Epidemiological and immunological reasons for pertussis vaccination in adolescents and adults.

Abstract:

:The resurgence of pertussis has been the subject of considerable debate. Hypotheses to explain increased reporting in developed countries have focused mainly on three aspects: (1) increased recognition of the disease in adolescents and adults; (2) waning of vaccine-induced immunity and (3) loss of vaccine efficacy due to an antigenic shift of Bordetella pertussis. Waning immunity after vaccination or natural infection combined with the absence of regular boosters either in the form of vaccine boosters or natural exposure to B. pertussis - due to the low circulation of the bacterium in well-immunized populations - has been suggested to explain this shift in the age distribution of pertussis. The highest incidence of the disease is currently reported among adolescents and adults who may additionally serve as the source of infection for susceptible infants. Immunological and epidemiological data indicates the need for a universal booster vaccination against pertussis for adolescents and adults.

authors

Nitsch-Osuch A,Korzeniewski K,Kuchar E,Zielonka T,Życińska K,Wardyn K

doi

10.1016/j.resp.2013.02.007

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

99-103

issue

1

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(13)00038-4

journal_volume

187

pub_type

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