decreased mass flow of NO into nasal air in addition to decreased minute ventilation. Our findings suggest a role of nasal NO in sleep or in the physiologic processes accompanying sleep.

journal_name

Respir Physiol Neurobiol

journal_title

Respiratory physiology & neurobiology

authors

O'Hearn DJ,Giraud GD,Sippel JM,Edwards C,Chan B,Holden WE

doi

10.1016/j.resp.2006.08.002

subject

Has Abstract

pub_date

2007-04-16 00:00:00

pages

94-101

issue

1

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(06)00226-6

journal_volume

156

pub_type

杂志文章

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